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Abstractband 15. Kongress des Bundesverbandes Legasthenie mit Traurigsein, Selbstmordgedanken, Schlaf- und Essstörungen herum (Esser und Schmidt 1993). Psychotherapie kann nur die psychiatrische Zusatzsymptomatik positiv beeinflussen, bereitet aber zum Teil erst das Feld für eine erfolgreiche spezifische Übungsbehandlung. Literatur: Esser u. Schmidt, Zeitschrift für Klinische Psychologie 22, 1993; Esser, Wyschkon u. Schmidt, Zeitschrift für Klinische Psychologie 31, 2002 Korrespondenzautor: Ulrike Lehmkuhl ulrike.lehmkuhl@charite.de ++49 030 450566201 ++49 030 450566921 Brain responses as early predictors of reading problems and indices of persistent processing differences *Paavo H. T. Leppänen (1), Tomi K. Guttorm (2), Jarmo Hämäläinen (2), Minna Torppa (2), Anne Puolakanaho (2), Anna-Maija Poikkeus (2), Kenneth M. Eklund (2), Paula Lyytinen (2), Heikki Lyytinen (2) (1) Jyväskylä Longitudinal Study of Dyslexia, University of Jyväskylä, Jyväskylä, Finland; (2) We examined the association of infant brain responses with reading and writing skills in children with risk for familial dyslexia and brain activation differences in those who became poor readers at school age. We had earlier found differences between 6-month-old infants with and without risk for familial dyslexia in event-related brain potentials (ERPs) for consonant duration change in two-syllable pseudowords (/ata/ vs. /atta/) presented in a mismatch negativity (MMN) -paradigm. The sixmonth-ERPs were also found to predict later language and phonological skills. We present here findings of associations of the infant brain responses with 1st and 2nd grade reading skills and brain activation differences at pre-school and school age. The correlations between 6-month-ERPs and later reading and writing skills were more consistent among at-risk children. Both response amplitude and latency measures, found for both the standard and deviant stimuli, were associated with reading and writing skills. Poor readers also differed from good readers in 6-month-ERP measures. The ERPs measured in the similar MMN-paradigms for the same /ata/ and /atta/ pseudowords at pre-school age (6.5 years) and at the 3rd grade (9 years) also revealed differences between at-risk and control children as well as between poor and good readers, respectively. The high-dense array recordings at the 3rd grade showed differences in both the scalp current density maps as well as in the waveform of the ERPs. Our findings suggest persisting developmental differences in the organization of the neural networks sub-serving speech perception with cascading effects on later reading skills in children with familial background for dyslexia. Korrespondenzautor: Paavo Leppänen Paavo.Leppanen@psyka.jyu.fi ++358 14 2602882 ++358 14 2604400 52
15. Kongress des Bundesverbandes Legasthenie Abstractband Functional brain correlates of phonological processing Bernhard Blanz (1), *Carolin Ligges University Clinic Jena, Department of Child and Adolescent Psychiatry, Jena, Deutschland Although the debate about the etiological mechanism in dyslexia is still going on, empirical evidence strongly supports the phonological deficit hypothesis, describing the fact that difficulties in phonological processing are supposed to be the major cause for developmental dyslexia. Firstly an overview about neuroimaging and electrophysiological findings of undisturbed phonological language processing will be given, followed by recent international empirical evidence (fMRI- and EEG-data) supporting the phonological deficit hypothesis. In the last ten years, a multitude of international neuroimaging studies demonstrated that even across different language systems (shallow vs. deep orthographies) the phonological processing deficit can be associated with an under activation in posterior temporal language areas, accompanied most of the time by an over activation in frontal language areas. This over activation meanwhile has consistently been interpreted to reflect a compensational process for the weak phonological processing capacities. Although there are less electrophysiological studies investigating the phonological processing deficit with event-related potentials in EEG, evidence for a phonological deficit seems to be reflected in a diminished negativity in the range of 400-600 ms, when phonologically demanding tasks have to be processed. In the second part of the talk, own empirical findings examining phonological processing deficits in dyslexia with functional MRI as well as EEG will be described and discussed. This study has been supported by the Interdisziplinäres Zentrum für klinische Forschung (IZKF), Grant B307-04004. Korrespondenzautor: Carolin Ligges Carolin.Ligges@med.uni-jena.de ++49 03641 935536 ++49 03641 935536 Überprüfung verschiedener Ursachenmodelle bei der Lese-Rechtschreibstörung mittels fMRT und EEG – ein Werkstattbericht *Carolin Ligges (1), Tanja Jungmann (1), Marc Ligges (1), Ralph Houker (2), Bernhard Blanz (1), Marc Ligges (1) (1) Klinik für Kinder- und Jugendpsychiatrie, Universitätsklinikum Jena, Jena, Deutschland; (2) Biomagnetisches Zentrum, Universitätsklinikum Jena, Jena, Deutschland Zielsetzung: Bei der Lese-Rechtschreibstörung (LRS) handelt es sich um ein Störungsbild, in dessen Rahmen unterschiedliche Ursachenmodelle diskutiert werden, die jeweils 53
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