LabAutomation 2006 - SLAS

TP93
Holger Gumm
Sepiatec GmbH
Berlin, Germany
hgumm@sepiatec.com
LabAutomation2006
Fast Chiral Column Screening and Evaluation With the CCS Wizard
Quick chiral column screening has become an increasing challenge for all pharmaceutical companies. The Sepmatix System offers
unsurpassed quick screening for the optimal column/mobile phase combination for separation of enantiomers. Up to 8 different columns
can be screened in parallel with mixtures of up to 24 different solvents and under different temperatures. This parallel chromatography
approach considerably speeds up method development for optimal separation of chiral compounds, normally a tedious and time
consuming process.
To circumvent this bottleneck, the patented Sepmatix 8x FlowControl splits the flow from one HPLC pump onto 8 columns, ensuring the
same flow rate in each parallel channel even with individual column back pressures differing as much as 1450 psi. The new Sepmatix 8x
ColumnOven allows individual temperature regulation for each column and thereby simultaneous temperature screening. This unique 8-fold
parallel chiral column screening yields the chromatography data of a working week in less than one day.
Quick data evaluation is imperative, so Sepiatec has recently launched an upgraded version of its proprietary software with several
innovative features: The new Sepmatix CCS Wizard shows up to 80 different chromatograms on one screen. All chromatograms can be
checked at a glance, easily re-integrated if necessary and ranked according to e.g. selectivity, capacity and resolution. Printouts of the
chromatograms containing all essential parameters allow quick identification and documentation of the optimal separation conditions for
chiral samples.
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