Wellness Foods + Supplements 3/2022
Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.
Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages.
Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.
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No. 3, November/Dezember <strong>2022</strong><br />
www.harnisch.com | ISSN 2364-8104<br />
Women's health Gut health<br />
Mental health Antioxidants<br />
Lactoferrin Stress Tinnitus<br />
Heart & Brain health Skin health<br />
Photo © : Adobe Stock/nobeastofierce
Joints<br />
Heart<br />
Respiratory<br />
Sports<br />
Skin<br />
Eye<br />
Women<br />
Brain<br />
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Editorial<br />
SILKE WATKINS, Editor-in-Chief<br />
Pervasive global shortage of raw materials?<br />
Early November I attended SPS in Nuremberg,<br />
one of the largest international trade<br />
fairs for electrical automation technology. All<br />
the euphoria of the trade fair notwithstanding,<br />
the issues of raw material scarcity and supply<br />
chain disruptions occupied both companies<br />
and trade fair visitors. Manufacturers offered<br />
assurances that they are well prepared<br />
and have many parts for their pro ducts in<br />
stock. However, they also admitted that long<br />
delivery terms or component allocations are<br />
in part forcing them to find different solutions<br />
to produce the pro ducts that are in demand.<br />
Then there is the matter of price increases<br />
that have become entirely unpredictable. At<br />
least outwardly, manufacturers are projecting<br />
optimism. Nobody can predict how long this<br />
dry spell is going to last.<br />
When this topic is viewed through the lens of<br />
food production, we can clearly see during<br />
our shopping how the higher costs are being<br />
passed on to consumers. Food prices have<br />
increased to such an extent in recent months<br />
that many consumers are being forced to<br />
consider exactly what to actually buy. High<br />
energy prices are particularly problematic<br />
for producers that use a lot of energy, such<br />
as bakeries. It is therefore little wonder that<br />
even long-standing businesses are facing<br />
great hardship when, in addition to high raw<br />
material costs, energy costs now keep on<br />
rising more and more as well.<br />
What are politicians doing about this? There seems to be a general<br />
feeling of helplessness in Germany, even as the government attempts<br />
to calm the nation’s people with onomatopoeic announcements of<br />
the oomph in June and the double oomph in the autumn. Facing a<br />
winter with gas shortages, the citizens on the other hand seem to be<br />
asking: What’s next?<br />
Raw material scarcity, rising raw material costs and high energy<br />
prices are interrelated. Not only do manufacturers need assurances<br />
that they will be able to maintain their operations into the future,<br />
consumers also have to be in a position to afford foodstuffs going<br />
forward. What’s more, the quality of these should not suffer from<br />
adverse conditions. I don’t know exactly what the situation is like in<br />
other countries, but surely I am not the only one looking to the future<br />
with concern.<br />
With this edition 3 of <strong>Wellness</strong> <strong>Foods</strong> & <strong>Supplements</strong>, we are also<br />
presenting ourselves at Fi & Hi Europe in Paris.<br />
With kind regards,<br />
Silke Watkins<br />
No. 3 November/Dezember <strong>2022</strong><br />
3
Contents<br />
Health<br />
Convenience Food<br />
Food & Beverages<br />
Confectionary<br />
Cover Photo © : Adobe Stock/nobeastsofierce<br />
The microbiome is the community of microorganisms<br />
(such as fungi, bacteria and viruses) that exists in a<br />
particular environment. In humans, the term is often<br />
used to describe the microorganisms that live in or on a<br />
particular part of the body, such as the skin or gastrointestinal<br />
tract. These groups of microorganisms are<br />
dynamic and change in response to a host of environmental<br />
factors, such as exercise, diet, medication and<br />
other exposures. (Definition by NIH, National Human<br />
Genome Research Institute)<br />
Sports Nutrition<br />
Health Care<br />
Contents<br />
Personal Care<br />
Women's health<br />
06 Active at every stage of life: Focus on women<br />
Gut health<br />
11 The benefits of acacia gum in gut health<br />
Mental health<br />
14 Coping with occasional stress to support mental health<br />
Antioxidant capacity of caramel<br />
17 Antioxydant properties<br />
Lactoferrin<br />
18 Lactoferrin – also a real alternative for urinary tract infections<br />
Stress<br />
22 Balm for the soul – Melissa officinalis L. alleviates stress symptoms<br />
28 The hyper-specialization of anti-stress solutions<br />
31 Cultivating a sustainable source of a stress-busting adaptogen<br />
Brain health<br />
34 Highly bioavailable solution for brain health<br />
Heart and brain health<br />
38 With heart and brain: leading a healthy life<br />
Skin health<br />
42 Protection and stimulation<br />
Tinnitus<br />
45 Effective relief from tinnitus symptoms<br />
Fi & Hi Europe <strong>2022</strong><br />
48 Let’s meet in Paris!<br />
50 Impressum<br />
4 No. 3 November/Dezember <strong>2022</strong>
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Women's health<br />
Photo © : Freepik/gpointstudio<br />
Active at every stage of life: Focus on women<br />
Anita Käser, Brigitte Hicks<br />
Women and men are now equal in many areas [1]. Nevertheless,<br />
women have different strengths, experiences, circumstances and<br />
visions and also experience changes in the different phases of life.<br />
A possible desire to have children, pregnancy, breastfeeding and<br />
menopause demand a different lifestyle and diet and have specific<br />
nutrient requirements [2]. But even in everyday life, when it comes<br />
to organizing work, family and the household, a healthy body and a<br />
positive mindset are essential. As a result, the interest in women’s<br />
health has been growing steadily. In 2021, the dietary supplement<br />
market reported an average growth of + 17% [3]. The following article<br />
looks at the different phases of a woman's life in more detail.<br />
Planning to have children<br />
Women planning to have children should pay attention to a few<br />
things. For example, it may be advisable to provide the body with<br />
ideal conditions for a pregnancy. Healthy eating and exercise as well<br />
as patience and joy of life should of course be part of this phase. Similarly,<br />
negative triggers, such as smoking or drinking alcohol, should<br />
be eliminated when trying to conceive. [4] Additionally, food supplements<br />
can provide specific nutrients during<br />
this time. In particular, folic acid, also known<br />
as vitamin B9, should be taken before pregnancy<br />
to reduce the risk of malformations,<br />
such as the neural tube defect in the growing<br />
fetus. The German Society of Nutrition (DGE)<br />
recommends an additional daily intake of<br />
400 µg folate (folic acid) for any woman who<br />
wishes to have children. In addition, vitamin<br />
D and iodine are usually recommended, as<br />
they are equally essential for the body. Folate<br />
and vitamin D also have a function in cell<br />
division, which is an authorized health claim.<br />
[5,6,7]<br />
Pregnancy<br />
With successful fertilization and implantation<br />
into the endometrium, the need for vitamins<br />
& minerals for the body of the expectant<br />
6 No. 3 November/Dezember <strong>2022</strong>
Women's health<br />
mother increases. The extra demand can be<br />
compensated by foods with a high nutrient<br />
density. These include whole grains, fruits,<br />
vegetables, potatoes, and dairy products. [8]<br />
One of the most important vitamins for<br />
women planning to have a baby, for pregnant<br />
and breastfeeding women is folic acid<br />
or folate. It takes on critical functions in<br />
cell division and growth processes in the<br />
body and is involved in numerous metabolic<br />
processes. To support the increased<br />
need for folic acid, foods rich in folate such<br />
as lettuce, spinach, broccoli and whole<br />
grains are beneficial. The D-A-CH societies<br />
(Germany, Austria, Switzerland) for nutrition<br />
recommend that pregnant and breastfeeding<br />
women supplement their daily diet<br />
with 400 µg folic acid. A lack of folate during<br />
pregnancy can have an extremely negative<br />
effect on the development of the fetus and<br />
can lead to a low birth weight or increase the<br />
risk of a miscarriage. Folate supplementation<br />
also reduces the risk of neural tube defects<br />
in the unborn child.<br />
Another important part of the diet during pregnancy<br />
is iodine. Iodine is an essential trace<br />
element maintaining many important body<br />
functions and which must be supplied via<br />
the diet. The thyroid gland needs the mineral<br />
mainly for the build-up of thyroid hormones.<br />
These are crucial for the growth and development<br />
of the nervous system, musculature<br />
and internal organs of the child. They also<br />
regulate crucial processes in metabolism,<br />
even before birth. Intake recommendations<br />
depend, for example, on age, gender, and<br />
state of health. The thyroid gland of the fetus<br />
matures only in the 18 th -20 th week of pregnancy<br />
and is therefore depending on the<br />
supply from the mother. The German Society<br />
of Nutrition (DGE) recommends a total daily<br />
intake of 230-260 µg iodine for pregnant<br />
and breastfeeding women, with 100-150 µg<br />
taken in capsule or tablet form. [6]<br />
In addition to folic acid, iodine and vitamin D,<br />
omega 3 fatty acids also play a crucial role<br />
in pregnancy. Omega 3 fatty acids cannot<br />
be made by the body itself and need to be<br />
supplied through food or supplements. The<br />
intake of mono- and polyunsaturated fatty<br />
acids, such as omega 3 from vegetable oils or the consumption of<br />
cold-water fish, is crucial in the last trimester of pregnancy. During<br />
this phase, long-chain fatty acids, especially arachidonic acid and<br />
docosahexaenoic acid (AA, DHA) are stored in the brain of the fetus.<br />
The DHA status of the mother is significant here, as DHA can affect<br />
the structure and function of the brain and eyes of the fetus. Also,<br />
the duration of pregnancy can be influenced by the formation of<br />
hormone-like substances from the fatty acid eicosapentaenoic acid<br />
(EPA). The recommendation of DHA intake for pregnant women is at<br />
least 200 mg DHA per day. The exact fatty acid status can be determined<br />
at the beginning by the Omega 3 Index as a blood test to<br />
prevent a deficiency. Goerlich Pharma offers a wide range of marine<br />
and vegan Omega 3 capsules in the desired private label packaging.<br />
Additional vitamins that can be taken if needed, including vitamin<br />
C, vitamin B1 (thiamine), vitamin B2 (riboflavin), niacin, vitamin B6,<br />
vitamin B12, vitamin A and vitamin E as well as the minerals calcium,<br />
iron and zinc. [9]<br />
For this purpose, Goerlich Pharma developed a new basic formulation:<br />
A pregnancy capsule containing valuable micronutrients such<br />
as iodine, folic acid, vitamin D, B12, magnesium, zinc, and choline.<br />
The capsule is vegan and can be customized with other vitamins,<br />
minerals or trend ingredients to a Plus product. In combination with<br />
Omega 3 products containing algae or fish oil, customer-specific<br />
product concepts for pregnancy can be offered.<br />
Breastfeeding<br />
The amount of breast milk depends, among other things, on the<br />
mother’s diet and lifestyle. More attention should be paid to a healthy,<br />
balanced diet with lots of fruits, vegetables and whole grains. The<br />
length of time the baby is breastfed depends on the individual situation<br />
and can range from three months to one year and more. [10] An<br />
additional energy intake of 635 kcal daily is recommended in the first<br />
four months of lactation, as the need for vitamins and minerals can<br />
be higher than during pregnancy. A daily calcium intake of 1000 mg<br />
and iron intake of 20 mg per day is advised during the first four to six<br />
months of breastfeeding. In addition, the need for iodine increases to<br />
approx. 260 µg daily. [9] A blood test is also recommended here in<br />
order to prevent deficiencies and to specifically provide support with<br />
supplements.<br />
Female cycle<br />
A woman’s cycle is a real miracle of nature and changes steadily from<br />
birth to first menstruation and possible pregnancy to menopause. At<br />
birth, the ovaries already contain the entire supply of eggs for the later<br />
life of a woman. Egg cells are enclosed in small bubbles, so-called<br />
follicles. At puberty, a part of the hormones will maturate the 1st<br />
follicle and release an egg cell into the uterus. In addition, hormones<br />
control the body temperature and the menstrual cycle by triggering<br />
ovulation once a month. [11] If the egg is not fertilized subsequently,<br />
No. 3 November/Dezember <strong>2022</strong><br />
7
Women's health<br />
gut, it is also important to maintain good bowel health [15]. Pre-, pro-,<br />
and postbiotics can help in this area. Goerlich Pharma offers a probiotic<br />
mixture in the form of capsules and as a direct stick, as well as a<br />
direct stick with beta-glucan from the walls of yeast cells.<br />
it dies and is excreted as menstrual period along with the top layer<br />
of the endometrium. On average, approximately 20 to 60 milliliters<br />
of blood are lost per menstrual period. During this time, iron supplements<br />
can be used to support the body and ensure iron supply. [11,<br />
12] Goerlich Pharma offers, for example, an iron acerola stick in the<br />
flavors of raspberry or blackcurrants delivering 14 mg iron and 80 mg<br />
vitamin C. Vitamin C helps the body to achieve better and higher<br />
iron absorption as well as many other EFSA-approved health claims.<br />
Additionally, health claims have been authorized for iron. It contributes<br />
to normal oxygen transport in the body, as well as to the normal<br />
formation of red blood cells and hemoglobin. Beyond that, magnesium<br />
can help to relax the muscles when suffering from menstrual<br />
cramps. Magnesium contributes to normal muscle function and the<br />
function of the nervous system. Goerlich Pharma offers a magnesium<br />
stick with 375 mg magnesium as a basic formulation, which can be<br />
customized with additional vitamins or minerals. The stick formulations<br />
are also available in capsule or tablet form.<br />
The middle years: Balance in everyday life<br />
Photo © : Adobe Stock/ssstocker<br />
Women still do 80 % of care work, and often juggle between different<br />
roles: They are employed, responsible for taking care of the children<br />
and the household. They are partners, caregivers and managing<br />
the tasks of everyday life [24]. In <strong>2022</strong>, around 75 % of mothers are<br />
employed [13]. Organizational talent, resilience and good physical<br />
and mental health are the prerequisites to maintain this balance in<br />
everyday life. Moreover, there often is not enough time left for hobbies<br />
or sports as compensation to the daily tasks.<br />
Children, pets and household chores also need to be taken care of<br />
when you feel sick and the energy level is low. A strong immune system<br />
is required to avoid getting sick. Exercise, a balanced diet and enough<br />
sleep are essential to strengthen the immune system. Various vitamins<br />
and minerals can also contribute to the normal function of our<br />
immune system. For example, the EFSA has approved corresponding<br />
health claims for copper, folic acid, iron, selenium, zinc and vitamin A,<br />
B12, B6, C and D [14]. Because most of our immune system is in the<br />
In addition to physical health, mental health also plays a major<br />
role in meeting all the challenges in the everyday life of a modern<br />
woman. Mental strength is required in particular during phases with<br />
unplanned, unexpected and short-term changes, such as restrictions<br />
on child care, overtime on the job, etc. Here too, the EFSA has<br />
approved health claims for numerous vitamins and minerals [16].<br />
In addition, there are indications that adaptogens can increase the<br />
body's resis tance to stress. [17] The herbal adaptogen Rhodiola can<br />
be found in the Anti-Stress capsule of Goerlich Pharma. Other basic<br />
formulations include the vitamin B complex capsule, the magnesium<br />
direct stick and the duo-magnesium capsule.<br />
The daily routine of a working mother might look like this: Getting up<br />
– Caring for pets – Making lunch/snack(s) – Waking up child(ren)<br />
– Getting everyone ready and out of the house – Working – Picking<br />
up child(ren) – Shopping – Taking care of the household – Cooking<br />
– Eating dinner – Cleaning up – Family time – Going to sleep – the<br />
day is usually filled with a variety of tasks from morning to evening.<br />
In order for the body to have sufficient energy and strength, a normal<br />
energy metabolism is necessary. Biotin, calcium, copper, iodine,<br />
iron, magnesium, manganese, niacin, pantothenic acid, phosphorus,<br />
riboflavin, thiamine, vitamin B12, B6 and C may help, which was<br />
confirmed by the EFSA with the approval of a corresponding health<br />
claim. However, if you feel tired or exhausted, folic acid, iron, magnesium,<br />
niacin, pantothenic acid, riboflavin, vitamin B12, V6 and C can<br />
help to reduce this feeling. [14] Here it is possible to select from<br />
several basic formulations containing B vitamins, magnesium or iron.<br />
Often underestimated, but very important is, of course, finding or<br />
creating enough time to look after yourself. For some this is reading a<br />
good book, spending time with friends, playing sports or going to the<br />
Photo © : Freepik/pressfoto<br />
8 No. 3 November/Dezember <strong>2022</strong>
Women's health<br />
hairdresser or a cosmetician. If there is a lack<br />
of time due to a fully packed daily scedule,<br />
“beauty from the inside” is the keyword.<br />
Goerlich Pharma’s skin-hair-nails capsule<br />
contains ingredients that can help maintain<br />
normal skin, hair and nails, or normal skin<br />
and hair pigmentation.<br />
Menopause/climacteric period<br />
Menopause refers to the period of hormonal<br />
changes at the end of the fertile life phase of<br />
a woman. The concentration of female sex<br />
hormones decreases, resulting in the loss<br />
of the period at the end of menopause and<br />
thus no natural pregnancy being possible<br />
any longer. The beginning, duration and<br />
course of this period of life vary in each<br />
woman, but at the age of 52, about half of all<br />
women have had their last menstrual period.<br />
The appearance and severity of menopause<br />
symptoms vary just as much. These include<br />
hot flashes, sweating, sleep disturbances,<br />
dryness of the mucous membranes, e.g. in<br />
the urogenital area, mood swings, weight<br />
gain and memory problems. [18.19] In addition,<br />
the risk of osteoporosis in women after<br />
menopause is approximately twice as high<br />
as in men due to the lowering of estrogen<br />
levels. [20.21]<br />
calcium through the intestines and the incorporation<br />
of the mineral in the bones. This<br />
prevents a decrease in bone density and<br />
osteoporosis. If the vitamin D level is low,<br />
supplementation can be useful. Targeted<br />
strength training can also stimulate bone<br />
formation. [21]<br />
In addition to the above-mentioned menopause<br />
symptoms, the decrease in estrogen<br />
levels can often also be felt in the joints.<br />
Blood circulation to muscles and joints<br />
is reduced, collagen production and the<br />
amount of joint fluid decrease and the joint<br />
