LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
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TP49<br />
Michael Raimo<br />
Arqule Inc.<br />
Woburn, Massachusetts<br />
mraimo@arqule.com<br />
<strong>LabAutomation</strong><strong>2006</strong><br />
Automated Centralized Solvent Delivery/ Waste Removal System<br />
Automated parallel synthesis is a widely adopted approach, able to generate large numbers of small organic molecules for high throughput<br />
screening. Most synthetic reactions require a work-up to achieve a suitable compound purity to ensure reliable results from biological<br />
assays. Due to the broad range of polarity and large diversity of molecules encountered in early discovery, RP-HPLC with MS detection has<br />
become the most commonly used technology for the preparative separation and analytical characterization of such molecules. In a high<br />
throughput operation where hundreds of thousands of molecules are synthesized annually, this process requires an effective infrastructure<br />
to deliver the significant amounts of organic solvents and remove waste. This presentation will detail how we acomplished this task by<br />
installing an automated, centralized solvent delivery and waste removal system with multiple distribution points throughout our 125,000<br />
sq. ft. facility. An account of the benefits of installing a gravity fed system, such as significantly reducing the amount of gas dissolved in the<br />
solvents and reduced operator dependency will be included.<br />
TP50<br />
Charles Reichel<br />
EDC Biosystems<br />
San Jose, California<br />
creichel@edcbiosystems.com<br />
Co-Author(s)<br />
Michael Forbush<br />
Humphrey Chow<br />
James Chiao<br />
Andrew Rose<br />
Non-Invasive Fluid Property Measurements Using Acoustic Methods<br />
The properties of a fluid are normally determined using invasive methods. These methods may lead to possibly contaminating or<br />
consuming the sample. When only very small amounts of a valuable sample exist non-invasive measurement methods are preferred. The<br />
properties of fluids can then be used to deduce additional properties based on known relationships. In one case the surface tension of a<br />
fluid may be used to determine the concentration of a fluid. We describe a measurement technique involving excitation of the surface of the<br />
fluid and the measurement of its response. An acoustic wave is used to both excite and monitor the surface of the liquid. This technique is<br />
employed in determining the concentration of DMSO and water in solution and the result determines the amount of fluid needed to deliver<br />
an accurate amount of solute in solution.<br />
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