Kompendium 2021 Forschung & Klinik

Kompendium 2021
Forschung & Klinik
Universitätsklinik für
Orthopädie und Unfallchirurgie
MedUni Wien und AKH Wien
ISBN 978-3-200-08547-3
www.meduniwien.ac.at/ortho-unfall

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Inhalt/Impressum
3
Die Klinik
4 Editorial
6 Klinische Leistungen und Operationen
9 Spezialambulanzen zunehmend gefragt
10 Interview mit o. Univ.-Prof. Dr. Reinhard Windhager:
„Unsere Forschung orientiert sich an den täglichen
klinischen Problemen“
14 Die Expertinnen und Experten auf einen Blick
18 Ambulanzverzeichnis der Universitätsklinik
für Orthopädie und Unfallchirurgie
Impressum:
Herausgeber:
Universitätsklinik für
Orthopädie und Unfallchirurgie
MedUni Wien und AKH Wien
o. Univ.-Prof. Dr. Reinhard
Windhager
Währinger Gürtel 18–20
1090 Wien
Redaktion & Gestaltung:
Unlimited Media
www.unlimitedmedia.at
Lektorat: Sophie Hermann,
BSc, Alexandra Lechner
Fotos: iStock-458810669/
SomkiatFakmee,
Unlimited Media, MedUni
Wien/Christian Houdek,
Mark Glassner, Alexander
Bumberger
Druckerei: Copydruck KG
Sandleitengasse 9–13
1160 Wien
Wien, Juli 2022
ISBN 978-3-200-08547-3
TOP-Studien
22 Clinical Comparison of Four Different Graft Types in
Matrix-Associated Autologous Chondrocyte transplantation
26 Patient-Specific Implants for Pelvic Tumor Resections
30 Size Matters as Critical Parameter for the Reliability
of Spheroids in Drug Screening Applications
34 Pseudotumors in Metal-on-Metal Total Hip Arthroplasty
37 Safe Bone Block Harvesting for Quadriceps Tendon Autografts
40 Semi-Quantitative and Quantitative MRI for the
Assessment of Cartilage Repair and Intervertebral Discs
43 Bone Mineral Density of the Thoracic Spine
46 Asso ci a tion of Varus Deformity and Coronal
Tibiofemoral Subluxation
49 Outcome after Arthroscopically Assisted TFCC Refixation
52 Osseointegration Can Be Improved by Conventionally Used
Anti-Osteoporotic Drugs Proven in a Clinically Relevant
Murine Implant Model
56 Mimicking the Zonal Organization of Articular
Cartilage in Vitro
58 Relevance of Follow-up CCT in Patients on Intracranial
Pressure Monitoring
Publikationen
62 Originalarbeiten 2021
E-Book
www.meduniwien.ac.at/ortho-unfall
www.unlimitedmedia.at/orthopaedie2021

Editorial
4
Liebe Leserinnen und Leser!
o. Univ.-Prof. Dr. Reinhard Windhager
Ein Bild sagt mehr als tausend Worte. Wie Sie den Histogrammen
entnehmen können, erzielte die Universitätsklinik für Orthopädie
und Unfallchirurgie seit ihrer Zusammenlegung nicht nur eine
Steigerung des gesamten wissenschaftlichen Outputs, sondern
auch der Leistungen pro MitarbeiterIn. Besonders erfreulich ist,
dass das Ranking der Klinik kontinuierlich verbessert werden
konnte und dies vor dem Hintergrund, dass die Publikationsleistung
universitätsweit unentwegt ansteigt. Da hier nicht der Platz
ist, Ihnen alle Studien überblicksmäßig darzustellen, haben wir
wie immer eine Auswahl von zehn wichtigen, in Top-Journalen publizierten
Veröffentlichungen ausgewählt, die sowohl in der Klinik
als auch im Labor wesentliche Ergebnisse generieren konnten und
international Beachtung gefunden haben. Nehmen Sie die Zusammenstellung
nicht nur als Leistungsschau, sondern auch als Anregung,
um in Zukunft weitere Kooperationen etablieren zu können.
Ich wünsche Ihnen viel Vergnügen beim Studium dieser Lektüre.
Ihr Reinhard Windhager
Gesamtoutput
245
286
199 193
50
83
82
104
Output pro MitarbeiterIn
1,84
2,33
1,72 1,67
2,11
2,43
1,065
0,65

Ihr Rehabilitationszentrum für Orthopädie und Neurologie
Wir richten Sie auf !
ambulantes rehazentrum
WIEN BAUMGARTEN
Schwerpunkte:
• aktivierte und chronische Abnützungserscheinungen
der Gelenke (Arthrosen)
• Erkrankungen der Wirbelsäule und Zustand
nach operativen Eingriffen an der Wirbelsäule
• Zustand nach arthroskopischen Eingriffen
an Gelenken
• Zustand nach Gelenksersatz
• Zustand nach offenen Operationen am
Bewegungsapparat
• orthopädisch-rehabilitative Schmerztherapie
• Cerebrale Gefäßerkrankungen
• Polyneuropathien
• Bewegungsstörungen (z.B.Morbus Parkinson)
• Neuromuskuläre Erkrankungen
• Multiple Sklerose und ähnliche entzündliche
Erkrankungen
Ambulante Rehabilitation
mit den Schwerpunkten:
• Kardiologie (Phase 2 und 3)
• Neurologie (Phase 3)
• Onkologie (Phase 2)
• Orthopädie (Phase 2 und 3)
• Psychiatrie (Phase 2 und 3)
• Stoffwechselerkrankungen (Phase 2 und 3)
Vorteile der ambulanten Rehabilitation:
• Wohnortnah und im gewohnten Umfeld
• Vereinbarkeit von Behandlung - Familie - Beruf
• Fortschritte können im Alltag geübt und
überprüft werden
• Anpassung der Therapien an persönliche
Bedürfnisse
• Verschiedene Rehaphasen unter einem Dach
• Kostenübernahme durch die Sozialversicherung
www.rehawienbaumgarten.at
Rehaklinik Wien Baumgarten Betriebs-GmbH, 1140 Wien, Reizenpfenninggasse 1, Tel: +43 1 41500-0

Zahlen und Fakten
6
Klinische Leistungen
und Operationen
Trotz der Einschränkungen durch die Corona-Pandemie im Jahr
2021 wurden an der Universitätsklinik für Orthopädie und
Unfallchirurgie insgesamt 5.863 Operationen durchgeführt.
Die Universitätsklinik für Orthopädie und Unfallchirurgie ist eine Groß klinik mit
einem breitgefächerten Leistungsspektrum. Im Bereich der Orthopädie
wurden insgesamt 2.413 Operationen durchgeführt. Dabei handelte es sich
vielfach um hochspezifische Eingriffe, die oft an anderen Spitälern in Österreich
nicht durchgeführt werden konnten: 293 Hüftendoprothesen, 265 Knieendoprothesen
und 168 Fusionen der Wirbelsäule. Hinzu kamen 417 Arthroskopien,
102 Fußoperationen, 298 Tumorresektionen und 83 Osteosynthesen.
An der Klinischen Abteilung für Unfallchirurgie wurden im Jahr 2021
insgesamt 3.450 Operationen vorgenommen.
Klinische Leistung Orthopädie 2020 2021
Operationen gesamt 2.449 2.413
unter anderem:
Fusionen der Wirbelsäule 149 168
Endoprothetische Versorgungen (gesamt) 653 621
davon Hüftendoprothesen 315 293
davon Knieendoprothesen 277 295
Arthroskopien (alle Gelenke) 341 417
Fußoperationen 78 102
Tumorresektionen 286 298
Osteosynthesen 83 83
Klinische Leistung Unfallchirurgie
Anzahl Operationen 3.265 3.450
unter anderem:
Endoprothetische Versorgungen (gesamt) 192 218
Schädel-Hirn-Trauma 57 30
Wirbelsäulen-OP 70 39
Becken-/Acetabulum-Frakturen 32 33
Knie-Binnenverletzungen 334 379
Rekonstruktive Operationen an der Schulter 83 93
Handverletzungen 329 427
Thorax-/Abdomenverletzungen 24 32
Periprothetische Frakturen 46 37
Osteosynthesen 606 603
Stationäre Aufnahmen 6.054 6.342

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Zahlen und Fakten
9
Spezialambulanzen
zunehmend gefragt
Die Diagnose, Therapie und Prävention von angeborenen und
erworbenen Erkrankungen des Bewegungsapparates sind die
zentrale Ausrichtung der Universitätsklinik für Orthopädie und
Unfallchirur gie im AKH Wien. Die hochgradige Spezialisierung
auf bestimmte Fachgebiete hat dazu geführt, dass die mittlerweile
22 Spezial ambulanzen im vergangenen Jahr eine
steigende Frequenz aufweisen konnten.
Im Vergleich zum Jahr 2020 wurden in allen Ambulanzen im Jahr 2021
höhere Frequenzen verzeichnet. So kam es im Jahr 2021 zu 24.993
Ambulanzbesuchen (im Vergleich zu 23.306 im Jahre 2020). Die höchsten
Frequenzen wiesen folgende Ambulanzen auf: Schmerztherapie (2.047),
Tumororthopädie (3.192), Rheumaorthopädie (2.364), Kinderorthopädie
(2.138), Wirbelsäule (1.578), Sportorthopädie (1.486), Endoprothetik (1.046),
Sarkome (666) und die Fußambulanz (581).
Die ambulanten Frequenzen der Klinischen Abteilung für Unfallchirurgie
lagen ebenfalls über den Vorjahreszahlen. So wurden 2021 insgesamt
51.293 ambulante Besuche in der Erstversorgung verzeichnet
(2020: 49.342) und auch die ambulanten Kontrollen bei den Nachbehandlungen
lagen mit 36.476 höher als im Jahr davor (2020: 34.704).
2020 2021
Ambulante Frequenzen Orthopädie (gesamt) 23.306 24.993
Schmerztherapie 2.343 2.047
Tumororthopädie 2.872 3.192
Rheumaorthopädie 2.468 2.364
Kinderorthopädie 1.805 2.138
Wirbelsäule 1.550 1.578
Sportorthopädie 1.512 1.486
Endoprothetik 1.133 1.046
Sarkome 852 666
Fußambulanz 403 581
Ambulante Frequenzen Unfallchirurgie
Ambulante Frequenzen (ABF) Erstversorgung 49.342 51.293
Ambulante Kontrollen (ABK) Nachbehandlung 34.704 36.476
SchockraumpatientInnen 507 566
Eingriffe in der Wundversorgung 3.616 3.872
Versorgungen im Gipszimmer 19.579 21.017

Klinik
10
Unsere Forschung orientiert
sich an den täglichen
klinischen Problemen
Die Universitätsklinik für Orthopädie und Unfallchirurgie ist
eine der größten im AKH Wien und der MedUni Wien und genießt
vor allem im Bereich der hochspezialisierten Operationen
interna tionalen Ruhm. Die Corona-Pandemie hat aber bei der
Behandlung der Patientinnen und Patienten massive Probleme
bereitet und zu Rückgängen der über die letzten Jahre steigenden
Operations fallzahlen geführt. Die Auswirkungen im Bereich der
Forschung und Lehre waren unterschiedlich.
o. Univ.-Prof. Dr. Reinhard Windhager
Für welche hochspezialisierten Operationen, die sonst kaum in Österreich
gemacht werden, ist die Universitätsklinik für Orthopädie und Unfallchirurgie
bekannt?
Hierzu zählt in erster Linie die Tumororthopädie mit allen ihren Facetten und
Detailbereichen. So wurden an der Universitätsklinik für Orthopädie und
Unfallchirurgie En-Block-Resektionen bei hochmalignen Knochentumoren
der Wirbelsäule bereits vor 30 Jahren als weltweit führende Klinik begonnen
und in weiterer Folge perfektioniert, sodass diese heutzutage Routineoperationen
darstellen, die aber kaum anderswo durchgeführt werden.
Weiters zu erwähnen sind komplexe Eingriffe bei Infektionen des Knochens
in verschiedenen Lokalisationen und vor allem der Wirbelsäule, die ein interdisziplinäres
Management voraussetzen, ebenso wie eine hohe Expertise in
Bezug auf Planung der Operationsabfolgen und Umsetzung derselben.
Ein weiterer herausragender Schwerpunkt ist die Deformitätenkorrektur nicht
nur im Bereich der Extremitäten, die häufig interdisziplinär mit der plastischen
Chirurgie durchgeführt wird, sondern auch im Bereich der Wirbelsäule. Ein
weiterer Spezialbereich ist die moderne Amputationschirurgie mit direkter
Verbindung der Exoprothesen an den Knochen, wodurch vor allem im Oberschenkelbereich
enorme Funktionsvorteile zu registrieren sind.
Schließlich ist noch das hochspezialisierte Polytraumamanagement zu
erwähnen, welches aufgrund der hohen Frequenz und der Schwere der
Fälle nicht nur im nationalen, sondern im internationalen Vergleich hervorragend
repräsentiert ist.
Die Zuweisungen für diese Spezialeingriffe erfolgen nicht nur aus den umgebenden
Bundesländern und Gesamtösterreich, sondern sehr häufig auch
aus dem benachbarten, aber auch fernen Ausland.

Klinik
11
Über 20 Spezialambulanzen werden von der Universitätsklinik für
Orthopädie und Unfallchirurgie angeboten. Wie wichtig sind diese für
die Versorgung der Patientinnen und Patienten?
Die hohe Zahl an Spezialambulanzen repräsentiert die Differenziertheit in
der Behandlung und die zunehmende Spezialisierung dieses umfangreichen
Faches. Diese Spezialambulanzen werden von hochengagierten Kolleginnen
und Kollegen betrieben, die aufgrund ihrer Expertise und Hingebung an diese
spezielle Tätigkeit eine enorme Attraktion für die PatientInnen darstellen.
Wie überlastet sind diese Ambulanzen?
Alle Spezialambulanzen werden als Terminambulanzen geführt, sodass eine
Überlastung regulierbar ist. Allerdings entstehen in einzelnen Bereichen sehr
lange Vormerkzeiten, sodass zu Alternativen, wie telemedizinische Beratung,
gegriffen werden musste.
Wie funktioniert die Zusammenarbeit mit den niedergelassenen
ÄrztInnen – bei der Zuweisung und auch Nachsorge?
Die Kooperation mit dem niedergelassenen Bereich ist hervorragend und
hat sich in der Vergangenheit in erster Linie auf die Nachsorge beschränkt.
Neuerdings werden auch telemedizinische Beratungen angeboten, wodurch
einerseits die Wartezeiten verkürzt werden können, andererseits eine bessere
Vorbereitung der Patienten auf die Erstvorstellung gewährleistet wird.
„Die Zuweisungen für die hochspezialisierten
Operationen erfolgen nicht nur
aus den umgebenden Bundesländern
und Gesamtösterreich, sondern sehr
häufig auch aus dem benachbarten, aber
auch fernen Ausland.“
Reinhard Windhager
Welche Leistungen bietet die neue Patellofemoral-Spezialambulanz an?
Der Fokus dieser Ambulanz liegt auf dem Patellofemoralgelenk, welches
einen Teilbereich des Kniegelenkes darstellt. Probleme mit dem Patellofemoralgelenk
sind extrem häufig und betreffen funktionelle Dysbalancen, die angeboren
sein oder nach Unfällen auftreten und zu dauerhaften Belastungen
der Patientinnen und Patienten führen können. Das Wissen in diesem Spezialbereich
hat sich in den letzten 30 Jahren enorm ausgeweitet und bedingt,
dass eine multimodale Abklärung zur Analyse der Probleme erforderlich ist,
um eine patientenspezifische Behandlung und Korrektur dieser Problematik
gewährleisten zu können.
Welche Neuentwicklungen gibt es bei den einzelnen Operationen und
Behandlungen – Knie, Hüfte, Wirbelsäule, Endoprothetik …?
Bei dem heutigen Wissensstand ist es schwer, von reinen Neuentwicklungen
zu sprechen, da viele diagnostische und therapeutische Ansätze bereits
versucht worden sind, allerdings heutzutage mit neuen Methoden andere
Zugänge ermöglichen und auch bessere Ergebnisse erwarten lassen.
Im Kniegelenksbereich ist sicherlich die kinematische Ausrichtung der
Gelenkachsen bei Implantationen der totalen Endoprothese ein Ansatz,
der neuerdings weitere Verbreitung findet. Dabei wird versucht, die individuellen
Achsverhältnisse mehr zu berücksichtigen und nicht alle Kniegelenke
einheitlich auf die gleichen Maße einzustellen.
Im Bereich der Hüftendo prothetik ist es vor allem die verbesserte Ausrichtung
der Gelenke unter Einbeziehung der Stellung zwischen Becken und
Wirbelsäule, bei welchen große individuelle Unterschiede bestehen. Verbesserungen
und Innovationen sind auch im Bereich Navigation und vor allem
Robotik zu verzeichnen, sowohl was die Endoprothetik betrifft als auch die
Wirbelsäulenchirurgie. Inwieweit diese Neuentwicklungen zu dauerhaften
Verbesserungen führen, bleibt momentan Gegenstand intensiver Forschung.

Klinik
12
Welche Forschungsthemen sind in naher Zukunft zu erwarten?
Da sich aus einer interessanten Studie immer neue Fragen ergeben, ist
eine Auflistung interessanter Forschungsthemen in der Zukunft hier nicht
abzuhandeln. Die Forschung bleibt weiterhin ausgerichtet auf die Individualisierung
therapeutischer Konzepte, Charakterisierung von Patientenansprüchen
auf Basis von PROMS (patient related outcome measures), wofür große
Datenmengen herangezogen werden müssen, Analyse von Dispositionen einzelner
Patienten für unerwünschte Krankheitsverläufe und Verhinderung von
Infektionen als schwerwiegendste Komplikation bei Operationen, vor allem
bei multimorbiden Patienten. Bei Durchsicht der ausgewählten Top-Publikationen
lassen sich unschwer wichtige Themen für die Zukunft erkennen.
Welches Standing hat die Wiener Universitätsklinik international?
Das Universitätsklinikum AKH Wien ist Teil der sogenannten European
University Hospital Alliance, in der sieben renommierte Kliniken Europas im
ständigen Austausch und Vergleich stehen. Somit ist ein direktes Benchmarking
gewährleistet und auch durch direkte Kooperationen die Möglichkeit
gegeben, Optimierungen in einzelnen Bereichen rasch herbeizuführen.
„Unsere Forschungsansätze sind translational,
das heißt, dass Forschungsthemen
aus der Klinik und von klinischen
Problemen generiert werden und
durch Entwicklungen im Labor mit den
entsprechenden Ergebnissen wieder
Eingang in die Klinik finden und damit
den Patientinnen und Patienten zugutekommen.“
Reinhard Windhager
Wie wichtig sind für Sie Kooperationen mit Firmen bzw. anderen Kliniken?
Was erwarten Sie sich davon?
Die Kooperation mit anderen Kliniken ist im Forschungsbereich zur Generierung
größerer Fallzahlen unabdingbar, um international mit größten Institutionen,
vor allem im asiatischen Bereich, mithalten zu können. Kooperationen
mit Firmen sind in Bezug auf Produktentwicklungen interessant, um durch
komplementäre Vermengung verschiedener Expertisen rascher zu Ergebnissen
und Produktentwicklungen zu kommen. Die Abteilung Technologie Transfer
der Medizinischen Universität Wien bietet hierfür eine ausgezeichnete
Plattform und unterstützt unsere Forscherinnen und Forscher bei Patentanmeldungen
und weiteren Entwicklungen.
Wie wirkt sich die laufende Forschungstätigkeit auf die tägliche Arbeit
für die Patientinnen und Patienten aus?
Unsere Forschungsansätze sind in erster Linie translational, das heißt, dass
Forschungsthemen aus der Klinik und von klinischen Problemen generiert
werden und durch Entwicklungen im Labor mit den entsprechenden Ergebnissen
wieder Eingang in die Klinik finden und damit den Patientinnen und
Patienten zugutekommen.
Wie wirkt sich die Coronakrise derzeit noch auf die Klinik aus?
Die früher noch aufwendigen organisatorischen Änderungen haben sich
gut eingespielt und in den Alltag integrieren lassen, allerdings sind wegen
Corona-bedingter Personalausfälle noch Engpässe zu verzeichnen gewesen.
Auch wenn die Situation derzeit als stabil gewertet werden kann, ist nicht
abzu sehen, was an weiteren Änderungen auf uns zukommen wird. Wichtig ist
hierbei, die Motivation der Mitarbeiterinnen und Mitarbeiter hochzuhalten
und zu bündeln, da sich dauerhafte Restriktionen negativ auf das Gesamtergebnis
der Leistung sowohl im klinischen als auch im wissenschaftlichen
Bereich auswirken können. Überraschend ist immer noch die gelegentlich
hohe Kumulation von Ereignissen, wie die positive Covid-19-Testung von
Mitarbeiterinnen und Mitarbeitern oder aber Patientinnen und Patienten,
die vereinzelt zu plötzlichen Ausfällen führen können, die nicht aufgefüllt
werden können, und somit kostbare Behandlungsressourcen verloren gehen.