cartilage becomes thinner. In addition, with<br />
age and also due to the lack of estrogen,<br />
the skin becomes thinner, dryer, less elastic<br />
and more prone to injury. [18] An adequate<br />
supply of vitamin C can support the function<br />
of the joints and the skin. The vitamin<br />
contributes to normal collagen formation,<br />
which is responsible for the normal functioning<br />
of bones, cartilage and skin. [22].<br />
Goerlich Pharma can offer a collagen stick<br />
for dissolving in water as a basic formulation.<br />
Outlook for probiotics<br />
A future topic, which is becoming increasingly<br />
important in women’s health, are<br />
Bioactive Collagen Peptides (BCP ® )<br />
stimulate the body’s own collagen<br />
metabolism<br />
Body Toning<br />
Beauty from Within<br />
In order to maintain the usual quality of<br />
life in this phase of life, there are different<br />
approaches to treat the symptoms,<br />
depending on their severity. This can range<br />
from general measures to hormone replacement<br />
therapy. However, the latter is disputed<br />
due to possible serious side effects (e. g.<br />
increased risk of breast or uterine cancer<br />
and increased risk of blood clots) and is only<br />
prescribed by doctors to women with severe<br />
complaints.<br />
Bone Health<br />
Joint Health<br />
Connective Tissue<br />
Improvement<br />
However, general measures such as relaxation<br />
exercises, exercising outdoors, targeted<br />
strength training and a healthy diet and<br />
lifestyle can actively combat some of the<br />
unwanted symptoms. Exercise can have a<br />
positive effect on our mood, help with weight<br />
loss, and counteract age-related muscle<br />
loss. If the exercise takes place outside, the<br />
body’s own vitamin D production is stimulated.<br />
Vitamin D promotes the absorption of<br />
GELITA AG · Uferstr. 7 · 69412 Eberbach · Germany · www.gelita.com
Women's health<br />
Photo © : Freepik/mego-studio<br />
probiotics. The interest in finding solutions to women’s health problems<br />
is increasing the demand for natural ingredients such as probiotics.<br />
Benefits include specific applications of bacteria that offer a<br />
natural, over-the-counter and easily ingestible alternative without side<br />
effects to women’s health. From puberty to menopause, there are<br />
charac teristic probiotics for every woman at every stage of life that<br />
can affect the intestinal or vaginal microbiota. The balance of the<br />
microflora is a key factor in supporting health, is increasingly recog-<br />
nized and supported by studies. Above all,<br />
the probiotic genus of Lactobacilli, must<br />
be mentioned here. They have shown in<br />
some studies, that they can help to find the<br />
balance of the microflora and lead to better<br />
well-being. The Health Canada Ministry of<br />
Health approved the additional indication<br />
for the probiotic L. Plantarum Rosella that<br />
has been shown to support the health of the<br />
female intimate area. In order to be able to<br />
colonize the vaginal microflora as accurately<br />
as possible in the future, the choice of the<br />
right bacterial strain is essential. In addition<br />
to vaginal health, the most important growth<br />
areas in women’s health include urinary tract<br />
infections, pregnancy and skin health. [23]<br />
In this area, Goerlich Pharma also offers<br />
basic formulations: the probiotic immune<br />
and probiotic gastrointestinal direct stick,<br />
as well as a probiotic capsule containing a<br />
variety of bacterial strains. Those products<br />
can be customized to a Plus product by<br />
adding other raw materials.<br />
References<br />
[1] https://www.bundesregierung.de/breg-de/themen/nachhaltigkeitspolitik/rechtliche-gleichstellung-841120<br />
[2] https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/f/frauengesundheit.html<br />
[3] https://www.nutritioninsight.com/key-trends/b-life-womens/npd-in-action-womens-health.html<br />
[4] https://www.apotheken-umschau.de/familie/kinderwunsch/schwanger-werden/schwanger-werden-das-sollten-sie-vorher-beachten-790043.html<br />
[5] https://www.femibion.de/produkte/femibion-babyplanung#naehrwerte<br />
[6] https://www.pharmazeutische-zeitung.de/ausgabe-362006/iod-und-folsaeure-supplementieren/<br />
[7] https://www.femibion.de/schwangerschaft/vitamine-mineralstoffe<br />
[8] https://www.ernaehrung.de/tipps/schwangerschaft/schwanger11.php<br />
[9] https://fet-ev.eu/schwangerschaft-stillzeit/<br />
[10] https://www.femibion.de/stillzeit/ernaehrung-stillen<br />
[11] https://www.gesundheitsinformation.de/wie-funktioniert-der-weibliche-zyklus.html<br />
[12] https://www.frauenaerzte-im-netz.de/koerper-sexualitaet/zyklus-hormone/<br />
[13] https://www.destatis.de/DE/Presse/Pressemitteilungen/<strong>2022</strong>/03/PD22_N012_12.html#:~:text=M%C3%BCtter%20in%20Deutschland%20waren%20damit,noch%20bei%20<br />
69%2C3%20%25<br />
[14]https://ec.europa.eu/food/safety/labelling_nutrition/claims/register/public/?event=search<br />
[15] https://www.bzfe.de/ernaehrung/ernaehrungswissen/gesundheit/das-immunsystem-staerken/<br />
[16] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:32012R0432&from=DE<br />
[17] https://www.mdpi.com/2072-6643/13/8/2861<br />
[18] https://www.frauenaerzte-im-netz.de/koerper-sexualitaet/wechseljahre-klimakterium/<br />
[19] https://www.msdmanuals.com/de-de/heim/gesundheitsprobleme-von-frauen/wechseljahre/wechseljahre<br />
[20] https://www.msdmanuals.com/de-de/heim/knochen-,-gelenk-und-muskelerkrankungen/osteoporose/osteoporose<br />
[21] https://www.apotheken-umschau.de/krankheiten-symptome/gelenks-und-knochenerkrankungen/osteoporose-risikofaktoren-diagnose-therapie-734881.html<br />
[22] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:32012R0432&from=EN<br />
[23] https://www.nutritioninsight.com/news/probiotics-for-womens-health-no-longer-taboo-as-lallemand-projects-market-growth.html<br />
[24] https://www.gender-mediathek.de/de/care-arbeit<br />
For more information, please contact<br />
Goerlich Pharma GmbH<br />
Edling, Germany<br />
sales@goerlich-pharma.com<br />
www.goerlich-pharma.com<br />
10 No. 3 November/Dezember <strong>2022</strong>
Gut health<br />
The benefits of acacia gum in gut health<br />
According to a study by Alland & Robert,<br />
80 % of people who consumed acacia gum<br />
every day for 2 months improved their intestinal<br />
health<br />
Acacia gum, also known as gum arabic, is<br />
a natural, safe and plant-based additive or<br />
ingredient. It comes from an exudation of<br />
Acacia trees after the incision of their stems<br />
and branches. Acacia gum has been used for<br />
centuries and provides many different functional<br />
properties such as emulsifying properties<br />
or fibre enrichment. It is now adays found<br />
in a wide variety of consumer products all<br />
over the world.<br />
Now, in addition to its versatility, digestive health can be added to the<br />
list the benefits of acacia gum. Alland & Robert, a leading manufacturer<br />
of acacia gum and expert of natural gums since 1884, recently<br />
conducted a study that confirms that people who consume acacia<br />
gum every day improve their intestinal health. The objective of the<br />
Alland & Robert study was to provide scientific data that support the<br />
use of acacia gum as a gut health improver. Scientific research has<br />
already highlighted that in addition to being a fibre, acacia gum is a<br />
prebiotic. Alland & Robert decided to go further and conducted a<br />
study to evaluate the impact of acacia gum on consumers who suffer<br />
from intestinal disorders regularly.<br />
In recent years, the gastrointestinal system has been linked to general<br />
health: from weight management to immunity to chronic illnesses,<br />
and even to sleep problems or skin health. About 70 million Ameri-<br />
No. 3 November/Dezember <strong>2022</strong><br />
11
Gut health<br />
cans are estimated to be affected by digestion discomforts. As scientists<br />
continue to explore the role played by the GI on human health,<br />
there is no doubt that the digestive health market will continue to<br />
boom: the global digestive health products market is expected to<br />
grow to $ 59 billion by 2025 1 . Many consumers today know that a<br />
happy, healthy gut is key for overall wellbeing. There is significant<br />
demand for food, beverage and dietary supplements with digestive<br />
health advantages. Manufacturers must understand the expectations<br />
of consumers and provide safe and natural products that answer their<br />
demands, and acacia gum is a multi-functional and natural option to<br />
formulate gut-friendly food and beverages.<br />
Consuming acacia gum daily improves intestinal<br />
discomfort and pain<br />
Alland & Robert worked with a leading company in consumer insight.<br />
The study consisted in the recruitment of 240 consumers who<br />
declared they suffer regularly from intestinal disorders such as flatulence,<br />
bloating, stomach aches, accelerated or slowed down transit.<br />
Consumers were separated in 3 groups and took various dosages of<br />
acacia gum daily for 2 months. After 60 days, 80 % of the consumers<br />
declared their intestinal discomfort had improved. 78 % of consumers<br />
agreed the intake of acacia gum daily had a beneficial effect on their<br />
digestive health, and 88 % of the participants said they had low intestinal<br />
pain after 2 months of consuming acacia gum. According to Dr<br />
Isabelle Jaouen, R&D Director of Alland & Robert, this study shows<br />
that acacia gum improves global digestive wellness and relieves<br />
the symptoms of intestinal discomfort. She<br />
declared: “Intestinal disorders impact the<br />
daily lives of a large portion of the human<br />
population. At Alland & Robert, we wanted to<br />
explore the possibility that acacia gum would<br />
provide an answer to these needs. Thanks<br />
to this study, we can affirm that acacia gum<br />
contributes to the improvement of the gut<br />
health and therefore the general well-being<br />
of a large majority of those tested. It is very<br />
likely that acacia gum, a natural fibre, favourably<br />
feeds our microbiota, which has already<br />
been described in the scientific literature in<br />
connection with its prebiotic effects“.<br />
As a prebiotic fibre, acacia gum can<br />
be used for the formulation of many<br />
applications<br />
Scientific research has shown that acacia<br />
gum is a prebiotic fibre. Its functional properties<br />
make it a perfect ingredient to enhance<br />
the fibre content of food and beverages. And<br />
the addition of acacia gum doesn’t impact<br />
or compromise the texture, appearance<br />
or texture product. According to Professor<br />
Christian Sanchez who works on basic<br />
12 No. 3 November/Dezember <strong>2022</strong>
Gut health<br />
research on acacia gum at the IATE 2 laboratory<br />
at the University of Montpellier, France:<br />
“Because of its classification as a fibre and<br />
its emulsifying properties, acacia gum could,<br />
theoretically, be used in all formulated food<br />
products since it also has the advantage of<br />
being temperature stable. Think yogurts,<br />
dairy products and derivatives, as well as<br />
baked goods and, more broadly, any flourbased<br />
products”.<br />
Commenting on the FDA decision, Mr.<br />
Frédéric Alland, CEO at Alland & Robert said:<br />
“We are extremely satisfied that the FDA<br />
agrees with us that acacia gum is a fibre and<br />
can be labelled as such. It’s a great news for<br />
the American consumers, who will be able<br />
to enjoy this natural ingredient in their daily<br />
food. Alland & Robert remains committed to<br />
providing the highest quality of natural and<br />
non-GMO Acacia Fibre”.<br />
References<br />
1<br />
2018 to 2025. https://www.fiormarkets.com/report/digestivehealth-products-market-by-ingredients-dairyproducts-385973.html<br />
February 20, 2020.<br />
2<br />
In English: Agropolymers Engineering and Emerging<br />
Technolo gies/In French : Ingénierie des Agropolymères et<br />
Technologies Emergentes<br />
For more information, please contact<br />
Alland & Robert, France<br />
https://www.allandetrobert.com<br />
Violaine Fauvarque, Marketing Manager at<br />
Alland & Robert, added: “Multifunctional<br />
and versatile, acacia gum has many advantages.<br />
It can give texture, sweeten a taste or<br />
mask an aftertaste, and it can increase the<br />
fibre or prebiotic content with a very lowcalorie<br />
intake. Today, our study shows that<br />
acacia gum is a good fit in products formulated<br />
to improve digestive comfort. This also<br />
confirms that acacia gum responds in an<br />
innovative way to the challenges encountered<br />
in many industries!”<br />
Acacia gum, now a dietary fibre<br />
FDA approved<br />
In December 2021, a decision from the<br />
American FDA was made public acacia gum<br />
will be able to count as a dietary fibre on<br />
American Nutrition and Supplement Facts<br />
labels. The FDA agreed it has physiological<br />
effects beneficial to human health, such as<br />
the reduction of blood glucose and insulin<br />
levels after it is eaten with a meal containing a<br />
carbohydrate that raises blood glucose levels.<br />
Alland & Robert, along with a work group of<br />
other acacia gum stakeholders, submitted<br />
two science-backed citizen petitions in 2019<br />
and 2020, in order to provide the FDA with<br />
data showing proof that acacia gum has<br />
indeed “physiological benefits to human<br />
health”. Dr Isabelle Jaouen, R&D Director<br />
at Alland & Robert said: “We have provided<br />
the FDA with numerous data coming from<br />
several clinical trials to support our request<br />
that acacia gum be recognized as a dietary<br />
fibre. Two laboratories that specialize in clinical<br />
nutrition, including one university, have<br />
been mandated for the design and realization<br />
of the clinical tests. Our citizen petitions<br />
included data showing the benefits of acacia<br />
gum on blood glucose levels”.<br />
The flexitarian way of living.<br />
Tasty and nutritious plant-based ingredients.<br />
A mind-boggling 25% of consumers globally are flexitarians. They are drawn to plantbased<br />
options because of their healthful appeal, ecological convictions or the pleasure<br />
of trying something new. BENEO helps you develop plant-inspired options that are<br />
simply delicious. Sharpen up your recipe with natural ingredients that bring out pure<br />
flavours and exciting textures. Create a taste experience consumers will thoroughly<br />
enjoy with new and inspiring dairy-free or meat-free recipes. What will be your<br />
signature ingredient?<br />
Follow us on:<br />
www.beneo.com
Mental health<br />
Photo © : Adobe Stock/Prostock-studio<br />
Coping with occasional stress to support<br />
mental health<br />
The World Health Organization defines mental health as “a state of<br />
mental well-being that enables people to cope with the stresses of<br />
life, realize their abilities, learn well and work well, and contribute to<br />
their community”. With globally one third of consumers that are not<br />
satisfied with their mental well-being 1 it is indeed quite concerning<br />
and worth talking about.<br />
Mental well-being in healthy individuals<br />
One of the burdens of modern lifestyle is everyday stress – heavily<br />
impacting mental well-being. Stress is common across the globe, but<br />
in the last two years it has been drastically increasing, with half of the<br />
population stating they experience stress most of the time or all the<br />
time 2 . No matter their age, half of global consumers claim that they<br />
are currently undergoing moderate, high, or extreme stress levels 3 .<br />
Just as stress, stress-induced digestive discomfort, and anxietylike<br />
symptoms, can in turns impact sleep quality, hence worsening<br />
mental well-being… establishing an unwelcomed pattern 4 .<br />
When asked about what they think causes their stress and troubles<br />
their sleep, consumers mention being most concerned about the<br />
health and well-being of loved ones, followed by being concerned<br />
about their own health, financial situation,<br />
work obligations, or feeling insecure<br />
about worldwide problems such as global<br />
warming 5 . Recurring bad night sleep can<br />
in turn impact learning capacity, memory,<br />
decision making, and even creativity.<br />
But there are good news! A large majority<br />
of consumers have a proactive approach<br />
towards their mental health and stress<br />
management, and they opt for natural solutions<br />
6 such as increasing physical activit<br />
ies. According to the Physical Activity<br />
Guidelines for Americans, being physically<br />
active on a regular basis, is one of<br />
the most important things people can do to<br />
improve both physical and mental health 7 .<br />
Other solutions include taking actions<br />
to address familial, work, or financial<br />
issues. Consumers also understand that<br />
by improving their mental wellbeing, they<br />
can improve their quality of sleep. Estab-<br />
14 No. 3 November/Dezember <strong>2022</strong>
Mental health<br />
lishing a soothing bedtime routine is also<br />
relevant. Warm comforting drinks such as<br />
herbal tea or milk, and taking nutritional<br />
supplements, are cited by consumers to<br />
help lowering stress levels before bedtime 8 .<br />
Specific probiotic supplements also appeal<br />
to consumers to improve sleep, as they help<br />
cope with day-to-day stressors 9 . Beside<br />
dietary supplements, an increased number<br />
of consumers are exploring the power of<br />
botanical extracts, to manage their stress<br />
and enhance their moods.<br />
Carefully selected botanical extracts<br />
to boost mood<br />
Turning to natural health solutions is<br />
rooted in traditional methods to help maintain<br />
holistic health. Over time and years of<br />
research, scientists came to harness microorganisms<br />
and plants benefits leading<br />
more precisely to proven health applications.<br />
Modern science allows to skillfully<br />
isolate specific bioactive compounds and<br />
study how botanical extract have an impact. For example, ashwagandha<br />
traditionally used in Indian, or Ayurvedic, medicine, is well<br />
known for its stress-lowering effects. It helps decrease levels of<br />
cortisol; a hormone produced by the adrenal glands in response<br />
to stress. Saffron was conventionally used to bring joy and happiness.<br />
Thanks to an isolate from saffron, safranal, involved in serotonin<br />
amplification, Safr’Inside, an Active’Inside product, naturally<br />
supports positive mood and emotional health.<br />
The most documented probiotic to support a healthy<br />
response to occasional daily stress<br />
In 2019, a good proportion of consumers bought probiotic pro ducts<br />
to support mental health. This proportion is in constant increase<br />
and in 2020, it has raised to reach 23.7 % globally 10 . When comes<br />
the time to deal with the physical and psychological symptoms of<br />
everyday stress and feelings of anxiety, one natural solution stands<br />
out from the crowd and it’s the probiotic formula Cerebiome ®<br />
(L. helveticus Rosell ® -52 and B. longum Rosell ® -175). Cerebiome ®<br />
has been largely documented on the reduction of psychologi cal stress<br />
in humans by five clinical studies and over ten translational studies.<br />
Clinically proven, it offers natural support to help enhance mood and<br />
acts on the microbiome-gut brain axis to support a healthy response<br />
to everyday stress.<br />
Lipoid GmbH | info@lipoid.com | www.Lipoid.com<br />
MADE WITH<br />
100% NATURAL<br />
INGREDIENTS<br />
PHOSAL ® Curcumin – An Innovative<br />
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With highly purified phosphatidylcholine<br />
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bioavailability in a natural way.<br />
We Invest in Quality.
