LabAutomation 2006 - SLAS

Where Laboratory Technologies Emerge and Merge
11:00 am Monday, January 23, 2006 Track 3: High-Throughput Technologies Room: Learning Center
Wyndham Palm Springs Hotel
Stefan Werner
University of Pittsburgh
Pittsburgh, Pennsylvania
stw15@pitt.edu
From Chemical Methodologies to Library Development: Design, Synthesis and
Biological Evaluation of Small Molecule Libraries in the UPCMLD
The University of Pittsburgh Center for Chemical Methodologies and Library Development (UPCMLD) applies methodologies that were
developed in our Department to library synthesis. Library compounds are screened in biological assays and all results are made accessible
to the scientific community.
This talk will focus on examples from several mid-size solution phase small molecule libraries. E-alkene and cyclopropyl dipeptide isosteres
will be discussed as well as the synthesis of novel heterocycles via transition metal catalyzed carbon-carbon bond forming reactions.
Skeletal diversity is introduced by the choice of the metal catalyst or by the order of reagents. Microwave assisted organic synthesis, polymer
bound reagents, scavenging techniques and SPE play an important role in the automated synthesis of the presented compound libraries.
11:30 am Monday, January 23, 2006 Track 3: High-Throughput Technologies Room: Learning Center
Wyndham Palm Springs Hotel
Jeffrey Noonan
Neurogen Corporation
Branford, Connecticutt
jnoonan@nrgn.com
Advancing Drug Discovery Through Integrated Parallel Solution Phase Library Synthesis
Automated library synthesis has become an essential component in modern drug discovery efforts supporting a spectrum of activities
from file enrichment through lead optimization. Common to each pursuit is the aspiration to advance the pace of drug discovery by offering
an unprecedented combination of synthesis speed, value, and quantity. To meet these challenges, the Neurogen High Speed Synthesis
(HSS) group strategy focuses on the continuing creation and characterization of chemical libraries using parallel solution phase techniques.
Central to our effort is a collection of novel workstations that are tightly integrated into our informatics architecture supporting the efficient
movement of library samples and data. Ultimately, our pragmatic approach facilitates synthesis throughput and the utilization of equipment,
creating a cost effective library production environment.
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