LabAutomation 2006 - SLAS

TP03
Donat Elsener
REMP AG
CH-3672 Oberdiessbach,
Switzerland
donat.elsener@remp.com
Where Laboratory Technologies Emerge and Merge
Co-Author
Michael Girardi
REMP
Centralized vs. Multi-Site Compound Management
The cost of drug development has soared over the last decades, as well as, the efforts into sales and marketing of the end-product drugs.
Companies realize that the larger they are the easier it is to bare large investments and leverage their marketing activities. In order to
maximize return-on-investment, the companies are engaging in continuous merging activities. Life Science Research companies, nowadays,
consist of multiple R&D sites distributed all around the world. Individual sites often work on dedicated targets or on specific therapeutic areas
with synergies generated through access to each others research results. In order to maximize global research effectiveness, all research
scientists need an overview and physical access to the entire compound collection of independently built up libraries.
TP04
Nancy Elser
Eksigent Technologies
Dublin, California
nelser@eksigent.com
Co-Author(s)
Ring-Ling Chien
David Rakestraw
Eksigent Technologies
David Emlyn Hughes
Chromatographic Excellence
Method Development of Liquid Chromatographic Procedures for Pharmaceutical
and Biotechnological Entities by Use of the ExpressLC-800 Multi-channel Capillary
LC System
Liquid chromatographic (LC) development of methods for conventional and proteineous drug analysis is a time-consuming but critical
task. Development of a method without sufficient experimentation to produce optimized selectivity often causes significant problems at
some time in the drug development cycle. A method development chemist would ideally study a number of column stationary and mobile
phase conditions and choose the stationary/mobile phase combination that optimizes both resolution of important species and method
robustness. Such an extensive study with conventional LC is often impractical, since investigating multiple chromatographic conditions
requires time-consuming column exchanges and re-equilibrations. Computer-assisted column switching requires extensive re-equilibration
times and often produces unreliable results. Multi-channel capillary LC method development will be shown to generate an extensive set of
chromatograms whereby determination of the most selective separatory conditions can be made. In this presentation, a capillary LC with
eight independent channels (the ExpressLC-800) will be used to produce sample separations with eight columns, four pH conditions and
optimized gradient endpoints; typically, within four hours. The instrument provides method development data quickly by performing eight
separations simultaneously on a capillary LC system that produces high-resolution separations and requires very short re-equilibration times.
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