Mental health<br />
Photo © : Adobe Stock/Grispb<br />
Botanical extract and probiotics: The perfect mix<br />
Cerebiome ® can also be formulated with other relevant ingredients<br />
that promote relaxation, sleep, emotional and mood balance, such<br />
as melatonin and ashwagandha. And now, it is possible to combine<br />
the best of both worlds. Cerebiome ® and Safr’Inside is a unique,<br />
documented, and powerful combination for mental wellness and<br />
emotional balance. In a consumer satisfaction trial, 96 % of consumer’s<br />
reported a reduction on daily stress, and more than 80 % were<br />
satisfied by the product effectiveness. 11<br />
A unique formulation’s expertise<br />
Probiotic industrial production requires a precise expertise in the<br />
fermentation of living microorganisms. When adding botanical<br />
extracts in the mix, the level of complexity amplifies. New ingredients<br />
must follow a strict validation process to ensure product compatibility,<br />
stability, and shelf-life longevity. Formulations represent a real<br />
production challenge as microorganisms have complex nutritional<br />
needs and marked sensitivities at certain key stages of bioproduction.<br />
Lallemand Health Solutions cumulates over 85 years of microbial<br />
fermentation production know-how to successfully combine<br />
probiotics and other health ingredients, such as botanical extracts,<br />
prebiotics, bacteria, yeast, vitamins, and minerals.<br />
Along with a well-balanced diet and a healthy<br />
lifestyle, probiotics and carefully chosen<br />
ingredients synergistic effect in support to<br />
mental health is a trend to watch.<br />
References<br />
1<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020<br />
2<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 000 consumers in 15 countries,<br />
2019 and 2021<br />
³Euromonitor’s Health and Nutrition Survey 2020, 21 countries, 21 000 respondents<br />
4<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020<br />
5<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020<br />
6<br />
FMCG Gurus: Mental Wellbeing: Targeting Stressed and Anxious Consumers in 2020 and<br />
beyond October 2020<br />
7<br />
https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_<br />
edition.pdf<br />
8<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020<br />
9<br />
FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020<br />
10<br />
FMCG GURUS: Probiotic Survey, 15 000 consumers in 15 countries 2019 & 2020<br />
11<br />
Lallemand Health Solutions and Activ’Inside proprietary study<br />
For more information, please visit<br />
lallemand-health-solutions.com<br />
healthsolutions@lallemand.com<br />
16 No. 3 November/Dezember <strong>2022</strong>
Photo © : Adobe Stock/Apolikhina Anna<br />
Antioxidant capacity of caramel<br />
Antioxydant properties<br />
Nigay SAS has been carrying out researches<br />
for a better knowledge of caramel for many<br />
years. In order to do so, they worked with<br />
several laboratories to show the antioxidant<br />
properties of caramel.<br />
A scientific article describing the results of<br />
these studies has been published:<br />
Investigation of the antioxidant capacity of<br />
caramels: combination of laboratory assays<br />
and C. elegans model – Journal of Functional<br />
<strong>Foods</strong> – Volume 78 (2021) 104308.<br />
Caramel is produced by a controlled heating<br />
of sugars (sucrose – glucose syrup,...)<br />
with or without presence of caramelization<br />
promoters to provide a wide range of ingredients<br />
(aromatic caramels, burnt sugars or<br />
specialities) or additives (caramel colours).<br />
Caramelization is close to the Maillard reaction<br />
and begins with a dehydration of the<br />
sugars then a polymerization of the molecules<br />
formed. These multiple reactions<br />
create a complex mixture of compounds<br />
ranging from small molecules responsible<br />
for the typical taste of caramel (maltol – furaneol…)<br />
to large molecules responsible for<br />
the brown colour of caramel.<br />
Several methods have been tested simultaneously:<br />
1. Chemical analysis using a blue molecule<br />
called ABTS in solution which discolours in<br />
the presence of antioxidant<br />
2. Analysis of the effect of caramel on the<br />
lifespan of blood cells when they are<br />
attacked by strong oxidants<br />
3. Analysis of the impact of caramels on the<br />
lifespan of Caenorhabditis elegans worms<br />
in the presence of strong oxidants<br />
=> 40 % increase in worm lifespan after 18<br />
hours of exposition<br />
These three studies, using radically different<br />
methods, have jointly shown that caramel<br />
has antioxidant properties in caramels.<br />
The greater the degree of caramelization,<br />
the greater the antioxidant activity’s will be.<br />
Further studies will be carried out to identify<br />
the molecules or families of molecules<br />
responsible for this activity.<br />
In conclusion, caramel contributes significantly<br />
to the consumption of antioxidants<br />
that can lead to interesting nutritional benefits.<br />
Based on 2012 EFSA exposure data, the<br />
current daily intake of caramel colour would<br />
provide antioxidant equivalent to a glass of<br />
orange juice or a cup of coffee. The aim of<br />
the following studies will be to explore these<br />
potential benefits due to the antioxidant<br />
pro perties in caramels.<br />
Who’s the expert<br />
The family-run business is specialized in<br />
the production of caramels used in many<br />
forms (liquid, paste, powder, pieces) by artisans<br />
and food industries. Producing aromatic<br />
caramels, caramel colours, burnt sugars and<br />
caramel specialities, Nigay is unique in its<br />
dedication to the art and science of caramelization<br />
which has made its name “The expert<br />
in caramels” around the world.<br />
With a turnover of nearly 90 million euros<br />
(72 % in exports), the company ships its<br />
products on the 5 continents. Focused on<br />
human values and driven by their profession,<br />
Henri and Yves Nigay lead a team of<br />
more than 320 people. They aim to perpetuate<br />
their caramel expertise and to pass it<br />
on to the 6 th generation thanks to anchored<br />
company values: Passion, Tradition, Innovation,<br />
High Standards & Ethics.<br />
For more information, please visit<br />
www.nigay.com<br />
No. 3 November/Dezember <strong>2022</strong><br />
17
Lactoferrin<br />
Lactoferrin – also a real alternative for<br />
urinary tract infections<br />
A new preliminary study demonstrates the effect in cystitis<br />
Diana Kalustova<br />
Lactoferrin is a true all-rounder when it comes to treating various<br />
diseases and deficiency symptoms. As the name, composed of the<br />
Latin words milk and iron, suggests, the main function of lactoferrin<br />
is to bind and transport iron in the body. This special glycoprotein,<br />
which is found in mammals, for example in breast milk, and belongs<br />
to the transferrins, has antiviral as well as antimicrobial and antiinflammatory<br />
properties with its multifunctional enzyme activities.<br />
Effective from periodontitis to Alzheimer’s disease<br />
and infections<br />
The broad spectrum of activity of lactoferrin has been demonstrated<br />
in various studies for more than 100 years. As early as the beginning<br />
of the 21st century, lactoferrin was shown to have positive<br />
results in the treatment of chronic periodontitis. Since then, lactoferrin<br />
has demonstrated its efficacy in many areas. For example,<br />
a recent study* by neurologists in Cairo tested the effects of lactoferrin<br />
in Alzheimer’s patients. In this study, Alzheimer’s patients were<br />
treated with lactoferrin for 3 months and compared to both healthy<br />
patients and Alzheimer’s patients. Lactoferrin measurably reduced<br />
the levels of the disease markers amyloid-beta and tau proteins in<br />
Alzheimer’s patients. In addition, thinking performance improved<br />
after treatment. Lactoferrin also showed potential in the treatment of<br />
Covid-19. Preliminary results from a recently published meta study**<br />
in the U.K. show that lactoferrin has a detectable effect in reducing<br />
the risk of respiratory infection and also as a supplement in Covid-19.<br />
Recent study on positive effects in urinary tract infections<br />
A brand-new study*** on bovine lactoferrin (bLf) shows that there is<br />
much more to lactoferrin. It shows that this glycoprotein can be used as<br />
an alternative or adjunct to antibiotic treatments for urinary tract infections.<br />
A disease that affects more than 15 million people each year.<br />
Urinary tract infections (UTI) are most commonly caused by uropathogenic<br />
Escheria coli (UPEC) strains. Cystitis is defined as inflammation<br />
of the urinary bladder and is characterized by dysuria, frequent<br />
urination, and urinary urgency with or without suprapubic pain.<br />
18 No. 3 November/Dezember <strong>2022</strong>
Lactoferrin<br />
Supplementary Fig. S1. Incidence rate of cystitis before and after the date of enrolment by treatment groups. Data are expressed<br />
as events per 100 persons-month, and 95% confidence interval (CI). Given the fact that the number of patients treated with “bovine<br />
lactoferrin (bLf) + probiotics” and that of those treated with “bLf + probiotics + antibiotics” was relatively low (n=3 and n=5,<br />
respectively), these two groups were merged together (n=8) for the scope of this analysis.<br />
An effective antibiotic alternative<br />
The traditional treatment for urinary tract<br />
infections is antibiotic therapy. However, due<br />
to increasing bacterial resistance, effective<br />
non-antibiotic alternatives are being sought.<br />
The use of bLf as an alternative or complementary<br />
treatment to conventional antibiotics<br />
is based on its systemic effects in<br />
balancing, in particular, disturbances in<br />
iron and inflammatory homeostasis. What<br />
the tested bovine lactoferrin can do in this<br />
regard has now been investigated by several Italian scientists in a first<br />
study at the University of Rome.<br />
Lactoferrin in recurrent urinary tract infections:<br />
In vitro and in vivo evidence<br />
The bovine lactoferrin (bLf) study was conducted in patients with<br />
recurrent cystitis and showed a significant decrease in the number<br />
of such episodes over the observation period. Exceptionally positive<br />
results were observed both with bLf alone and as an adjunct to antibiotics,<br />
probiotics or both. The current, scientific findings are preliminary,<br />
promising studies whose results should be verified in further<br />
studies. Already today, the bovine lactoferrin under investigation is<br />
No. 3 November/Dezember <strong>2022</strong><br />
19
Lactoferrin<br />
produced in Australia at the same purity level (99%) as NatraFerrin.<br />
NatraFerrin is derived from the milk of free-range and grass-fed<br />
cattle, which is explicitly emphasized by both the partner manufacturer<br />
Saputo, as well as Vivatis Pharma.<br />
Supplementary Fig. S2. Incidence rate reduction (and 95% CI) from pre- to<br />
post-study period. Data are point estimates, 95% confidence interval (CI),<br />
and p-values.<br />
References<br />
*A pilot study on the effect of lactoferrin on Alzheimer’s disease pathological sequelae: Impact of the p-Akt/PTEN pathway<br />
Mohamed et al., Kairo<br />
Published: Biomed Pharmacother, March 2019<br />
**Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials<br />
Ali et al., University of Huddersfield<br />
Published: Clin Nutr ESPEN, October 2021<br />
***Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences<br />
Conte et al., University or Rome<br />
Published: Biometals, 29. June <strong>2022</strong><br />
For more information, please contact<br />
Diana Kalustova,<br />
Business Development Manager<br />
Vivatis Pharma GmbH<br />
Hamburg, Germany<br />
20 No. 3 November/Dezember <strong>2022</strong>
Pioneering psychobiotic.<br />
Game-changing science.<br />
• 5 clinical studies<br />
• 8 elucidated modes of action<br />
on the brain-gut axis<br />
• Exclusive and strong health claims<br />
on mood and stress granted<br />
in Canada and Brazil<br />
Visit the dedicated website<br />
cerebiomebylallemand.com
Stress<br />
Photo © : Adobe Stock/Prostock-studio (adapted)<br />
Balm for the soul – Melissa officinalis L.<br />
alleviates stress symptoms<br />
Dr Annette Masuch<br />
In today's ever-accelerating world, almost everyone has probably<br />
heard the phrase: take care of yourself, too much stress can make<br />
you sick. But, how much is too much? Certainly, there is no universal<br />
answer and one person might be able to cope with more stress<br />
compared to another. Fortunately, our body is able to signal that we<br />
are reaching our limits. And we should listen and react.<br />
Stress<br />
First of all, we should remember, a stress reaction is nothing negative.<br />
Stress enables us to act quickly in a threatening environment to<br />
ensure our survival. However, from the biological point of view, the<br />
aim of the stress reaction is to quickly deal with the acute danger<br />
by fight or flight. Nowadays, however, we mainly experience stress<br />
situations that cannot be solved simply by flight or attack, e. g. overtime<br />
and performance pressure at work, being constantly available<br />
or the continuous flood of information we are exposed to through<br />
the internet. If we classify these circumstances as threatening and<br />
the situation persists, the stress reaction<br />
may become a health risk. Symptoms of<br />
chronic stress may be diverse and affect the<br />
body, the psyche, the mind and behaviour.<br />
The following symptoms may occur among<br />
others [1]:<br />
– Physical: e. g. trembling, accelerated<br />
heartbeat, sweating, tension (mostly in the<br />
neck and shoulders), reduced performance,<br />
exhaustion, headaches and backaches,<br />
sleep disorders, gastrointestinal<br />
complaints (constipation, diarrhoea).<br />
– Psychological and emotional: e. g. nervousness,<br />
inner restlessness, irritability<br />
(“thin nerves”), panic, anxiety, anger.<br />
– Mental (cognitive): e. g. reduced ability to<br />
concentrate, slowed thinking, reduced<br />
ability to react, forgetfulness.<br />
22 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
Usage of medicinal plants as remedy for all kind of symptoms has long<br />
tradition all over the world. One plant appears to be extra ordinarily<br />
suitable to address stress-related symptoms: Melissa officinalis L.,<br />
commonly known as lemon balm.<br />
Lemon balm – used for centuries not without reason<br />
Indeed, lemon balm has a very long history of medicinal use for about<br />
2000 years and was already described by Dioskurides (40-90 AD) in<br />
his De materia medica [2]. Paracelsus recommended the plant for<br />
“all complaints supposed to proceed from a disordered state of the<br />
nervous system”; it would completely revivify a man [3]. One of the<br />
most famous remedies containing lemon balm is the Carmelite Water,<br />
crafted originally in the 14 th century by Carmelite nuns from the Abbey<br />
of St. Just for King Charles V. of France [4]. Later on, the nun Maria<br />
Clementine Martin, came to Cologne in the 19 th century and founded<br />
her business Maria Clementine Martin Klosterfrau. Her Carmelite Water<br />
is still sold today as Klosterfrau Melissengeist ® [5]. Over the course of<br />
the centuries, the plant found its way into handbooks and pharmacopoeias.<br />
According to the European Union Herbal Monograph its use<br />
in Europe is traditionally indicated for a) the relief of mild symptoms<br />
of mental stress and to aid sleep, and b) for the symptomatic relief<br />
of mild gastrointestinal complaints including bloating and flatulence<br />
[6]. The ESCOP monograph “MELISSAE FOLIUM” gives the following<br />
therapeutic indications for internal use: tenseness, restlessness, and<br />
irritability; symptomatic treatment of digestive disorders such as minor<br />
spasms. Notably, also external use within a cream is described for the<br />
treatment of Herpes simplex labialis (cold sores) [7].<br />
Major constituents and molecular targets<br />
Lemon Balm or Melissa officinalis L. taxonomically belongs to the<br />
family of Lamiaceae. Originating probably from the Eastern Mediterranean<br />
region to Western Asia lemon balm is today naturalised all<br />
over the world. This perennial herbaceous plant has an intense lemon<br />
scent, growing erect to a height of about 30–70 cm. The branched<br />
stem is quadrangular and the soft hairy leaves are heart-shaped to<br />
ovate and arranged in decussate pairs. The leaf edge is scalloped or<br />
toothed and the leaf nervature is strongly protruding underneath [8].<br />
Only the leaves are used as herbal drug itself, for infusions, as<br />
comminuted powder and for the preparation of various herbal drug<br />
preparations ranging from aqueous or alcoholic dry or soft extracts to<br />
tinctures [6]. The quality of the herbal substance is described in the<br />
European Pharmacopoeia in the monograph 1447 “Melissa leaf”.<br />
According to the HMPC assessment report on Melissa officinalis L.<br />
folium [6], the major characteristic components of lemon balm are:<br />
– Essential oil (0.06–0.8 % containing monoterpene aldehydes,<br />
mainly citral, neral and citronellal);<br />
– Sesquiterpene derivates β-caryophyllen and germacren-D (10 %<br />
each in essential oil);<br />
– Monoterpene glycoside;<br />
– Flavonoids with glycoside of lutein, quercetin, apigenin and<br />
kaempferol;<br />
– Phenylpropanoids including hydroxycinnamic acids derivatives<br />
such as caffeic and chlorogenic acid and in particular rosmarinic<br />
acid (up to 6 %);<br />
– Tannins<br />
– Triterpene including ursolic and oleanolic acids<br />
Of note, the exact mechanism of action and therapeutically active<br />
constituents are not yet identified and, further complicating the topic,<br />
different preparations appear to have diverging effect.<br />
Very intriguing, lemon balm extracts and essential oil have been<br />
reported to interfere with the signalling mediated by the neurotransmitter<br />
gamma-aminobutyric acid (GABA). In animal studies,<br />
lemon balm extract inhibited or decreased GABA transaminase.<br />
Furthermore, lemon balm essential oil has been reported to bind<br />
to GABA A<br />
receptors. GABA is the major inhibitory neurotransmitter<br />
in the human brain and is involved in sleep regulation and arousal.<br />
Indeed, several hypnotics as well as tranquilizers are targeting GABA<br />
metabol ism and/or GABAergic signal transduction [2,9] (please refer<br />
also to the info box).<br />
From in vitro studies, using brain membranes prepared by homogenizing<br />
grey matter from human occipital cortex, it has been reported<br />
that ethanolic extracts prepared from lemon balm are able to replace<br />
[ 3 H]-nicotine and [ 3 H]-scopolamine from membranes bearing acetylcholine<br />
receptors [10,11] implicating a direct binding to them (see<br />
below and please refer also to the info box). Furthermore, extracts as<br />
well as the essential oil of lemon balm have been reported to inhibit<br />
the acetylcholine (ACh) esterase activity in a dose-dependent manner,<br />
enhancing the ACh-receptor activation [2]. Both findings implicate a<br />
cholinergic effect of lemon balm herbal preparations and/or essential<br />
oil, which has been reported to be associated with an enhancement<br />