Comparative 3 Year
ACTIS Stem data
Survival analysis for all-cause
revision following primary total hip
arthroplasty with a medial collared,
triple-tapered primary hip stem versus
other implants in real-world settings.
Chitnis A, Mantel J, Ruppenkamp J, Bourcet A, Holy C
Current Medical Research Opinion. 2020 Sep 22:1-7.
• A retrospective cohort study identified 1,213 patients who received the
ACTIS Total Hip. This group was compared to 6,916 patients who
received other THA implants.
• Data was drawn from the Mercy Healthcare Systems Orthopedics
Database, a large US based multi-state database.
• Kaplan-Meier survival curves were generated, and a multivariable
Cox proportional hazard model was used to compare the relative risk
of revision.
57% lower risk of revisions
Adjusted Hazard Ratio 0.43 ((0.19-0.97) p=0.042)
3
ACTIS Stem revision rate estimated
at 1.08% at years 2 and 3
2.63%
(2.19%-3.16%)
2
1.9%
(1.57%-2.29%)
2.29%
(1.91%-2.74%)
2.63%
(2.19%-3.16%)
1.08%
(0.43%-2.72%)
ALL-CAUSE REVISION RATE AT 3 YEARS
1
0
0.64%
(0.28%-1.43%)
1.08%
(0.43%-2.72%)
1.08%
(0.43%-2.72%)
YR 1 YR 2 YR 3
ACTIS STEM
OTHER THA IMPLANTS
57% Reduced Risk of Revision when
Compared to Other THA Implants
Please refer to the instructions for use for a complete list of indications, contraindications, warnings and precautions.
Johnson & Johnson Medical Limited. Baird House, 4 Lower Gilmore Bank, Edinburgh, EH3 9QP, United Kingdom.
Incorporated and registered in Scotland under company number SC132162.
www.jnjmedicaldevices.com
© DePuy Synthes 2020. All Rights Reserved.
155950-201015 DSUS/EMEA

Das ÄrztInnenteam
14
Die Expertinnen und
Experten auf einen Blick
Neben dem Fortschritt in der Medizintechnik und innovativen
Medikamenten sind vor allem die Mitarbeiterinnen und Mitarbeiter
ein essenzieller Garant für den optimalen medizinischen
Erfolg. Die rund 100 ÄrztInnen der Universitätsklinik für
Orthopädie und Unfallchirurgie von MedUni Wien und AKH
Wien profitieren dabei auch vom exzellenten Netzwerk, dem
wertschätzenden Umgang miteinander und der zielorientierten,
individuellen Fort- und Weiterbildung.

Das ÄrztInnenteam
15
Universitätsklinik für Orthopädie und Unfallchirurgie
Leiter: o. Univ.-Prof. Dr. Reinhard WINDHAGER
Klinische Abteilung für Orthopädie
o. Univ.-Prof. Dr. Reinhard WINDHAGER
ao. Univ.-Prof. in Dr. in Catharina CHIARI, MSc
Univ.-Prof. Dr. Alexander GIUREA
Klinische Abteilung für Unfallchirurgie
Assoz. Prof. Priv.-Doz. Dr. Stefan HAJDU, MBA
Assoz. Prof. in Priv.-Doz. in Dr. in Silke ALDRIAN
Mitarbeiterinnen und Mitarbeiter
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Mag. a Dr. in Rita BABELUK
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DDr. Gabriel HALAT
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Dr. Stephan HEISINGER
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Dr. in Monika LUXL
Ass.-Prof. Dr. Wolfgang MACHOLD
Dr. Bernhard MAIER

Das ÄrztInnenteam
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Dr. in Ulrike MARQUART
Dr. Michael MATZNER
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DI in Dr. in Anna RIENMÜLLER
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PhD (karenziert)
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WARTENBERG
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Priv.-Doz. Dr. Lukas ZAK
Dr. in Cornelia ZEITLER (karenziert)
Mitarbeiterinnen und Mitarbeiter in Forschungslabors
(in alphabetischer Reihenfolge):
Melanie ACOSTA, BSc
Ana BREIL
Isabel CASADO LOSADA, MU
Marian FÜRSATZ, MSc MMSc
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Dr. Jürgen ALPHONSUS
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Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan TÖGEL
Mitarbeiterinnen des Studiensekretariats
(in alphabetischer Reihenfolge):
Sandra HACKER, MSc
Anna-Theresia KOURIMSKY, BSc
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Carmen TROST, BA MA

COPAL ® – ERFOLGREICH GEGEN INFEKTIONEN
COPAL
Bei infektionsgefährdeten Patienten & Revisionseingriffen
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Vakuummischsystem mit Sammeln
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Zweifach antibiotikahaltiger
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Effektiv auch gegen
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Tel.: + 43 (0) 1 5 22 25 80
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(10) (1)
Sprowson AP. et al. Bone Joint J. 2016.
(11) (2)
Engesaeter in Wahlenkamp. Local Antibiotics in arthroplasty.
2007, p. 152.
www.heraeus-medical.com
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Das ÄrztInnenteam
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Wiener Gesundheitsverbund
Teilunternehmung AKH Wien
Universitätsklinik für
Klinische Abteilung für Orthopädie
PatientInnenversorgung
Forschung
Spezialambulanzen
Schulter und Ellbogen
Sportchirurgie Knie
Hand
Fuß
Orthopädische
Schmerzambulanz
Hüfte
Knie
Knorpelschäden
Neuromuskuläre
Fußamb.
Patellofemoral
Knochen- und
Weichteilsarkome
Klumpfuß
Extremitätendeformität
Spezialteams
Sportorthopädie
Rheumaorthopädie
Rehabilitation
und Prothetik
Komplexe Revision und
Extremitätenrekonstruktionen
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Forschungscluster
Arthrose und
Geweberegeneration
Deformitäten und
Frakturheilung
Endoprothetik
Hand
Infektionen
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Spezielle
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Verfahren
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Bilddiagnostik
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Deformitäten
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Das ÄrztInnenteam
19
Medizinische Universität Wien
Orthopädie und Unfallchirurgie
Klinische Abteilung für Unfallchirurgie
Lehre
PatientInnenversorgung
Orthopädie
Diplom- und
Doktoratsstudium
Unfallchirurgie
Diplom- und
Doktoratsstudium
Erstbehandlungsambulanz
+
Nachbehandlungsambulanz
Spezialambulanzen
Postgraduelle Aus-/
Weiterbildung
inkl. PhD
Facharztausbildung
Postgraduelle Aus-/
Weiterbildung
inkl. PhD
Facharztausbildung
Wirbelsäulenverletzungen
Traumatische Knorpelschäden
Posttraumat. Deformitäten
und Gliedmaßenrekonstruktion
Kindertraumatologie
Sportambulanz
Handambulanz
Schulterambulanz
Hüftambulanz

Ambulanzen
20
Ambulanzverzeichnis der
Universitätsklinik für
Orthopädie und Unfallchirurgie
Die Spezialambulanzen der Klinischen Abteilung für Ortho pädie
befinden sich im AKH Wien auf Ebene 7D unter dem grünen
Betten haus. Für diese Bestellambulanzen sind telefonische Terminvereinbarungen
unter der Telefonnummer +43/1/404 00-40800
erforderlich. Zuweisungen erfolgen jeweils durch die niedergelassenen
Fachärztinnen und -ärzte für Orthopädie.
Die Spezialambulanzen der Klinischen Abteilung für Unfallchirurgie
und die Nachbehandlung in der Unfallambulanz
befinden sich auf Ebene 6B und sind unter der Telefonnummer
+43/1/404 00-59380 zu kontaktieren.

Ambulanzen
21
Spezialambulanzen Klinische Abteilung für Orthopädie
Spezialambulanz für orthopädische Schmerztherapie
Endoprothesenzentrum der Maximalversorgung
• Spezialambulanz für Endoprothetik
• Spezialambulanz für Knie
• Spezialambulanz für Hüfte
• Spezialambulanz für komplexe Revisionen und Extremitätenrekonstruktionen
• Patellofemoral-Spezialambulanz
Tumororthopädie
• Spezialambulanz für Tumororthopädie
• Spezialambulanz für Knochen- und Weichteilsarkome
• Spezialambulanz für Rehabilitation und Prothetik
Wirbelsäulenorthopädie
• Spezialambulanz für Wirbelsäule
• Spezialambulanz für Skoliose und Wirbelsäulendeformitäten
Kinderorthopädie
• Spezialambulanz für Kinderorthopädie
• Spezialambulanz für Knorpelschäden
• Spezialambulanz für Klumpfuß
• Spezialambulanz für Extremitätendeformitäten
• Neuromuskuläre Fußambulanz
Rheumaorthopädie
• Spezialambulanz für Rheumaorthopädie
• Spezialambulanz für Fuß
• Spezialambulanz für Hand
Sportorthopädie
• Spezialambulanz für Sportorthopädie
• Spezialambulanz für Sportchirurgie Knie
• Spezialambulanz für Schulter und Ellbogen
Spezialambulanzen Klinische Abteilung für Unfallchirurgie
• Allgemeine Unfallambulanz – Erstversorgung
• Allgemeine Unfallambulanz – Nachbehandlung
• Ambulanz für Kindertraumatologie
• Ambulanz für Handchirurgie
• Ambulanz für Hüftverletzungen und posttraumatische Hüftbeschwerden
• Schulterambulanz
• Ambulanz für traumatische Knorpelschäden
• Ambulanz für posttraumatische Deformitäten und Gliedmaßenrekonstruktion
• Ambulanz für Sportverletzungen
• Ambulanz für posttraumatische Wirbelsäulenbeschwerden

TOP-Studien
22
Clinical Comparison of Four
Different Graft Types in
Matrix-Associated Autologous
Chondrocyte transplantation
Articular cartilage lesions are one of the most frequent types of
injuries encountered in orthopaedic practice: They show no
spontaneous healing response and often lead to unicompartmental
osteoarthritis (OA), which is a common problem among
young and active people. Focal defects to the cartilage lead to
progredient cartilage self-destruction and joint pain, ultimately
resulting in secondary OA.
Because of improvements and developments in cartilage repair, autologous
chon-drocyte transplantation (ACT) has become an increasingly popular
treatment method. The most common techniques are third-generation
matrix-associated autologous chondrocyte transplantation (MACT) procedures,
which follow a two-step surgical approach: First, a three-dimensional
biocompatible scaffold serving as cell growth carrier is seeded with
chondrocytes from an initial arthroscopy, to be then implanted in the patient
during a subsequent mini-arthrotomy.
Study:
Binder H, Hoffman L, Zak L,
Tiefenboeck T, Aldrian S,
Albrecht C.
Clinical evaluation after
matrix-associated autologous
chondrocyte transplantation:
A comparison of four different
graft types.
Bone Joint Res. 2021
Jul;10(7):370-379. doi:
10.1302/2046-3758.107.
BJR-2020-0370.R1.
This scaffold is composed of cartilage extracellular matrix molecules or biopolymers,
forming a biological matrix leading to more hyaline-like repair tissue
in articular cartilage defects. The matrix traps the cells in the chondral defect
and provides cell-matrix interactions, stimulating differentiation into articular
chondrocytes and the production of a hyaline-like extracellular matrix.
Compared to bone marrow-stimulating techniques such as MFX, MACT
provides the possibility of differentiation of the cartilage repair tissue, leading
to the reformation of hyaline or hyaline-like cartilage. It has also been
shown that MACT consistently improves patient-reported functional outcomes
compared with microfracture.
However, comparisons between different types of MACT grafts are lacking
in the literature. The four most common ones are Hyalograft ® C autografts
(Fidia Advanced Biomaterials, Italy), MACI ® (Genzyme, USA, former Verigen,
Germany), CaReS ® (Arthro Kinetics Biotechnology GmbH; Krems, Austria),
and Novocart ® 3D (TeTeC, Reutlingen, Germany).

TOP-Studien
23
A B C
Figure 1: Preoperative (A) and follow-up MRI after one year (B) and two years (C) of a 25-year-old female patient after matrix-associated autologous
chondrocyte transplantation procedure with the Hyalograft®C Transplantation system.
„Our data demonstrated that MACT
resulted in good clinical improvement
for tibio-femoral defects two years
after transplantation, regardless of
the graft type used.“
Harald Binder
Hyalograft ® C consists of a hyaluronan web seeded with previously obtained
cells that are cultivated in 2D for at least two weeks. MACI ® is a collagen
type I/III membrane seeded with Chondrocytes that are cultivated in 3D for
one week. CaReS ® is composed of a collagen type I gel, the obtained cells are
mixed with the gel directly without monolayer cultivation, instead, a three
weeklong 3D-cultivation is performed. Novocart ® 3D is a bilayered collagen
type I sponge, containing chondroitin-sulphate. The cells are isolated from
full depth cartilage cylinders, multiplied in monolayers, and seeded onto the
scaffold. Cultivation lasts for two days and is performed in 3D.
Aim and Methods
This retrospective study aims to determine the possible differences in shortterm
clinical outcome among these four different types of MACT, since up to
now, no comparison of these four commonly used transplant types has been
documented.
This case control study includes 88 patients (mean age: 34 years, mean
BMI: 25) with full-thickness chondral lesions of the tibiofemoral joint who
underwent MACT. Clinical examinations were performed preoperatively, and
24 months after transplantation. Clinical outcomes were evaluated using the
International Knee Documentation Committee (IKDC), the Brittberg score,
the Tegner Activity Scale, and the visual analog scale (VAS) for pain. The
Kruskal-Wallis test by ranks was used to compare the clinical scores of the
different transplant types.
Results and Conclusion
The average defect size of the tibiofemoral joint compartment was 4.28 cm 2 .
Eleven patients (12.6 %) underwent transplantation with Chondro-Gide
(MACI), 40 patients (46.0 %) with Hyalograft (HYAFF) (Figure 1), 21 patients
(24.1 %) with CaReS and 15 patients (17.2 %) with Novocart 3D. The mean
IKDC score improved from 35.71 (± 6,44) preoperatively to 75.26 (± 18.36)

TOP-Studien
24
after 24 months postoperatively in the Hyalograft group, from 35.94 (± 10.29)
to 71.57 (± 16.31) in the Chondro-Gide (MACI) group, from 37.06 (± 5.42) to
71.49 (± 6.76) in the Novocart 3D group and from 45.05 (± 15.83) to 70.33
(± 19.65) in the CaReS group. Similar improvements were observed in the VAS
and Brittberg scores.
Our data demonstrated that MACT resulted in good clinical improvement for
tibiofemoral defects two years after transplantation, regardless of the graft
type used. Different transplant composition and architecture did not significantly
influence clinical outcomes in our study population.
Resume
The novelty of the herein presented study is the comparison of four different
graft types among their clinical results in human. Published studies
have varied in terms of their quality and which techniques have been compared
with one another. To our knowledge, there are no studies comparing
more than two different matrices in a clinical trial. Therefore, this is the
first study comparing 2-year clinical outcomes of patients treated with different
graft types for symptomatic, traumatic chondral defects restricted
to the tibiofemoral joint area. The major finding of this study was that our
data showed no significant differences in the clinical outcomes regarding
the graft types used.
References:
[1] Curl, W.W., et al., Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy, 1997.
13(4): p. 456-60.
Dr. Harald Binder, MSc
Author:
As a member of the outpatient’s
clinic for traumatic cartilage
defects and shoulder surgery
of the AKH Vienna, Harald
Binder specialises in trauma
surgery and orthopaedics. His
clinical and scientific
focus includes shoulder surgery,
cartilage trauma, traumatic
brain injuries, clinical
paediatric traumatology, and
sports medicine.
[2] Hunziker, E.B., Articular cartilage repair: basic science and clinical progress. A review of the
current status and prospects. Osteoarthritis Cartilage, 2002. 10(6): p. 432-63.
[3] Schinhan, M., et al., Critical-size defect induces unicompartmental osteoar-thritis in a stable
ovine knee. J Orthop Res, 2012. 30(2): p. 214-20.
[4] Schulze-Tanzil, G., Activation and dedifferentiation of chondrocytes: implica-tions in
[5] Brittberg, M., Autologous chondrocyte transplantation. Clin Orthop Relat Res, 1999(367 Suppl):
p. S147-55.
[6] Marlovits, S., et al., Cartilage repair: generations of autologous chondrocyte transplantation. Eur
J Radiol, 2006. 57(1): p. 24-31.
[7] Bartlett, W., et al., Autologous chondrocyte implantation versus matrix-induced autologous
chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised
study. J Bone Joint Surg Br, 2005. 87(5): p. 640-5.
[8] Knutsen, G., et al., Autologous chondrocyte implantation compared with mi-crofracture in the
knee. A randomized trial. J Bone Joint Surg Am, 2004. 86(3): p. 455-64.
[9] Wondrasch, B., et al., Effect of accelerated weightbearing after matrix-associated autologous
chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after
2 years: a prospective, randomized controlled pilot study. Am J Sports Med, 2009. 37 Suppl 1: p.
88s-96s.
[10] Albrecht, C., et al., Gene expression and cell differentiation in matrix-associated chondrocyte
transplantation grafts: a comparative study. Osteoar-thritis Cartilage, 2011. 19(10): p. 1
219-27.

