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14 Canada:<br />
Canadian Agency for Drugs and Technologies in Health; HTA Issue 87; Technology report<br />
on Short-Acting Insulin Analogues for Diabetes Mellitus: Meta-analysis of Clinical<br />
Outcomes and Assessment of Cost-effectiveness March 2007; Executive Summary, Seite<br />
V, Conclusion<br />
15 Canada: Canadian Agency for Drugs and Technologies in Health; HTA Issue 87;<br />
Technology report on Short-Acting Insulin Analogues for Diabetes Mellitus: Meta-analysis<br />
of Clinical Outcomes and Assessment of Cost-effectiveness March 2007; 4.2.3 Data<br />
analyses and synthesis; a) HbA1c; Seite 13/14<br />
16 Canada: Canadian Agency for Drugs and Technologies in Health; HTA Issue 87;<br />
Technology report on Short-Acting Insulin Analogues for Diabetes Mellitus: Meta-analysis<br />
of Clinical Outcomes and Assessment of Cost-effectiveness March 2007; 4.2.3 Data<br />
analyses and synthesis; c) Hypoglycemia; Seite 22<br />
17 Canada: Canadian Agency for Drugs and Technologies in Health; HTA Issue 87;<br />
Technology report on Short-Acting Insulin Analogues for Diabetes Mellitus: Meta-analysis<br />
of Clinical Outcomes and Assessment of Cost-effectiveness March 2007; 4.2.3 Data<br />
analyses and synthesis; b) Blood Glucose; Seite 17<br />
18 Cochrane Review: Siebenhofer A at al; Short acting insulin analogues versus regular<br />
human insulin in patients with diabetes mellitus; Cochrane Database of Systematic<br />
Reviews, Issue 2, Art.No.: CD003287. DOI: 10.1002/ 14651858. CD003287.pub.4.<br />
Abstract, Main results, Seite 1<br />
19 Cochrane Review: Siebenhofer A at al; Short acting insulin analogues versus regular<br />
human insulin in patients with diabetes mellitus; Cochrane Database of Systematic<br />
Reviews, Issue 2, Art.No.: CD003287. DOI: 10.1002/ 14651858. CD003287.pub.4.<br />
Abstract, Main results, Seite 1<br />
20 Cochrane Review: Siebenhofer A at al; Short acting insulin analogues versus regular<br />
human insulin in patients with diabetes mellitus; Cochrane Database of Systematic<br />
Reviews, Issue 2, Art.No.: CD003287. DOI: 10.1002/ 14651858. CD003287.pub.4.<br />
Discussion, Seite 10<br />
21 Cochrane Review: Siebenhofer A at al; Short acting insulin analogues versus regular<br />
human insulin in patients with diabetes mellitus; Cochrane Database of Systematic<br />
Reviews, Issue 2, Art.No.: CD003287. DOI: 10.1002/ 14651858. CD003287. pub.4.<br />
results section, overall hypoglycaemic episodes- children, adolescents pregnant type 1<br />
patients… page 9<br />
22 De Witt Review, 2003: CLINICIAN'S CORNER, Outpatient Insulin Therapy in Type 1 and<br />
Type 2 Diabetes Mellitus Scientific Review Dawn E. DeWitt, MD, MSc; Irl B. Hirsch, MD<br />
JAMA. 2003;289:2254-2264<br />
23<br />
Haycox A., Insulin aspart: an evidence-based medicine review, Clin Drug Investig.<br />
2004;24(12):695-717<br />
24 NICE guideline: Type 1 diabetes diagnosis and management of type 1 diabetes in<br />
children and young people, Clinical Guideline, September 2004, Chapter 4.3, Insulin<br />
preparations, Recommendations , Seite 57<br />
25 NICE guideline CG015: Type 1 diabetes diagnosis and management of type 1 diabetes<br />
in children and young people, Clinical Guideline, July 2004, 1.9.3.6, Seite 44<br />
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