of memory and cognitive function. Of note, not every extract preparation<br />
appears to have cholinergic properties and results may be inconsistent<br />
depending on the type of preparation.<br />
Clinical evidence for the relief of stress symptoms<br />
To transfer molecular findings into clinically relevant observations<br />
several human studies have been performed. In 2002, 2003 and<br />
2004 Kennedy and co-workers reported results from three studies<br />
on hydro-alcoholic extracts from lemon balm leaves [11–13]. All<br />
three studies were randomized, placebo-controlled, double-blind,<br />
balanced cross-over studies. In the first one, 20 healthy volunteers<br />
were included and received 300 mg, 600 mg or 900 mg of<br />
an aqueous-methanolic lemon balm extract or matched placebo.<br />
Participants received the dosage and completed all required tests<br />
pre-dose and at 1 h, 2.5 h, 4 h, and 6 h post dosage, following 7<br />
days wash-out period. This test regimen was repeated three further<br />
times. Overall, the data show sustained improvement in accuracy<br />
of attention following 600 mg of lemon balm extract and time- and<br />
No. 3 November/Dezember <strong>2022</strong><br />
23
Stress<br />
dose-dependent reductions in both secondary memory and working<br />
memory factors. Self-rated “calmness” was elevated already by the<br />
lowest dose and at the earliest time point, whilst “alertness” was<br />
significantly reduced at all time points following the highest dose<br />
of 900 mg [12]. In the following study, different aqueous-ethanolic<br />
extract preparations of lemon balm were screened for the ability<br />
to bind to ACh receptor in vitro since the extract used in the first<br />
study did not show considerable ACh receptor binding abilities. The<br />
extract with highest cholinergic binding properties was then used in<br />
a study with 20 healthy volunteers. The dosage was 600 mg, 1,000<br />
mg, 1,600 mg or matched placebo and tests were performed predose<br />
and at 1 h, 3 h, and 6 h post-dose followed by 7 days washout<br />
period and three times repeat of this regimen. The highest dose<br />
(1,600 mg) results in improved memory performance and increased<br />
calmness at all post-dose time-points [11]. In the third study, the<br />
aqueous-methanolic lemon balm extract utilized in the first study<br />
was examined in 18 healthy volunteers for its effects on laboratoryinduced<br />
psychological stress induced by means of the Defined Intensity<br />
Stressor Simulation (DISS) Computerized Battery. Dosage was<br />
300 mg, 600 mg or matched placebo and cognitive performance and<br />
mood were assessed pre-dose and 1 h after administration followed<br />
by 7 days wash-out period. The procedure was repeated further two<br />
times. The results of this study implicate that ingestion of extract of<br />
lemon balm can directly alleviate effects of stress. The higher dose<br />
(600 mg) mitigated the negative mood effects induced by the DISS<br />
in terms of increased self-rating of calmness and reduced self-rated<br />
alertness [13]. Apparently, lemon balm may support memory performance<br />
depending on the type of extract. Whilst an aqueous-methanolic<br />
extract rather reduced secondary and working memory performance,<br />
the aqueous-ethanolic extract preparation with cholinergic<br />
properties improved memory performance.<br />
Cases et al. report results from a prospective, single-centre, open<br />
label study. Twenty stressed volunteers were included who were<br />
affected by mild-to-moderate anxiety disorder and sleep disturbances.<br />
The participants received for 15 days a standardized lemon<br />
balm leaf aqueous-ethanolic extract that contained more than 7 %<br />
rosmarinic acid and more than 15 % hydroxycinnamic acid derivatives.<br />
Significant improvement of anxiety-related symptoms as well<br />
as insomnia and no adverse effects were reported. Anxiety with associated<br />
symptoms, insomnia at baseline and post-treatment were<br />
assessed by means of the Free Rating Scale of Anxiety (FRSA) and<br />
the Hamilton Rating Scale for Depression (HRSD), respectively. The<br />
overall anxiety manifestation, including agitation, hyperactivity and<br />
tension, was significantly reduced by 18 %. Insomnia was clinically<br />
significant improved. Notably, full remission of symptoms within the<br />
15-day treatment was reached in 17 out of 20 participants [14].<br />
The efficacy of an aqueous lemon balm extract in food products<br />
(drinks and yoghurt) was examined in one pilot and two behavioural<br />
studies in healthy adults. The latter ones were designed as<br />
randomised, placebo-controlled, balanced cross-over studies to<br />
examine the effects of lemon balm extract on the mood, stress-level<br />
and also cognitive function. The findings<br />
support the notion that supplementation of<br />
food with lemon balm extract lowers levels<br />
of anxiety and stress. This was also associated<br />
with reduced cortisol levels as a physiological<br />
measure of stress. The cognitive<br />
performance as assessed by a multi-tasking<br />
framework of four simultaneous tasks was<br />
also enhanced [3].<br />
Taken together, these observations strongly<br />
underline the traditional use of lemon balm<br />
to aid sleep and relief symptoms of stress like<br />
anxiety or tension related to stress.<br />
Lemon balm and its calming effect<br />
on the gut<br />
At the first glance, the indications “relief of<br />
mild symptoms of stress and to aid sleep”<br />
and “relief of mild symptoms of gastrointestinal<br />
complaints” appear to have nothing to<br />
do with each other. Yet, surprisingly, dosages<br />
and preparations are basically identical for<br />
both. Considering bodily signs of stress, one<br />
or the other reader might have already said<br />
the phrase “I am getting a stress ulcer over<br />
this”. Of note, the term “functional gastrointestinal<br />
(GI) complaints” means complaints<br />
like abdominal pain, dyspepsia, diarrhoea,<br />
constipation and bloating in the absence<br />
of demonstrable pathologic condition like<br />
inflammation, GI infection or food intolerance<br />
for instance. Historically, they have<br />
been defined as “of no organic basis”, but<br />
today alterations in the gut-brain communication<br />
are strongly implicated in the aetiology<br />
including altered gut-microbiota [15].<br />
Maybe the connection between brain and<br />
gut might be of importance as well for the<br />
efficacy of lemon balm for the treatment of<br />
mild GI complaints. But, so far this remains<br />
only a speculation. Notably, the use of lemon<br />
balm for this indication is based only on longstanding<br />
tradition and clinical studies are not<br />
available.<br />
The spasmolytic effects of lemon balm<br />
extracts have been shown in ex vivo studies,<br />
however. It was reported that an aqueousethanolic<br />
extract from lemon balm leaves<br />
has site- and dose-dependent effects on<br />
the contractile activity of the GI tract. Aubert<br />
24 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
and colleagues examined the response of<br />
different segments of the mouse GI tract<br />
under basal conditions as well as precontracted<br />
to observe spasmolytic properties.<br />
Whereas no effects were reported for antrum<br />
and colon, lemon balm extract significantly<br />
and dose-dependently reduced the contractile<br />
activity in ileum and jejunum. The authors<br />
describe that treatment with the extract also<br />
reduced the spontaneous phasic contraction<br />
and overall lemon balm might slow the<br />
GI transit [16].<br />
Several other studies reported spasmolytic<br />
effects of lemon balm essential oil on<br />
isolated guinea pig ileum, rat duodenum and<br />
vas deferens, and on the jejunum of rabbits<br />
[7]. In line with these findings, Sadraei et al.<br />
reported inhibitory effects of lemon balm<br />
essential oil and especially citral as one of<br />
the major components of the essential oil<br />
on rat ileum. Contractions were induced<br />
by addition of 80 mM KCl, 320 nM ACh or<br />
1.28 µM 5-HT (5-Hydroxytryptamine) to the<br />
bath solution of the isolated ileum [17]. The later findings implicate<br />
the essential oil to mediate spasmolytic effects, however, the study of<br />
Aubert et al. analysed the investigated extract phytochemically and<br />
did not detect essential oil [16]. Thus, spasmolytic effects may not<br />
only be attributable to the essential oil but also to other not yet specified<br />
components present in an aqueous-ethanolic extract. Though<br />
clinical data are not available, the use of lemon balm against GI<br />
complaints has long tradition and numerous products are present in<br />
the market.<br />
Antiviral effect to treat cold sores<br />
Lemon balm shows antiviral effects. However, the European Union<br />
Herbal monograph does not cover the indication. A highly concentrated<br />
lemon balm extract with a drug to extract ratio of 70:1 is<br />
contained in a cream for the topic treatment of recurrent Herpes<br />
simplex labialis. The extract is standardised with respect to the antiviral<br />
activity using plaque inhibition test [6]. Symptoms of infections<br />
with Herpex simplex virus (HSV)-1 comprise pain and blistering on<br />
the lips and perioral area (cold sores). Usually, the primary infection<br />
occurs in the childhood and the virus is presumably remaining<br />
latent in the trigeminal ganglion. Of note, stress may be one factor<br />
to trigger recurrence [18]. Clinical studies for this special extract<br />
are available from the 1990s. Application of the cream significantly<br />
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25
Stress<br />
reduced the healing time of cutaneous lesions and extended the<br />
interval of recurrences in a multicentre, open, controlled study with<br />
115 patients. These finding were confirmed in a multicentre, doubleblind,<br />
placebo-controlled study including 116 patients [7, 19]. Independent<br />
from the first studies, Koytchev and coworkers performed<br />
a double-blind, placebo-controlled, randomized trial including 66<br />
patients to investigate the efficacy of the cream containing the above<br />
mentioned standardised aqueous extract. They also reported shortened<br />
healing period and, furthermore, the prevention of spreading of<br />
the infection and rapid effects on typical symptoms [20]. Also other<br />
lemon balm extracts and the essential oil appear to have antiviral<br />
properties at least in vitro. As summarised by Shakeri et al., both<br />
aqueous-alcoholic and aqueous extracts of lemon balm exert antiviral<br />
activity against HSV-1 and HSV-2 in cell-based experiments. Also for<br />
the essential oil inhibition of HSV-1 and HSV-2 has been reported<br />
from in vitro plaque reduction tests [2].<br />
Taken together, lemon balm and various preparations from its leaves<br />
have been under investigation already for a long time and its efficacy<br />
has been reported in several clinical studies. In view of today’s<br />
challenging and fast-moving everyday life, the experience of somatic<br />
signs of stress – like difficulty to fall asleep due to running thoughts,<br />
gastrointestinal complaints, or even recurrent cold sore – is widespread<br />
and well-known to many people. Melissa officinalis L. has<br />
been used successfully for centuries as a<br />
remedy, though still not all her secrets are<br />
elucidated by now.<br />
About Anklam Extrakt GmbH<br />
Anklam Extrakt GmbH is a German company<br />
that stands for top expertise in development,<br />
production and research of high-quality plant<br />
extracts. Our extract portfolio includes both<br />
extracts for the pharmaceutical and nutraceutical<br />
industry. As a specialist in innovative<br />
ingredients, Anklam Extrakt ® also develops<br />
brand concepts that are based on scientific<br />
studies for the healthcare sector.<br />
With a rosmarinic acid content of ≥ 2.0 %<br />
our lemon balm extract is suitable for food<br />
supplement and pharmaceutical applications.<br />
The extract is compliant with the<br />
Ph. Eur. and we can support the registration<br />
process of our customers with a CEP (Certificate<br />
of Suitability of Monographs of the European<br />
Pharmacopoeia).<br />
Info box: Transmitter systems<br />
a) γ-amino butyric acid (GABA)<br />
GABA is the major inhibitory neurotransmitter maintaining the excitatory/inhibitory balance in the human central<br />
nervous system. GABA can bind to two main types of receptors:<br />
– ionotropic GABA A<br />
receptors: fast-acting ligand-gated Cl - channels; increased influx of chloride ions induces an<br />
inhibitory postsynaptic potential (IPSP)<br />
– metabotropic GABA B<br />
receptors: slow-acting dimeric receptors linked to Gα i/o<br />
activating ligand gated Cl - channels in<br />
the postsynaptic cell (slow IPSP) or closing voltage-gated Ca 2+ channels in the presynapse (consequently reducing<br />
transmitter release)<br />
GABA is cleared from the synaptic cleft by GABA-transporters and about 80 % of the transmitter is recycled. Breakdown<br />
of GABA occurs through the GABA transaminase removing a nitrogen group from GABA to create L-glutamate<br />
in the so-called GABA shunt.<br />
b) Acetylcholine (ACh)<br />
ACh is a ubiquitous signalling molecule. It is an excitatory neurotransmitter in the human central nervous system and<br />
also modulates signal transduction of other transmitter systems. ACh is the transmitter at the neuromuscular junction<br />
(transmitting the signal from the nerve to the muscle), is one of the major transmitters in the autonomic nervous<br />
system (internal transmitter in the sympathetic system and final output transmitter in the parasympathetic system),<br />
and is even involved in non-neuronal signalling. ACh can bind to two main types of receptors:<br />
– nicotinergic ACh (nACh) receptors (ionotropic): fast-acting ligand-gated non-selective cation channels: increased<br />
permeability to Na + and K + (and sometimes Ca 2+ , depending on subunit composition) induces an excitatory postsynaptic<br />
potential (EPSP) in neurons; nicotine is a selective agonist<br />
– muscarinergic ACh (mACh) receptor (metabotropic): slow-acting monomeric receptors with 7 transmembrane<br />
domains coupled to G-proteins (Gα q<br />
or Gα i/o<br />
depending on the receptor subtype). There are 5 subtypes of mACh<br />
receptors with different effectors, thus the downstream signalling varies depending on the subtype; muscarine is a<br />
selective agonist, scopolamine is a high-affinity antagonist<br />
ACh action is terminated by acetylcholine esterase breaking down the molecule into choline and acetate.<br />
26 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
References<br />
[1] Stress. Univ Zür https://www.usz.ch/krankheit/stress/ (accessed August 26, <strong>2022</strong>).<br />
[2] Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol<br />
2016;188:204–28. https://doi.org/10.1016/j.jep.2016.05.010.<br />
[3] Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, et al. Anti-stress effects of lemon balm-containing foods. Nutrients 2014;6:4805–21.<br />
https://doi.org/10.3390/nu6114805.<br />
[4] Groom N. The Perfume Handbook. Chapman & Hall; 1992.<br />
[5] Ein Unternehmen mit Tradition: Alles über Klosterfrau erfahren. Klosterfrau | Heilkraft der Pflanzen – wo Wirksamkeit wächst https://www.klosterfrau.de/<br />
ueber-klosterfrau.html (accessed August 26, <strong>2022</strong>).<br />
[6] Committee on Herbal Medicinal Products (HMPC). Assessment report on Melissa officinalis L., folium (EMA/HMPC/196746/2012). Eur Med Agency<br />
2013:1–20.<br />
[7] ESCOP. MELISSAE FOLIUM Melissa Leaf. ESCOP Monographs 2009;2nd Edition:324–8.<br />
[8] Wichtl M. Teedrogen und Phytopharmaka. 5 th Edition 2009.<br />
[9] Bruni O, Ferini-Strambi L, Giacomoni E, Pellegrino P. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Nutrients<br />
2021;13:530. https://doi.org/10.3390/nu13020530.<br />
[10] Wake G, Court J, Pickering A, Lewis R, Wilkins R, Perry E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve<br />
failing memory. J Ethnopharmacol 2000;69:105–14. https://doi.org/10.1016/s0378-8741(99)00113-0.<br />
[11] Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA, et al. Modulation of mood and cognitive performance following acute administration<br />
of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacol<br />
2003;28:1871–81. https://doi.org/10.1038/sj.npp.1300230.<br />
[12] Kennedy DO, Scholey AB, Tildesley NTJ, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa<br />
officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953–64. https://doi.org/10.1016/s0091-3057(02)00777-3.<br />
[13] Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).<br />
Psychosom Med 2004;66:607–13. https://doi.org/10.1097/01.psy.0000132877.72833.71.<br />
[14] Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-tomoderate<br />
anxiety disorders and sleep disturbances. Mediterr J Nutr Metab 2011;4:211–8. https://doi.org/10.1007/s12349-010-0045-4.<br />
[15] Fikree A, Byrne P. Management of functional gastrointestinal disorders. Clin Med Lond Engl 2021;21:44–52. https://doi.org/10.7861/clinmed.2020-<br />
0980.<br />
[16] Aubert P, Guinobert I, Blondeau C, Bardot V, Ripoche I, Chalard P, et al. Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis<br />
L. on Intestinal Motility: An Ex Vivo Study. J Med Food 2019;22:653–62. https://doi.org/10.1089/jmf.2018.0154.<br />
[17] Sadraei H, Ghannadi A, Malekshahi K. Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. Fitoterapia 2003;74:445–<br />
52. https://doi.org/10.1016/s0367-326x(03)00109-6.<br />
[18] Worrall G. Herpes labialis. BMJ Clin Evid 2009;2009:1704.<br />
[19] Wölbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine Int J Phytother Phytopharm<br />
1994;1:25–31. https://doi.org/10.1016/S0944-7113(11)80019-X.<br />
[20] Koytchev R, Alken R, Dundarov S. Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Phytomedicine Int J Phytother Phytopharm<br />
1999;6. https://doi.org/10.1016/S0944-7113(99)80013-0.<br />
For more information, please contact<br />
Dr Annette Masuch,<br />
Regulatory Affairs Manager<br />
Anklam Extrakt GmbH, Germany<br />
www.anklam-extrakt.de<br />
Photo © : Adobe Stock/GCapture<br />
No. 3 November/Dezember <strong>2022</strong><br />
27
Stress<br />
The hyper-specialization of anti-stress solutions<br />
Laure Egoumenides<br />
Stress is a protective reaction of the body when it is in a situation of<br />
perceived danger or when faced with a major challenge. Considered<br />
the defining disease of the 21 st century due to its association with<br />
negative emotions, stress is a major general health problem.<br />
The global prevalence of anxiety and depression has increased by a<br />
massive 25 % since the Covid-19 pandemic. In 2020, 29.6 % of the<br />
world population were reported to be suffering from stress, 31.9 %<br />
with anxiety and 33.7 % depression. 1<br />
Exposure to stress is not without consequences; it results in several<br />
psychological and physical disorders such as burn out, irritability,<br />
physical and emotional exhaustion, eating disorders or even bodily<br />
dysfunction when this exposure is prolonged. Consumers are therefore<br />
looking for effective solutions to relieve their stress-related<br />
ailments.<br />
The stress management market is well-established and mature.<br />
Sales for anxiety/stress relief dietary supplements in 2020 have<br />
grown by 79 % since 2018. 2 Thus, there is a wide variety of solutions<br />