Integriertes Patientenversorgungskonzept zur MACT-
Gelenksknorpelrekonstruktion
Exakte Indikationsstellung
Indikations- und Durchführungs empfehlungen
der Arbeits gemeinschaft „Geweberegeneration
und Gewebe ersatz“ zur Autologen
Chondrozyten-Transplanta tion (ACT). Behrens
P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier
C, Krackhardt T, Löhnert J, Marlovits S, Meenen NM,
Mollenhauer J, Nehrer S, Niethard FU, Nöth U, Perka C,
Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K
(2004). Z Orthop 142: 529-539
Hohe Zelldichte und hohe Zellvitalität
des Implantats
Effect of cell seeding concentration on the quality
of tissue engineered constructs loaded with adult
human articular chondrocytes. Concaro S, Nick lasson E,
Ellowsson L, Lindahl A, Brittberg M, Gatenholm P (2008).
J Tissue Eng Regen Med
Flexible Anpassung des Implantats bei
der Trans plantation und Wahrung einer
homogenen Zellmatrix
Stabilization of fibrin-chondrocyte constructs for
cartilage reconstruction. Meinhart J, Fussenegger M, Höbling W
(1999), Ann Plast Surg 42(6): 673-678
Knorpelbiobsat­Entnahme
Zellkultur züchten
MACT­Transplantation
Seit 2001 züchtet das Institut
für Gewebe- und Organrekonstruk
tion, kurz igo®,
autologe Zell kul turen für die
Knorpel zell rekon struk tion für mehr als 1.500 Patienten
erfolgreich an.
igo® ist ein privates biopharmazeutisches Unternehmen
und Pionier auf dem Gebiet der Zellkulturtechnik
und des Tissue Engineerings und aktiv
beteiligt an Entwicklung neuer Heilmethoden. Als
österreichisches Unternehmen glänzen wir mit
der besonderen räumlichen Nähe und dem direkten
Kontakt zu unseren Kunden.
Informieren Sie sich unter www.igor.at
Hohe Compliance des Patienten: Die für
die Nachtherapie verwendeten Geräte,
CPM Schiene sowie HPM Gerät verfügen
über eine Compliance­Überwachung. Wenn
der Patient hier compliant ist, kann man
davon ausgehen, dass er auch bei der
Physio therapie konsequent mitarbeitet, was
für den Erfolg der Therapie wesentlich ist.
Low frequency EMF regulates chondrocyte
differentiation and expression of matrix proteins.
Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002).
J Orthop Res, Vol. 20(1): 40-50
Postoperative Therapie
Die Kontrollierte Nachtherapie: wird
durch das Netz werk von geschulten Physiotherapeuten
unterstützt
MACT­Langzeittherapie
Autologous chondrocyte implantation postoperative
care and rehabilitation. Hambly K, Bobic V, Wondrasch B,
VanAssche D, Marlovits S (2006). Science and Practice.
Am J Sports Med 34(6): 1020-1038
A prospective, randomized comparison of traditional
and accelerated approaches to postoperative
rehabilitation following autologous chondrocyte
implantation: 2-year clinical outcomes. Jay R. Ebert,
William B. Robertson, David G. Lloyd, M.H. Zheng, David J. Wood,
Timothy Ackland (2010). Catilage 1(3)180-187
Wissenschaftliche Publikationen
mit igor Chondro­Systems
Clinical experience with matrix associated
autologous chondrocyte transplantation
(MACT). Ramadani F, Orthner E, Kitzler B,
Wallner B, Burghuber C, Fußenegger M, Meinhart J
(2005). Revista de ortopedie si traumatologie 1(6):
106-110
Transplantation of chondrocytes – longtime
experiments. Prof. Dr. Lars Peterson (2006)
Ergebnis nach ca. 18 Monaten
Quelle:
Klinik Diakonissen
Schladming
Seit 2006 läuft das Koopera ti onsprojekt Leomed/
Igor der integrierten Patientenver sorgung für
Knor pel rekon struktion.
Nach Implantation unterstützt Leomed die
Patienten bei der Organisation der Nachtherapie.
Informieren Sie sich unter www.leomed.at

TOP-Studien
26
Patient-Specific Implants
for Pelvic Tumor Resections
„Internal hemipelvectomy and
reconstruction using custom-made
implants comes with a high risk for
postoperative complications. However,
good functional outcomes can be
regularly achieved.“
Kevin Döring
Limb-sparing surgery of primary malignant pelvic tumors has
become the treatment of choice over the last decade, mainly due
to improvement in surgical technique, imaging, and perioperative
management. However, limb-sparing surgery remains challenging
with respect to defect reconstruction and management of complications.
Several methods have been applied for reconstruction
after periacetabular tumor resections, such as iliofemoral arthrodesis,
allograft reconstruction, irradiated, autoclaved or frozen
autografts, and allograft-prosthetic composites.
Endo prosthetic replacement bears the advantage of immediate stability and
allows early weight bearing, which is of utmost importance in this mainly
young patient group. Among the endoprosthetic replacements, custom-made
endoprostheses have been used in the last three decades and still represent
the technique of choice due to high variability in pelvic anatomy (Figure 1).
However, as pelvic reconstruction using custom-made implants is only rarely
necessary, follow up data on this type of reconstruction are rare. Thus, we
conducted this study to analyse the outcome of custom-made prostheses in
a single centre setting over a follow-up period of three decades.
Patients and Methods
Between 1990 and 2000, 26 patients underwent resection of pelvic malign
bone tumors at the orthopaedic department of the Medical University of
Vienna and received reconstruction using custom made pelvic prostheses
(Howmedica, Kiel, Germany). Except of oncological survival analyses, 6 of
these 26 patients were excluded due to a follow up below one year and, thus,
no possibility of an adequate prosthesis assessment regarding function and
complications. The median (range) age at surgery was 25 (13–63) years, the
median follow-up after surgery was 5 (1–17) years.
Study:
Döring K, Staats K, Puchner S,
Windhager R.
Patient-Specific Implants for
Pelvic Tumor Resections.
J Pers Med. 2021 Jul
21;11(8):683.
Results
At the time of last follow up, four patients had no surgical revision after prosthesis
implantation, while 16 patients had at least one revision. The median
number of revision surgeries per patient was 1.5 (0–7). The first surgical
revision was performed with a median of 27 (0 days – 6 years) days after surgery.
Regarding type I complications according to the ISOLS classification by
Henderson et al., we found a revision free survival of 90 % after one year and
84 % after two and five years. Type I complications occurred in three patients
suffering from dislocation of their pelvic prosthesis, which required surgical
revision after a median of five months (14 days – 20 months) after surgery.
Type II complications or aseptic loosening showed a revision free survival of

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Figure 1: Real-size planning model for preoperative prosthesis and osteotomy planning.
95 % after one year, 89 % after two years and 78 % after five years. Aseptic
loosening occurred in four patients after a median of 38.5 (10–80) months.
Type IV complications or deep infections were the most prevalent surgical
complications, with 9 out of 20 patients suffering from infections which
needed surgical revision after a median of 86 days (13 days – 5 years) after
primary prosthesis implantation. Although most of these infections could
be treated with debridement and antibiotic therapy, three patients required
implant removal due to otherwise uncontrollable infections after a median of
15 months (95 days – 16 years) after surgery. There were no revisions due to
type III complications or periprosthetic fractures, as well as type V complications
or tumor progression in this study.
Four patients suffered from sciatic nerve lesions, of whom 2 patients received
singular surgical neurolysis with a median of 26 (24–28) months after
surgery. Thromboembolic events were frequently observed after surgery,
with 5 out of 20 patients suffering from thromboses. Three of these patients
required immediate revision surgery at the day of prosthesis implantation,
while two patients were successfully treated conservatively.
15 patients with a minimum follow up of one year could be functionally
assessed, while a complete Harris Hip Score (HHS) could be retrieved in
eleven patients, showing good results with a median score of 81 (37–92)
points at time of last follow up visit at the outpatient clinic. Six patients were
able to walk without walking aid and six patients needed one walking stick,
while three patients were mobilized with two crutches. No information regarding
walking limitations could be assessed in five patients.

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Figure 2: Left: Twenty-four-year-old patient with pelvic osteosarcoma. Middle: Same patient after receiving a modern 3D-printed custom-made prosthesis
(Materialise, Gilching, GER), with a cemented Durasul inlay (Zimmer Biomet, Warsaw, IN, USA) articulating with an Actis femoral stem (DePuy
Synthes, Raynham, MA, USA). Right: Two years after the surgery, the patient is pain free and has a moderately limb walk with no walking aid required.
Discussion
Although the use of custom-made prostheses led to primary stable reconstructions,
complications were common at medium- to long-term follow ups.
Especially in reflection of a high postoperative prosthesis morbidity with
potentially devastating complications, patients need to be carefully selected,
thoroughly educated, and integrated into the decision-making process.
At our institution, these high complication numbers led to a diminished use
of custom-made endoprostheses at the expense of saddle endoprostheses
or ice-cone shaped endoprostheses in the last decade.
However, not all types of periacetabular tumors may be addressed with
saddle- or ice-cone shaped endoprostheses, as enough iliac bone is required
for implant fixation. We believe that emerging 3D-printed custom-made
prostheses show great promise in reconstruction of extensive periacetabular
tumors, due to a potential reduction of duration of surgery and thus
postoperative complications, a higher prosthesis survival and stability, and
better availability due to a fast 3D-printing process (Figure 2).
Dr. Kevin Döring
Author:
Kevin Döring has been a
resident at the Department
of Orthopedics and Trauma
Surgery at the Medical University
of Vienna since 2018.
His research focuses on the
promotion of patient-centered
implant solutions in foot surgery,
tumor orthopaedics and
arthroplasty.
In frontiers of limb salvage surgery, functional outcomes are of particular importance
to justify invasive and complication-ridden procedures. This study
showed good functional results, with a median HHS of 81 (37–92) points at
time of last follow up. More than half of all patients showed a high weight
bearing capability, as six patients walked without walking aid and six other
patients only needed one walking stick.
Conclusion
Internal hemipelvectomy and reconstruction using custom-made implants
comes with a high risk for postoperative complications. However, good
functional outcomes can be regularly achieved. This information may help
treating surgeons to find adequate indications, as eligible patients need
to be critically selected. Future studies evaluating new generations of
3D-printed custom-made pelvic implants are needed to determine their
clinical value.

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30
Size Matters as Critical
Parameter for the Reliability
of Spheroids in Drug Screening
Applications
Study:
Eilenberger C, Rothbauer M,
Selinger F, Gerhartl A, Neuhaus
W, Jordan C, Harasek M,
Schädl B, Grillari J, Küpcü S,
Weghuber J, Ertl P, A microfluidic
multi-size spheroid array
for multi-parametric screening
of anti-cancer drugs and
blood-brain barrier transport
properties, Advanced Science,
2021, 2004856, 4. (16,806)
In 2021, a cooperative project of researchers of the ‚Karl Chiari
Lab for Orthopaedic Biology‘ in collaboration with partners at
the Vienna University of Technology, the University of Natural
Resources and Life Sciences Vienna (BOKU), the Austrian Institute
of Technology GmbH, the Ludwig-Boltzmann-Institute for
Experimen tal and Clinical Traumatology, and the University of Applied
Sciences Upper Austria developed a microfluidic multi-size
spheroid array platform to standardize and validate spheroid
tissue models for drug screening. The study resulted in the article
entitled ‘A Microfluidic Multisize Spheroid Array for Multiparametric
Screening of Anticancer Drugs and Blood–Brain Barrier
Transport Properties’ in Wiley Advanced Science (IF 16.8). The
work is a result of years of interdisciplinary research at the interface
of basic biological research, engineering, and bioengineering.

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„This study overall proves that size is
a vital parameter that needs to be
considered in the future to allow
validation and standardization of
organotypic spheroid-based models for
pharmaceutical research, because
it severely affects study outcome.“
Mario Rothbauer
The disadvantages associated with the development of novel drugs include
the high costs for development, regulatory approval, and market introduction.
Even though remaining the golden standard for clinical trials to this day, animal
testing does not reflect what happens in the human body. Consequently, most
drug candidates fail during development, with approx. 1 out of 20 successful
drug candidates entering the market. Over the last two decades, in vitro assays
based on artificial human tissues as three-dimensional cultures have gained
momentum in pharmaceutical development, toxicology, and biomedicine.
These complex three-dimensional tissue-like structures are not only
intended to circumvent expensive animal experiments, but also to replace
the currently existing and inadequate in vitro models, because both approaches
that fail to resemble human tissue architecture and function. Thus,
various culture techniques have been established over the years (e.g., pellet
cultures, micro masses, Trans-wells, etc.) that aim to resemble function of
human tissues on architectural down to molecular levels. The undisputed
most promising technology for drug screening, allowing for the high scalability
requirements of pharmaceutical industry, are multi-cellular organotypic
spheroids, which create complex tissue structures based on the proficiency
of primary cells to form tissue-like structures when being joined together as
heterogenous aggregates.
Even though the research community has promised that such next-generation
models are of physiological relevance and ideal for improving the efficiency
of drug screening during clinical studies, so far artificial human tissue
technologies still severely lack the proper validation necessary for integration
into development and production pipelines and certification procedures.
Furthermore, not a single well-plate derived solution can maintain cells under
the dynamic and perfused conditions needed to create a tissue-like microenvironment.
Aside from variations in donor tissue and consequently cell
function, the most significant drawback to use organ-like spheroids is simple:
Every laboratory – be it academic or industrial – has its own protocol and
recipe how to fabricate organotypic spheroids including variations in initial
cell density, cell mixture ratios, spheroid size, culture duration as well as the
utilization of medium composition and supplements. These simple facts lead
to the nearly impossible task of comparing different study outcomes.
Since 2019, tissue modelling with microfluidic biochips has been a new additional
research focus of bioengineer Dr. Mario Rothbauer at the ‚Karl Chiari
Lab for Orthopaedic Biology‘ (KCLOB) of the Department of Orthopaedics and
Trauma Surgery. His microsystems team wants to use organotypic tissue-like
microsystems as three-dimensional disease models for basic science and
drug screening applications.
As vice president of the European Society for Alternatives to Animal Experiments
(EUSAAT), Dr. Rothbauer aims at a patient-derived approach, focusing
on animal-free methods and approaches as complimentary tools to animal
experiments.
Aim and Methods
Due to the current shortcomings of spheroid model validation and comparability,
in the current study the team developed a scalable microfluidic biochip
tool that can create multiple differently sized spheroids within a micro-

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32
fluidic biochip-plate using a single step injection. The tool is compatible with
multi-pipetting and pipetting robots and allows to reproducibly produce 360
spheroids of five sizes on a single well plate by minimal user interaction of
six cell suspension injections per plate. To demonstrate the broad applicability
and effectiveness of our multi-spheroid array, we investigated the most
common microwell shapes against our new hemispherical microwells that
are replicated from optical micro lens-like shapes, hoping to prove that size
control as well as placement accuracy of our approach outperforms standard
elliptical as well as spherical and cylindrical approaches.
To create a scalable model that facilitates perfused culture of multiple sizes
of organoids under controllable flow profiles, liquids in our multi-tissue
spheroid arrays are driven by hydrostatic pressure on a simple tilting plate
that can hold multi-spheroid arrays. As initial screening demonstration we
identified the best initial seeding densities for a pool of human cancer and
primary cells frequently used in drug screening (e.g., liver cancer, intestinal
cancer, lung cancer, dermal fibroblasts, and brain endothelial cells). As more
practical demonstration, the team decided to investigate the anti-cancer effect
of combinatorial drug screening on lung cancer spheroids, as well as the
pharmaceutical function and barrier properties of a complex triple-co-culture
model of the human blood brain barrier.
Results and Conclusion
The first demonstration on combinatorial drug treatment demonstrated
that the most effective concentration against A549 lung cancer spheroids
is 50 µM Doxorubicin with 5µM CIS-Platin independently of cancer spheroid
size. In the latter demonstration, for the first time we investigated transport
properties of a human blood-brain barrier (BBB) triple-coculture spheroids
of brain endothelial with astrocytes and pericytes in a microfluidic environment,
optimized seeding densities as well as cell ratios to identify the
healthiest barriers, and tested the effect of mannitol as well as verapamil on
paracellular transport of molecules through the BBB. This study overall proves
that size is a vital parameter that needs to be considered in the future to
allow validation and standardization of organotypic spheroid-based models
for pharmaceutical research, because it severely affects study outcome.
Dr. Mario Rothbauer, MSc
Author:
Mario Rothbauer is currently
working on the bioengineering
of human disease models
using organ- and lab-on-a-chip
technologies as University
Assistant and group leader at
the „Karl Chiari Lab for Orthopaedic
Biology“. In 2015, he
received his doctorate in biotechnology
from the University
of Natural Resources and Life
Sciences Vienna (BOKU).
This technology, which was awarded with the 2022 state award for alternative
methods to animal tests of the Austrian Ministry of Science (BMBWF)
to collaborator Prof. Ertl, will be used in the future to demonstrate that the
size of the tissue models also affects the performance and reproducibility of
musculoskeletal tissue models in the orthopaedic drug screening sector.
References:
[1] A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status
Report on Progress in Toxicology and Pharmacology“ Micromachines 2021, 12 (5), 470, M Rothbauer,
BEM Bachmann, C Eilenberger, SRA Kratz, S Spitz, G Höll, and P Ertl.
[2] Recent Advances in Additive Manufacturing and 3D Bioprinting for Organs-On-A-Chip and Microphysiological
Systems. Frontiers in Bioengineering and Biotechnology 2022, 10. M Rothbauer, C
Eilenberger, S Spitz, BEM Bachmann, SRA Kratz, EI Reihs, R Windhager, S Toegel and P Ertl.
[3] A microfluidic multi-size spheroid array for multi-parametric screening of anti-cancer drugs
and blood-brain barrier transport properties, Advanced Science, 2021, 2004856, 4. C Eilenberger,
M Rothbauer, F Selinger, A Gerhartl, W Neuhaus, C Jordan, M Harasek, B Schädl, J Grillari, S
Küpcü, J Weghuber and P Ertl.
[4] https://www.bmbwf.gv.at/Ministerium/Presse/20220413.html

Der Weg der Shark Screw®
Vom Spenderknochen zu
Patientenknochen
Die Spenderauswahl
Bevor der für die Produktion der Shark Screw® verwendete kortikale
Spenderknochen für den weiteren Herstellungsprozess in Österreich
und Deutschland freigegeben wird, werden zahlreiche Tests
durchgeführt, Proben entnommen und der serologische Status
erhoben. Dadurch kann maximale Sicherheit für Arzt und Patient
gewährleistet werden. Die Wahrscheinlichkeit einer
Krankheitsübertragung mit einem solchen Allograft liegt dabei bei
1
1:10.000.000.000.000.000.
Der Herstellungsprozess
Die Formgebung von Shark Screw® erfolgt in Linz, Oberösterreich.
Damit aus kortikalem Knochen schlussendlich eine einwandfreie
Shark Screw® wird, durchläuft jede Schraube eine aufwendige
Qualitätskontrolle, bevor diese einen seit Jahrzehnten erprobten
Sterilisationsprozess durchlaufen. Schrauben, welche die
Qualitätskontrolle nicht bestanden haben, werden für die klinische
Anwendung ausgeschlossen. Diese Schrauben stehen jedoch den
ChirurgInnen bei Shark Screw® Wet-Labs zur Verfügung.
Mission 2030
surgebright ist die österreichische
Gewebebank für Spitäler und Ihre
Ansprechperson für Knochen- und
Gewebeersatz sowie biointelligente
Osteosynthesen. Gemeinsam mit Shark
Screw® Chirurgen möchten wir durch den
Einsatz von Shark Screw® bis 2030,
500.000 Patienten das Risiko einer zweiten
Operation zur Metallentfernung ersparen.
In Shark Screw® Workshops sollen 5.000
ChirurgInnen die Verwendung von Shark
Screw trainieren können. Werden Sie jetzt
Teil der Shark Screw® Peer Group auf:
www.surgebright.com
Der erste klinische Einsatz der
Shark Screw®
Nach dem erfolgreich absolvierten Shark Screw® Workshop
können die ersten Operationen mit der allogenen
Knochenschraube durchgeführt werden und die Shark
Screw® in die klinische Routine implementiert werden.
OP-Videos und Betreuung vor Ort werden hierbei als
Unterstützung angeboten.
Remodeling & Integration in
Knochenstoffwechsel
Nach und nach wird Shark Screw® von
Stammzellen, Osteoblasten, Osteoklasten,
und Osteozyten besiedelt und in
Patientenknochen remodelt. Dabei löst
sich Shark Screw® nicht auf, sondern wird
narbenlos ein und umgebaut. Bereits
nach wenigen Monaten ist die humane
Knochenschraube gänzlich remodelt.²
1 J. Brune, Update: Allogene Gewebetransplantation in Deutschland, AFRO Expertengremium Pontresina 2019 | Association for Orthopaedic Research
2 I. Brcic, K. Pastl, H. Plank, J. Igrec, J. E. Schanda, E. Pastl, M. Werner. Incorporation of an Allogenic Cortical Bone Graft Following Arthrodesis of the First
Metatarsophalangeal Joint in a Patient with Hallux Rigidus Life (2021)
Mehr Infos unter:
www.surgebright.com

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Figure 1: Transversal T1-TSE MRI with arrows showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3
Pseudotumors in Metal-on-Metal
Total Hip Arthroplasty
Study:
Kolbitsch P, Noebauer-
Huhmann IM, Giurea A,
Kubista B, Windhager R,
Lass R. Pseudotumors in
Small-Head Metal-on-Metal
Total Hip Arthroplasties at
a Minimum Follow-Up of 20
Years. J Arthroplasty. 2021
Aug;36(8):2871-2877. doi:
10.1016/j.arth.2021.03.022.
Epub 2021 Mar 10. (4,757)
Total hip arthroplasty (THA) is one of the most successful
surgeries nowadays and the method of choice for end stage
osteo arthritis (OA) of the hip joint with good clinical results and
long survivorship of implants. Metal-on-metal (MOM) surfaces
have been used for a long time and are still used nowadays in
some young and active patients, because of their hardness and
their reduced risk of wear. These bearings have shown high
survival rates and very satisfying clinical results, but there is the
risk of metal ion release and systemic accumulation. Consequently,
carcinogenicity, neurological, cardiovascular, and endocrine
deficits can result. Adverse reactions to metal debris (ARMD) and
pseudotumors are possible complications in MOM THAs. Literature
shows rates of up to 69 % of pseudotumors in symptomatic
patients, and up to 61 % in asymptomatic patients.

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35
Figure 2: Transversal T1-TIRM MRI with arrow showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3
Serum Cobalt and Chromium levels are recommended as monitoring tool for
the detection of elevated metal ion levels. For evaluating pseudotumors in
symptomatic or asymptomatic patients, either magnetic resonance imaging
or ultrasound is preferred. The data of this cohort have already been published
at the follow-up period of 10, 17 and 18 years.
„The most important finding of our
study is the presence of pseudotumors
also in asymptomatic patients, along
with the conclusion that serum metal
ion levels alone were not enough for
following-up metal-on-metal THAs […].“
Paul Kolbitsch
These prior publications resulted in our recent publication with the title
„Pseudotumors in Small-Head Metal-on-Metal Total Hip Arthroplasties at a
Minimum Follow-Up of 20 Years.“ in the Journal of Arthroplasty (IF 4.757).
The purpose of this study was to detect pseudotumors in patients with
28mm-head MOM-THA using MRI at a minimum follow-up of 20 years. In
addition, we analysed the correlation between serum metal levels, clinical
outcome scores, activity scores and pseudotumors. For conducting our study
we were supported by the „Medizinisch-Wissenschaftliche Fonds des Bürgermeisters
der Bundeshauptstadt Wien“ in 2017.
Methods
We were able to recruit 26 patients with 29 THAs for the follow-up investigation
at a minimum of 20 years after initial surgery with a mean age of 72.2
years (range, 51–87 years) and a mean body-mass-index (BMI) of 28.5 (range,
15.9–38.3). In all cases cementless tapered stems (Alloclassic ® Zweymüller ® ,
Zimmer GmbH, Winterthur, Switzerland) with 28mm high-carbide-concentration
metal-on-metal surfaces (Metasul ® , Zimmer GmbH) and a titanium made
conical screw cup (CSF ® , Zimmer GmbH) were used. For the clinical investigation
several scores were evaluated, including Harris Hip Score, University of
California Los Angeles (UCLA) activity score, Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS).

