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2.3.10 Solvent recovery
*019A,I*
Chapter 2
Solvent recovery is carried out on-site or off-site. Figure 2.8 shows the typically applied
processing units.
Factors that influence whether a solvent is recovered are:
• purity requirements for internal re-use in the process (e.g. cGMP requirements)
• purity requirements for commercial re-use
• complexity of the purification process to reach the required purity, e.g. if mixtures form
azeotropes
• gap between the boiling points in the case of solvent mixtures
• purchase costs for the fresh solvent compared to the work-up costs
• amount of waste streams created
• safety requirements
• other, e.g. process variation procedures under cGMP.
The waste streams can be re-used or recovered, but many need to be considered for a disposal
route.
Figure 2.8: Typically applied processing units for solvent recovery on OFC sites
OFC_BREF Dezember 2005 33