and becoming more and more specialized. They respond to different<br />
levels of stress e. g., temporary stress, anxiety and depression, as<br />
well as to the consequences of stress, such as sleep disorders, mood<br />
swings and variations in immune function.<br />
The mechanisms of stress and its consequences<br />
The mechanisms of stress<br />
Stress reactions are triggered by a stimulus. This stimulus can be of<br />
a number of different kinds. Modern sources of stress include work,<br />
geopolitical and climatic conditions, family situations and changes in<br />
daily life.<br />
The body reacts to this stimulus in several phases<br />
The alarm phase immediately follows the stimulus. This is an immediate<br />
survival reaction involving, in particular, the release of adrenaline.<br />
This induces an increase in heart rate, body temperature and<br />
blood pressure. Thus, the body’s vigilance is at its peak, entering<br />
“fight or flight” mode in order to get out of the stressful situation as<br />
quickly as possible.<br />
Then comes the resistance phase. This corresponds to a prolonged<br />
period of stress. The body secretes cortisol, which stimulates the<br />
metabolism of glucose. The released glucose supplies the organs<br />
28 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
with energy, which allows the body to defend itself and adapt. It also<br />
releases dopamine and serotonin which increase concentration and<br />
motivation.<br />
Finally, if the period of exposure to stress is prolonged, the exhaustion<br />
phase arrives (corresponding to burn out, depression or chronic<br />
stress disorders). The metabolism is disrupted, and the body<br />
becomes physically and psychologically exhausted.<br />
The consequences of exposure to stress<br />
The consequences of stress are multiple, and manifest themselves<br />
in different ways:<br />
– Poor sleep quality and/or excessive fatigue<br />
– Irritability and/or poor emotional management<br />
– Eating disorders (loss of appetite or, on the<br />
contrary, compulsive eating)<br />
– A lack of productivity, concentration, memory problems<br />
– And many others...<br />
Unique bioactive<br />
for Healthy blood sugar levels<br />
In addition to general malaise, exposure to stress can lead to metabolic<br />
dysfunctions. The hormonal cascade leads in particular to the<br />
secretion of molecules of the corticoid family, responsible for disturbances<br />
in the body’s oxidative status. These molecules can be<br />
responsible for mood disorders such as irritability or anxiety.<br />
The resulting oxidative damage has a signifi cant impact on health<br />
and well-being. Indeed, the excess of free radicals in the body (linked<br />
to oxidative stress) degrade cells and certain metabolites, leading to<br />
dysfunctions.<br />
Composed of 60 % lipids and representing more than 20 % of our<br />
total oxygen consumption, our brain is particularly sensitive to oxidative<br />
stress.<br />
Several studies suggest that oxidative stress may have a role to<br />
play in the onset of feelings of stress and anxiety. There is therefore<br />
a link between oxidative metabolism and the management of<br />
anxiety disorders.<br />
Moreover, stress is also associated with abnormal inflammatory<br />
activity, impacting the digestive system and the intestinal microbiota.<br />
Finally, it induces increased risks of cardiovascular and immune<br />
disorders.<br />
Stress regulation:<br />
hyper-specialized solutions<br />
There are many ways to manage stress naturally. It is important to<br />
adapt one’s diet in order to promote the development of the intestinal<br />
microbiota. Indeed, the microbiota has a great influence on the ability<br />
to manage stress, especially because the intestine produces 95 % of<br />
serotonin (the so-called “happiness hormone”), and this secretion is<br />
induced by the intestinal microbiota.<br />
CLINICALLY<br />
PROVEN<br />
NATURAL<br />
INGREDIENT<br />
www.pep2dia.com<br />
REGULATORY<br />
APPROVED<br />
No. 3 November/Dezember <strong>2022</strong><br />
29
Stress<br />
Stress is a phenomenon that is becoming<br />
increasingly well known: numerous scientific<br />
studies have looked into its mode of action,<br />
as well as its impact on the metabolism,<br />
the brain, and mental states. Thanks to this<br />
in-depth knowledge of stress, the nutraceutical<br />
industry can offer solutions that respond<br />
to extremely specific problems. Thus, we<br />
can observe different categories of solutions:<br />
Robertet Health & Beauty has therefore<br />
developed an ingredient with clinically proven<br />
efficacy to help relieve stress. A unique melon<br />
juice concentrate, Extramel ® is obtained from<br />
a patented process of cantaloupe, grown<br />
exclusively in the South of France.<br />
Naturally rich in SOD (Superoxide Dismutase),<br />
a powerful anti-oxidant, Extramel ® helps overcome<br />
feelings of stress: people who take<br />
Extramel ® experience less irritability and<br />
weariness, and enjoy a better quality of life.<br />
The development of anti-stress solutions is<br />
thus no longer limited to offering products<br />
that only reduce stress. It is now essential to<br />
also target the consequences and even the<br />
causes of stress.<br />
Solutions responding to different degrees<br />
of stress<br />
– Temporary stress<br />
– Intense stress<br />
– Oxidative stress<br />
– Anxiety<br />
Solutions acting on stress and its consequences<br />
– Stress and reduction of fatigue<br />
– Stress and sleep quality<br />
– Positive mood<br />
– Stress and immunity<br />
– Stress and energy<br />
Solutions targeting a specific problem<br />
related to stress<br />
– Nervous balance<br />
– Cardiovascular system and oxidative stress<br />
– Calming emotional stress<br />
– Relaxation<br />
– Physical and mental resistance to stress<br />
There is therefore a real challenge ahead for<br />
players positioning themselves in the stress<br />
market in three key areas:<br />
– Scientific support, which plays a crucial<br />
role: this allows players to demonstrate<br />
modes of action and the effectiveness of<br />
the solutions, thus justifying their positioning<br />
– The combination of effective ingredients to<br />
meet several objectives (treating stress<br />
and fatigue for example), without negative<br />
interactions between the active ingredients<br />
– The use of holistic ingredients to relieve<br />
different ailments<br />
For more information, please contact<br />
Laure Egoumenides, Product Manager<br />
Robertet S.A., France<br />
www.robertet.com<br />
Fig. 1: Secondly, Extramel ® helps maintain cognitive and physical performance by significantly increasing<br />
mental concentration and decreasing fatigue, sleep disorders and physical pain.<br />
Fig. 2: In fact, by targeting oxidative stress, Extramel ® acts on both the consequences of stress and<br />
its possible causes. It therefore allows for the development of holistic solutions, which will help attain<br />
several objectives.<br />
References<br />
1<br />
OMS. Les cas d’anxiété et de dépression sont en hausse de 25 % dans le monde en raison de la pandémie de COVID-19.<br />
Mars <strong>2022</strong><br />
2<br />
Francis E. COVID-19 Stress Drives Anxiety-Reducing Supplement Sales Up 79 % In US Since 2018. HBW Insight. 30 Apr<br />
2021. Retrieved July 22, 2021<br />
30 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
Cultivating a sustainable source of<br />
a stress-busting adaptogen<br />
Growing demand for Rhodiola rosea is creating pressure on wild-harvested supplies. Nektium’s Deborah<br />
Thoma explains how a pioneering cultivation strategy is delivering a sustainable solution<br />
Deborah Thoma<br />
Physical and emotional stress are part of<br />
everyday life for people all over the world<br />
– and the impacts can be severe. In fact,<br />
stress-related non-communicable diseases<br />
such as coronary artery disease, diabetes,<br />
and cancer have been described as “the<br />
major health crisis in the 21 st century.” 1 In<br />
this context, it is little surprise that adaptogens<br />
– ancient plants and herbs that can<br />
help the body adapt to stress – are seeing a<br />
significant increase in demand. 2<br />
The term adaptogen was coined by Dr.<br />
Nikolai Lazarev in 1947 and referred to<br />
substances that meet three criteria. First,<br />
they need to help the body contend with an<br />
array of conditions, such as physical, chemical,<br />
or biological stress. Secondly, they must<br />
regulate homeostasis, which means either<br />
offsetting or resisting physical disorders resulting from external stress.<br />
Thirdly, they must not damage the body’s normal function. 3<br />
While there are many adaptogens on the market today, Rhodiola<br />
rosea, primarily growing wild in the remote Altai mountains, is the<br />
one that best matches Dr. Lazarev’s original definition.<br />
Sustainable sourcing<br />
With demand for Rhodiola rosea accelerating, there is now considerable<br />
pressure on wild supplies – leading to concerns around overharvesting.<br />
Botanical extract manufacturer Nektium is therefore<br />
taking steps to secure the long-term sustainability of its standardized<br />
Rhodiola rosea extract by switching a significant proportion of its<br />
sourcing to cultivated plants.<br />
The company is implementing this pioneering cultivation strategy in<br />
close cooperation with its long-standing partner in the Altai mountains.<br />
The material used to grow the cultivated Rhodiola rosea for<br />
No. 3 November/Dezember <strong>2022</strong><br />
31
Stress<br />
presents significant challenges, especially in maintaining the levels<br />
of actives. Nonetheless, the company’s vegetative propagation technique<br />
is not only faster and more reliable but ensures that the molecular<br />
composition of the cultivated Rhodiola rosea is identical to the<br />
wild-grown plant. This achievement was the outcome of many years<br />
of experimentation, testing, and refinement of techniques.<br />
Growing Rhodiola rosea in a controlled setting also limits unknown<br />
factors and results in a more predictable and secure long-term raw<br />
material supply. Cultivation means improved price stability, superior<br />
safety, and more effective quality control. With a Quality Assurance<br />
system put in place with Good Agricultural and Collection Practices<br />
(GACPs) governing rules of production, harvesting, storage, and record<br />
keeping is monitored. This is accompanied by training programs, as<br />
well as traceability and recall plans, all of which has allowed the initiative<br />
to be established as a successful long-term project.<br />
Harnessing the benefits<br />
Rhodiola rosea’s adaptogenic activity is usually attributed to four<br />
principal active compounds – salidroside, rosin, rosavin, and rosarin<br />
– which are found at high concentrations in the roots. Ensuring the<br />
final ingredient delivers the appropriate quantity of the desired bioactive<br />
components is a task that requires skill and care. Apart from the<br />
expertise in manufacturing the botanical extract, an understanding<br />
for how growing conditions affect the plants and, in turn, when to<br />
harvest them, while putting in place a quality management system<br />
together with the local partner, was developed.<br />
Rhodiola rosea is an extremely hardy plant that is well suited to the<br />
harsh weather conditions in the Altai mountains. The coldest months<br />
are January and February, when the average temperature falls as low<br />
as -15°C. The snow usually begins to melt in early May, providing the<br />
plants with a short window in which to grow.<br />
The bioactive compounds in the Rhodiola rosea root reach their<br />
highest levels between three and five years of growth. If harvested<br />
too early, the overall level of actives is likely to be substantially lower.<br />
Through visual inspection and by analyzing climatic conditions, it is<br />
possible to determine the ideal time to harvest the plant.<br />
the ingredient was originally taken from wild-harvested plants from<br />
the area where the cultivation fields are now established. To ensure<br />
the plant will flourish, Nektium has worked with its partner to establish<br />
fields that offer optimal conditions for the controlled growing of<br />
Rhodiola rosea.<br />
Barren land in undeveloped and unpopulated locations was<br />
selected for conversion to ensure minimal impact on local communities.<br />
Subsequent expansion of the initial cultivated area has been<br />
carried out not from seeds but through vegetative propagation of root<br />
rhizomes extracted from the cultivated Rhodiola rosea. Cultivation<br />
Scientific research<br />
Rhodiola rosea is supported by centuries of traditional use for mental<br />
and physical stress. In the modern era, studies have found that it offers<br />
a range of cognitive health benefits, including reduced stress and<br />
fatigue as well as improved mental sharpness. In addition, Rhodiola<br />
rosea has been shown to deliver a boost to athletic performance by<br />
aiding recovery and enhancing immune health after exercise. 4<br />
A pilot study set out to evaluate whether the ingredient can reduce<br />
symptoms of generalized anxiety disorder (GAD). Ten participants<br />
with a DSM-IV diagnosis of GAD received a total daily dose of 340 mg<br />
32 No. 3 November/Dezember <strong>2022</strong>
Stress<br />
References<br />
1<br />
Fricchione, G.L. 'The Challenge of Stress-Related Non-Communicable Diseases' Medical<br />
Science Monitor Basic Research (2018)<br />
2<br />
NielsenIQ 'What are nootropics and adaptogens?' (<strong>2022</strong>)<br />
3<br />
Liao, L.Y. et al. 'A preliminary review of studies on adaptogens: comparison of their bioactivity<br />
in TCM with that of ginseng-like herbs used worldwide' Chinese Medical Journal<br />
(2018)<br />
4<br />
Stojcheva. E.I. et al. “The Effectiveness of Rhodiola rosea L. Preparations in Alleviating<br />
Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging<br />
Clinical Evidence.” Molecules (<strong>2022</strong>)<br />
5<br />
Bystritsky, A. et al. 'A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder<br />
(GAD)' Journal of Integrative and Complementary Medicine (2008)<br />
6<br />
Abidov, M. et al. 'Extract of Rhodiola rosea radix reduces the level of C-reactive protein<br />
and creatinine kinase in the blood' Bulletin of Experimental Biology and Medicine (2004)<br />
7<br />
Ahmed, M. et al. 'Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive<br />
Marathon Race' Frontiers in Nutrition (2015)<br />
of the Rhodiola rosea extract over a period of ten weeks. Significant<br />
improvements in symptoms, with reduced scores on both the<br />
Hamilton Anxiety Rating Scale and the Four-Dimensional Anxiety and<br />
Depression Scale were demonstrated. 5<br />
Rhodiola rosea extract also has a long history of use among professional<br />
athletes to improve endurance and rapid recovery of muscles.<br />
A double-blind placebo-controlled study explored the effects of the<br />
ingredient on blood levels of inflammatory C-reactive protein (CRP)<br />
and creatinine kinase (CK) before and after exhausting exercise.<br />
Among 36 healthy, untrained volunteers, the extract was found to<br />
exhibit an anti-inflammatory effect and protect muscle tissue during<br />
exercise. Blood levels of CRP were less pronounced among those<br />
taking the Rhodiola rosea extract, while the exercise-induced rise in<br />
CK was also blunted. 6<br />
A further study provided evidence that the ingredient can increase<br />
immune protection after sports. Marathon runners are prone to viral<br />
illnesses shortly after competing in a race. A study set out to measure<br />
the antiviral and antibacterial properties of the bioactive metabolites of<br />
Rhodiola rosea in the serum of experienced marathon runners. The<br />
study found that the use of Rhodiola rosea induced antiviral activity at<br />
early times post-infection by delaying an exercise-dependent increase<br />
in virus replication. This suggests it exerts protective effects against<br />
virus replication following intense and prolonged exercise. 7<br />
For more information, please contact<br />
Deborah Thoma<br />
Marketing Manager<br />
Nektium Pharma S.L.<br />
customerservice@nektium.com<br />
www.nektium.com<br />
DEPUIS<br />
SAVOIR-FAIRE<br />
F R A N Ç A<br />
I S<br />
1855<br />
Plant power<br />
Miam<br />
As one of the most powerful adaptogens found in nature, Rhodiola<br />
rosea is seeing a surge in popularity. Rhodiolife ® is a sustainably<br />
produced root extract with a phytochemical profile that reflects all the<br />
natural active ingredient content of the wild Siberian Rhodiola rosea<br />
in terms of both composition and relative concentrations. It is ideally<br />
suited to supplements and can also be used across a wide range of<br />
food and beverage applications, including sports and energy drinks,<br />
dairy products, gummies, and cereal bars.<br />
savoureux<br />
frais<br />
délicieux<br />
Supported by scientific research, the ingredient offers wide-ranging<br />
benefits for product development objectives across sports and<br />
cognitive health.<br />
No. 3 November/Dezember <strong>2022</strong><br />
33
Brain health<br />
Photo © : Fotolia/Okea<br />
Phospholife ®<br />
Highly bioavailable solution for brain health<br />
Stephanie Lennon, Gildas Breton<br />
Phospholife ® is an innovative patented vegan solution, made of<br />
sustainable and highly bioavailable resources. It brings high content<br />
of pure and ultra-stable Omega-3 (DHA) from microalgae and phospholipids<br />
very rich in Phosphatidylcholine. This solution gives higher<br />
bioavailability than standard Omega-3 oils (TG & EE) and it has been<br />
specially designed to target brain health through all stages of life:<br />
from the beginning of intrauterine life to the maintenance of cognitive<br />
faculties in the elderly.<br />
DHA, an essential fatty acid for brain development<br />
and cognitive maintenance<br />
DHA (Docosahexaenoic acid) is an essential long-chain polyunsaturated<br />
fatty acids (PUFAs) Omega-3, highly concentrated in the<br />
brain and retina, which is critical for normal nervous development<br />
and function. DHA accounts for up to 97 % of the Omega-3 fatty<br />
acids in the brain and 93 % of the omega-3 fatty acids in the eyes.<br />
The presence of DHA in the membranes helps for the optimal functioning<br />
of membrane receptors and transporters, signal transduction<br />
and neurotransmission. Furthermore, DHA counteracts pro-inflammatory<br />
effect of Omega 6 arachidonic acid (AA), and the metabolites<br />
of DHA (resolvins, protectins, maresins) play critical roles in the resolution<br />
of inflammation.<br />
Most studies indicates that the DHA accumulation is mainly influenced<br />
by dietary intake, specifically of preformed DHA.<br />
Maternal DHA supplementation and brain development<br />
DHA intake is most important during pregnancy and lactation for<br />
both mom and baby alike. During the prenatal time, there is a very<br />
high demand and rapid accumulation of specific fatty acids including<br />
AA and DHA in the infant brain. The human brain relies on DHA<br />
for proper growth and development. The most active accumulation<br />
occurs during gestation until the age of 2 years and continues until<br />
the age of 18 years. DHA can be synthetized from its essential fatty<br />
acid precursor, α-linolenic acid (ALA). However, the capacity of brain<br />
