Bioidentical Hormones - U.S. Senate Special Committee on Aging

RISKS AND BENEFITS OF ESTROGEN PLUS PROGESTIN
167
ment recommnendations for healthy post- Author Coetetbotf ... DrAnderon,. a
menopausal
-ponopal sity, Chieogn/E.nenton,
women It: and
with
Robedt Wafoace,
an
Uni-
intact iervesgotor of tre Worrrrn
Conrdiating
Health Initiatnve
Center. hudsU
Chinscal
arenssto
versty of
the
Iowa.
datate.
I-w
the
City/Daerrpsl
Sian. toquEs
Progarr
R. Ilssom
Of.
Nationa f-ear,
uterus.
Lung, and
This trial did not address the stdyand tahesr-ponbdity on thteintegrity of fte
short-termi Blond Instf~t.te
risks and
Clinical C~oodinasrg
benefits of
Center
hor
An-
dots sod rte accurac of rthe data anlyses
Study conept
dt Z. LoC.on.
and denigo,
noon
RosIonun
E, Pattersn,
Anderson,
and Ros L. Prentice,
fed H.isuctin
mones Cance
givenfor Reserrh
the
Cente
treasmentrofsneno- Prentan. Data and Safety Muontltorte Based: Janet Wittls
pausal nymptoms. On she basis ofHlERS Acquislitio
.I
of data:
Kooperbntg
Anderson Preotire,
Stnfasrrck,
LaCrais,
tack-n, tcftelr
BeresO.d.
Eugtene
Howad.
8surood,
cry
Margaret
Cohten. EUleahei
Chenern
Barrtt-Connr,
Hasand
other secondary prevention trials, Doid Detoets.
Jolhmarn Kotchen, Ocleve. ten Darn. fohanna Dwyer, Robert P. Heantey, Victo
the American Heart Association recoin- Analynis and inierpretatn ofdata
mended
RossuorcAndeaginst
iniiating fisimen
Vogei, L.eRoy Waiter,
oe, Pr-nnor
sod toter,
IaCr-c4
YVusuf
mendedagaint
Ropebkeg,tStefanck,lJadnson.
snitaltri postteno- Drafting or
Pond1eglSatpprt
the waecipt Rsoa.Anderse,
The Bahonal
Blond
Heat.t
lnstitstn
Lung,
funds the
and
WHI program. Wyethpausal
hormones for the secondary pre- Prenice
t Ayrrt lR-notcs p-ouded tine study mednacn tavcntio
cadiovasular ventin ofcrdiovscul, of disase."The dsease. The Critcal
inlfertoa
reviooo
cntent:
of the
R.sso-,
--aonyf for
Andersor.
inportant in-
LaCrnis.
tIne and ptocebhuf
American Acbr-otdgrreti
Hearts Associ.ation
The WIl Steeleong
made Coireittee
no t
iKooyedsrtg. Stefani ck. alsn, aerenfonn, Homad, goate~fucknonstedge
the dednatd ryfon of
firm
the
recommendation for prsmary pre- Johnson, Koscien. Oskeon.
Staiissica
WHI
penyetise
poticiponti
Andersn.
and
Prentice,
of key WHI-
Coopeincrstget-r
staff
and
venison while awaiting the
at
results
the danicul
from rnter
berg
aind the Clinical Coodinat-
mg Center A fat Itoting of the W951 roresgaros ai
randomized clinical trials such as WHII, Obtained funding, Ronsoon. Andersn, Prentic,, be fsoond at htrypc/cesw- hi.nrg
and stated that contunuauion of she treat- St1fanok, beresfond, Ho.ard,
Adnrantrac.
Ktother.
tcisnial,
Ockern
or watevel supptn Ron- ___________________
mini should be considered on the ba- snre And-ror, Pretice. L.Criora, loopenberg. REPO~aPCs
sss of established noncoronarv benefists Stefanick. iocksn, tiresford, Howad, lohns..n, 1. The
corcten,
W -nsensHealth
Ockene.
Initiaftiv Stedy Crony D.-
and risks, possibhle coronary beneftss and Studs sopewmion R-ossu, Anderon, loCroin sign of tine Wo-nen Healt Inittonn canica teial and
risks, and patient preference. Stefa-icti, Jackso, Oeresfod, Howard, sohnso obeco1 nl tdr1otolCi
Results ros9sat
from XVrHI indicate that the Ktotcn "Orline. 1. O nf9 MCIl .E~e p-~
combbsned postmsneoopuLhomne .Stefonoc Ictrint. Stanfond Center, for
pausal hor
fRech in th-rpyiandcnrnay
namones eton
hseatdoresn.
Safod
aq-athtuWn
nnrit.
a-
eono
CEE,
.