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For radiologic follow-up standard X-rays as well as metal artifact reduction
sequence (MARS) magnetic resonance imaging (MRI) were used (Figure 1).
The detected pseudotumors were classified using a grading system described
by Hauptfleisch et al. in 2012. It describes four different subtypes of
pseudotumors regarding its walls, shape, and fluid or solid behaviour.
The systemic blood metal ion levels of Cobalt and Chromium were evaluated
using atomic absorption spectrometer.
Of the initially included 98 patients and 105 hips included between November
1992 and May 1994, 43 patients have died, 14 patients remained lost
to follow-up, 6 patients could only be contacted via phone and 9 patients
underwent revision surgery.
Blood metal ion levels showed a mean serum cobalt level of 1.87μg/L (± 3.44)
and mean chromium level of 2.23μg/L (± 2.96). For further analysis patients
were divided in in a „single-metal“, and „multi-metal“ group, showing significantly
higher levels in the second group (p = 0.018 for cobalt levels and
p = 0.020 for chromium levels).
The clinical scores showed good results in both groups. Mean HHS was 88.6
(range, 62.0–100), UCLA 6.4 (range 3–10 points), VAS 0.76 (range, 0–5) and WO-
MAC was at 1.66 (range 0–5.75 points). No significant differences were found
between patients with pseudotumors in MRI and those with no alterations.
MRI showed pseudotumors in 21 of 29 investigated hips (72 %). Comparing
the serum metal ion levels showed mean cobalt and chromium of 2.2μg/L
(± 3.98) and 2.39μg/L (± 3.41) in the pseudotumor group and 0.88μg/L (± 0.64)
and 1.80μg/L (± 1.23) in the other group. Though levels were clearly higher
in pseudotumor group, no statistically significant difference was found
(p = 0.139 for cobalt and p = 0.504 for chromium). We found a cumulative rate
of survival counting revision with aseptic loosening as the end point of 91.4 %
at 22.8 years (95 % confidence interval).
Dr. Paul Kolbitsch
Author:
Paul Kolbitsch is currently a
resident at the Department
of Orthopaedics and Trauma
Surgery at the Medical University
of Vienna. Since his time
as student, he has actively
participated in several studies
of the adult reconstruction
team of the Division of Orthopaedics.
He has finished his
medical school in 2017.
Results
The most important finding of our study is the presence of pseudotumors
also in asymptomatic patients, along with the conclusion that serum metal
ion levels alone were not enough for following-up metal-on-metal THAs,
as most of our patients with pseudotumor were below the recommended
threshold of 7μg/L. In addition, we could show that 28mm metal-on-metal
bearings have a high incidence of pseudotumors in long term follow-up. The
consequences that should be taken in cases of asymptomatic pseudotumor
patients have not yet been clearly stated and will need further investigations.
References:
[1] Kolb A, Schneckener CD, Chiari C, et al. Cementless total hip arthroplasty with the rectangular
titanium Zweymüller stem: a concise follow-up, at a minimum of twenty years, of previous
reports. J Bone Joint Surg Am. 2012;94(18):1681-1684. doi:10.2106/JBJS.K.01574
[2] Kolbitsch P, Noebauer-Huhmann IM, Giurea A, Kubista B, Windhager R, Lass R. Pseudotumors
in Small-Head Metal-on-Metal Total Hip Arthroplasties at a Minimum Follow-Up of 20 Years. J
Arthroplasty. 2021;36(8):2871-2877. doi:10.1016/J.ARTH.2021.03.022
[3] Hauptfleisch J, Pandit H, Grammatopoulos G, Gill HS, Murray DW, Ostlere S. A MRI classification
of periprosthetic soft tissue masses (pseudotumours) associated with metal-on-metal resurfacing
hip arthroplasty. Skeletal Radiol. 2012;41(2):149-155. doi:10.1007/S00256-011-1329-6

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Safe Bone Block Harvesting for
Quadriceps Tendon Autografts
37
Quadriceps tendon (QT) autografts with and without a bone
block have gained popularity in recent years for both primary
and revision anterior cruciate ligament reconstruction due to
the shortcomings of other graft choices. A bone block facilitates
length and can also be used for tibial bone defects in revision
surgery if necessary. However, the main advantage of an
autograft with a bone block lies in quicker bone-to-bone healing.
Unfortunately, it is associated with a potential risk for intra- and
postoperative patellar fractures.
Study:
Negrin LL, Zeitler C, Hofbauer
M. Patellar Size Variation at
the Quadriceps Tendon-Bone
Block Harvest Site: A Magnetic
Resonance Imaging Study
to Evaluate the Safe Zone for
Harvesting a Sufficient Bone
Block. Am J Sports Med. 2021
Dec;49(14):3850-3858. doi:
10.1177/03635465211049226.
Epub 2021 Oct 21. (6,202)
Aim and Methods
The objective of this study was to assess the maximum individual-related
patellar bone block depth and length and to identify the location and the
dimensions of the bone block (in mm), which can be safely excised in most
individuals with high success probability, by performing measurements on
patellar geometry. Since guidelines for patellar bone block harvesting have
been based solely on personal experience, we intended to derive recommendations
from physical regularities and objective criteria. Our study population
of 50 males and 50 females, all Caucasians and aged ≥ 18 years, underwent
3.0-T magnetic resonance imaging of their knees at our institution.
Figure 1A presents the patella in coronal view. The length of the centerline
corresponds to the superoinferior height of the patella, the medial (lateral)
Figure 1: Patella in coronal (A) and axial (B) views. C: Harvest site of BBmedial (open box in white) and subjacent bone bridge (closed box in dotted lines).
D: Safe harvesting of a QT bone block (open box in white). The central area of the patella is shaded. The medial endpoint represents the suggested starting
point for initial saw placement.

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38
Figure 2: Frequency distributions of
patients providing/not providing
bone blocks with a depth
of 8mm and a length of 15mm.
„The objective of this study was to assess
the maximum individual-related patellar
bone block depth and length and to
identify the location and the dimensions
of the bone block (in mm), which can be
safely excised in most individuals with
high success probability, by performing
measurements on patellar geometry.“
Lukas Negrin
patellar height is defined by the length of the medial (lateral) line. The medial
and lateral lines border the central area (shaded). The medial, central, and
lateral thickness of the patella was measured at the height of each of the
three midpoints in the axial view (Figure 1B).
Our patients (mean age, 29.4 ± 7.9 years; mean height 174.4 ± 10.3cm) provided
a mean QT width and thickness of 49.0 ± 7.6mm and 7.3 ± 1.0mm, respectively.
The mean patellar thickness in reference to the medial endpoint, the center,
and the lateral endpoint was 18.3 ± 2.4mm, 17.9 ± 2.3mm, and 15.1 ± 2.3mm,
respectively, whereas the mean patellar height was 35.1 ± 4.1mm,
36.7 ± 4.2mm, and 35.1 ± 3.9mm. As expected, the tendon and patellar
dimensions were significantly larger in males than in females (p ≤ 0.016).
We focused on physical modeling to provide limits for the bone block dimensions.
In general, the 3-point bending force in knee flexion or a direct blow to
the knee is believed to cause patellar fractures.

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After bone block harvesting, these forces act directly on the bone bridge,
which is defined as the remaining bone posterior to the harvest site, and
may lead to its fracture. The maximum bending stress turned out to be
inversely proportional to the squared depth of the bone bridge, indicating
that the risk for a patellar fracture increases with increasing bone block
depth. On one hand, the bone block should be deep enough to enable standard
interference screw fixation techniques, on the other hand, the bone
bridge depth should be sufficient to minimize fracture risk. To satisfy both
prerequisites, we restricted the bone block depth to 50 % of the patellar
thickness at the harvest site. Because the patella is asymmetrically thickest
in its proximal half, we limited the bone block length to 50 % of the patellar
height measured at its harvest site.
Ap. Prof. Priv.-Doz. Dr. Lukas Negrin, PhD, MMSc
Author:
Lukas Negrin has devoted
most of his research work to
severely injured and multipletraumatized
patients from
the beginning of his scientific
career. Currently, he leads
the interdisciplinary working
group „Biomarkers in polytrauma“,
and the research cluster
„Polytrauma and traumatic
brain injury“. Moreover, he is
the head of the working group
„Polytrauma“ and the task
force „Special trauma surgery“
of the Austrian Society for
Trauma Surgery (ÖGU). Additionally,
he has already drawn
his interest to knee injuries
early during his career. During
his work as team doctor of the
Austrian alpine skiing world
cup team and the Austrian
Olympic Committee, he
rediscovered his passion for
research in sports injuries.
After setting the maximal dimensions of the bone block, its exact location
had to be analyzed. Inherently, it has to be attached to the graft, which is
commonly excised from the middle third of the QT, as it primarily consists of
fibers from the rectus femoris and vastus intermedius, resulting in a natural
plane. Following these fibers roughly indicates the bone block harvest
site on the superior pole of the patella. To highlight the effect of the patellar
geometry on osseous graft volume, we created three virtual bone blocks –
BBlateral , BBcentral, and BBmedial – following our specifications within the
central area in all patient knees, each with a given width of 10mm. BBmedial
represented the outermost region of safe graft harvesting medially. Its length
was 50 % of the medial patellar height, and its depth was 50 % of the patellar
thickness at the medial midpoint (Figure 1C). BBlateral was characterized
analogously. BBcentral was symmetrical to the centerline with a length of
50 % of the patellar length and a depth of 50 % of the patellar thickness at
the central midpoint.
Results and Conclusion
Pair-by-pair comparisons of the three bone block depths revealed significant
differences in all cases (BBmedial, 9.2 ± 1.1mm, BBcentral, 8.9 ± 1.1mm;
BBlateral, 7.6 ± 1.1mm; p < 0001). Whereas the mean length of BBcentral
was significantly larger than the lengths of both BBmedial and BBlateral
(18.4 ± 2.1mm versus 17.6 ± 2.0mm and 17.6 ± 1.9; p < 0.0001), there was no
significant difference between the mean lengths of BBmedial and BBlateral
(p = 0.887).
As the patella is more shallow at the lateral side than at the center or the
medial side, harvesting BBlateral should be avoided. Unfortunately, both
maximal graft length and depth can neither be provided by BBcentral nor
by BBmedial. Since the squared depth of the bone bridge is included in the
formula of the maximum bending stress, the bone block depth has to be
considered the determining factor of patellar fracture risk. Consequently, we
gave particular emphasis to the patellar thickness.
Bone block harvesting, with its depth not exceeding 50 % of the patellar
thickness and its length accounting for < 50 % of the patellar height, poses
the least risk for a patellar fracture when the bone block is excised from
the medial half of the central area, with the outer edge of the saw positioned
at the medial border of the central area (Figure 1 D). In almost all of our
patients, a bone block of 15mm length, 10mm width, and 8mm depth could
be safely harvested (Figure 2). Only in five females the depth and length of
BBmedial did not reach 8mm and 15mm, respectively.

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Semi-Quantitative and
Quantitative MRI for the
Assessment of Cartilage Repair
and Intervertebral Discs
Studies:
Schreiner MM, Raudner M,
Marlovits S et al (2021) The
MOCART (Magnetic Resonance
Observation of Cartilage
Repair Tissue) 2.0 Knee Score
and Atlas.
Schreiner MM, Raudner M, Rohrich
S et al (2021) Reliability of
the MOCART (Magnetic Resonance
Observation of Cartilage
Repair Tissue) 2.0 knee score
for different cartilage repair
techniques-a retrospective observational
study. Eur Radiol.
Schreiner MM, Raudner M,
Szomolanyi P et al (2020)
Chondral and Osteochondral
Femoral Cartilage Lesions,
Treated with GelrinC: Significant
Improvement of Radiological
Outcome Over Time and
Zonal Variation of the Repair
Tissue Based on T2 Mapping
at 24 Months.
Raudner M, Toth DF, Schreiner
MM et al (2021) Synthetic
T2-weighted images of the
lumbar spine derived from
an accelerated T2 mapping
sequence: Comparison to
conventional T2w turbo spin
echo. Magn Reson Imaging
84:92-100
Morphological MRI has become the method of choice for
the assessment of cartilage lesions and repair as well as intervertebral
discs. However, radiographic reports from morphological
MRI are inherently subjective and not standardised.
The ability to measure and accurately define the extent of
pathology and outcome after surgical treatment is a prerequisite
for high-quality studies that use a radiological endpoint.
One solution could be the introduction of semi-quantitative
scoring systems. Another possibility is the use of quantitative
MRI techniques that promise correlation with the composition
and ultrastructure of the tissues studied. With respect to articular
cartilage and intervertebral discs, T2 mapping is the most widely
used and extensively studied technique. However, multi-echo
spin-echo T2 mapping is time-consuming and therefore rarely
feasible in the clinical setting.
It is challenges like these on which the biomedical MR-imaging Cluster of
orthopaedic disorders focuses. This fruitful collaboration between the High
field MR Centre (Prof. Siegfried Trattnig) and the Department of Orthopaedics
and Trauma Surgery involves physicists, radiologists as well as orthopaedic
surgeons with a special interest in MRI of the musculoskeletal system.
The increasing number of different surgical repair techniques of articular
cartilage lesions required a non-invasive and reproducible tool to evaluate
the outcome. In this endeavour, the MOCART (Magnetic Resonance Observation
of Cartilage Repair Tissue) score was developed in collaboration between
radiologists and orthopaedic surgeons and was widely accepted.
However, with advances in surgical techniques, MRI hardware, and software,
the original MOCART score was overdue for an update. Therefore, the
MOCART 2.0 Knee Score and Atlas was introduced. In addition to revising the
scoring system, a comprehensive atlas was introduced to increase reproducibility
by providing an example for each possible score on the MOCART 2.0
Knee Score. The new MOCART 2.0 knee score was then used by two experi-

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Figure 1:
T2w turbo spin echo image witch CPMG overlay
(left), on the right synthetic T2w image with
GRAPPATINI overlay (right) – with courtesy of
Marcus Raudner MD, PhD.
„These developments of novel
semi-quantitative and quantitative
imaging techniques greatly increase
the possibilities for reproducible
non-invasive diagnosis, characterisation,
and monitoring of both
disease and surgical repair.“
Markus Schreiner
enced radiologists and two junior radiologists with little or no experience in
musculoskeletal radiology to evaluate the MRI examination of 24 patients
after MACI. To assess whether access to the atlas would improve reproducibility,
the inexperienced readers performed a second examination after
a four-week interval and were allowed to use the atlas. The expert readers
demonstrated almost perfect overall intrarater (ICC = 0.88, p < 0.001) as well
as the interrater (ICC = 0.84, p < 0.001) reliability. The overall interrater reliability
of the inexperienced readers increased from poor (ICC = 0.34, p < 0.019)
to moderate (ICC = 0.59, p = 0.001), with additional access to the atlas during
assessment.
A limitation of the study, in which the MOCART 2.0 knee score was introduced,
was that only patients after MACI were included, leaving its application
to other cartilage repair techniques or lesion types, i.e., chondral vs.
osteochondral lesion, unclear. Therefore, another study was performed,
showing similar reproducibility of the MOCART 2.0 knee score in patients
after MACI, MFX as well as osteochondral repair techniques. Interestingly,
we observed higher reproducibility in patients with osteochondral lesions

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compared to chondral lesions.However, semi-quantitative and quantitative
imaging techniques can also be used complementing each other as in the
following study: „Chondral and Osteochondral Femoral Cartilage Lesions
Treated with GelrinC: Significant Improvement of Radiological Outcome
Over Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at
24 Months“. In this prospective multicenter study, the MOCART score and
multi-echo spin-echo (MESE) T2 mapping were used to assess the outcome
of cartilage repair of femoral cartilage lesions using GelrinC at different time
points with a maximum follow-up of 24 months. In this study, the MOCART
score increased significantly during the follow-up period. In addition, based
on T2 mapping, significant zonal variation was observed between the deep
and superficial zones of cartilage repair, which is considered a hallmark of
hyaline cartilage.
Dr. Markus Schreiner
Author:
Since 2016, Markus Schreiner
has been a resident at the
Department of Orthopaedics
and Trauma Surgery at the
Medical University of Vienna
and a member of the biomedical
MR-imaging Cluster of orthopaedic
disorders. Together
with Sebastian Apprich M.D.,
he coordinates the scientific
collaborations between the
Orthopaedic department and
the High Field MR Centre (Prof.
Siegfried Trattnig) at the Medical
University of Vienna.
Within the biomedical
MR-imaging cluster, his research
focuses on the development
and implementation of
MR-imaging techniques used
for qualitative and quantitative
assessment of cartilage,
tendons, and intervertebral discs,
as well as clinical projects
on cartilage repair surgery.
More possibilities for reproducible non-invasive diagnosis
However, as mentioned above, T2 mapping with a classical multi-echo spinecho
technique is time-consuming and therefore not commonly used in
daily clinical routine. To overcome this limitation, GRAPPATINI was recently
developed. GRAPPATINI is a novel MR sequence that combines „model-based
accelerated relaxometry by iterative nonlinear inversion“ (MARTINI) and
„generalized autocalibrated partial parallel acquisition“ (GRAPPA). It allows
accelerated T2 mapping and additionally provides synthetic morphological
images, which in theory significantly reduce scan time, as one acquisition
should provide both the T2 map and the morphological images. While the
quality of the T2 maps of the intervertebral discs generated with GRAPPATINI
has already been evaluated and compared with MESE T2 mapping, the quality
of the synthetic T2-weighted images has not been evaluated and compared
with conventional T2w turbo spin echo (TSE) images. Therefore, we studied
58 patients with both sequences. All images were assessed by two blinded
readers who determined disc degeneration and the presence of herniation or
annular tear. Interrater and intrarater agreement correlated significantly in
both sequences, and the agreement was substantial to near perfect.
Overall, these developments of novel semi-quantitative and quantitative
imaging techniques greatly increase the possibilities for reproducible
non-invasive diagnosis, characterisation, and monitoring of both disease
and surgical repair. This, in turn, could accelerate the understanding of
underlying pathological processes and drive the development of new
therapeutics.
References:
[1] Schreiner MM, Raudner M, Marlovits S et al (2021) The MOCART (Magnetic Resonance Observation
of Cartilage Repair Tissue) 2.0 Knee Score and Atlas. Cartilage 13:571S-587S
[2] Schreiner MM, Raudner M, Rohrich S et al (2021) Reliability of the MOCART (Magnetic Resonance
Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair
techniques-a retrospective observational study. Eur Radiol. 10.1007/s00330-021-07688-1
[3] Schreiner MM, Raudner M, Szomolanyi P et al (2020) Chondral and Osteochondral Femoral
Cartilage Lesions Treated with GelrinC: Significant Improvement of Radiological Outcome Over
Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at 24 Months. Cartilage. 10.
1177/1947603520926702:1947603520926702
[4] Raudner M, Toth DF, Schreiner MM et al (2021) Synthetic T2-weighted images of the lumbar spine
derived from an accelerated T2 mapping sequence: Comparison to conventional T2w turbo
spin echo. Magn Reson Imaging 84:92-100