for synthesizing DHA is very limited especially in early life stage, thus<br />
this fatty acid is mainly supplied via the uteroplacental circulation<br />
during pregnancy and the breast milk during nursing. Because the<br />
mother is the sole source of DHA for the developing baby, it is critical<br />
that a pregnant, and nursing-, mother consumes enough Omega-3s<br />
to ensure brain development for her baby. [1-2]<br />
The composition of human breast milk reflects the nutritional status<br />
and dietary intake of the lactating mother. Over the first 6 months of<br />
life, which is the time exclusive breastfeeding is recommended, the<br />
34 No. 3 November/Dezember <strong>2022</strong>
Brain health<br />
with age-related cognitive decline and mild cognitive impairment,<br />
particularly for improving memory. [5-6]<br />
Choline, an essential nutrient for brain health<br />
Choline is recognized by the National Academy of Medicine as an<br />
essential nutrient that must be acquired from diet, as de novo biosynthesis<br />
is insufficient to meet human requirements. Choline plays a<br />
key role in lipid transport and cell membrane structural support (as<br />
phosphatidylcholine), neurotransmission (as acetylcholine), and as a<br />
source of methyl group (as a precursor of betaine).<br />
infant brain doubles in weight, and the large<br />
brain/body weight ratio for infants compared<br />
with adults may put the infant at greater risk<br />
to deficits in nutrients and energy. Much<br />
of the increase in brain weight is attributed<br />
to increased grey matter, corresponding to<br />
the formation of neural synapses which are<br />
rich in DHA. Neurite outgrowth, dendritic<br />
complexity and neurotransmitter metabolism<br />
are also highly reliant on DHA.<br />
DHA supplementation<br />
and brain health<br />
Photo © : Fotolia/Monkey Business<br />
Under its ability to control membrane<br />
fluidity, the DHA also modulated neuronal<br />
density, neurotransmitter concentration, and<br />
synaptic activity by regulating the brain’s<br />
neuro-inflammatory state. Neurons are<br />
the core component of the central nervous<br />
system and are exceptionally rich in DHA. A<br />
diet deficient in DHA will deprive the nervous<br />
system of a critical nutritional component<br />
that could impair your body’s ability to learn,<br />
think, and remember. [3-4]<br />
DHA has been shown to accumulate in areas<br />
of the brain associated with learning and<br />
memory, cerebral cortex and hippocampus.<br />
DHA helps maintaining healthy brain at all<br />
stages of life. The current evidence suggests<br />
that DHA may be of benefit for older adults<br />
In addition to the role of choline in general physiology, choline is critically<br />
during pregnancy. Lower serum choline levels are associated<br />
with increased risk of neural tube defects [7], suggesting that choline<br />
intakes should be increased prior to pregnancy. Choline, transferred<br />
across the placenta from the mother to the foetus, plays a significant<br />
role in foetal development, and particularly brain development. It has<br />
been observed that prenatal choline is essential to the neurophysiological<br />
development of the hippocampus, the so-called “Memory<br />
Centre” of the brain. Furthermore, Choline is needed after birth, as<br />
well, as part of the synaptic connections that continue to be formed<br />
in the hippocampus and basal forebrain after birth. [8-9] Moreover, in<br />
a recent clinical study at Cornell University, increased choline intake<br />
during pregnancy was correlated with improved processing speed in<br />
infants. [10]<br />
Choline is also an essential nutrient for cognitive performance.<br />
Choline has been shown to be associated with lower risk of incident<br />
dementia and better cognitive performance in men. [11] A<br />
reduction in acetylcholine, an essential neurotransmitter for memory<br />
and learning synthesised from choline, has been observed among<br />
patients with Alzheimer’s disease. [12]. Furthermore, researches<br />
have shown the neuroprotective effect of choline supplementation.<br />
[13-14] Another study has shown that Choline supplementa-<br />
Photo © : Adobe Stock/Alex Mit<br />
No. 3 November/Dezember <strong>2022</strong><br />
35
Brain health<br />
tion is associated with improved cognitive function among young<br />
and middle-aged adults. [15] And to complete the picture, a recent<br />
study has shown that Choline intake has a protective effect on cognitive<br />
function, including learning ability, processing speed, sustained<br />
attention, and working memory. [16]<br />
Phospholife ® , a highly available solution for the brain<br />
DHA and advance memory-related behaviour in mice expressing<br />
human Apolipoprotein E4 (APOE4). Indeed, APOE4 human genotype<br />
was related to cognitive decline and risks of age-related neurological<br />
disorders. A decrease of APOE4 could be related to low levels<br />
of DHA, thus suggesting that a long-term treatment rich with DHA<br />
can protect from neurodegenerative disease. [22]<br />
DHA & Choline are both important components in our brain and<br />
increased intake is better for brain development. The form in which<br />
these two specific nutrients are consumed is important for their<br />
uptake and use in the body. Indeed, DHA and Choline need to cross<br />
2 barriers on the way to our brain: the intestinal barrier and the highly<br />
selective blood-brain barrier (BBD).<br />
DHA as part of this solution is under Re-esterified triglyceride form<br />
(rTG), which has been shown to have a higher index of bioavailability<br />
(124 %) compared to natural triglycerides, free fatty acids<br />
and ethyl-esters forms. Besides, bioavailability of DHA is enhanced<br />
by the plant-based phospholipids. Indeed, studies have shown that<br />
the association of DHA with Phospholipids allows a better emulsification,<br />
increasing the speed of gastrointestinal hydrolysis which<br />
is a crucial step for Omega 3 biovailability. The improvement of<br />
intestinal absorption of Omega 3 would result in a modification of<br />
lipid micellization and would favour the Omega 3 absorption within<br />
enterocytes and would promote the accretion of TG into chylomicrons<br />
in lymph. [17-19]<br />
Fig. 2: Mechanisms of DHA uptake to the brain [24]<br />
Choline, is bound in a lipid-soluble form as phosphatidylcholine,<br />
which is the main form present in tissues. Clinical trials show that<br />
Choline as part of the phospholipids is absorbed to 4 times more efficiently<br />
compared to salt form. [23]<br />
Polaris’ solution<br />
Fig. 1: Polaris illustration<br />
Furthermore, Phosphatidylcholine plays a crucial role in the accretion<br />
of the DHA in the brain. In the liver, the association of Phosphatidylcholine<br />
and DHA leads to Lyso-Phosphatidylcholine-DHA (LPC-<br />
DHA) in sn-2 position, which is the major carrier of DHA responsible<br />
for brain enrichment. Blood DHA is transported across the<br />
BBD more efficiently when esterified at the physi ological sn-2 position<br />
of lyso-phosphat idylcholine. [20] The uptake of LPC-DHA across<br />
the BBD is carried by one transporter, constitutively and exclusively<br />
expressed by brain endothelial cells, named ‘Major facilitator superfamily<br />
domain-containing protein 2A’ (Mfsd2a). The Mfsd2a transports<br />
DHA across the BBD only in the LPC form but not as a nonesterified<br />
fatty acid. [21]<br />
Previous studies highlighted the crucial role of LPC-DHA in brain<br />
development and neuronal cell growth. More recently, studies show<br />
the neuroprotection role of LPC-DHA diets to increase the brain<br />
Polaris’ patented Phospholife ® is the sustainable solution for maintaining<br />
healthy brain at all stages of life via the accretion of DHA<br />
directly to the cerebral cortex and hippocampus which are important<br />
in cognitive functions including memory, thoughts… and for targeting<br />
the brain development of foetus and infant during pregnancy and<br />
lactating. This product is declined in oil and in hard-shell capsules to<br />
meet all development projects. Further bioavailability studies will be<br />
carried out later in 2023.<br />
References<br />
[1] Brenna JT et al. Docosahexaenoic acid and human brain development: evidence that a<br />
dietary supply is needed for optimal development. J Hum Evol 2012, Apr 26<br />
[2] Shcoltz SA et al. Clinical overview of effects of dietary long-chain polyunsaturated fatty<br />
acids during the perinatal period. Nestel Nutr Inst Workshop Ser 2012;77:145-154<br />
[1] Brenna JT et al. Docosahexaenoic acid and human brain development: evidence that a<br />
dietary supply is needed for optimal development. J Hum Evol 2012, Apr 26<br />
[3] Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY. Docosahexaenoic acid<br />
promotes hippocampal neuronal development and synaptic function. J Neurochem<br />
2009;111: 510–521.<br />
[4] Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction<br />
of decreased brain docosahexaenoic acid concentration. J Neurochem 2000;75: 2563–2573<br />
36 No. 3 November/Dezember <strong>2022</strong>
[5] Yurko-Mauro et al. 2010. Beneficial effects of docosahexaenoic acid on cognition in<br />
age-related cognitive decline. Alzheimer’s & Dementia 6 456–464<br />
[6] Yurko-Mauro et al. 2015.Docosahexaenoic Acid and Adult Memory: A Systematic Review<br />
and Meta-Analysis. PLOS ONE<br />
[7] Shaw G.M et al. Choline and risk of neural tube defects in a folate-fortified population.<br />
Epidemiology 2009, 20, 714-719<br />
[8] Li Q, Guo-Ross S, Lewis DV, Turner D, White AM, Wilson WA et al. Dietary prenatal choline<br />
supplementation alters postnatal hippocampal structure and function. J Neurophysiol<br />
2004;91:1545-55.<br />
[9] Albright CD, Tsai AY, Friedrich CB, Mar MH, Zeisel SH. Choline availability alters embryonic<br />
development of the hippocampus and septum in the rat. Brain Res 1999;113:13-20.<br />
[10] Caudill MA, et al. FASEB J, 2017<br />
[11] Amija PT Ylilauri et al. Associations of dietary choline intake with risk of incident<br />
dementia and with cognitive performance : the Kuopio Ischaemic Heat Disease Risk Factor<br />
Study. Am J Clin Nutr. 2019; 110:1416-1423<br />
[12] W. M. Mcdonald and C. B. Nemeroff, “Neurotransmitters and neuropeptides in Alzheimer’s<br />
disease,” Psychiatric Clinics of North America, vol. 14, no. 2, pp. 421–442, 1991.<br />
[13] R. A. Bekdash, “Neuroprotective effects of choline and other methyl donors,” Nutrients,<br />
vol. 11, no. 12, 2019.<br />
[14] J. K. Blusztajn, B. E. Slack, and T. J. Mellott, “Neuroprotective actions of dietary<br />
choline,” Nutrients, vol. 9, no. 8, 2017.<br />
[15] C. Poly, J. M. Massaro, S. Seshadri et al., “The relation of dietary choline to cognitive<br />
performance and white-matter hyperintensity in the Framingham Offspring Cohort1234,”<br />
The American Journal of Clinical Nutrition, vol. 94, no. 6, pp. 1584–1591, 2011.<br />
[16] Lu Liu, Song Qiao, Liying Zhuang, Shanhu Xu, Linhui Chen, Qilun Lai , and Wenfeng<br />
Wang (2021). Choline Intake Correlates with Cognitive Performance among Elder Adults in<br />
the United States. Behavioural Neurology Volume 2021, Article ID 2962245.<br />
[17] Cansell M., Nacka F. and Combe N. (2003). Marine Lipid-Based Liposomes Increase in<br />
vivo Fatty Acid Bioavailability. Lipids, Volume 38, N°5, 10p<br />
[18] Garaiova I., Guschina I.A., Plummer S.F., Tang J., Wang D. and Plummer N.T. (2007). A<br />
randomised cross-over trial in healthy adults indicating improved absorption of omega-3<br />
fatty acids by pre-emulsification. Nutrition Journal, Volume 6, Issue 4, 9p.<br />
[19]Pafumi Y., Lairon D., De la Porte P.L., Juhel C., Storch J., Hamosh M. and Armand M.<br />
(2002). Mechanisms of Inhibition of Triacylglycerol Hydrolysis by Human Gastric Lipase. The<br />
Journal of Biological Chemistry, Volume 277, N°31, p28070-28079.<br />
[20] Mayssa Hachem et al. Efficient docosahexaenoic acid uptake by the brain from a<br />
structured phospholipids. Mol Neurobiol. 2016 Jul;53(5):3205-3215<br />
[21] Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL et<br />
al (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic<br />
acid. Nature 509:503–506<br />
[22] Mayssa Hachem et al. Emerging role of phospholipids and lysophospholipids for<br />
improving brain docosahexaenoic aicd as potential preventive and therapeutic strategies<br />
for neurological diseases. In J Mol Sci. <strong>2022</strong> Apr; 23(7): 3969<br />
[23] Yvonne Mödinger et al. Plasma Kinetics of Choline and Choline Metabolites After A<br />
Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers. Nutrients.<br />
2019 Oct; 11(10): 2548.<br />
[24] DhavamaniSugasini et al. Potential role of hepatic lipase in the accretion of docosahexaenoic<br />
acid (DHA) by the brain. (BBA) - Molecular and Cell Biology of Lipids, Volume<br />
1866, Issue 10, October 2021<br />
For more information, please contact<br />
Stephanie Lennon,<br />
Product development manager<br />
Gildas Breton, R&D Director<br />
Polaris, France<br />
No. 3 November/Dezember <strong>2022</strong>
Heart and brain health<br />
Photo © : Stockphoto/unsplash<br />
With heart and brain: leading a healthy life<br />
Astaxanthin, the red diamond amongst free radical scavengers, supports physical and mental fitness<br />
Katharina Müller, Monika Siebel<br />
Natural astaxanthin has a strong inflammatory effect and is highly<br />
efficient fighting against reactive oxygen species (ROS). Astaxanthin’s<br />
power as strongest antioxidant has lately become increasingly known.<br />
Thanks to its special chemical structure, natural astaxanthin can pass<br />
the blood-brain barrier and take full effect – a property that only few<br />
compounds possess.[1] Furthermore, the blood flow within the body<br />
is impacted in a positive way by an oral intake of natural astaxanthin,<br />
which is not only of great significance for cardiovascular health but<br />
also improves oxygen and nutrient transport to/towards the human<br />
brain.[2] A clinical study from 2019 has proven the holistic positive<br />
effect of natural astaxanthin on the psychophysiological heart-brain<br />
axis and enables new applications of the red diamond as co-therapeutic<br />
agent.[3]<br />
The positive effect of natural<br />
asta xanthin on the cardiovascular<br />
system and on the brain<br />
Chronic inflammations and increased oxidative<br />
stress significantly add to cardiovascular<br />
diseases and arteriosclerosis. In the case of<br />
arteriosclerosis, fat is deposited at the inner<br />
lining of the arterial walls, oxidates and may<br />
cause inflammations in the body. This can<br />
lead to a dangerous accumulation of plaques<br />
which constrict arteries and restrict perfusion<br />
and oxygen supply.[4],[5]<br />
38 No. 3 November/Dezember <strong>2022</strong>
Heart and brain health<br />
Astaxanthin obstructs the oxidation of lowdensity<br />
lipoprotein (LDL) and raises the level<br />
of high-density lipoprotein (HDL) cholesterol<br />
and adiponectin, a fat tissue hormone that<br />
is, together with other hormones, responsible<br />
for the regulation of the energy metabolism.<br />
Adiponectin originates from fat tissue<br />
and influences insulin activity in the glucose<br />
and fat metabolism. Extensive studies have<br />
demonstrated that astaxanthin can act preemptively<br />
against arteriosclerotic cardiovascular<br />
diseases as it may alleviate oxidative<br />
stress and resultant inflammations as well as<br />
lipid and glucose metabolism.[6],[7]<br />
Cardioprotective effects of natural astaxanthin<br />
have, for instance, been ascertained<br />
in a clinical, randomised, placebocontrolled<br />
double-blind study. In the study,<br />
44 probands with type 2 diabetes were daily<br />
supplemented with 8 mg of asta xanthin<br />
over 8 weeks. The intake of astaxanthin led<br />
to a significant increase of the adiponectin<br />
concentration in the serum (p < 0.05) and<br />
to a reduction of the visceral body fat mass. Moreover, a significant<br />
astaxanthin-induced reduction of triglyceride and LDL cholesterol in<br />
the blood and a lowering of the systolic blood pressure were demonstrated.[7]<br />
These results affirmed findings from previous studies and<br />
illustrated the high potential of natural astaxanthin to pre-emptively<br />
counteract arteriosclerotic cardiovascular diseases. Cognitive health<br />
also plays a major role in maintaining all important body functions.<br />
In some ways, our brain is the control centre of the body. Due to<br />
several blood vessels, it has high oxygen consumption and is susceptible<br />
to oxidative stress. Especially with advancing age, natural antioxidative<br />
enzymes in the body become less effective, through which<br />
inflammations and, consequently, neurodegenerative diseases may<br />
occur. Astaxanthin is one of the less known compounds that can overcome<br />
all the blood-brain barrier by which its antioxidative properties<br />
are also enhanced in the human brain.[8],[9]<br />
A randomised placebo-controlled double-blind study with 89 participants<br />
has shown that a 3-months nutritional supplement with a daily<br />
dose of 12 mg of natural astaxanthin influences the cognitive performance<br />
of older probands. In this clinical study, various parameters to<br />
determine the cognitive performance like working memory, delayed<br />
memory to measure accuracy or short-term working memory were<br />
significantly enhanced in participants supplemented with astaxan-<br />
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Heart and brain health<br />
thin. Probands who had been complaining of age-related obliviousness,<br />
showed better results regarding mental performance and multitasking.[10]<br />
Positive influences of natural astaxanthin on the psychophysiological<br />
hearth-brain axis<br />
Heart and brain communicate in various ways with each other. Best<br />
known are the communication regarding the nervous system and<br />
the electrical impulses that are triggered; in this context, particularly<br />
the sympathetic and parasympathetic nervous system can be<br />
mentioned. The sympathetic nerve fibres originate in the cervical<br />
ganglions and are also termed cardiac nerves (Nervi cardiaci); they<br />
are responsible for the acceleration of the heart rate. The parasympathetic<br />
nerve fibres that are responsible for relaxation and the deceleration<br />
of the heart rate stem from the tenth cranial nerve. These nerve<br />
fibres end in a neuroplexus, the so-called Plexus cardiacus, at the<br />
base of the heart. The stimulation of the Nervus vagus as therapeutic<br />
agent for various diseases plays a central role in today’s research (see<br />
Fig. 1).[12],[13]<br />
tion), investigation of the psychological state by a validated survey<br />
regarding the profile of mood state (POMS) as well as the evaluation<br />
of the global mood. The results of the astaxanthin reference group<br />
were astonishing.<br />
The probands with astaxanthin supplementation showed a significant<br />
decrease of the average heart rate at submaximal stress intensity by<br />
10 percent compared to the placebo group. As shown in Table 1,<br />
their heart beats per minute (bpm) could be reduced significantly<br />
after an 8-week supplement at the aerobic (AeT) as well as at the<br />
anaerobic (AT) threshold. This suggests a substantial easing of the<br />
cardiovascular system. After the astaxanthin supplementation, the<br />
