LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
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TP59<br />
Tia Smallwood<br />
CerionX<br />
Pennsauken, New Jersey<br />
tia_smallwood@cerionx.com<br />
Where Laboratory Technologies Emerge and Merge<br />
Co-Author<br />
Paul Hensley<br />
Cerionx<br />
Using Plasma Technology to Clean Pipettes: Analysis of Bacteria and Yeast Removal<br />
The use of automated liquid handling devices in diagnostic, forensic, and general laboratory operation has made quantitative studies<br />
much more rapid and reliable. Despite recent advances in assay technology, most such procedures still require at least one liquid transfer<br />
operation. The liquid handling system must be able to change a disposable tip or exhaustively wash the cannula or pin tool used in the<br />
transfer operation. Plasma technology has been shown to be a reliable alternative to the more typical tip wash or replacement techniques<br />
currently used with automated liquid handling devices throughout the biopharmaceutical and diagnostic industries. In this presentation,<br />
we will discuss the efficacy of The TipCharger System by Cerionx in the elimination of bacteria and yeast from disposable polypropylene<br />
pipette tips as well as pin tools. A two-dimensional matrix relating initial live cell concentration to cleaning time (i.e. plasma exposure) and<br />
quantitative data further validating the cleaning protocol will be presented.<br />
TP60<br />
N Somasiri<br />
3M Company<br />
Austin, Texas<br />
nlsomasiri@mmm.com<br />
Co-Author(s)<br />
Robert Wilson<br />
Moses David<br />
Steven Johnson<br />
Mark Richmond<br />
Paul Huynh<br />
Enabling Technologies for High Throughput Fabrication of Polymer Microfluidic Devices<br />
with Integrated Metal Electrodes<br />
Due to the emergence of point-of-care diagnostics, the demand for polymer based microfluidic devices is expected to rise very rapidly<br />
over the next few years. Polymer based devices offer significant advantages in design flexibility, ease of fabrication and ultimately the<br />
low cost solution for disposable biochips. During the past few years, significant attention has been focused on electrochemical methods<br />
for developing more accurate, fast and reliable detection systems. In this poster, we will present some of the enabling technologies that<br />
are required to develop such systems for high throughput manufacturing. These technologies involve flexible circuitry, polymer substrate<br />
patterning, surface modification and coverlay structures. Flexible circuit fabrication methods have been used to pattern inert metal<br />
electrodes with microfluidic channels. Polymeric substrates have been used to form various microfluidic channels and reservoir structures<br />
by using wet chemical processes. The surface of the polymer channels has been modified to impart hydrophilic and hydrophobic<br />
properties. Polymer coverlay materials have been used to seal the microfluidic channels. The electrochemical test results of a prototype<br />
device that demonstrates the viability of these technologies will also be presented.<br />
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