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43
Bone Mineral Density
of the Thoracic Spine
„From a purely BMD standpoint,
choosing UIVs in the upper thoracic
spine for long fusion constructs might
enhance instrumentation performance,
especially in patients with osteoporosis.“
Stephan Salzmann
The thoracic spine is commonly affected by osteoporotic vertebral
fractures, which occur in a bimodal distribution. The peak
frequencies are at the thoracolumbar junction and the midthoracic
spine. Besides osteoporotic vertebral fractures, the thoracic
spine is a typical location for instrumentation failure after long
spinal fusion procedures. Patients undergoing surgery for adult
spinal deformity with low local bone mineral density (BMD) at
the upper instrumented vertebra (UIV) have a higher risk for
complications including proximal junctional kyphosis.
Regional BMD variation has already been described for the cervical, lumbar,
and sacral regions of the spine and the association between BMD and postoperative
complications is well established. Despite the clinical importance of
osteoporotic vertebral fractures, as well as instrumentation failure after long
spinal fusions, no prior studies have comprehensively assessed level-specific
BMD of the entire thoracic spine in patient undergoing spine surgery.
The current gold standard to assess BMD in the spine is thought to be dual
energy x-ray absorptiometry (DXA). However, due to the projectional nature
of DXA measurements, the overlying sternum and ribs interfere with thoracic
DXA measurements in the clinical setting. Quantitative computed tomography
(QCT) is one of the alternatives to assess spinal BMD, circumventing
several limitations of DXA measurements allowing for level-specific BMD
measurements of the entire thoracic spine.
Study:
Salzmann SN, Okano I, Jones
C, Basile E, Iuso A, Zhu J,
Reisener MJ, Chiapparelli E,
Shue J, Carrino JA, Girardi FP,
Cammisa FP, Sama AA, Hughes
AP. Thoracic bone mineral
density measured by quantitative
computed tomography
in patients undergoing
spine surgery. Spine J. 2021
Nov;21(11):1866-1872. (4,166)
Aim
This study was created not only to assess the reliability of newly described
thoracic QCT measurement protocol, but also to quantify the level-specific
BMD of the thoracic spine in patients undergoing spinal surgery and to examine
the correlation between the BMDs of the thoracic levels T1–T12.
Material and Methods
The study was approved by the hospital institutional review board. Spine surgery
patients from 2016–2020 at a single, academic institution with available
preoperative thoracic spine CT imaging were included in this study. Exclusion
criteria included previous instrumentation at any thoracic level, concurrent
vertebral fractures, a Cobb angle of more than 20 degrees, or incomplete
thoracic spine CT imaging. Quantitative computed tomography measurements
of the thoracic vertebra T1 to T12 were performed using the previously
described asynchronous QCT. The method for thoracic QCT bone mineral

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Figure 2: T1aT12 mean quantitative computed tomography (QCT) bone mineral density (BMD)
in mg/cm 3 with standard deviation (SD).
Figure 1: Representative thoracic QCT
measurement. Axial (top) and sagittal (bottom)
view of the region of interest (ROI).
density measurements was similar to the clinically established approach to
lumbar spine QCT measurements using a commercially available software
program (QCT Pro, Mindways Software, Inc., Austin, TX, USA). Since the thoracic
vertebra are smaller compared to the lumbar vertebrae, the predefined
height of the volume of interested was adjusted to 7mm (predefined to 9mm
for lumbar QCT measurements). An elliptical region of interest was placed in
the trabecular bone at mid-vertebral height and displaced from the vertebral
cortex (Figure 1). Bone islands or sclerotic regions were avoided. However, if
this was not possible due to the extent of the lesion, the vertebra had to be
excluded from the analysis.
To assess intra- and inter-observer reliability of the experimental thoracic
QCT measurements, a validation study was performed. A subsample of 120
vertebrae in ten randomly selected patients were remeasured by another
independent rater. In addition, the same rater remeasured the selected
subsample six weeks after the first measurements. To assess inter- and
intra-observer reliability the interclass correlation coefficient (ICC) was
calculated. The ICC cut-offs were defined as follows: Values below 0.70
indicated poor, 0.70 – 0.80 acceptable, 0.80 – 0.90 good, and ≥ 0.90 excellent
agreement. A pairwise comparison of BMD was performed using the paired
t-test, and correlations between each spinal level were evaluated using the
Pearson’s correlation coefficient. The statistical significance level was set at
p < 0.05 and all analyses were performed in R software (R for 3.5.3 GUI 1.64).
Results
In all, 60 patients (men, 51.7 %) undergoing spine surgery met the inclusion
criteria. The study population was 90 % Caucasian with a mean age of 62.2
years and a mean BMI of 30.2 kg/m². The inter-observer (ICC of 0.97, 95 %
confidence interval 0.86–0.99) and intra-observer (ICC of 0.97, 95 % confidence
interval 0.88–0.99) reliability of the thoracic QCT measurements was excellent.
The highest trabecular BMD was found in the upper thoracic spine and
decreased in the caudal direction (T1 = 182.3 mg/cm³, T2 = 168.1 mg/cm³,
T3 = 163.5 mg/cm³, T4 = 164.7 mg/cm³, T5 = 161.4 mg/cm³, T6 = 152.5 mg/cm³,
T7 = 143.5 mg/cm³, T8 = 141.3 mg/cm³, T9 = 143.5 mg/cm³, T10 = 145.1 mg/cm³,

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T11 = 145.3 mg/cm³, T12 = 133.6 mg/cm³) (Figure 2). The BMD of all thoracic
levels caudal to T6 was statistically lower than the BMD of all levels cranial
to T6 (p < 0.001). Nonetheless, there were significant correlations in BMDs
among all measured thoracic levels. The Pearson’s correlation coefficient
ranged from 0.74 to 0.97.
Discussion
The results of this study indicate significant regional BMD differences in the
thoracic spine depending on spinal level. The variation in thoracic BMD might
contribute to several clinically observed phenomena:
Firstly, vertebral fractures have a bimodal distribution and occur most
commonly at the thoracolumbar junction (T12-L1), followed by the midthoracic
region (T7-T8) as the second most common site. Besides mechanical
reasons, this could be partially attributed to the thoracic BMD, which has
been shown to be lowest at the T12 level (133.6 mg/cm³), followed by the T8
level (141.3 mg/cm³).
Secondly, choosing the optimal upper instrumented vertebra for stopping
long fusions to the sacrum and pelvis is controversial. In this study, surgically
relevant upper thoracic stopping points (T2-T4) showed significantly higher
BMDs than lower thoracic stopping points (T10-T12). In addition to stress
concentration at the relatively mobile lower thoracic segments, the low BMD
at these levels might contribute to previously suggested higher rates of junctional
failures of fusion constructs with UIVs in the lower thoracic spine.
Conclusion
In conclusion, the BMD is not uniform across the entire thoracic spine. It
significantly varies by spinal level with a higher BMD in the upper thoracic
levels compared to the lower thoracic levels. The data of this study might be
used as a reference for future investigations and aid surgical planning. From
a purely BMD standpoint, choosing UIVs in the upper thoracic spine for long
fusion constructs might enhance instrumentation performance, especially in
patients with osteoporosis.
References:
Dr. Stephan Salzmann
Author:
Stephan Salzmann is an orthopaedic
surgery resident. His
research interests include
novel clinical tools to assess
bone quality. He completed
a re search fellowship at the
Hospital for Special Surgery
(NY) and received the Austrian
Ministry of Science Honorary
Prize and the Lumbar Spine
Research Society Best Paper
Award.
[1] Wasnich RD. Vertebral fracture epidemiology. Bone 1996;18:S179–83. https://doi.
org/10.1016/8756-3282(95)00499-8.
[2] Smith MW, Annis P, Lawrence BD, Daubs MD, Brodke DS. Acute proximal junctional failure in patients
with preoperative sagittal imbalance. Spine J 2015;15:2142–8. https://doi.org/10.1016/j.
spinee.2015.05.028.
[3] Duan P-G, Mummaneni P V, Rivera J, Guinn JM V, Wang M, XiZ, et al. The association between
lower Hounsfield units of the upper instrumented vertebra and proximal junctional kyphosis in
adult spinal deformity surgery with a minimum 2-year follow-up. Neurosurg Focus 2020;49:E7.
https://doi.org/10.3171/2020.5.FOCUS20192.
[4] Salzmann SN, Okano I, Ortiz Miller C, Chiapparelli E, Reisener M-J, Winter F, et al. Regional
bone mineral density differences measured by quantitative computed tomography in patients
undergoing anterior cervical spine surgery. Spine J 2020;20:1056–64. https://doi.org/10.1016/j.
spinee.2020.02.011.
[5] Salzmann SN, Shirahata T, Yang J, Miller CO, Carlson BB, Rentenberger C, et al. Regional
bone mineral density differences measured by quantitative computed tomography: does the
standard clinically used L1-L2 average correlate with the entire lumbosacral spine? Spine J
2019;19:695–702. https://doi.org/10.1016/j.spinee.2018.10.007.
[6] Salzmann SN, Ortiz Miller C, Carrino JA, Yang J, Shue J, Sama AA, et al. BMI and gender increase
risk of sacral fractures after multilevel instrumented spinal fusion compared with bone mineral
density and pelvic parameters. Spine J 2018:1–8. https://doi.org/10.1016/j.spinee.2018.05.021.

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46
Association of Varus
Deformity and Coronal
Tibiofemoral Subluxation
Osteoarthritis (OA) of the knee is one of the most common orthopaedic
disorders, a burden to health care systems, and a major
reason for knee pain, with Varus OA of the knee occurring more
frequently than valgus OA. Total knee arthroplasty (TKA) and
unicompartmental knee arthroplasty (UKA) are two reliable and
successful treatment options for patients with end- stage OA with
benefits on patient’s quality of life. Before scheduling patients
for TKA or UKA, a critical preoperative evaluation is crucial. For
UKA, an unstable knee joint is problematic. A functionally insufficient
anterior cruciate ligament (ACL) often induces meniscus
lesions and ultimately medial compartment OA and varus
deformity of the knee. The current literature only provides a few
studies investigating combined UKA and ACL reconstruction.
An additional radiographic finding that gained recognition over the last few
years is coronal tibiofemoral subluxation (CTFS). It has been shown that CTFS
already develops in early stages of joint degeneration and continuously contributes
to varus OA of the knee. It was also associated with impingement of the
medial aspect of the lateral femoral condyle on the tibial spine. Furthermore,
CTFS was considered as a potential reason for unexplained knee pain following
UKA. Even if CTFS is a well- recognized radiographic finding, its impact
on biomechanics and clinical symptoms are still not clear. The current study
evaluates the association of a functional status of the ACL and the overall varus
deformity of the knee or CTFS.
Study:
Springer B*, Waldstein W*,
Bechler U, Jungwirth-
Weinberger A, Windhager R,
Boettner F.
J Arthroplasty. 2021
Feb;36(2):501-506. doi:
10.1016/j.arth.2020.08.049.
*Both authors contributed equally
Materials and Methods
The current study prospectively enrolled 100 consecutive knees in 84 patients
who underwent primary TKA for varus OA between July 2010 and January
2012. A standardised radiological work-up was performed pre operatively
including a hip-to- ankle AP standing radiograph, an AP standing knee
radiograph, a lateral radiograph, a valgus stress radiograph, and a magnetic
resonance imaging (MRI) of the affected knee. After exclusion, 79 knees in 63
patients were available for evaluation. The study-cohort consisted of 29 men
(46 %) and 34 women (54 %) with a mean age of 69 years (range 50 – 89 years)
and a mean body mass index of 26.1 kg/m 2 (range 17 – 47). Hip-to-ankle AP
standing radiographs were used to assess the alignment of the lower limb.
Alignment (mechanical tibiofemoral angle, mFTA) was measured as the angle

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11,0
10,0
∆ ACL –
• ACL +
Figure 1: Illustration of the distribution of
CTFS and mTFA in the entire cohort.
Most knees (98 %, 40/41) with

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„A functionally intact anterior cruciate
ligament (ACL) is essential for medial
unicompartmental knee arthroplasty.
The current study showed that varus
alignment and coronal tibiofemoral
subluxation are associated with ACLinsufficiency.
It remains unknown if the
functional insufficiency of the ACL is a
result of end-stage arthritic changes, or
if an insufficient ACL leads to accelerated
degenerative changes in the medial
compartment with higher degrees of
varus deformity.“
Bernhard Springer
used to evaluate the degree of correctability of mTFA. Finally, an MRI was
used to evaluate the structural integrity of the ACL. The categorisation used
differed between three cases: intact, with degenerative changes, or completely
torn. The grading was based on the report of a blinded board-certified
radiologist.
In addition, the amount of intact posterior tibial cartilage (TCPOST) in the
medial compartment was evaluated on sagittal T1-weighted images. A previously
published study showed that a functionally insufficient ACL is likely
if the intact TCPOST is < 14 %. Two groups were formed based on ACL grading
and proportion of intact TCPOST. The first group included patients that had
an intact ACL or a degenerative altered ACL with < 14 % intact TCPOST. These
patients were considered to have a functionally intact ACL (ACL+).
On the other hand, patients with a torn ACL or a degenerative altered ACL
with < 14 % intact TCPOST were considered to have a functionally insufficient
ACL (ACL-).
Results
68 knees (86 %) of the included 79 knees were considered as ACL+. Regarding
KL classification in the lateral compartment, there was no difference between
knees with a functionally intact ACL and ACL- deficient knees (p = 0.116).
ACL- deficient knees showed significantly more femoral and tibial osteophytes
in the medial compartment compared to knees with a functionally
intact ACL (p < .001). ACL-deficient knees also showed a significantly higher
mTFA on hip- to-ankle AP standing radiographs (p < 0.001) and on valgus
stress radiographs (p = 0.017) than knees with a functionally intact ACL.
The performed measurements are summarised in Table 1.
Dr. Bernhard Springer
Author:
Bernhard Springer has been a
resident at the Department of
Orthopaedics and Trauma Surgery
at the Medical University
of Vienna since 2020. His research
is focused on the knee,
specialising in injuries of the
anterior cruciate ligament and
consequences of ACL-injuries.
Seventy-three per cent of the ACL- deficient knees and 24 % of the knees
with a functionally intact ACL had a mechanical varus alignment of ≥ 10°
(p = 0.001). The mTFA correlated significantly with the functional status of
the ACL (rs = 0.362; p = 0.001). In 64 % of the knees with a functionally insufficient
ACL and in 22 % of the knees with a functionally intact ACL, a CTFS
≥ 6mm was observed (p = 0.004). The CTFS also correlated significantly with
the functional status of the ACL (rs = 0.227; p = 0.044). Eight patients (10 %)
had ≥ 10° of varus and ≥ 6mm CTFS on AP radiographs (Figure 1). 98 % of the
knees with < 10° varus and < 6mm CTFS had a functionally intact ACL. There
was only one single patient with a functionally insufficient ACL when a mechanical
varus of

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Outcome after Arthroscopically
Assisted TFCC Refixation
49
In 2011, Dr. Thalhammer was given the opportunity to complete
a one-year hand surgery training programme in the private
practice of Dr. Heinrich-Geert Tünnerhoff and Dr. Martin Lauffer,
the former being a European pioneer of wrist arthroscopy and
arthroscopic TFCC repair. Among other things, Dr. Thalhammer
was able to expand her knowledge in this field and has since
promoted the use of arthroscopic techniques at the Clinical
Department of Trauma Surgery. The idea for this study also
arose during this stay.
Study:
Thalhammer G, Haider T, Lauffer
M, Tünnerhoff HG. Mid- and
Long-Term Outcome After
Arthros copically Assisted
Trans osseous Triangular Fibrocartilage
Complex Refixation-Good
to Excellent Results
in Spite of Some Loss of
Stability of the Distal Radioulnar
Joint. Arthroscopy. 2021
May;37(5):1458-1466. doi:
10.1016/j.arthro.2021.01.056.
Epub 2021 Feb 6. (4,772)
Ulnar-sided wrist pain is frequently caused by either degenerative or
traumatic lesions of the triangular fibrocartilage complex (TFCC). Espe -
cially a rupture of the deep part of the radioulnar ligaments (RUL), which
are considered to be the primary stabilizers of the distal radioulnar joint
(DRUJ) during forearm rotation, may cause pain and recognizable instability.
Because clinical diagnosis of TFCC lesions remains difficult, and also
magnetic resonance imaging does not provide clear answers in all cases,
arthroscopy of the wrist is crucial to detect and localize tears of the superficial
or deep parts of the RUL.
Arthroscopy proves to be not only a diagnostic, but also a therapeutic procedure,
with the advantage of small skin incisions, less destruction of the surrounding
structures, and the possibility of precise reattachment of the deep fibers
of the RUL at the ulnar fovea with transosseous sutures or suture anchors.
Short- and mid-term outcome reports of these methods indicate favourable
results, but data regarding long-term outcome remain scarce.
a
b
Figure 1: (a) Schematic illustration of a rupture of the RUL (purple; superficial layer of TFCC in orange) with dorsal subluxation of the ulnar head,
(b) and after transosseous reattachment running dorsally and palmarly of the PSU (ulnar styloid process) and through an transosseous channel created
with a K-wire in the centre of the ulnar fovea (©Tünnerhoff).

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100
***
*** **
60
***
***
Mayo Wrist Score
80
60
40
DASH
40
20
0
Preoperative
1 st Follow-up
2 nd Follow-up
n=28 – 29 n=24 – 30
Preoperative
1 st Follow-up
2 nd Follow-up
Figure 2: Time course of the Modified Mayo Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and Hand (DASH) score. Squares
and whiskers represent mean and SEM; **…p < 0.01, ***…p < 0.001.
Aim and Method
The surgical technique used in this study was developed by Heinrich-Geert
Tünnerhoff: He adapted the principles of open reattachment and developed
an arthroscopically assisted procedure. The aim of this study was to evaluate
mid- and long-term outcome of this technique and to analyse the association
of DRUJ stability with the clinical outcome.
„[…] arthroscopically assisted
reattachment of the RUL provides
reliable and satisfying long-term
results. All study participants achieved
good to excellent clinical outcome, as
indicated by the MMWS at a median
follow-up of 106 months.“
Gerhild Thalhammer
Patients with ulnar-sided wrist pain who underwent diagnostic wrist arthroscopy
and arthroscopically assisted transosseous reattachment of the
TFCC to the fovea between 2000 and 2009 were retrospectively evaluated.
Inclusion criteria were arthroscopically confirmed avulsion of the deep RUL
classified as Palmer type 1B and a minimum of 12 months for mid-term and
4-years for long-term follow-up. The indication for surgery was persistent
pain after unsuccessful conservative treatment of acute or chronic traumatic
TFCC lesions. All surgeries were performed by either one of the senior
authors (ML and HGT).
Patient surveys were obtained at three separate time points, including
preoperative assessment and two follow-up examinations. To reduce possible
bias, the two postoperative evaluations of all patients were performed by
two experienced hand surgeons not involved in the primary treatment. These
included measurements of functional and clinical outcome using the Mayo
Modified Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and
Hand (DASH) Score. At the third follow–up examination, the Patient Rated
Wrist Evaluation (PRWE) score was surveyed additionally.
Pain was assessed using a visual analogue scale (VAS). Physical examination
included quantification of active range of motion (ROM), including flexion/
extension, radial/ulnar abduction, forearm rotation, and grip strength of

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both wrist joints. The ballottement test was used to assess DRUJ instability
pre- and postoperatively. The severity of the instability was graded as either
dynamically unstable, statically unstable, or stable.
Patients and Results
A total of 30 patients were included in this study. Preoperatively, the median
MMWS was 60 (50 – 75), the DASH score was at a median of 48.3 (25.0 – 56.7),
and VAS scores ranged from 3 to 10 with a median of 7 (6.0 – 8.0). The first
evaluation took place at a median of 30 months postoperatively (2.5 years,
range 12 – 83 months). Stability assessment showed a stable DRUJ in 23
(76.7 %) patients and a dynamic instability in 5 (16.7 %) patients. All collected
scores demonstrated statistically significant improvements following
TFCC-repair (preoperative vs. 1st follow-up; MMWS: 60 vs. 100, p < 0.001;
DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1, p < 0.001).
At a median of 106 months (8.83 years, range 52 – 215 months), the second
clinical assessment was performed. Stability assessment showed a stable
DRUJ in 19 patients (63.3 %), while nine patients (30 %) had a dynamically
unstable DRUJ, and two patients (6.7 %) had a statically unstable DRUJ. At
the final follow-up, the PRWE was additionally performed with a median
score of 5 (0 – 18).
When compared to preoperative measures, evaluated scores demonstrated
persisting and significant improvement (preoperative vs. 2nd follow-up;
MMWS: 60 vs. 90, p < 0.001; DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1.8,
p < 0.001). Comparing patients with DRUJ instability to patients with stable
DRUJ at final follow-up, no significant differences in evaluated scores between
these two groups were found.
Dr. in Gerhild Thalhammer
Author:
Gerhild Thalhammer is a certified
hand surgeon and head
of the outpatient hand clinic
at the Department of Trauma
Surgery. She has been a
senior physician at the Clinical
Department of Traumatology
since 2013 and is specialist in
Trauma Surgery and Orthopaedics
and Traumatology.
Her research focuses on new
techniques in wrist arthroscopy
and the treatment of distal
radius fractures and scaphoid
fractures.
These results demonstrate that arthroscopically assisted reattachment
of the RUL provides reliable and satisfying long-term results. All study
partici pants achieved good to excellent clinical outcome, as indicated by
the MMWS at a median follow-up of 106 months. DASH-score and VAS also
showed a statistically significant improvement in all patients compared to
preoperative findings. Moderate deterioration of MMWS and VAS was observed
at the final examination compared to the mid-term results, whereas
the DASH score remained unchanged and the more wrist-specific PRWE
score showed an average of 5 points.
Regarding the stability of the DRUJ, we found no difference in clinical outcome
between patients with static or dynamic DRUJ instability preoperatively,
neither in mid-term follow-up examinations, nor in the long-term
follow-up. Comparing the mid-term and long-term results of our study population,
we found loss of DRUJ stability in some cases. This loss of stability of
the DRUJ did not correlate with any of the evaluated scores in our statistical
analysis. Despite this increase of instability, overall satisfying results in clinical
outcome and high rates of patient satisfaction were observed.
Conclusion
Arthroscopically assisted transosseous reattachment of the deep fibres
of RUL leads to excellent and good clinical results in mid- and long-term
follow-up. Loss of DRUJ stability during follow-up was not associated with
deterioration of clinical parameters or diminution of patient satisfaction.