0.625
sensnent
mg/d,
of
plus
the
MPA,
rdenpid
2.5
olo
mg/d, evidenc
Di.-
Pre
P-enonStanfnlUniiwtC
Sled
eb 1 a. Gray9,91 een20 Pti47fet63ooon
should not be inuiiated orcontinued for i. AMen. Unioerstyofshtcnoin, foodisn: A-snifrs therain te preent di..os and profog life in p05 t
the primary
.
prevenrison of CH D. In ad- B. Assf, B-na Urronityr. Providenc, RI: Tomn meoasa .oeren Ann tneter Med. 1992;1 17:
dision, the substanstial risks for cardio- Bi.My A LAhresyforAc owTcfiinsr Cowe ReSN itti7
vascular disease and breaost cancer must serh Center, Henry gOan. RosinPrebyterian-St fAc Rfpin A.t-. vn e SndrAn RfOf f
be wesgbed agatinst she benefit for frac- Lokes hfndicol
Unesi-dy
Cente,. Choago,.I.
of Nevda, Seem
fitRbert
Gregoy
BrOn,
L.
r.
Bathe.
trerayonseraniphtsandhyioprncerns
Wake, untan. 1990;t2:2s9-2os.
-Are - Ma4
sure sin selectisng from she available baret Itorcerty Schoof of Medicine, Winston. 5. Adam MR.
ogents
Ktaplan
so prevent
Jo. Manisc St.
osteoporosis.
et al1 lohihi-
Deere, NC, Mtle Caun, Kan-rP-intanefewisn sonfso-enoyarterythrruscle-osbys7-ketaer-
W
of Ilenhni. Oaklnd, Calif; Roma T. Chlebnnmst, trastlo in vanectomend monkeys: fork ot an effert
Wrikeg Grap foe the Wnmos.W Reaso eassass.na. Harinu-UCLA Researh nod Educatin Institte, To- of added
-etigutprogestron.
orn aqun
Arteroncleris_
F.RuoM
1990.10.
rB MD. N- roe ColA, Dard Curb, 0 Unmeor"a of Hama, Ho- 10s1-to57.
It cf.W. nd ore,., Iliosncrra w ---,ttrys- w,.ia~~
Ga-ns iCin~u,
L. Audrrs, PhD,
Ca,- B.
Bas 1. Prentie, PhD.
Werss
An-.
NS.
cinn
Ore CL,
. Ohio.
.B fad
Jennifer
ifH. Wd4ant
Hays.
AB,
Baylor
Wahng
Collge
dm
of JR Derneaud risk of fratoMs uf Z. LaCena., PhD, and Ch 'K-lopbekeg,
tine
PhD.
hip and
Medokire,
lower
Houton. Tev, Gerrd Hel~s. Un-osty
FIn~dnatdron-Cac-ueeR
of Iorroerovn pstnenop..asa
sh Cenmer Seattle,
-n
Wash
ofetg-nt
Nnstir
NFoci
Caoia a 1fc ;s Susa Hendro,
Mama
Wayne
L. stfnckk
I Med.
PhD
l9oScasn31195-1198.
St-nor Unoeroty Cncl State Snroerdy, School of Medklne/Htaef Honystal
CenoterStantntd.
7. Genat
Cald,
HKc.
RreccaD
Bylink
lavso.unoMD
Di. Gallagher )C,
hro
Ham
Detroit.
ST,
Win,h Borbara V. Ho-cad,
State
MedStar
Unootnty
Re-
Clinica
Steig,,rfPHerbersn.
Center. CoabS:htiid
ffenr ofestnenesafateonnp-rt-
A. neahi lointid, Wonhivofon, DC; ladion Hssa, Georg e rropuosa hone
A.
los.
Be-eford,
cusses Cynecol
PhD, Fred HaclorN
1990:7k:
Carm esarh Woshrgten Lln-fty, Wavyhrgtoo,
Cevim,
DC, F-
Seaftil,
dl~er Nb-
Wash. Baiboar
579 t5B4.
Hoadi. e bt Uwenityrof
Star Reveurci
Caliloria,
Institate,
loome
ufntnDR
Orange KooC. S. Steinihng
inhono,
on arhker
unronstyof
taSSitinSi,
Tennese,
eta.
Memphis;
Amt-U
Hnoard airhyn nthe effert ofestroen
MDkso ,M.
piacmnntrhrrapy
MPH, Uonesl ofToeseMo. add. U.Niersty of Catevorar, Los Aigde,;s sane 510- on Bhe rkobfn
ph
brass caer. JAMA. n591,2655r9B5.
th
lasefdodey fKatchenMOMD. duogutl. fy Xitrcnen, Medical Coflege
-ono, Miknaake,l.dth
of Wucon~n, Mlifoo-
OchrhDinut
1990.
kt en; Le--n curler, tiN-vrityof Pittsburgh,
M.ncactraei
Pitts. 9. Gerhordonde
Medical atos.
