LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
LabAutomation 2006 - SLAS
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
TP01<br />
Marc Pfeifer<br />
Roche Molecular Systems, Inc.<br />
Pleasanton, California<br />
marc.pfeifer@roche.com<br />
<strong>LabAutomation</strong><strong>2006</strong><br />
Co-Author(s)<br />
Josh Weinberger<br />
Dan Bristol<br />
Mike Takeuchi<br />
Paulette Thomas<br />
Imre Trefil<br />
Jon Nunes<br />
LeadStream – Galileo Integration Yields a Complete Process and Results Management<br />
Solution for ADME/Tox<br />
LeadStream is a fully integrated ADME/Tox screening solution, that combines role-specific automation for sample distribution and preparation,<br />
integrated LC/MS for analysis, and orchestration software for coordination of laboratory workflow. A LeadStream implementation is able<br />
to simplify the entire testing process from request to result, including end-to-end data tracking, automated data reduction and reporting.<br />
Recently LeadStream has been integrated with Galileo, a purpose built ADME/Tox LIMS designed to enhance the manual process of data<br />
analysis, review and approval. The combined workflow of these two products provides a significant improvement in data quality, processing<br />
time, and results reporting for a range of Tier 1 and Tier 2 ADME/Tox Screens.<br />
TP02<br />
Richard Ellson<br />
Labcyte<br />
Sunnyvale, California<br />
ellson@labcyte.com<br />
Co-Author(s)<br />
Jean Shieh, Labcyte Inc.<br />
Joseph Olechno<br />
Using Acoustic Droplet Ejection for Aqueous Samples – The Transfer of Bovine Serum<br />
Albumin Solutions and the Effect of Salt Concentrations<br />
We show the application of acoustic droplet ejection (ADE) to the transfer of protein solutions. Effects of buffer concentrations to ADE are<br />
measured and discussed. Precision and accuracy of transferring 5-100nL fluorescein-doped bovine serum albumin (BSA) droplets are<br />
measured with fluorescence. We show the effects on ADE of varying concentrations of different typical biological additives that are known to<br />
change viscosity and surface tension. We illustrate that ADE is only mildly affected by these changes in fluid viscosity and surface tension.<br />
The ability to precisely place sample droplets of protein solution on a solid surface or in a well significantly expands potential applications.<br />
We will show examples of arrays of nanoliter droplets of protein solutions on surfaces.<br />
152
Change language