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Osseointegration Can Be
Improved by Conventionally Used
Anti-Osteoporotic Drugs Proven
in a Clinically Relevant Murine
Implant Model
„This study reveals that post-operative,
short-term bisphosphonate treatment
enhances osseointegration by increasing
bone quantity. Furthermore, the
decrease in osteoclast number and
activity caused by bisphosphonates
does not adversely affect osteogenesis
and angiogenesis. Taken these together,
bisphosphonates are potential therapeutic
candidates for patients with a
high risk of aseptic loosening caused by
the failure of initial osseointegration.“
Klemens Vertesich
Study:
Vertesich K, Sosa BR, Niu Y, Ji G,
Suhardi V, Turajane K, Mun S,
Xu R, Windhager R, Park-Min
KH, Greenblatt MB, Bostrom
MP, Yang X. Alendronate enhances
osseointegration
in a murine implant model.
J Orthop Res 2021
Apr;39(4):719-726. doi:
10.1002/jor.24853 (3.494)
Reliable and stable fixation of implants in total joint arthroplasty
represents a crucial factor for long-term survival after
adult joint reconstruction. In this study, the Department of
Orthopaedics in collaboration with the Arthroplasty Research
Laboratory at the Hospital for Special Surgery investigated
the impact of bisphosphonates on osseointegration of
cementless titanium implants.
The success and longevity of cementless total joint arthroplasties depends
on sufficient osseointegration and the process of structural and functional
attachment of implants to the surrounding bone. Early and excessive implant
micromotion impairs bone formation and induces the formation of fibrotic
tissue, which leads to aseptic loosening and further to expensive and complex
revision surgery. Bisphosphonates represent the most frequently used
agents to treat osteoporosis. Arthroplasty registry studies have demonstrated
that bisphosphonate treatment before, during, or after total joint arthroplasty
is beneficial for long term survival.
However, these studies do not allow the assessment of the cellular mechanism
of osseointegration and mechanical properties of the bone-implant
interface. Therefore, a reliable murine implant model has been developed,
that encompasses all critical factors of cementless arthroplasty: implant
positioning in metaphyseal cancellous bone, intraarticular positioning of the
implant, and the ability of postoperative physiological weight-bearing.
This study aimed to assess the ability of bisphosphonates to promote peri-implant
bone formation, the inhibition of osteoclastogenesis at the bone-implant
interface, and the enhancement of osseointegration. The hypothesis was that
postoperative, short-term bisphosphonate treatment improves mechanical
stability of the implant by increasing peri‐ implant bone volume, decreasing
peri‐implant osteoclasts without impairing osteoblasts or angiogenesis.

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Figure 1: (A) Lateral radiograph 28 days after proximal tibial implantation surgery. (B) Schematic overview on regions of interest for µCT measurements. (C)
Biomechanical testing revealed a significant increase in maximum pull-out load in the alendronate group compared with the vehicle group. (D) Significant
increase of bone volume over trabecular volume (BV/TV) in the peri-implant and distal to implant region in the alendronate group compared to vehicle.
Methods
In this study 44 female C57BL/6 mice at the age of 17-weeks underwent
arthroplasty surgery of the right knee joint. Under isoflurane anaesthesia
and sterile conditions, a 8mm midline incision was made over the right knee.
A medial parapatellar approach was used to dislocate the patella. Menisci
and anterior cruciate ligaments were resected. The articular cartilage of
the tibia was removed and a 0.9mm diameter hole was drilled into the tibial
medullary canal. A 3D-printed titanium implant, with a smooth oval formed
articular surface (2.0mm x 1.5mm x 0.2mm) and with an intramedullary stem
with rough surface (1.0mm in diameter and 2.0mm in length), was press-fitted
into the hole (Figure 1A). Joint capsule and skin were closed in layers. The
mice started to ambulate with full weight‐bearing on both knees immediately
after recovery from anaesthesia.
Postoperatively, the mice were randomly divided into two groups and injected
with the bisphosphonate, alendronate (BioVision Inc.; n = 22, 73 μg/kg, i.p.), or
vehicle (n = 22, 200 μl phosphate‐buffered saline, i.p.) 5 days a week starting
from the day of surgery until the day of euthanasia. The animals were
euthanized by CO2 for histological assessment on postoperative days 1, 3, 7,

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Figure 2: (A) TRAP staining revealed a significant reduction of osteoclasts per bone perimeter (N.Oc/B.Pm) and a significant increase in bone area percent
(BV/TV) with 14 days of alendronate treatment. (B) Immunofluorescence staining showed a reduction of peri-implant cathepsin K at 7-days post-implantation
with alendronate treatment. (C) Immunofluorescent imaging of the proximal tibia and peri-implant region highlights a robust presence of endothelial
cells and osteoblasts through endomucin (EMCN) and osteocalcin (OCN) staining, respectively.
14, and 28, or microcomputed tomography (µCT) analysis and pull-out testing
at day 28 after surgery. µCT was performed to assess bone volume fraction,
trabecular number, trabecular thickness, and trabecular separation in two
regions of interest: Peri-implant region (cancellous bone around the distal
500µm of the stem) and distal to implant (cancellous bone 500µm distal
from the tip of the stem) (Figure 1B). Pull-out tests were performed to assess
the mechanical stability. Immunofluorescence staining was performed to
assess the impact of bisphosphonates on osteogenesis, angiogenesis, and
osteoclastogenesis. Antibodies for anti-Osteocalcin (OCN), anti-Endomucin
(EMCN), and anti-cathepsin K (CTSK) were used. Further, frozen sections
were stained for tartrate‐resistant acid phosphatase (TRAP), and histomorphometry
according to recommendations of the Nomenclature Committee of
the American Society for Bone and Mineral Research was performed.
Results
Short-term, postoperative bisphosphonate treatment ultimately increased
implant stability. The maximum load of pull-out was significantly increased
by 45 % (p < 0.001) (Figure 1C). µCT showed that alendronate increased both
peri‐implant and distal‐to‐implant bone mass compared with the control
group (Figure 1D). In the distal‐to‐implant region, the alendronate treatment
increased bone volume fraction by 139 % (p < 0.001), trabecular number by
31 % (p < 0.001), and trabecular thickness by 18 % (p < 0.01). In the peri‐implant
region, alendronate treatment increased bone volume fraction by 60 %
(p < 0.05), trabecular thickness by 7 % (p < 0 .05), and trabecular spacing by
22 % (p < 0.001).
Although peri‐implant bone formation increased over time in both the
alendronate‐treated and control mice, alendronate accelerated the rate of
peri‐implant ossification with increased peri‐implant bone mass at 7‐ and
14‐day postoperative. Histology demonstrated that alendronate increased

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the percent of the bone area in the total area from 12.7 ± 1.6 in the control
group to 20.7 ± 0.9 in the alendronate group at 14 days after surgery (p < 0.05)
(Figure 2A). Immunofluorescence imaging showed that short‐term, post-operative
alendronate treatment did decrease the presence of osteoclasts
marked by cathepsin K (CTSK) (Figure 2B) but did not attenuate peri‐implant
EMCN‐positive endothelial cells or OCN‐positive osteoblasts after 7 and 14
days of treatment (Figure 2C).
Conclusion
This study reveals that post-operative, short-term bisphosphonate
treatment enhances osseointegration by increasing bone quantity.
Furthermore, the decrease in osteoclast number and activity caused by
bisphosphonates does not adversely affect osteogenesis and angiogenesis.
Taken these together, bisphosphonates are potential therapeutic candidates
for patients with a high risk of aseptic loosening caused by the failure of
initial osseointegration.
References:
[1] Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated Titanium Implants:
Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man. Acta
Orthopaedica Scandinavica 52(2): 155, 2009
[2] Bishop NE, Hohn JC, Rothstock S, Damm NB, Morlock MM. The influence of bone damage on
press-fit mechanics. J Biomech 47(6): 1472, 2014
Dr. Klemens Vertesich
Author:
Klemens Vertesich started his
residency at the Department of
Orthopaedics and Trauma Surgery
at the Medical University
of Vienna in 2018. His research
interests are total joint arthroplasty
and revision arthroplasty,
osseointegration of implants
as well as hip-preservation
surgery. He was awarded the
Ines Mandl Research Fellowship
in 2018 and got the opportunity
to conduct research on
the impact of bone formation
on implant osseointegration
ant the Arthroplasty Research
Laboratory at the Hospital for
Special Surgery/Weill Cornell
University, New York City.
[3] Ollivere B, Wimhurst JA, Clark IM, Donell ST. Current concepts in osteolysis. J Bone Joint Surg Br
94(1): 10, 2012
[4] Mann KA, Miller MA, Costa PA, Race A, Izant TH. Interface micromotion of uncemented femoral
components from postmortem retrieved total hip replacements. J Arthroplasty 27(2): 238, 2012
[5] Fehring TK, Murphy JA, Hayes TD, Roberts DW, Pomeroy DL, Griffin WL. The Coventry Award
Paper: Factors Influencing Wear and Osteolysis in Press-Fit Condylar Modular Total Knee Replacements.
Clinical Orthopaedics and Related Research 428: 40, 2004
[6] Favus MJ. Bisphosphonates for osteoporosis. The New England journal of medicine 363(21):
2027, 2010
[7] Russell RG. Bisphosphonates: the first 40 years. Bone 49(1): 2, 2011
[8] Rogers MJ, Crockett JC, Coxon FP, Monkkonen J. Biochemical and molecular mechanisms of
action of bisphosphonates. Bone 49(1): 34, 2011
[9] Khatod M, Inacio MC, Dell RM, Bini SA, Paxton EW, Namba RS. Association of Bisphosphonate
Use and Risk of Revision After THA: Outcomes From a US Total Joint Replacement Registry. Clin
Orthop Relat Res 473(11): 3412, 2015
[10] Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C, Arden NK. Association
between bisphosphonate use and implant survival after primary total arthroplasty of the knee
or hip: population based retrospective cohort study. BMJ 343: d7222, 2011
[11] Prieto-Alhambra D, Lalmohamed A, Abrahamsen B, Arden NK, de Boer A, Vestergaard P, de
Vries F. Oral bisphosphonate use and total knee/hip implant survival: validation of results in an
external population-based cohort. Arthritis Rheumatol 66(11): 3233, 2014
[12] Thillemann TM, Pedersen AB, Mehnert F, Johnsen SP, Soballe K. Postoperative use of bisphosphonates
and risk of revision after primary total hip arthroplasty: a nationwide population-based
study. Bone 46(4): 946, 2010
[13] Yang X, Ricciardi BF, Dvorzhinskiy A, Brial C, Lane Z, Bhimani S, Burket JC, Hu B, Sarkisian
AM, Ross FP, van der Meulen MC, Bostrom MP. Intermittent Parathyroid Hormone Enhances
Cancellous Osseointegration of a Novel Murine Tibial Implant. J Bone Joint Surg Am 97(13):
1074, 2015

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Figure 1: Fiber orientation in
the collagen matrix of chondroprogenitor
pellets. Birefringent
collagen fibers show developing
zonation in the newly formed
hyaline matrix. (A) Horizontally
arranged birefringent fibers
parallel to the pellet surface (PS).
(B) Randomly organized collagen
fibers were found in the central
area. (C) Perpendicularly oriented
birefringent fibers were located
in proximity to the pellet center
(PC). Scale bar equals 30 µm,
400× magnification.
Mimicking the Zonal Organization
of Articular Cartilage in Vitro
In 2021, the Karl Chiari Lab for Orthopaedic Biology described an in
vitro based cell model comprising human chondroprogenitor cells
that form zonally organized engineered hyaline tissue comparable
to the three zones of native cartilage. The collaboration of the Department
of Orthopedics and Trauma Surgery (MedUni Vienna and
AKH Wien) with the Hospital Speising, the Medical University of
Graz, and the Danube University Krems resulted in the publica tion
of an article entitled „A 3-Dimensional In Vitro Model of Zonally
Organized Extracellular Matrix“ in the scientific journal „Cartilage“.
Study:
Walzer SM, Toegel S, Chiari C,
Farr S, Rinner B, Weinberg
AM, Weinmann D, Fischer MB,
Windhager R. A 3-Dimensional
In Vitro Model of Zonally
Organized Extracellular
Matrix. Cartilage 2021;13(2_
suppl):336S-345S. (4,634)
In articular joints, cartilage integrity is key for patients’ mobility and activity.
The sophisticated architecture of the extracellular matrix (ECM), in particular
regarding the zonal distribution of collagen fibers across the cross-section of
cartilage, contributes to the unique properties of the tissue. Injuries or degenerative
changes often result in cartilage lesions that cause tremendous burden
for patients and healthcare systems worldwide. Numerous tissue engineering
approaches aim to restore the functionality of damaged cartilage, but so far fail
to reconstruct zonally organized hyaline tissue that might fulfil the expectations
of long-term functionality. To study hyaline cartilage repair in vitro, endogenous
stem cells of the mesenchymal lineage resident in growth plate tissue could
represent a promising cell source. Previously, we showed that these human
chondroprogenitors (CPs) can be isolated from polydactyl digits 2 . The hyaline
cartilage formation of human CPs in vitro, however, as well as their ability to
differentiate into the three mesenchymal linages remained largely unknown.

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„To study hyaline cartilage repair
in vitro, endogenous stem cells of
the mesenchymal lineage resident in
growth plate tissue could represent
a promising cell source.“
Stefan Toegel
Methods
Clinical specimens of the human growth plate were obtained from the supernumerary
digits of eight different donors (age < 36 months) with polydactylism
at the time of surgical excision. Isolated CPs were characterized by
FACS analysis using specific antibodies (CD45−, CD34−, CD73+, CD90+, and
CD105+). Three-dimensional cell constructs were prepared by centrifugation
and cultured for up to five weeks. Constructs were processed for histology
and stained with Alcian blue or Picrosirius red (PSR) and analysed using light
microscopy and polarised light microscopy (PLM). In addition, deparaffinised
sectiones were stained with antibodies against collagen I or collagen II and
DAPI, prior to analysis with an LSM 700 confocal laser scanning microscope.
In vitro osteogenic and adipogenic differentiation of CPs was confirmed
using RT-qPCR of respective target genes as well as alkaline phosphatase
(ALP) activity assay, Alizarin Red S (ARS) staining and oil red O staining.
Results
In presence of osteogenic medium, ALP staining as well as ARS quantification
significantly increased over time for up to 21 days, as compared to
undifferentiated controls. In agreement, mRNA levels of ALP, a marker for
early osteogenesis, and BGLAP, a marker of late osteogenesis, were increased
20.9 ± 25.2-fold and 6.7 ± 4.69-fold, respectively, while those for transcription
factor RUNX2 were significantly upregulated 2.88 ± 1.04-fold, supporting the
osteoinduction of CPs. Adipogenic differentiation of cultures stimulated with
adipogenic medium was demonstrated by oil red O staining of lipid droplets,
with simultaneous upregulation of mRNA levels of early (PPARG: 2.0 ± 0.6-
fold) and late (LPL: 1054 ± 906-fold)) adipogenic markers. The chondrogenic
phenotype of CPs was promoted in self-assembling pellet cultures.
Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel
After 21 days, histological analyses showed an augmented amount of glycosaminoglycans
(Alcian blue) as well as column-like formations of cells.
Collagen type II positivity was detected in the newly formed ECM around the
centre of the pellet, whereas collagen type I immunostaining was mainly
found in the superficial zone, with weak positivity in the central area of the
CP pellet. PSR staining and PLM after five weeks of cultivation revealed
horizontally arranged birefringent fibers, parallel to the pellet surface, as
well as randomly organized collagen fibers, and perpendicularly oriented
birefringent fibers in the central and deep areas of the cartilaginous matrix,
respectively (Figure 1). Equally processed native articular cartilage indicated
similar collagen fibril assembly.
Author:
Stefan Toegel is head of the Karl
Chiari Lab for Orthopaedic
Biology. In 2015, he became
an Associate Professor at the
Medical University of Vienna,
and he obtained his habilitation
in Cell Biology in 2018.
The main focus of his research
is on the pathomechanisms of
osteoarthritis.
Concluding remarks
Confirming the trilineage potential of CPs, osteogenic and adipogenic differentiation
was induced in monolayer cultures using differentiation media. Under
conditions promoting the chondrogenic signature in 3D constructs, CPs formed
an aligned extracellular matrix positive for glycosaminoglycans and collagen
type II, showing developing zonation of birefringent collagen fibers along the
cross section of pellets, which reflect the distribution of collagen fibers in hyaline
cartilage.
References:
[1] Walzer S.M. et al. A 3-Dimensional In Vitro Model of Zonally Organized Extracellular Matrix.
Cartilage 2021;13:336S-345S.
[2] Walzer S.M. et al. Vascularization of primary and secondary ossification centres in the human
growth plate. BMC Dev Biol. 2014;14(1):36.