probands did manual work at reduced heart rate and, hence, with<br />
higher cardiovascular efficiency, and were altogether more powerful.<br />
Table. 1: The heart rates of the aerobic (AeT) and the anaerobic threshold<br />
(AT) were significantly lower after the supplementation of natural astaxanthin<br />
compared to PL (AeT; astaxanthin 130+17 vs. PL 145+14 and AT;<br />
astaxanthin 139+20 vs. PL 154+11, p < 0.05), suggesting that the astaxanthin<br />
probands were able to do a certain degree of manual work with lower<br />
relative intensity or higher cardiovascular efficiency. Modified illustration<br />
based on the data from the study by S. Talbott et al., Effect of Astaxanthin<br />
supplementation on psychophysiological heart-brain axis dynamics in<br />
healthy subjects.[3]<br />
Fig. 1: Schematic diagram of the efferent (motoric) projections of the parasympathetic<br />
autonomic nervous system (ANS). Postganglionic axons from<br />
ganglionic cells innervate the heart (deceleration of the heart rate, reduction<br />
of the heart contractility) and other organs.[12]<br />
Most recent studies from the year 2020 addressed that heart-brain<br />
axis and analysed the significance of antioxidants like natural astaxanthin<br />
in connection with cardiovascular and cognitive health. In<br />
this randomised, placebo-controlled double-blind study, 28 healthy<br />
probands were supplemented with a daily dose of 12 mg of natural<br />
astaxanthin or with a respective placebo over 8 weeks. The interaction<br />
of the heart-brain axis was determined through cardiovascular<br />
stress tests (measuring of heart rate and oxygen consump-<br />
Furthermore, there were significant improvements in the astaxanthin<br />
group regarding the evaluation of the psychological state. The parameters<br />
for tension, depression, anger, tiredness and confusion were<br />
significantly reduced and suggested an altogether positive state of<br />
mind. Natural astaxanthin, thus, influences the psychophysiologi cal<br />
heart-brain axis verifiably positively and substantially supports the<br />
physical and mental wellbeing.[3]<br />
Summary<br />
An intake of micronutrients of highly dosed natural astaxanthin of<br />
12 mg significantly contributes to physical and mental fitness. While<br />
earlier studies have shown how astaxanthin positively influences<br />
heart health and the cognitive performance, the herein presented<br />
results are the first to prove that supplementation with natural asta-<br />
40 No. 3 November/Dezember <strong>2022</strong>
Heart and brain health<br />
xanthin supports the psychophysiological<br />
heart-brain axis with simultaneous enhancement<br />
of the physical and mental wellbeing.<br />
In addition to these psychophysiological<br />
benefits for the heart-brain axis, the results<br />
suggest that a supplementation with natural<br />
astaxanthin from the microalga Haematococcus<br />
pluvialis as co-therapeutic agent<br />
can support persons with physical and<br />
psychological needs. Particularly in old age,<br />
the degree of free radicals can be reduced<br />
through taking antioxidants as by doing so,<br />
endogenous antioxidative enzymes increasingly<br />
lose effect. However, also long-distance<br />
and ultra-distance endurance athletes (e. g.,<br />
marathon runner, ironman triathletes and<br />
ultra-runner/-cyclists) benefit from nutritional<br />
supplementation with antioxidants as<br />
the physiological endurance as well as the<br />
psychological balance are strained, and<br />
their support could be a new approach to<br />
enhance the physical/mental performance.<br />
Due to the double effect of natural astaxanthin<br />
on the health of heart and brain, future<br />
studies will be even more important to also<br />
support other groups of persons signifi cantly.<br />
[9] S. Fakhri, I. Y. Aneva, M. H. Farzaei, and E. Sobarzo-Sánchez, “The neuroprotective<br />
effects of astaxanthin: Therapeutic targets and clinical perspective,” Molecules, vol. 24,<br />
no. 14, pp. 1–19, 2019.<br />
[10] M. Katagiri, A. Satoh, S. Tsuji, and T. Shirasawa, “Effects of astaxanthin-rich Haematococcus<br />
pluvialis extract on cognitive function: a randomised, double-blind, placebocontrolled<br />
study,” J. Clin. Biochem. Nutr., pp. 2012–2013.<br />
[11] D. Zanotta, S. Puricelli, and G. Bonoldi, “Cognitive effects of a dietary supplement<br />
made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in<br />
subjects with mild cognitive impairment: A noncomparative, exploratory clinical study,”<br />
Neuropsychiatr. Dis. Treat., vol. 10, pp. 225–230, 2014.<br />
[12] M. J. Capilupi, S. M. Kerath, and L. B. Becker, “Vagus nerve stimulation and the cardiovascular<br />
system,” Cold Spring Harb. Perspect. Med., vol. 10, no. 2, pp. 1–18, 2020.<br />
[13] E. Al et al., “Heart-brain interactions shape somatosensory perception and evoked<br />
potentials,” Proceedings of the National Academy of Sciences of the United States of<br />
America, vol. 117, no. 19. pp. 10575–10584, 2020.<br />
For more information, please contact<br />
Katharina Müller<br />
Monika Siebel<br />
BDI-BioLife Science<br />
www.bdi-biolifescience.com<br />
References<br />
[1] C. Galasso et al., “On the neuroprotective role of astaxanthin:<br />
New perspectives?,” Mar. Drugs, vol. 16, no. 8, pp.<br />
1–16, 2018.<br />
[2] H. Miyawaki, J. Takahashi, H. Tsukahara, and I. Takehara,<br />
“Effects of astaxanthin on human blood rheology,” J.<br />
Clin. Biochem. Nutr., vol. 43, no. 2, pp. 69–74, 2008.<br />
[3] S. Talbott, D. Hantla, B. Capelli, L. Ding, Y. Li, and<br />
C. Artaria, “Effect of Astaxanthin supplementation on<br />
psychophysiological heart-brain axis dynamics in healthy<br />
subjects,” Funct. <strong>Foods</strong> Heal. Dis., vol. 9, no. 8, pp.<br />
521–531, 2019.<br />
[4] F. Visioli and C. Artaria, “Astaxanthin in cardiovascular<br />
health and disease: Mechanisms of action, therapeutic<br />
merits, and knowledge gaps,” Food Funct., vol. 8, no. 1,<br />
pp. 39–63, 2017.<br />
[5] K. Cervantes Gracia, D. Llanas-Cornejo, and H. Husi,<br />
“CVD and Oxidative Stress,” J. Clin. Med., vol. 6, no. 2, p.<br />
22, 2017.<br />
[6] Y. Kishimoto, H. Yoshida, and K. Kondo, “Potential antiatherosclerotic<br />
properties of astaxanthin,” Mar. Drugs, vol.<br />
14, no. 2, pp. 1–13, 2016.<br />
[7] N. S. Mashhadi, M. Zakerkish, J. Mohammadiasl, M.<br />
Zarei, M. Mohammadshahi, and M. H. Haghighizadeh,<br />
“Astaxanthin improves glucose metabolism and reduces<br />
blood pressure in patients with type 2 diabetes mellitus,”<br />
Asia Pac. J. Clin. Nutr., vol. 27, no. 2, pp. 341–346, 2018.<br />
[8] M. Perluigi et al., “Redox proteomics identification of<br />
4-hydroxynonenal-modified brain proteins in Alzheimer’s<br />
disease: Role of lipid peroxidation in Alzheimer’s disease<br />
pathogenesis,” PROTEOMICS – Clin. Appl., vol. 3, no. 6, pp.<br />
682–693, Jun. 2009.<br />
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No. 3 November/Dezember <strong>2022</strong><br />
41
Skin health<br />
Photo © : Yuri Arcurs<br />
Protection and stimulation<br />
Natural astaxanthin and bioactive collagen peptides are proven<br />
to improve skin health from the inside out<br />
Behnaz Shakersain, Oliver Wolf<br />
Let’s go on a journey into the past. We are on a beach or at an outdoor<br />
pool; all around us are people sunbathing … just lying in the blazing<br />
heat for hours. Remember that? Today, things are very different. Most<br />
people now take sunshades, hats, beach tents, etc., and factor 50<br />
sun protection is an absolute essential. Our awareness of skin health<br />
has increased, and now, more and more consumers are looking for<br />
ways to keep their skin healthy, young and supple for longer. Nutricosmetics<br />
that work from the inside out can make a significant contribution<br />
here.<br />
Creams and other topical products such as gels or serums are increasingly<br />
popular when it comes to preventing sunburn or providing shortterm<br />
relief from dry skin. However, they only work on the top layer of<br />
skin: the epidermis. The two underlying layers, the dermis and the<br />
hypodermis, remain literally untouched. Yet, they play an essential<br />
role in keeping the skin elastic and supplying it with nutrients.<br />
An excellent way to reach these deeper layers – and exert a targeted<br />
influence – is through nutrition and the use of dietary supplements.<br />
The latter are demonstrably gaining in popularity: according to the<br />
market research company, Grand View<br />
Research, the beauty and health sector is<br />
predicted to grow at an average annual rate<br />
of 4.8 % between <strong>2022</strong> and 2030. In 2021,<br />
their market was already valued at approximately<br />
$55 billion [1].<br />
Power from algae<br />
One thing is certain, though, dietary supplements<br />
are only as good for the skin as their<br />
ingredients. One promising candidate comes<br />
from the freshwater green alga, Haematococcus<br />
pluvialis. This unicellular microalga<br />
produces astaxanthin in extreme temperatures<br />
and other stressful situations, like<br />
high UV exposure, to maintain its vitality and<br />
function. Being consumed in the aquatic<br />
food web, this red carotenoid not only determines<br />
the colour of salmon or crustaceans,<br />
42 No. 3 November/Dezember <strong>2022</strong>
Skin health<br />
Other studies show a similar picture:<br />
CYa<br />
placebo-controlled double-blind study CMY<br />
showed that natural astaxanthin (with a daily K<br />
intake of 4 mg for 9 weeks) protects against<br />
UV-induced skin changes [4]. The astaxanthin<br />
group showed a higher minimum<br />
erythema dose (a measure of skin tolerance<br />
to solar radiation) and less moisture<br />
loss in the irradiated skin region than the<br />
placebo group. In their subjective perception,<br />
the participants in the astaxanthin group also rated their skin<br />
to be smoother. In another study involving 28 women, an 8-week<br />
daily intake of 6 mg of asta xanthin combined with topical treatment<br />
resulted in a decrease in the depth and width of wrinkles in the eye<br />
region [5]. In a second part of the study, Tominaga et al. also treated<br />
healthy young men with a daily dose of 6 mg of natural astaxanthin<br />
for 6 weeks. The majority experienced improved skin and a balanced<br />
sebum production, compared with a control group receiving a<br />
placebo, opening up an interesting opportunity for acne control with<br />
natural astaxanthin.<br />
Photo © : AstaReal<br />
it also serves as one of the most powerful<br />
antioxidants in nature – with an effect that<br />
is 110 times stronger than vitamin E [2]. In<br />
contrast to other antioxidants, it can penetrate<br />
both the hydrophilic and hydrophobic<br />
layers of the cell membrane, protecting the<br />
cell from free radicals from the outside and<br />
inside at the same time. It is these same free<br />
radicals that plague the skin and lead to its<br />
visible aging.<br />
The positive antioxidant and anti-inflammatory<br />
effects of astaxanthin on the skin<br />
– as well as for other body functions such<br />
as immune health and visual acuity – have<br />
been demonstrated in more than 500 peerreviewed<br />
studies. The most intensively scientifically<br />
researched brand of natural astaxanthin<br />
is produced by AstaReal. A study<br />
with AstaReal ® Astaxanthin showed that it<br />
protects the skin from the seasonal wear and<br />
tear caused by UV radiation and dryness.<br />
From August to December, participants took<br />
a daily dose of 6 or 12 mg astaxanthin, and<br />
C<br />
during this time, their skin remained resilient.<br />
In contrast, wrinkles and dryness were<br />
M<br />
Y<br />
more pronounced in the non-supplemented<br />
CM<br />
control group [3].<br />
Collagen peptides: help for self-help<br />
Just like astaxanthin, collagen peptides also act on the skin from<br />
within but have a completely different mechanism of action. Highly<br />
pure collagen peptides can be obtained from native animal-origin<br />
collagen using a partial hydrolysis process. Quickly absorbed and<br />
utilized by the body, studies have shown that specific Bioactive<br />
Collagen Peptides (VERISOL ® from GELITA) stimulate the fibroblasts<br />
in the dermis after ingestion, and to a certain extent, encourage the<br />
skin to regenerate itself. This significantly increases the production of<br />
collagen, elastin and proteoglycans. These compounds are essential<br />
for the elasticity of the skin. Thus, the epidermis is supported from<br />
within and wrinkling is reduced.<br />
EN Anzeige WFS <strong>2022</strong> Q4 DE Frauengesundheit_CS5_Pfade_beschnitt_3mm.pdf 1 18.10.<br />
MY<br />
No. 3 November/Dezember <strong>2022</strong>
Skin health<br />
still detectable 4 weeks after discontinuation of use, indicating a longlasting<br />
stimulation. A clinical follow-up study showed that the intake<br />
of collagen peptides can reduce the depth of skin wrinkles in the eye<br />
area and promote the synthesis of important structural skin components<br />
such as collagen type I, elastin and fibrillin [7].<br />
In addition, VERISOL ® is able to causally combat cellulite in normal<br />
and overweight women. In a double-blind placebo-controlled study,<br />
105 women between the ages of 24 and 50 received 2.5 g of<br />
VERISOL ® or a placebo daily [8]. After just 3 months, the extent of<br />
cellulite had decreased significantly. At the end of the 6-month study,<br />
the researchers noted an average 9 % reduction in participants with<br />
a normal BMI compared with the placebo group. In subjects with a<br />
BMI > 25, this positive effect was also visible but less pronounced<br />
(4 % reduction).<br />
As today’s consumers become more aware about the correlation<br />
between skin health and nutrition, they are starting to favour beautyfrom-within<br />
products with the greatest amount of scientific research<br />
to support them. Natural astaxanthin and collagen peptides can<br />
satisfy these demands and effectively target this growing market.<br />
Three placebo-controlled human studies confirm the positive effects<br />
of supplementation with VERISOL ® collagen peptides on the epidermis<br />
and dermis. The first study investigated the effectiveness of collagen<br />
peptides using biophysical parameters related to skin aging [6]. In<br />
this study, 69 women aged between 35 and 55 took either 2.5 or 5 g<br />
of VERISOL ® or a placebo daily during an 8-week study period. After<br />
only 4 weeks, both VERISOL ® groups showed a statistically significant<br />
improvement in skin elasticity. Interestingly, the positive effect was<br />
more pronounced in participants older than 50. The benefits were<br />
For more information, please contact<br />
Behnaz Shakersain, PhD<br />
Scientific Affairs Manager<br />
AstaReal AB<br />
behnaz.shakersain@astareal.se<br />
www.astareal.se<br />
Photo © : Fotolia/ Leonid & Anna Dedukh<br />
References<br />
[1] Grand View Research: Women’s Health And Beauty <strong>Supplements</strong> Market Size, Share &<br />
Trends Analysis Report By Product, By Application, By Age Group, By Consumer Group, By<br />
Sales Channel, By Region, And Segment Forecasts, <strong>2022</strong> – 2030. 2021. www.grandviewresearch.com/industry-analysis/women-health-beauty-supplements-market;<br />
(5/10/<strong>2022</strong>).<br />
[2] Nishida Y et al.: Quenching activities of common hydrophilic and lipophilic antioxidants<br />
against singlet oxygen using chemiluminescence detection system. Carotenoid Science.<br />
2007;11(6):16-20.<br />
[3] Tominaga K et al.: Protective effects of astaxanthin on skin deterioration. J Clin Biochem<br />
Nutr. 2017;61(1):33-39.<br />
[4] Ito N et al.: The Protective Role of Astaxanthin for UV-Induced Skin Deterioration<br />
in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients.<br />
2018;10(7).pii: E817.<br />
[5] Tominaga K et al.: Cosmetic benefits of astaxanthin on human subjects. Acta Biochim<br />
Pol. 2012;59(1):43-7.<br />
[6] Proksch E et al.: Oral supplementation of specific collagen peptides has beneficial<br />
effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol.<br />
Physiol. 2014;27,47-55.<br />
[7] Proksch E et al.: Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles<br />
and Increases Dermal Matrix Synthesis. Skin Pharmacol. Physiol. 2014;27,113-119.<br />
[8] Schunck M et al.: Dietary Supplementation with Specific Collagen Peptides Has<br />
a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food.<br />
2015;18(12):1340-1348.<br />
Oliver Wolf<br />
Global Communication<br />
Gelita AG<br />
oliver.wolf@gelita.com<br />
www.gelita.com<br />
44 No. 3 November/Dezember <strong>2022</strong>
Tinnitus<br />
Photo © : Adobe Stock/andriano_cz<br />
Effective relief from tinnitus symptoms<br />
Dr Franziska Weichmann<br />
Subjective tinnitus is the perception of<br />
sound without any external acoustic noise.<br />
This sound is mostly described as ringing,<br />
sometimes as a buzzing, roaring, whistling<br />
or hissing sensation (1). Several people with<br />
tinnitus suffer from an associated hearing<br />
loss, at least on one ear (1). With a prevalence<br />
of 10 to 20 % of the population worldwide,<br />
tinnitus is one of the most common<br />
and distressing ear-related problems in the<br />
world (2). In many cases, tinnitus affects the<br />
quality of life and can be accompanied by<br />
anxiety, depression, insomnia or increased<br />
sensitivity to noises (hyperacusis) (2).<br />
Effectiveness against tinnitus<br />
Two studies could show that supplementation with Pycnogenol ®<br />
ameliorates the symptoms of tinnitus (4, 5).<br />
In the first clinical study with 82 patients, a supplementation for 4<br />
weeks had an impressive influence on the tinnitus scale (4). In this<br />
subjective scale, presence, intensity and duration of tinnitus, as well<br />
as the changes in the quality of life and drug intake to relieve tinnitus<br />
were each rated from 0 (none/low) to 3 (always/severe). The control<br />
group did not show a significant change in the personal tinnitus rating<br />
with only 16 % reduction, whereas 100 mg Pycnogenol ® per day<br />
improved the tinnitus rating by 41 % and 150 mg Pycnogenol ® per<br />
day even led to a reduction of 63 % on the tinnitus scale.<br />
No medication is currently officially approved<br />
to treat tinnitus, but several medications are<br />
in use, such as anesthetics, antidepressants,<br />
antihistamines, anxiolytics, vasodilators or<br />
calcium channel blockers (3). Many of those<br />
medications come with serious risks for side<br />
effects.<br />
The natural extract from French maritime<br />
pine bark Pycnogenol ® was shown to be efficacious<br />
in relieving symptoms of tinnitus<br />
(4, 5). By improving microcirculation (4-8),<br />
normalizing hypertension (9-12), enhancing<br />
endothelial health (11-17) and reducing<br />
inflammation (18-20), Pycnogenol ® positively<br />
affects mechanisms that are associated<br />
with the development of tinnitus.<br />
No. 3 November/Dezember <strong>2022</strong><br />
45
Tinnitus<br />
The study further investigated the effects of<br />
the supplementation on microcirculation in<br />
the inner ear. For that, the blood flow velocity<br />
in the cochlea was measured using ultrasonography.<br />
Only one ear of the patients was<br />
affected by tinnitus, the “tinnitus ear”, while<br />
the other ear was referenced as the “healthy<br />
ear”. The effect of a 4-week supplementation<br />
on the microcirculation in the healthy<br />
