LabAutomation 2006 - SLAS
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LabAutomation 2006 - SLAS

LabAutomation 2006 - SLAS LabAutomation 2006 - SLAS

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LabAutomation2006 4:30 pm Monday, January 23, 2006 Track 3: High-Throughput Technologies Room: Learning Center Wyndham Palm Springs Hotel Lara Marchetti Co-Author(s) Greiner Bio-One GmbH Frickenhausen, Germany N. Gottschlich, Greiner Bio-One GmbH lara.marchetti@gbo.com R. Ehret, BIONAS GmbH Non-Invasive, Label-Free, Microsensor-Based Cellular Analyzing System for 96- and 384-Well Plates Screening of new pharmaceuticals has been strongly driven by the need to test thousands of novel compounds against an increasing number of drug targets to select new classes of substances. BIONAS and Greiner Bio-One have established a unique non-invasive and label-free microsensor-based system for cellular assays, rapid detection of cytotoxic effects and pharmacological studies. InterDigitated Electrode Structures [IDES] located on the bottom of either 96 or 384 well plates are used for impedance measurements to monitor cell adhesion, morphology and cell-to-cell contact. The presence of intact cell membranes on the electrodes has a direct impact on the current flow (

Where Laboratory Technologies Emerge and Merge 11:00 am Tuesday, January 24, 2006 Track 3: High-Throughput Technologies Room: Learning Center Wyndham Palm Springs Hotel Laurent Martin Co-Author Takeda San Diego, Inc. John Palan San Diego, California laurent.martin@takedasd.com Takeda San Diego Approaches Required When Developing a Very High-Throughput Automated Crystallography System This presentation will discuss the technical challenges faced when implementing very high throughput crystallography (VHTC) infrastructure. An overall review of the commercial systems currently available for low to medium throughput operations will provide a lens to compare technological and operational alternatives that system designers and scientists face implementing automated crystallography system. VHTC requires a fundamental organizational commitments that encompasses multiple scientific functions which needs to be efficiently coordinated through a streamlined informatics infrastructure. Although each biotech and pharmaceutical company faces unique technological challenges in supporting its science, the systematic analytical process required to “industrialize” a scientific process is similar. Takeda through its acquisition of Syrrx has unique perspective on the operational hurdles that emerge when daily throughput needs to be expanded by a 50-fold factor. 11:30 am Tuesday, January 24, 2006 Track 3: High-Throughput Technologies Room: Learning Center Wyndham Palm Springs Hotel Stan Martens GlaxoSmithKline stan.f.martens@gsk.com Issues and Aspects of Integration Into a Drug Discovery Research Facility at GSK In this talk, we will discuss some of the concepts that were used to optimize the screening processes at GlaxoSmithKline’s Upper Providence Drug Discovery Research and Automation Facility. Aspects will highlight various facets such as our efforts to streamline the assay to screen process, the integration of compound handling with screening activities as well as the philosophy applied to automation of screening and compound profiling. 75

<strong>LabAutomation</strong><strong>2006</strong><br />

4:30 pm Monday, January 23, <strong>2006</strong> Track 3: High-Throughput Technologies Room: Learning Center<br />

Wyndham Palm Springs Hotel<br />

Lara Marchetti<br />

Co-Author(s)<br />

Greiner Bio-One GmbH<br />

Frickenhausen, Germany<br />

N. Gottschlich, Greiner Bio-One GmbH<br />

lara.marchetti@gbo.com<br />

R. Ehret, BIONAS GmbH<br />

Non-Invasive, Label-Free, Microsensor-Based Cellular Analyzing System for 96- and<br />

384-Well Plates<br />

Screening of new pharmaceuticals has been strongly driven by the need to test thousands of novel compounds against an increasing<br />

number of drug targets to select new classes of substances.<br />

BIONAS and Greiner Bio-One have established a unique non-invasive and label-free microsensor-based system for cellular assays, rapid<br />

detection of cytotoxic effects and pharmacological studies. InterDigitated Electrode Structures [IDES] located on the bottom of either 96 or<br />

384 well plates are used for impedance measurements to monitor cell adhesion, morphology and cell-to-cell contact. The presence of intact<br />

cell membranes on the electrodes has a direct impact on the current flow (

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