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Relevance of Follow-up CCT
in Patients on Intracranial
Pressure Monitoring
„The standard of care in patients suffering from a severe
traumatic brain injury (TBI) includes an invasive monitoring of
the intra cranial pressure (ICP) via a probe that is surgically placed
in the brain parenchyma. Based on the clinical observation that
cranial computed-tomography (CCT) follow-ups are frequently
performed even in patients on continuous ICP monitoring
within physiological limits, the authors of our study questioned
the clinical relevance and necessity of these scans.“
Study:
Bumberger A, Braunsteiner T,
Leitgeb J, Haider T. Intracranial
pressure monitoring following
traumatic brain injury:
evaluation of indications,
complications, and significance
of follow-up imaging-an
exploratory, retrospective
study of consecutive patients
at a level I trauma center.
Eur J Trauma Emerg Surg.
2022 Apr;48(2):863-870.
doi: 10.1007/s00068-020-
01570-3. Epub 2020 Dec 22.
PMID: 33351163; PMCID:
PMC7754179.
According to a recent meta-analysis the overall incidence of traumatic brain
injury (TBI) in Europe is around 262/100.000 with considerable heterogeneity
between the included studies. Cranial computed tomography (CCT) is
the gold standard of imaging in these patients and can guide further treatment
strategies. Furthermore, the Brain Trauma Foundation recommends
ICP-monitoring for patients with severe TBI (Glasgow Coma Scale 3 – 8 after
resuscitation). While ICP-monitoring can be associated with catheterrelated
complications, such as focal haemorrhage and local infection in
about 6 percent of the interventions, it is considered an essential monitoring
tool in sedated patients following severe TBI. Neurological examination of intubated
patients is limited, prompting frequent follow-up CCT examinations
which require patient transportation and positioning, both potentially increasing
ICP. Moreover, suspected compartmentalization and flawed ICP-monitoring
due to technical issues can prompt physicians to perform follow-up CCT
scans, even in patients under ICP monitoring.
The aim of the present study was threefold: To evaluate indications for follow-up
CCT imaging with respect to ICP-monitoring and clinical findings, to
analyse frequency and findings of follow-up CCTs and their impact on clinical
decision making, and to report on complications associated with invasive
ICP-monitoring.
Methods
We performed a systematic database search for patients on ICP-monitoring
between January 2007 and September 2017 at an urban level I trauma centre.
Initial CCT scans as well as the first two follow-up CCT scans were reviewed
regarding relevant features indicating TBI (intracranial haemorrhage, fracture,
edema, and midline-shift) and their spatiotemporal characteristics. As

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„The aim of the present study was
threefold: To evaluate indications for
follow-up CCT imaging with respect to
ICP-monitoring and clinical findings,
to analyse frequency and findings of
follow-up CCTs and their impact on
clinical decision making, and to report
on complications associated with
invasive ICP-monitoring.“
Alexander Bumberger
follow-up scans were routinely performed after implantation of the ICP-probe,
the third follow-up CT scan was considered the first „true“ follow-up scan.
Indications for these scans were extracted from clinical records and stratified
as „routine follow-up“ (without clinical deterioration or elevated ICP), „follow-up
due to clinical deterioration“ (new onset of anisocoria, cardiovascular
decompensation etc.), and „follow-up due to elevated ICP“ (> 20 mmHg).
The physical and neurological status of patients was extracted from letters of
discharge and then quantified according to the Glasgow Outcome Scale (GOS).
In case of patient decease, time and cause of death were recorded. All statistical
analyses were performed using SPSS Statistics 25.0 (IBM, Armonk, NY, USA).
Results
A total of 214 patients at a mean age of 44 (range 1–92) years were on ICP-monitoring
at our department between January 2007 and September 2017. The
overall in-hospital mortality was 21.6 %. There were 12 (5.6 %) complications
associated with the ICP-probe leading to 5 cases of surgical revision. Altogether,
there were no severe adverse events (major bleeding, death) directly related to
the probe or its implantation, and no catheter-associated infections.
There were 192 cases where at least one follow-up CCT was performed, with
an average of 7 CCT scans per patient. Most scans were routine follow-up
scans (n = 137, 64.3 %). One out of four follow-up scans (n = 55, 25.8 %) was
performed due to either clinical deterioration or elevated ICP. The prevalence
of bleeding progression on routinely performed follow-up CCTs was 16.1 %
(22/137). In case of clinical deterioration or elevated ICP, deterioration of findings
(i.e. bleeding progression, additional intracranial haemorrhage, and/or
increase of cerebral edema) was observed in 50.0 % (6/12) and 55.8 % (24/43)
of the cases, respectively. Follow-up scans performed due to clinical deteriora-

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Figure 1: Side-by-side comparison
of progression and non-progression
of cranial computed tomography (CCT)
findings grouped by indication of
follow-up CCT.
( intracranial pressure)
tion or elevated ICP were both more frequently associated with a deterioration
of CCT findings, as compared to routine follow-up scans (clinical deterioration:
x2(1) = 8.94, p < 0.01, OR = 5.52, 95 % CI 1.63 – 18.77; elevated ICP: x2(1) = 28.61,
p < 0.001, OR = 6.98, 95 % CI 3.26 – 14.93). Figure 1 demonstrates the prevalence
of bleeding progression according to the indication of CCT.
Dr. Alexander Bumberger
Routine follow-up CCT did not prompt any intervention in 94.9 % (130/137)
of the cases. In case of aggravation of findings, the percentage was 68.2 %
(15/22). The most common clinical consequence was a delay of antithrombotic
therapy in 18 % (4/22) of the cases. There was one case of surgical
intervention with removal of a newly detected epidural hematoma on routine
follow-up. When CCT was performed due to either clinical deterioration or
elevated ICP, a deterioration of findings was detected in 54.5 % (30/55) of the
cases. In most of these patients (76.7 %, 23/30), haemorrhage progression on
CCT did not result in any clinical consequence regarding the further treatment.
The most common consequence was a craniectomy in 10 % (3/30) of
the cases. Overall, a total of six patients (3.1 %) underwent surgical intervention
prompted by follow-up imaging.
Author:
Alexander Bumberger started
his residency at the Department
of Orthopaedics and
Traumatology at the Medical
University of Vienna in 2018
and is currently working at the
OCM Orthopaedic Surgery Munich.
While his primary research
interest and PhD project
focus on reconstructive knee
surgery and joint preservation,
he has been working on various
topics in the field of trauma
surgery and orthopaedics.
Conclusion
The present data show a high number of CCT scans performed in patients on
invasive ICP monitoring following severe TBI. The number of cases in which
a deterioration of findings on follow-up scans prompted any clinical intervention
was very low. Therefore, the necessity of CCT scans should be more
critically evaluated in each individual case, with respect to potential clinical
consequences.
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·

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Originalarbeiten 2021
Der Impact Factor ist eine errechnete Zahl, deren Höhe den Einfluss einer wissenschaftlichen
Fachzeitschrift wiedergibt. Er gibt an, wie häufig im Durchschnitt ein in
dieser Zeitschrift veröffentlichter Artikel von anderen wissenschaftlichen Artikeln
pro Jahr zitiert wird. Die ersten 20 Prozent der Zeitschriften des Fachgebietes im
Journal Citation Reports (geordnet nach Höhe des Impact Factors) sind Top-Journale.
Die zwischen 20 und 60 Prozent liegenden Zeitschriften gelten als Standard-Journale.
Folgend sind hier die Top- und Standard-Publikationen des Jahres 2021 angeführt.
Universitätsklinik für
Orthopädie und Unfallchirurgie
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tumors. EMSOS, 33rd Annual Meeting,
1. – 3.12.2021, Austria.
Hacker S, Kourimsky AT, Trost C, Funovics PT,
Panotopoulos J, Windhager R, Hobusch GM, Caring
for patients with primary malignant bone and soft
tissue tumors - a qualitative survey of their needs
during and after inpatient treatment. EMSOS, 33rd
Annual Meeting, 1. – 3.12.2021, Austria.
Heisinger S, Huber D, Matzner M, Hasenörhl T,
Palma S, Sternik J, Crevenna R, Grohs JG. YouTube
As A Source Of Physiotherapy Tutorials For Lumbar
Disc Herniation. 22. EFORT Annual Congress.
Hirtler L, Czerny K, Schuh R, Willegger M, Accessibility
of the metatarsal head comparing distraction
and plantarflexion in a 2-portal technique for
first metatarsophalangeal (MTP 1) joint arthroscopy,
FASEB JOURNAL35(Suppl1), 10.1096/fasebj.2021.35.S1.00258
Hofer C, Trost C, Panotopoulos J, Funovics PT,
Windhager R, Hobusch GM, Using means of transport
and walking aids after treatment for primary
malignant bone tumors in the lower extremity - A
minimum follow-up of 20 years. EMSOS, 33rd Annual
Meeting, 1. – 3.12.2021, Austria.
Hobusch GM, Smolle MA, Mrs. Trost C, Friesenbichler
J, Bergovec M, Windhager R, Leithner A,
Functional outcome and QOL after sarcomas of the
foot and ankle region. Is early amputation justified?
EMSOS, 33 rd Annual Meeting, 1. – 3.12.2021,
Austria.
Hobusch GM, Keusch F, Joyce M, Windhager R,
Expert Opinions about sports activity after Tumorendoprostheses
– Do they differ in different
parts of the world? EMSOS, 33rd Annual Meeting,
1. – 3.12.2021, Austria
Hecker-Nolting S, Sorg B, Baumhoer D, Dürr HR, Von
Eisenhart-Rothe R, Exner GU, Gosheger G, Hardes
J, Heise U, Hillmann A, Kevric M, Krieg AH, Lehner
B, Tunn PU, Windhager R, Wirth T, Bielack S, Does
choice of surgical procedure correlate with survival
in high-grade central osteosarcoma around
the knee? - A report from the Cooperative Osteosarcoma
Study Group (COSS). EMSOS, 33rd Annual
Meeting, 1. – 3.12.2021, Austria.
Laurent D, Scotti C, Schreiner M, Neubauer M, Muellner
T, Zaric O, Juras V, Szomolanyi P, Goldhahn
J, Praestgaard J, Gerwin N, Roubenoff R, Nehrer
S, Schieker M, Trattnig S. „Regeneration of hyaline
cartilage in response to a single injection of LNA043,
an ANGPTL3 mimetic, in the knee of patients with
a focal cartilage defect“, Abstracts / Osteoarthritis
and Cartilage 29 (2021) S10eS432
Lass R, Kolbitsch P, Nöbauer I, Giurea A, Kubista B,
Windhager R, Pseudotumoren bei Metall-Hüftendoprothesen
– Follow-up von mindestens 20 Jahren,
Deutscher Kongress für Orthopädie und Unfallchirurgie
(DKOU 2021), 26. – 29.10.2021, Berlin
Schreiner MM, Apprich S, Staats K, Aletaha D,
Windhager R, Böhler C, The influence of biologicals
on aseptic arthroplasty loosening, Deutscher Kongress
für Orthopädie und Unfallchirurgie (DKOU
2021), 26. – 29.10.2021, Berlin
Sigmund IK, McNally M, Luger M, Böhler C, Windhager
R, Sulzbacher I, Der optimale Grenzwert
der neutrophilen Granulozyten in histologisch
aufarbeiteten Gewebeproben zur Diagnostik von
periprothetischen Gelenksinfektionen, Deutscher
Kongress für Orthopädie und Unfallchirurgie (DKOU
2021), 26. – 29.10.2021, Berlin
Springer B, Stihsen C, Rienmüller A, Funovics P,
Krepler P, Grohs J, Windhager R. Surgical Treatment
of Spinal Metastases-Results of a Large
Single Centre Study. 22nd EFORT Annual Congress
30.6. – 2.7.2021
Springer B, Stihsen C, Rienmüller A, Funovics P,
Krepler P, Grohs J, Windhager R. Surgical Treatment
of Spinal Metastases – Results of a Large Single
Centre Study. Eurospine 2021

Publikationen
74
Trost C, Heisinger S, Funovics PT, Windhager R,
Hobusch GM, Stamm T, Patients’ Perceptions of
Changes and Consequences after Tumor Resection.
A Qualitative Study in Austrian Patients with
musculoskeletal Malignancies. EMSOS, 33. Annual
Meeting, 1. - 3.12.2021, Austria.
Vetchy V, Trost C, Funovics PT, Panotopoulos J,
Windhager R, Hobusch GM, Secondary Amputation –
A qualitative Study of Quality of Live in Patients
after Primary Limb Salvage Surgery and after later
Ablative Sarcoma Treatment”. EMSOS, 33. Annual
Meeting, 1. – 3.12.2021, Austria.
Sonstige Publikationen und Substandard 2021
Alfertshofer M, Frank K, Melnikov DV, Möllhoff N,
Gotkin RH, Freytag DL, Heisinger S, Giunta RE,
Schenck TL, Cotofana S. Performing Distance Measurements
in Curved Facial Regions: A Comparison
between Three-Dimensional Surface Scanning
and Ultrasound Imaging. Facial Plast Surg. 2021
Jun;37(3):395-399. doi: 10.1055/s-0041-1725166.
Epub 11.3.2021. (1.446)
Apprich S, Nia A, Schreiner MM, Friedrich K, Windhager
R, Trattnig S. The Vienna morphological Achilles
tendon score-VIMATS : Description, reproducibility
and initial clinical results. Wien Klin Wochenschr.
2021 Jun;133(11-12):560-7. Epub 6.4.2021. (1.704)
Apprich SR, Nia A, Schreiner MM, Jesch M, Böhler
C, Windhager R. Modular megaprostheses in the
treatment of periprosthetic fractures of the femur.
Wien Klin Wochenschr. 2021 Jun;133(11-12):550-
9. Epub 14.4.2021. (1.704)
Bumberger A, Borst K, Hobusch GM, Willegger M,
Stelzeneder D, Windhager R, Domayer S, Waldstein
W. Higher patient knowledge and resilience
improve the functional outcome of primary total
knee arthroplasty. Wien Klin Wochenschr. 2021
Jun;133(11-12):543-549. (1.704)
Casari FA, Navab N, Hruby LA, Kriechling P, Nakamura
R, Tori R, de Lourdes Dos Santos Nunes F,
Queiroz MC, Fürnstahl P, Farshad M. Augmented
Reality in Orthopedic Surgery Is Emerging from
Proof of Concept Towards Clinical Studies: a Literature
Review Explaining the Technology and Current
State of the Art. Curr Rev Musculoskelet Med.
2021 Apr;14(2):192-203. doi: 10.1007/s12178-
021-09699-3. Epub 5.2.2021
Carlin GL, Baumgartner JS, Moftakhar T, König D,
Negrin LL. Impact of COVID-19 lockdown on suicide
attempts: A retrospective analysis of the springtime
admissions to the trauma resuscitation room at
the Medical University of Vienna from 2015-2020.
Wien Klin Wochenschr. 2021 Sep;133(17-18):915-
922. doi: 10.1007/s00508-021-01839-6. Epub
31.3.2021. (1.704)
Chiari C, Willegger M, Kolb A, Windhager R, Epiphysiolysis
capitis femoris: Notfallversorgung Jatros
Orthopädie und Traumatologie 1/21: S 12-15.
Chiari C, Editorial Fokusthema Kinderorthopädie
und Kindertraumatologie, Jatros Orhopädie und
Traumatologie 4/21: S3.
Dekhne MS, Thomas HM, Haider T, Mortensen S,
Rodriguez EK, Weaver MJ, von Keudell A. Treatment
and outcomes of basicervical femoral neck
fractures: A systematic review. J Orthop Surg (Hong
Kong). 2021 Jan – Apr;29(1):23094990211003344.
doi: 10.1177/23094990211003344.
Farr S, Scheider P. The Molding Hands of Time:
Remodeling of Sagittal Plane Malunion After Pediatric
Supracondylar Humerus Fractures. J Pediatr
Orthop. 2021 Sep 1;41(8):e700.
Haider T, Hanna P, Mohamadi A, Merchan N, McNichol
M, Wixted JJ, Appleton PT, Nazarian A ,von Keudell AG,
Rodriguez EK. Revision Arthroplasty Versus Open Reduction
and Internal Fixation of Vancouver Type-B2
and B3 Periprosthetic Femoral Fractures. JBJS Rev.
20.8.2021, 9(8). doi: 10.2106/JBJS.RVW.21.00008.
Haider T, Notter L. Das funktionelle Querschnittsyndrom
– ein Fallbericht. Functional Para plegia –
A Case Report. Neurologie Open Access Published:
14.4.2021 psychopraxis. neuropraxis volume 24,
pages 178–181 (2021)

Publikationen
75
Lang NW, Kasparek MF, Synak L, Waldstein W,
Funovics PT, Windhager R, Hobusch GM. What
sports activity levels are achieved in long-term
survivors with modular endoprosthetic humerus
reconstruction following primary bone sarcoma
resection? Wien Klin Wochenschr. 2021 Jan;133(1-
2):14-20. (1.704)
Negrin LL. Knieverletzungen im alpinen Skibreiten-
und Skileistungssport – eine selektive Aufarbeitung
der aktuellen Literatur. Sports Orthop
Traumatol. 2021 37: 313 -321. doi: org/10.1016/j.
orthtr.2021.11.007.
Negrin LL und Puchwein P. REBOA in der Polytraumaversorgung:
State of the Art und Case Report.
Jatros Orthopädie & Traumatologie Rheumatologie
1/2021
Nia A, Popp D, Diendorfer C, Apprich S, Munteanu
A, Hajdu S, Widhalm HK. Impact of lockdown during
the COVID-19 pandemic on number of patients
and patterns of injuries at a level I trauma center.
Wien Klin Wochenschr. 2021 Apr;133(7-8):336-343.
(1.704)
Nürnberger S. Gewebekleber nach dem Vorbild der
Natur. Jatros Orthopädie & Traumatologie Rheumatologie
2/2021
Rentenberger C, Salzmann SN, Shue J, Hughes AP.
Heel Lift for Skiing to Compensate for Corrected
Sagittal Vertical Axis After Spinal Surgery: A Case
Report. Int J Spine Surg. 2021 Feb;14(s4): S33-S36.
doi: 10.14444/7162.
Salom M, Chiari C, Alessandri JMG, Willegger M,
Windhager R, Sanpera I. Diagnosis and staging
of malignant bone tumours in children: what is
due and what is new? J Child Orthop. 2021 Aug
20;15(4):312-321. (1.548)
Salzmann SN, Knochenqualität in der spinalen MRT
sagt Fragilitätsfrakturen voraus. Die Wirbelsäule
2021; 5: Seiten: 15 – 17, DOI: 10.1055/a-1222-6211
Schitz F, Rilk, S, Schabus R. Arthroskopische Versorgung
einer suprakondylären Femurfraktur bei
einliegender Knietotalendoprothese mittels retrogradem
Femurnagel. Arthroskopie 34, 74–79 (2021).
https://doi.org/10.1007/s00142-020-00422-x
Seilern Und Aspang J, Böckmann D, Erhart J,
Haider T. Ossification of the pseudarthrosis following
the Sauvé-Kapandji procedure: a case
report and review of the literature. Case Reports
Plast Surg Hand Surg. 2021 Apr 16;8(1):66-71. doi:
10.1080/23320885.2021.1910040.
Sigmund IK, Puchner SE, Windhager R. Serum
Inflammatory Biomarkers in the Diagnosis of Periprosthetic
Joint Infections. Review. Biomedicines
2021, 9(9), 1128. (6.081)
Sigmund IK, Windhager R, State of the Art: Behandlung
von periprothetischen Gelenksinfektionen
nach Implantation einer Hüft- bzw. Knietotalendoprothese.
JATROS, Orthopädie & Traumatologie
Rheumatologie 6/2021.
Soffin EM, Reisener MJ, Padgett DE, Kelly BT, Sama
AA, Zhu J, Salzmann SN, Chiapparelli E, Okano I,
Oezel L, Miller AO, Cammisa FP, Girardi FP, Hughes
AP. Coronavirus Disease 2019 Exposure in Surgeons
and Anesthesiologists at a New York City Specialty
Hospital: A Cross-Sectional Study of Symptoms
and SARS-CoV-2 Antibody Status. J Occup Environ
Med. 2021 Jun 1;63(6):521-527. doi: 10.1097/
JOM.0000000000002182. PMID: 34048384; PM-
CID: PMC8168673.
Ternovoy S, Ustyuzhanin D, Shariya M, Shabanova
M, Gaman S, Serova N, Mironov V, Merkulova I,
Rienmueller A, Meyer EL, Rienmueler T. Reliability
of coronary computed tomography angiography in
acute coronary syndrome in an emergency setting.
Heliyon. 1.2.2021;7(2):e06075
Trost C, Hofer C, Stamm T, Windhager R, Hobusch
GM, Cross-cultural adaption, translation and validation
of the Toronto extremity salvage score (TESS)
for patients in German-speaking countries; Wien
Klin Wochenschr. 2021 Jun;133(11-12):536-542.
Weihs V, Pogran E, Kunschitz E, Weihs W, Prinz E,
Eichenberg C, Fiegl J, Friedrich O, Huber K.
Psychocardiological assessment in the acute
phase of the takotsubo syndrome: Somatic and de