ear was neglectable, whereas the very low<br />
cochlear blood flow velocity in the tinnitus<br />
ear could be normalized with 4 weeks of<br />
Pycnogenol ® supplementation. Systolic<br />
as well as diastolic blood flow velocity was<br />
increased to almost normal values by 48 %<br />
and 95 %, respectively. There was however<br />
no observable change of the microcirculation<br />
in the control group.<br />
cally improved after the supplementation,<br />
which helps explain the beneficial effects of<br />
Pycnogenol ® on tinnitus symptoms.<br />
Pycnogenol ® improves microcirculation,<br />
normalizes hypertension and<br />
ameliorates endothelial health<br />
The development of tinnitus has been<br />
associated with cochlear microcirculatory<br />
dysfunction (21). As described in the<br />
previously mentioned studies, it has positively<br />
affects microcirculation in the inner<br />
ear (4, 5). This beneficial effect was not only<br />
observed in the ear but could be confirmed<br />
in other small blood vessels in the body, like<br />
the retinal capillaries in the eye or the very<br />
fine micro vessels in the fingertip (6-8). In<br />
Another study found beneficial effects of<br />
the supplementation on tinnitus in patients,<br />
suffering from Ménière’s disease (5). This<br />
condition is a disorder of the inner ear,<br />
presenting with symptoms such as vertigo,<br />
hearing loss and tinnitus. 107 patients took<br />
part in the 6-month study. The tinnitus scale<br />
of the patients taking Pycnogenol ® was<br />
significantly reduced by 53 %, compared<br />
to the control group with a reduction of only<br />
28 %. Interestingly, 87 % of the patients,<br />
supplemented with Pycnogenol ® stated to be<br />
asymptomatic after 6 months and only 35 %<br />
of the patients in the control group were<br />
symptomless. Furthermore, the supplementation<br />
could significantly improve the<br />
working and social life by 72 % and 81 %<br />
respectively, compared to 50 % and 9 % in<br />
the control group. As in the first study, blood<br />
flow velocity in the inner ear was drastia<br />
3-month study on diabetic retinopathy,<br />
the supplementation improved the retinal<br />
blood flow by around 30 % compared to<br />
no change in the control patients (6). In<br />
another study with patients suffering from<br />
coronary heart disease, microcirculation on<br />
the fingertip improved significantly in 54 %<br />
of the patients, taking Pycnogenol ® and in<br />
33 % of the placebo patients after 4 weeks<br />
(7). A third study showed improved microcirculation<br />
in the legs by 34 % after the intake,<br />
in patients with diabetic microangiopathy<br />
(8). Elevated blood pressure (hypertension)<br />
can also be a causal or at least an adjuvant<br />
factor for tinnitus (21). The normalizing effect<br />
of Pycnogenol ® supplementation on hypertension<br />
was investigated in several studies<br />
(9-12). A double-blind, placebo-controlled,<br />
crossover study with borderline hypertension<br />
patients showed that the supplementation<br />
for 8 weeks significantly lowered elevated<br />
systolic blood pressure by 5 % compared to<br />
placebo (10). Diastolic pressure was found to<br />
be lowered by 2 %. Another study with hypertensive<br />
patients, treated with calcium channel<br />
blockers found that after 3 months, 57 % of<br />
the patients supplemented with Pycnogenol ®<br />
were able to cut their individual hypertension<br />
medication dosage to a quarter of the previous<br />
dose to keep their blood pressure in a healthy<br />
range (11). Only 13 % of the placebo patients<br />
were able to do so.<br />
Microcirculatory problems and hypertension<br />
can both be explained by endothelial<br />
dysfunction, an impairment of the inner lining<br />
of blood vessels. Consistently, endothelial<br />
dysfunction has been described in patients<br />
with tinnitus (22). There is strong evidence<br />
that Pycnogenol ® improves endothelial health<br />
(11-17). One study, among others, showed<br />
that in patients with coronary artery disease,<br />
Pycnogenol ® supplementation had a beneficial<br />
effect on endothelial function (13).<br />
Endothelial function was assessed by flowmediated<br />
dilatation of the brachial artery (the<br />
widening of the artery in response to elevations<br />
in blood flow-associated shear stress).<br />
This 8-week randomized, double-blind,<br />
placebo-controlled cross-over study showed<br />
that flow-mediated dilation was improved by<br />
32 % in the Pycnogenol ® group, whereas it<br />
slightly decreased in the placebo group.<br />
Reduction of inflammatory processes<br />
Recent research has shown that inflammation,<br />
specifically neuroinflammation<br />
is involved in the development of several<br />
hearing disorders including tinnitus (23).<br />
In several studies, Pycnogenol ® exhibited<br />
potent anti-inflammatory activities (18-20).<br />
Already after 5 days of daily intake, a study<br />
reported that Pycnogenol ® significantly<br />
prevented the up-regulation of the proinflammatory<br />
enzymes 5-LOX and COX-2<br />
(18). In another study, plasma samples<br />
of volunteers after intake of Pycnogenol ®<br />
showed to significantly inhibit NF-κB activation<br />
by 15.5 % and matrix metalloproteinase<br />
9 (MMP-9) release by 25%, two important<br />
regulators in the inflammation process<br />
(19). In a similar study, significant inhibi-<br />
46 No. 3 November/Dezember <strong>2022</strong>
Tinnitus<br />
tion of inflammatory molecules COX-1 and<br />
COX-2 was observed after intake of 300 mg<br />
Pycnogenol ® (20).<br />
French maritime pine bark extract is an<br />
effective, safe and evidence-based natural<br />
solution to manage tinnitus by improving<br />
microcirculation, normalizing hypertension,<br />
enhancing endothelial health and reducing<br />
inflammation.<br />
References<br />
1. Chari DA, Limb CJ. Tinnitus. Med Clin North Am.<br />
2018;102(6):1081-93.<br />
2. Han BI, Lee HW, Ryu S, Kim J-S. Tinnitus Update. Journal of<br />
Clinical Neurology. 2021;17(1):1.<br />
3. Kim SH, Kim D, Lee J-M, Lee SK, Kang HJ, Yeo SG. Review<br />
of Pharmacotherapy for Tinnitus. Healthcare. 2021;9(6):779.<br />
4. Grossi MG, Belcaro G., Cesarone, M.R., Duggall, M., Hosoi,<br />
M Cacchio,. Improvement in cochlear flow with Pycnogenol ®<br />
in patients with tinnitus: a pilot evaluation. Panminerva<br />
Med. 2010;52(2):63-7.<br />
5. Luzzi R BG, Hu S, Dugall M, Hosoi M, Cacchio M, Ippolito<br />
E, Corsi M Improvement in symptoms and cochlear flow with<br />
Pycnogenol in patients with Meniere’s disease and tinnitus.<br />
Minerva Med 2014;105:245-54.<br />
6. Steigerwalt R, Belcaro G, Cesarone MR, Di Renzo A, Grossi<br />
MG, Ricci A, et al. Pycnogenol ® improves microcirculation,<br />
retinal edema, and visual acuity in early diabetic retinopathy.<br />
J Ocul Pharmacol Ther. 2009;25(6):537-40.<br />
7. Wang S, Tan D, Zhao Y, Gao G, Gao X, Hu L. The effect<br />
of Pycnogenol ® on the microcirculation, platelet function<br />
and ischaemic myocardium in patients with coronary<br />
artery diseases. European Bulletin of Drug Research.<br />
1999;7(2):19-25.<br />
8. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda<br />
A, Vinciguerra G, et al. Improvement of diabetic microangiopathy<br />
with pycnogenol: A prospective, controlled study.<br />
Angiology. 2006;57(4):431-6.<br />
9. Stuard SBG, Cesarone, M.R., Ricci, A., Dugall, M., Cornelli,<br />
U., Gizzi, G. Pellegrini L, Rohdewald, P.J. Kidney function<br />
in metabolic syndrome may be improved with Pycnogenol.<br />
Panminerva Med. 2010;52(2):27-32.<br />
10. Hosseini S LJ, Sepulveda RT, Rohdewald P, Watson RR. A<br />
randomized, double-blind, placebo-controlled, prospective,<br />
16 week crossover study to determine the role of Pycnogenol<br />
in modifying blood pressure in mildly hypertensive patients.<br />
Nutr Res. 2001;21(9):1251-60.<br />
11. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P.<br />
Pycnogenol, French maritime pine bark extract, improves<br />
endothelial function of hypertensive patients. Life Sci.<br />
2004;74(7):855-62.<br />
12. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction<br />
of cardiovascular risk factors in subjects with type<br />
2 diabetes by Pycnogenol supplementation. Nutr Res.<br />
2008;28(5):315-20.<br />
13. Enseleit F, Sudano I, Periat D, Winnik S, Wolfrum M,<br />
Flammer AJ, et al. Effects of Pycnogenol on endothelial<br />
function in patients with stable coronary artery disease: a<br />
double-blind, randomized, placebo-controlled, cross-over<br />
study. Eur Heart J. 2012;33(13):1589-97.<br />
14. Fitzpatrick DF, Bing B, Rohdewald P. Endotheliumdependent<br />
vascular effects of Pycnogenol. J Cardiovasc<br />
Pharmacol. 1998;32(4):509-15.<br />
15. Hu S BG, Cornelli U, et al Effects of Pycnogenol ® on<br />
endothelial dysfunction in borderline hypertensive, hyperlipidemic,<br />
and hyperglycemic individuals: the borderline study.<br />
Int Angiol 2015;34(1):43-52.<br />
16. Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D,<br />
Soga J, et al. Pycnogenol, French maritime pine bark extract,<br />
augments endothelium-dependent vasodilation in humans.<br />
Hypertens Res. 2007;30(9):775-80.<br />
17. Uhlenhut K, Högger P. Facilitated cellular uptake and<br />
suppression of inducible nitric oxide synthase by a metabolite<br />
of maritime pine bark extract (Pycnogenol). Free Radic<br />
Biol Med. 2012;53(2):305-13.<br />
18. Canali R, Comitato R, Schonlau F, Virgili F. The antiinflammatory<br />
pharmacology of Pycnogenol in humans<br />
involves COX-2 and 5-LOX mRNA expression in leukocytes.<br />
Int Immunopharmacol. 2009;9(10):1145-9.<br />
19. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova<br />
A, Durackova Z, et al. Inhibition of NF-kappaB activation<br />
and MMP-9 secretion by plasma of human volunteers<br />
after ingestion of maritime pine bark extract (Pycnogenol). J<br />
Inflamm (Lond). 2006;3:1.<br />
20. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova<br />
A, Durackova Z, et al. Inhibition of COX-1 and COX-2<br />
activity by plasma of human volunteers after ingestion of<br />
French maritime pine bark extract (Pycnogenol). Biomed<br />
Pharmacother. 2005;60(1):5-9.<br />
21. Figueiredo RR, de Azevedo AA, Penido Nde O. Tinnitus and<br />
arterial hypertension: a systematic review. Eur Arch Otorhinolaryngol.<br />
2015;272(11):3089-94.<br />
22. Neri S, Signorelli S, Pulvirenti D, Mauceri B, Cilio D,<br />
Bordonaro F, et al. Oxidative stress, nitric oxide, endothelial<br />
dysfunction and tinnitus. Free Radic Res. 2006;40(6):615-8.<br />
23. Shulman A, Wang W, Luo H, Bao S, Searchfield G, Zhang<br />
J. Neuroinflammation and Tinnitus. Curr Top Behav Neurosci.<br />
2021;51:161-74.<br />
For more information, please contact<br />
Dr. Franziska Weichmann,<br />
Manager of Scientific Communications<br />
and Product Development<br />
at Horphag Research<br />
Tapping into a calm state of<br />
mind amidst a hectic life<br />
A natural ingredient for stress relief,<br />
providing mental & physical well-being.<br />
Extramel ®<br />
extramel.com<br />
No. 3 November/Dezember <strong>2022</strong><br />
47
Fi & Hi Europe <strong>2022</strong><br />
Let’s meet in Paris!<br />
Leading ingredients trade show Fi & Hi Europe all set to welcome more than 20,000 visitors<br />
from around the world<br />
Fi & Hi Europe returns to France this year. From December 6 to 8,<br />
the leading ingredients fair will be held for the first time at the Paris<br />
Expo Porte de Versailles exhibition centre. More than 1,200 exhibitors<br />
– from leading ingredients manufacturers to highly specialized<br />
startups – will present themselves in four halls. The face-to-face exhibition<br />
will be complemented by a comprehensive online offering. A<br />
broad conference programme, as well as the renowned Innovation<br />
Awards and Startup Innovation Challenge, will complete the trade<br />
show experience.<br />
In the heart of Paris, Fi & Hi Europe is set to attract exhibitors and<br />
attendees from more than 135 countries around the world. The new<br />
Paris Expo Porte de Versailles location is within walking distance<br />
of many hotels, restaurants and bars, making logistics easier and<br />
the event more visitor-friendly than ever before. Many leading ingredient<br />
manufacturers have already confirmed their participation in<br />
Paris, including ADM, Beneo, Brenntag, Cargill, DSM and Ingredion.<br />
In addition to well- established companies, many new players<br />
have also announced their intention to present their solutions to the<br />
industry. In addition, there will be more country pavilions this year<br />
than ever before.<br />
Digitally enabled event concept<br />
This year, Informa Markets is focusing on<br />
a technologically enhanced hybrid show<br />
concept. The combination of online and faceto-face<br />
events offers participants the best of<br />
both worlds, including a wide variety of live<br />
and on-demand content as well as data-driven<br />
networking options. All exhibiting companies<br />
have their own online profile, allowing<br />
them to find relevant contacts, network and<br />
set up virtual or face-to-face meetings before<br />
the event. A smartphone app also facilitates<br />
on-site lead generation. “We look forward to<br />
welcoming visitors and exhibitors from around<br />
the world to an event that no one in the ingredients<br />
industry should miss,” says Julien<br />
Bonvallet, Group Brand Director at Informa<br />
Markets. “After months of restriction and<br />
uncertainty, many people have a great need<br />
for face-to-face meetings. But even those who<br />
48 No. 3 November/Dezember <strong>2022</strong>
Fi & Hi Europe <strong>2022</strong><br />
prefer to participate online can do so easily<br />
thanks to our technical solutions.”<br />
Multifaceted conference programme<br />
The online event will begin on 28 November,<br />
the week before doors open at Paris Expo<br />
Porte de Versailles. It offers an extensive<br />
conference programme covering the hottest<br />
topics in the industry, with a focus on plantbased<br />
nutrition, health & wellness, and reformulation.<br />
In addition, interested participants<br />
will find a wealth of information on application<br />
areas that are currently trending – such<br />
as baked goods, snacks, dairy products and<br />
dairy alternatives. Overall, the conference<br />
programme includes more than 55 expert<br />
sessions on-site and online, giving global<br />
audiences access to invaluable knowledge.<br />
The platform Fi Global insights provides a lot of additional information<br />
as well as exclusive reports covering the following topics:<br />
– Protein<br />
– Dairy and Dairy Alternatives<br />
– Snacks, Bakery and Confectionery<br />
– Plant-based<br />
– Sustainability<br />
– Beverages<br />
Market products in the spotlight<br />
On-site, the New Product Zone in cooperation with Innova Market<br />
Insights offers an extensive selection of the most innovative products,<br />
showcased alongside insightful information. It features product<br />
innovations from leading industry players and provides the perfect<br />
opportunity to give new ingredients the introduction to the market<br />
that they deserve. A popular area for visitors and the press, this<br />
feature has become a trendsetting spot for the nutrition industry.<br />
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+43 3332 32042 10 | bdi-biolifescience.com<br />
No. 3 November/Dezember <strong>2022</strong><br />
49
Fi & Hi Europe <strong>2022</strong><br />
Fi Europe Innovation Awards<br />
The renowned Fi Europe Innovation Awards will once again be<br />
adding extra value to the trade show. With one exception, the awards<br />
will only be presented among Fi Europe exhibitors: The new “Food<br />
Training & Education” category is also open to non-exhibitors. This<br />
award is intended to recognise a company, institution or organisation<br />
that contributes to better consumer health, for example, through<br />
an educational initiative or a pioneering approach. The “Sustainability<br />
Innovation Award” recognises environmentally, economi cally<br />
or socially sustainable approaches and practices in the food and<br />
beverage industry. Companies that create equal opportunities in<br />
the work environment receive the “Diversity & Inclusion Innovation<br />
Award”. The “Plant-based Innovation Award” acknowledges alternatives<br />
to animal products and is given for the best ingredient or<br />
application. In the “Sensory Innovation” category, the award is for<br />
an ingredient or process that improves the overall sensory properties<br />
of foods or beverages. The “Health Innovation Award” honours an<br />
ingredient or process that provides a health benefit. The “Food Tech<br />
Innovation Award” goes to companies that have developed innovative<br />
processes, packaging or waste reduction solutions.<br />
The decision as to who receives awards is made by industry experts<br />
from the fields of consulting, management, product development<br />
and trade media. Prof. Colin Dennis, Chairman of the Board of Trustees<br />
of the IFIS organization and member of the Board of Trustees<br />
of the British Nutrition Foundation, will again chair the jury this year.<br />
The winners of all categories will be announced during Fi & Hi Europe<br />
at a ceremony on December 6.<br />
For more information, please visit<br />
https://www.figlobal.com/fieurope/en/home.html<br />
Award for innovative startups<br />
The Fi Global Startup Innovation Challenge also enables young<br />
companies to present their innovative concepts, products and ideas<br />
to an international audience of experts, major companies and sponsors.<br />
All companies founded no more than five years ago are eligible<br />
to participate.<br />
They can apply in one or more of the following categories:<br />
Most innovative ingredient for food or beverage<br />
Most innovative plant-based or alternative ingredient<br />
Most innovative processing technology<br />
Most innovative service, technology or digital solution for the food and<br />
beverage industry<br />
Finalists and winners will have access to the Startup Lounge, where<br />
they can present their products and solutions on the Innovation Hub<br />
stage, and network with industry representatives. Both the pitches<br />
and the award ceremony will also be streamed via the Fi Europe<br />
online platform and remain permanently available. Winners will have<br />
a choice of several attractive prizes: A fully equipped booth at Fi<br />
Europe next year, a comprehensive online marketing package or an<br />
individual mentoring programme.<br />
The latter can be coaching, for example, or the implementation of a<br />
pilot project, or it can include access to corporate collaborations and<br />
business accelerator programmes.<br />
In addition to the Innovation Hub, visitors will find the new Sustainability<br />
Hub at the exhibition, which focuses on sustainable food solutions<br />
along the entire value chain. Here visitors will find information<br />
on food waste, circular economy, regenerative agriculture and many<br />
other topics. Finally, the Women’s Networking Breakfast, sponsored<br />
by DSM, Lunch & Learn and other events are perfect for building a<br />
professional network.<br />
Impressum<br />
ISSN 2364-8104<br />
<strong>Wellness</strong> <strong>Foods</strong> & <strong>Supplements</strong> | No. 3 /<strong>2022</strong><br />
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