LabAutomation 2006 - SLAS

MP79
Angelo Trivelli
J Craig Venter Institute
Rockville, Maryland
atrivelli@venterinstitute.org
LabAutomation2006
Co-Author(s)
Saul Kravitz
Indresh Singh
Christopher Lemieux
Peter Davies
Tom Dolafi
Bryan Yu
Adam Resnick
LIMS for a High Throughput Sequencing Facility: Instrument Integration
The J. Craig Venter Institute Joint Technology Center is a high throughput DNA sequencing facility. We have implemented a highly
adaptable LIMS that integrates fluid-handling robots, sequencers, barcode equipment, PDA’s, and workstations. Integration of all of these
devices is a challenge, requiring inter-operation with a variety of instrument protocols and interfaces. These interfaces range from simple
“file-based” data exchange all the way to more elaborate process control and monitoring using J2EE- or COM-based technologies. This
presentation will highlight the challenges presented by instrument integration, and the approaches and frameworks used to address these
challenges.
MP80
Han-Kuan Tsai
University of California, Irvine
Irvine, California
tsaih@uci.edu
Co-Author(s)
Kuo-Sheng Ma
Han Xu
Lawrence Kulinsky
Marc Madou
University of California, Irvine
Development of Integrated Protection for Implantable Controlled Drug Release Systems
The most common drug delivery methods are swallowing pills or receiving injections. However, precise control of the medication amount
and release rate is still problematic. The proposed implantable device includes independent energy source, sensors, actuator valves, and
drug storage reservoirs provide an alternative method for the responsive drug delivery system. In order to achieve responsive drug delivery,
a reliable release device (e.g., a valve) has to be developed.
A bi-layer structure where one layer is a thin metal film, functioning as a structural layer and a working electrode, and the other layer is a
polypyrrole (PPy) film electrochemically deposited on the working electrode was developed as a valve. The actuation mechanism of the
valve is based on ions flow in and out of the polypyrrole film upon oxidization and reduction. The voltage applied for actuation is less than
1 V and the current is lower than 1 mA for an actuator with a flap area of 0.04 mm2. An idea is proposed to simultaneously fabricate the
device reservoirs as well as protective packaging that will guarantee that valve actuation won’t be affected by the surrounding tissues.
A piece of PDMS with an array of reservoirs has been molded and sealed on the substrate to cover the flap. The testing platform with a
channel and two reservoirs is fabricated on an acrylic chip to test the efficiency of the valve opening. It is believed that this novel integration
can enhance a functional drug delivery device.
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