VM, Lnndn
orese
S. BeprIdaciesarbargh,
Pa, Oortfrj Lane, State Unicrsdyuof
Financf5
NrscYok
Dislosr.tor,
DInaCnn.
eugeno-a
in
femle
oi-vestigafo
hnormons and
ot Stony
cuinrecta
Brok: tben D. Langt, UvNurty of Caii- cance by safote Cane
on)2
Caunes
ossnop-ces
Cuntro 19923:3
.stahssparatly forded by Merk freon, Sue Diego. Lasftia/Choia
and Ptarr
Vita;
Dr tacm
Norma L-nse, 359-3600
in an inesingutor on I ostn- Lrcorroy nf Medicine and ON~tisfr of New
por-ss
iersy.
stdy funded
It, HidIny
by Mend
S. Grady
and
D,
1 hormone
Basin T. et 01. Ra.nizevad
stady N-madi Co.s
tina
E. Lends~, univrsty of Alabam at Bitun
libidninmncen
of estrgen PInsfandndtby
progesin
rntrr
for
&
sernday
GamtlrPlu.p-eentiur
wnmgtiam Munran Liacher, Unroersty of Flordd.
-aeuticak
nf cnocray hrartdis.eosin postnenpaasIomv
GoneAenuiytobsoes
Foe
).A.n
Camespod-e
Maono,. Begkm
lacquer
end
F.
aAMA.
R..-.am
t99820,605
Macho,
i-St13.
Wames Hmprtal, Hror Medial Schoblof,Boson.
MD,
11.
OiMo
Godstem
of
F,
W-mns~
Mansoni,
Healon
Stample
Irotiavie,
orf. Pustineen-
National Ma..: gore &argo. Uninrcrsdof Mnneuto.
Hear.
Mo-
Lang,
pos.frirnh
and Binod Insttt.W
r us and
0705
seconday
BRkfdedge
pitevnb.o
Dr.
aiof
-epnsis: ldith Ockene. univerity of Musach- nary
One
ecnnt
Rockiedgo
in the Nurse
Ctr
Healon
tote 300,
Stady
MSrl966,
dun intern
Bethsda setis Medal School, Woceste,
MD
May Jo
20017
O'SRivtmn,
e -ma
Med.
rsou
2001.t35s-B.
.ih~gonf Gamnes i. U.Ninoy ofcaioLMi. eami. Pla; Lor-ence
Andero,
Philips,
PhD , DMssno
12, orAndeig&,P.NesvyLKHnflk.mpAS~e.rti.lin
of Pablir ealthr Soenoeve Fred E.ma ry-ior ty, Agantm Ga; Cheryf Ritenbaugh.
Hutchin-o
Ka-
Cancer
cation
Reseach
of hormone
Center,
replacement
f tODO Fii-aer
therapy
.er
after
Peoannte
ouut
Center nI. Health
Ace-
Reseowi
N, MP-1002,
Port- nyicndiW
PO tnn 19020,
infarction
Seattle,
is assossted
WA
mite
land.
woe
Ors~uiiohnobmn.
cadiac
UnreNity of Cateonia, Dau. evnts dutng foow
Wino9
up. J2dm
10204e~o
Coil Candlot
goevetoroin
2001;
orgl. Sacannto
ORprlnt:
Rober
WHI
Schehenk,
Chrnrco
University
Coordinatung
of Tecas
Centon.,
3B
Divc
1-7.
Healtitorcr Centor, SandAniteaoyfciaWasnertrdnnon
of Pablic
'10.
Heelth
Heckbert
Sv~en-e, Son Koplin
Fred
RC,
Hosihinso
W~ins NS,
Con
et
-
01~ R~ik
tote,
of
Albert cinstei Coadege of Medicidne.
cer
Blows,
Researc
recrrnt
Contnc,
cornary
f tO Pairiem
-rol
Ace
in relui.ton
N,
teoc and r-
MP- NYr: M-mrn rreUno, State Unruersy uf New rek
1002,
cnt
PO
ivihoatino
sac 19024.
of pnstnenpa...aM
Seattlr, WA 9B109-f
hurrvne
020.
therapy
at Baiafl.; Linda Van H.n, BNotinwet-r Uneren. dmint It Med 2001,101:17W9 1173.
us2 JAAw.ylal 7i, 2002-SVcl200.14.Sn3(fRyinote 02if02 Aoserics Medical Asnir itun. Asll righf csrevr ed_
DDw loa de d frm. u-s cm nat -- at Notional l steirr c HIh, A on Apri 1 6. 2007