LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
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TP57<br />
Darcy Shave<br />
Waters Corporation<br />
Milford, Massachusetts<br />
darcy_shave@waters.com<br />
<strong>LabAutomation</strong><strong>2006</strong><br />
Co-Author(s)<br />
Warren Potts<br />
Michael D. Jones<br />
Paul Lefebvre<br />
Rob Plumb<br />
System Management Tools for a High Throughput Open Access UPLC/MS System<br />
Used During the Analysis of Thousands of Samples<br />
Many compound libraries contain compounds which were synthesized several years prior or obtained from outside resources. It is<br />
important that the expected composition of each compound be confirmed. LC/MS has become the standard technique for confirming<br />
the purity of a compound which has demonstrated activity in a biological screen. If unchecked, inaccurate structures, impurities and<br />
degradants can lead to incorrect physicochemical property results. Because these libraries may contain thousands, if not millions, of<br />
compounds, an open access UPLC/MS system was investigated for this high throughput library QC.<br />
Due to the large amount of data generated, a new software package was created which facilitated the administration of this open access<br />
system. It created new project directories for the open access users and moved the resulting project data (such as raw data files) across<br />
the network as it was created. Data processing could then be done on a separate dedicated computer. The software also monitored the<br />
instrument PC, providing on-the-fly information about its status and the status of its sample queue from a centralized location.<br />
TP58<br />
Stephen Skwish<br />
Merck & Company Inc.<br />
Rahway, New Jersey<br />
stephen_skwish@merck.com<br />
Co-Author<br />
Don Conway<br />
Merck & Co., Inc.<br />
Integrating a Matrix 2X2 with A Tecan Genesis System<br />
The matrix 2X2 can be configured with either a 96 or 384-well head using disposable tips or a 384 syringe head. However, there is no<br />
native integration from Matrix into a fully automated plate handling system, incubation or plate readers. We designed and implemented a<br />
fully automated system incorporating a Tecan Genesis for plate handling, a Heraeus Cytomat 6000 incubator and a BioTek PowerWaveHT<br />
as an absorbance reader. Tecan’s software FACTs was used as the scheduler and custom drivers were designed and written for the<br />
PowerWaveHT and the Matrix 2X2 utilizing Matrix’s ControlMate OLE component for communication with the instrument. All custom tables<br />
and deck layouts were made in house.<br />
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