Publikationen
76
pressive disorders, resilience and illness perception.
Wien Klin Wochenschr. 2021 Oct 20. doi:
10.1007/s00508-021-01957-1. Online ahead of
print. (1,704)
Willegger M, Schreiner M, Kolb A, Windhager R,
Chiari C. Epiphysiodesis for the treatment of tall
stature and leg length discrepancy. Wien Med Wochenschr.
2021 Apr;171(5-6):133-41.
Willegger M, Hirtler L, Schwarz GM, Windhager
RH, Chiari C. Peronealsehnenpathologien: Von der
Diagnose bis zur Behandlung [Peroneal tendon pathologies:
From the diagnosis to treatment]. Orthopade.
2021 Jul;50(7):589-604.
Willegger M., Kolb A., Chiari C. Timing von Epi- und
Hemiepiphysiodese an der unteren Extremität. Jatros
Orthopädie & Traumatologie, Rheumatologie
2021, 4:25-27
Windhager R. Tumorendoprothetik [Tumour arthroplasty].
Orthopade. 2021Oct;50(10):839-842.
Buchbeiträge 2021
Bostrom MP, Sosa B, Staats K; „Trochanteric Osteotomy“,
Advances in Specialist Hip Surgery, Seite:
225-235; Verlag: Springer Medizin, ISBN: 978-
3030618292
Chiari C, Kainberger F. Gliederschmerzen, Arthralgie,
Muskel- und Knochenschmerz, In Klinisches
und Kritisches Denken. Manual klinischer Symptome,
Syndrome und Risikofaktoren inklusive
e-Learning-Plattform Taschenbuch Facultas,
ISBN: 978-3-7089-2073-0; 2. Auflage 2021, Kainberger
F, Karanikas G, Schernthaner G, Szekeres T
(Herausgeber)
Grohs J, Kainberger F. Rückenbeschwerden. In Klinisches
und Kritisches Denken. Manual klinischer Symptome,
Syndrome und anderer Anlassfälle inklusive
e-Learning-Plattform. Franz Kainberger, Georgios
Karanikas, Gerit Schernthaner, Thomas Szekeres.
ISBN: 978-3-7089-2073-0; 2. Auflage 2021; 415-8
Hager B, Raudner M, Juras V, Zaric O, Szomolanyi
P, Schreiner M, Trattnig S. MRI of Early OA in: Early
Osteoarthritis - State-of-the-Art Approaches to
Diagnosis, Treatment and Controversies, Springer
2021, pp. 17-26
Hobusch GM, Windhager R, Chondrosarcoma of
the Pelvis, Book chapter in Surgery of Pelvis Bone
Tumors, Springer ISBN: 978-3-030-77007-5, Book
chapter, Pages 55-62
Hobusch GM et al, Implant Reconstruction of the
Distal Femur: Expandable Prosthesis.in Orthopedic
Surgical Oncology For Bone Tumors, A case Study
Atlas, DOI 10.1007/978-3-030-73327-8_24 book
Chapter
Hruby LA, Mayer JA, Aszmann OC. Inner Amputations
of the Upper Extremity. In: Bionic Limb Reconstruction,
Oskar C. Aszmann and Dario Farina.
2021, Springer
Hruby LA. Deafferentation Pain Following Brachial
Plexus Avulsion Injuries. In: Bionic Limb Reconstruction,
Oskar C. Aszmann and Dario Farina. 2021, Springer
Hruby LA, Sturma A.Treatment Algorithm for Bionic
Hand Reconstruction in Patients with Global Brachial
Plexopathies. In: Bionic Limb Reconstruction,
Oskar C. Aszmann and Dario Farina. 2021, Springer
Hruby LA, Sturma A, Pittermann A. Functional and
Psychosocial Outcomes of Bionic Reconstruction
and Impact on Quality of Life, Body Image Perception
and Deafferentation Pain In: Bionic Limb Reconstruction,
Oskar C. Aszmann and Dario Farina.
2021, Springer
Negrin LL: Epidemiology and Classification of Distal
Femur Fractures. In: Knee Fractures. Marc Hanschen,
Peter Biberthaler, James P. Waddell, Springer,
ISBN 978-3-030-8175-6. 297 Seiten
Pittermann A, Hruby LA, Sturma A, Aszmann OC.
Psychosocial Importance of the Hand and Consequences
of Severe Hand Trauma, Amputation and
Complete Brachial Plexus Injury. In: Bionic Limb Reconstruction,
Oskar C. Aszmann and Dario Farina.
2021, Springer

Publikationen
77
Pittermann A, Hruby LA, Sturma A, Aszmann OC.
Ethical Considerations and Psychosocial Evaluation
in Elective Amputation for Brachial Plexus
Injuries. In: Bionic Limb Reconstruction, Oskar C.
Aszmann and Dario Farina. 2021, Springer
Staats K, Mokrusa, Sauer, Kainberger; Medizininformatik,
Kritisches und Klinisches Denken, Seite:
43 - 53; Verlag: Facultas ISBN: 978-3708920719
Sturma A, Hruby LA, Diers M. Epidemiology and
Mechanisms of Phantom Limb Pain. In: Bionic Limb
Reconstruction, Oskar C. Aszmann and Dario Farina.
2021, Springer
Sturma A, Hruby LA, Vujakilija I, Østlie K, Farina
D. Treatment Strategies for Phantom Limb Pain.
In: Bionic Limb Reconstruction, Oskar C. Aszmann
and Dario Farina. 2021, Springer
Diplomarbeiten/Dissertationen 2021
Apprich S: Moritz Priol. Einfluss der medialen
Menis kusextrusion auf den Knorpel der Belastungszone
des femoromedialen Kompartiments im
Kniegelenkretrospektive Evaluierung anhand von
quantitativem T2 Mapping auf 3 Tesla
Benca E: Beatrice Ferrante (Politecnico di Milano).
Analysis of thermal effects in the bone cortex caused
by the implantation of transfemoral osseointegrated
prosthesis.
Giurea A: Franz Xaver Feichtinger: Vergleich: Navigationsdaten
und Röntgenanalyse
Giurea A: Richard Koza. Outcome von Knierevisionsprothesen
7 Jahresergebnisse
Gregori M, Aldrian S: Anna Hohensteiner. Mittelfristige
und Langzeitergebnisse nach operativer
Refixation von chondralen und osteochondralen
Abscherfrakturen im Kniegelenk (18.11.2020)
Haider T, Negrin L: Philipp Pauli. The role of thrombocytes
after severe thoracic trauma – a retrospective
study (17.12.2020)
Haider T, Hajdu S: Melanie Winter. Kalkaneus
Frakturen - Vergleich operativer und konservertiver
Therapie - eine retrospektive Studie (21.12.2020)
Hasenöhrl T, Widhalm H: Sebastian Rilk. Isokinetic
and Isometric Biodex quadriceps strength
testing following anterior cruciate ligament reconstruction:
A systematic review and meta-analysis.
(28.6.2021)
Hofbauer M, Binder H: Maximilian Gruber. Management
und Outcome der seltenen unteren Schulterluxation
(Luxation Erecta): eine single-center Studie
(8.10.2020)
Hofbauer M, Ostermann R: Claus Derek Bukowsky.
Ist der Discus acromioclavicularis durch eigene
Schmerzfasern eine mögliche Ursache für Schulterschmerzen?
(16.12.2020)
Humenberger M, Hajdu S: Cornelia Naß. Inzidenz
und Ursache der Peroneusläsion nach Verriegelungsnagelung
bei Unterschenkelfrakturen - Eine
retrospektive Studie (31.3.2021)
Kdolsky R: Jakob Ulreich. Effektivität der radialen
extrakorporalen Stoßwellentherapie im Vergleich
zu anderen konservativen Therapien und Placebo
für die laterale Epikondylitis des Ellenbogens.
Eine systematische Literaturarbeit und Metaanalyse
von randomisiert kontrollierten Studien
(8.10.2020)
Kdolsky R: Benjamin Nikolaus Janda. Die Rolle des
operativen Eingriffs in der Behandlung des lateralen
Bandapparates im oberen Sprunggelenk nach
Supinationstrauma (24.2.2021)
Lass R, Rentenberger C: Daniel Birgsteiner. Navigierte
Hüftendoprothetik – Verlaufsbeobachtung
einer prospektiv randomisierten Kontrollstudie.
Lass R: Co-Betreuer: Lukas Rabitsch. 10-Jahres
Untersuchung nach zementfreier Knietotalendoprothese.
Maier B, Aldrian S: Julia Strasser. Funktioneller
Outcome nach Therapie von Luxationen und Luxationsfrakturen
der Mittelhand (21.4.2021)

Publikationen
78
Negrin L: Greta Carlin. Serum level alterations of
matrix metalloproteinases (MMPs) and tissue
inhibitors of metalloproteinases (TIMPs) in polytraumatised
patients (24.2.2021)
Payr S, Hofbauer M: Karin Valentina Leitner.
Eine retrospektive und epidemiologische Datenanalyse
von Übergangsfrakturen – Inzidenz,
Ursachen, Diagnostik, Therapie und Outcome
einer Verletzung im Kindes- und Jugendalter
an einem Level I Trauma zentrum
(27.5.2021)
Payr S, Hofbauer M: Andrea Schuller. Spine injuries
in children and adolescents - frequency, causes,
diagnostics, therapy and outcome at a Level I
trauma center a retrospective, epidemiological
data analysis (29.9.2021)
Sarahrudi K, Tiefenböck T: Christian Schützner.
Die Inzidenz und Therapie von Frakturen nach
Lungentransplantationen - Eine explorative Single
Center Studie (4.12.2020)
Schreiner M: Ina Bischofs, Beinlängenausgleich
durch Epiphysiodese im Kindesalter – eine retrospektive
Vergleichsstudie zwischen RigidTack und
PETS (29.9.2021).
Staats K: Alexander Banyai. Der Einfluss des
Kragens auf das Prothesenüberleben bei zementfreien
Hüfttotalendoprothesen, eine retrospektive
Datenanalyse (21.4.2021).
Tiefenböck T, Hofbauer M: Manuel Wildtgrube.
The All-inside Anterior Cruciate Ligament Reconstruction
Technique? A Gender-Based Difference
in Results and Outcome After 2 Years of Experience
(21.4.2021)
Tiefenböck T: Thomas Sator. Surveillance von
postoperativen Wundinfektionen nach operativer
Versorgung pertrochantärer und subtrochantärer
Frakturen? Eine retrospektive Datenauswertung
(3.5.2021)
Tiefenböck T, Sarahrudi K: Olga Bajenov. Die Anwendung
von BMP-2 in der Therapie von Knochendefekten
am Mausmodell (10.6.2021)
Tiefenböck T: Thomas Böhm. Die Behandlung von
diaphysären Femurfrakturen mittels Fixateur externe
Versorgung bei PatientInnen im Alter von zwei
bis 16 Jahren (10.6.2021)
Tiefenböck T: Vinzenz Bussek. Sekundäre Nagelung
nach primärer Versorgung mittels Externen
Fixateur eine Single Center Studie (10.6.2021)
Tiefenböck T: Silvina Elena Ohnesorg. Thoraxverletzungen
bei polytraumatisierten Kindern und
Jugendlichen Epidemiologie, Behandlung und Ergebnisse
Eine retrospektive Studie (1.9.2021)
Toegel S: Patrick Mannsberger. Biocompatibility of
3D printed materials: Cytotoxicity tests with L929
cells, primary chondrocytes and synovial fibroblasts.
(4.5.2021)
Waldstein W: Eugen Lacic. Präoperative Beurteilung
der Meniskusrampe im MRT bei Patienten mit
Ruptur des vorderen Kreuzbands.
Walzer S, Toegel S: Christopher Bauer. Effects of
BMP-6 and inflammatory cytokines in human fibroblast-like
synoviocytes under mechanical stimulation.
(27.7.2021)
Widhalm H: Julia Elisabeth Zieger. Epidemiologische
Aspekte von Frakturen im Kindes- und Jugendalter
- Einfluss der Zunahme der Verwendung
elektronischer Geräte. Eine retrospektive Studie an
circa 5.000 Patienten. (7.7.2021)
Preise 2021
Casado Losada I: Best Poster Presentation 2. Prize,
Young Scientist Association (YSA)
Casado Losada I: Science Art contest,
Young Scientist Association (YSA)
Fürsatz M: Best Poster Chair Award, TERMIS 2021
Hobusch GM: Austrian Musculo-Skeletal-Oncologic
Society (AMSOS) Research Promotion Prize

Publikationen
79
2020/2021: Electronically Patient Reported Outcomes
(EPROS) Analysis in Patients with Musculoskeletal
Sarcomas.
Morgenbesser R: AUB Wissenschafts-Posterpreis.
Jahrestagung der Österreichischen Arbeitsgemeinschaft
für Urogynäkologie und rekonstruktive
Beckenbodenchirurgie (AUB)
Nürnberger S: Battle for the topic „Scaffolds“ on
EORS 15. – 17.9.2021, Rome/Italy
Willegger M, Karin Hebenstreit, Martin Zalaudek, Alexander
Kolb, Reinhard Windhager, Catharina Chiari,
1. Poster Preis, Use of the bimalleolar method shows
the highest reliability in measuring tibial torsion on
paediatric rotational MRI, Vereinigung für Kinderorthopädie
(VKO), Graz, Austria, Oktober 2021
Zak L: 2. Platz des ÖGU Förderpreises für Open
Access Publikationen “Third generation Autologous
Chondrocyte Implantation at the knee joint using
the Igo ® scaffold – a case series”
Drittmittelfinanzierte Projekte 2021
Projektleitung: Benca E
Fixation of the ACL using an allograft osteosynthesis
system. Surgebright GmbH (Industrie),
Projektlaufzeit: 22.2.2021 – 22.2.2022
Laufzeit: 12 Monate
Gesamtfördersumme: 6.000 €
Projektleitung: Halát G
Vorstellung einer innovativen, Anker-basierten
Rekonstruktionstechnik in der chirurgischen
Therapie der A2-Ringband Ruptur. Eine experimentelle
Studie am humanen Kadavermodell.
Medizinisch-Wissenschaftlichen Fonds des
Bürgermeisters der Bundeshauptstadt Wien
Projektnummer: 20029
Zuteilungsdatum: Juni 2020
Laufzeit: 18 Monate
Fertigstellung des Projektes: November 2021
Gesamtfördersumme 1.000 €
Projektleitung: Maier B
Beurteilung des Heilungsprozesses bei
konservativ behandelten distalen Radiusfrakturen
sowie Identifizierung osteoporotischer
Frakturen bei postmenopausalen Frauen mittels
HrPQCT (hochauflösende periphere quantitative
Computertomographie)
Medizinisch-Wissenschaftlicher Fonds des
Bürgermeisters der Bundeshauptstadt Wien
Projektnummer: 20043
Zuteilungsdatum: 4.6.2020
Laufzeit: 18 Monate bis Juni 2022
Gesamtfördersumme 2.000 €
Projektleitung: Negrin L
Welche Schlussfolgerungen lässt der
zeitliche Verlauf von Biomarkerspiegeln, die
im Blut von Polytrauma-Patienten erhoben
werden, zu? – Eine Pilotstudie
Förderung der Österreichischen Gesellschaft
für Unfallchirurgie
Start: Jänner 2019
Laufzeit: 48 Monate
Projektlaufzeit: 01.2019 – 12.2022
Gesamtfördersumme 10.000 €
Projektleitung: Nürnberger S
Cartilage for Cartilage regeneration: Laser engraved
decellularized cartilage as biomaterial for
defect treatment
FFG Bridge 1 Projekt
Projektnummer: 874759
Bewilligung: Juni 2019
Laufzeit: 36 Monate + 12 Monate
Projektlaufzeit: 1.10.2019 – 30.9.2023
Gesamtfördersumme 317.936 € (UCO 40.748 €)
Projektleitung: Nürnberger S
Laserbasierte Methode zur Wiederbesiedelung
von dezellularisierter Knorpelmatrix
(LaserScaffold) für die Knorpelregeneration
Lorenz Böhler Fonds
Projektnummer: 5/19
Bewilligung: Mai 2019
Laufzeit: 18 Monate + 10 Monate
Projektlaufzeit: 1.9.2019 – 31.12.2021
Gesamtfördersumme 33.464 €

Publikationen
80
Projektleitung: Schwarz G
Titel: Femorale Stabilität nach Marknagel-
Entfernung – Anatomische und biomechanische
Auswertung.
Geldgeber: Medizinisch-wissenschaftlicher Fonds
des Bürgermeisters der Bundeshauptstadt Wien
Nummer des Projektes: 21072
Zuteilungsdatum: 1.7.2021
Laufzeit: 12 Monate
Voraussichtliche Fertigstellung: Juli 2022
Gesamtfördersumme 13.500 €
Projektleitung: Staats K
Titel: Functionalization of Nanopatterned Titanium
(Ti) for Biomedical Application (FTiBA)
Geldgeber: CEST
Zuteilungsdatum: 15.9.2020
Laufzeit: 15,5 Monate
Voraussichtliche Fertigstellung: 31.12.2021
Gesamtfördersumme 33.696 €
Projektleitung: Toegel S.
Titel: Identifizierung von Galektinrezeptoren in
arthrotischen Knorpelzellen
Geldgeber: Johnson&Johnson
Zuteilungsdatum: 1.8.2019
Laufzeit: 18 Monate
Voraussichtliche Fertigstellung des Projekts:
Ende 2021
Gesamtfördersumme 75.000 €
Projektleitung: Toegel S.
Titel: AFOR Wissenschaftspreis 2020
Geldgeber: Association for Orthopaedic Research
Zuteilungsdatum: 1.11.2020
Laufzeit: 23 Monate
Voraussichtliche Fertigstellung des Projekts:
Ende 2022
Gesamtfördersumme 6.250 €
Projektleitung: Widhalm HK
The Clinical Relevance of micro RNAs in Mild
Traumatic Brain Injury - A Pilot Study
(Micro RNA Diagnostik bei Schädelhirntrauma)
Medizinisch-Wissenschaftlichen Fonds des
Bürgermeisters der Bundeshauptstadt Wien
Zuteilungsnummer des Projekts: 15113
Zuteilungsdatum: 1.12.2015
Laufzeit: 60 Monate
Fertigstellung des Projekts: Ende 2021
Gesamtfördersumme 13.000 €
Vorsitz bei Tagungen 2021
Aldrian S
Minimalinvasive Osteosynthesen II, 57. ÖGU &
2. ÖGOuT Jahrestagung (Online) „Minimalinvasive
Unfallchirurgie und Orthopädie“, 7. – 9.10.2021,
Österreich
Casado Losada I
Mechanisms of action in skeletal biology and repair,
6. World Congress of the Tissue Engineering and Regenerative
Medicine International Society (TERMIS),
Maastricht, 15. – 19.11.2021 (online), Niederlande;
Engineering extracellular matrices: fabrication methods,6.
World Congress of the Tissue Engineering
and Regenerative Medicine International Society
(TERMIS), Maastricht, 15. – 19.11.2021 (online)
Chiari C
Surgical Treatment: What is best for spine and pelvis?
39. EPOS Annual Meeting, European Paediatric
Orthopaedic Society, 14.4.2021 (online)
Deformitäten II, Trauma, Varia. 1.10.2021, 34. Jahrestag
und der Vereinigung der Kinderorthopädie e.V.,
30.9. – 2.10.2021, Graz
Kursorganisation. Ausbildungskurs der Medizinischen
Universität Wien - Sonografie der Säuglingshüfte
nach Graf – 15. – 16.10.2021
Vortragsblock 4: Wirbelsäule operative, ÖGO/BVDO
Tagung, 20.11.2021 Wien
Frenzel S
Workshop des Jungen Forums der ÖGU – „Minimalinvasive
Chirurgie“. 57. Jahrestagung der Österreichischen
Gesellschaft für Unfallchirurgie,
(7. – 9.10.2021): 7.10.2021
Fürsatz M
Postersession: Use of bioelectronic, biomagnetic
and biophysical approaches in Regenerative Medicine
6. World Congress of the Tissue Engineering and
Regenerative Medicine International Society (TER-
MIS 2021), Maastricht, 15. – 19.11.2021 Niederlande

Publikationen
81
Grohs J
22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.
virtuelle Live Diskussion Wirbelsäule mit
Abstand 20.2.2021. Wien, 30.1.2021
Halát G
Aktuelle Herausforderungen in der Schwerstverletztenversorgung
4. Interdisziplinären Polytraumasymposium
Österreich
Humenberger M
Sitzung des Jungen Forums der ÖGU & Assistent*innenversammlung
57. ÖGU & 2. ÖGOuT Jahrestagung
(Online) ‚Minimalinvasive Unfallchirurgie
und Orthopädie‘, 7. – 9.10.2021 Österreich
Kdolsky R
ESTES webinar: „Management of periarticular injuries
of the knee“, 22.3.2021,ESTES virtual week:
„Recommendations on thoraco-lumbar fractures“,
25.4.2021
Nürnberger S
Knorpel-Session, „Annual Meeting Austrian Cluster
for Tissue Regeneration“, 30. – 31.8.2021, Wien
Pajenda G
Postervorträge 57. ÖGU & 2. ÖGOuT Jahrestagung
(Online) „Minimalinvasive Unfallchirurgie und
Ortho pädie“, 7. – 9.10.2021 Österreich
Sigmund IK
Best Paper Session. 39. Annual Meeting of the European
Bone and Joint Infection Society. 7. – 9.10.2021
Ljubljana, Slovenia
Springer B
Workshop des Jungen Forums der ÖGU – „Minimalinvasive
Chirurgie“, 57. ÖGU & 2. ÖGOuT Jahrestagung
(Online) ‚Minimalinvasive Unfallchirurgie und
Orthopädie‘, 7. – 9.10.2021, Österreich
Thalhammer G
Spezielle Fragestellungen 57. ÖGU & 2. ÖGOuT
Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie
und Orthopädie‘ vom 7. – 9.10.2021, Wien
Widhalm H
Interdisziplinäres Management 5. Österreichisches
Symposium für Perioperative Medizin – Hybridveranstaltung,
MUW, 01. Oktober 2021 Österreich
Weill Cornell Seminar Weill Cornell Seminar: Trauma
& Emergency Surgery: Austrian American Foundation
(AAF), 12. – 18.12.2021, Salzburg Österreich
Willegger M
Ausbildungskurs der Medizinischen Universität
Wien – Sonografie der Säuglingshüfte nach Graf, ao.
Univ.-Prof. Dr. Catharina Chiari, MSc; OA Priv. Doz. Dr.
Alexander Kolb, Priv. Doz. Dr. Madeleine Willegger
FEBOT, Dr. Markus Schreiner
Windhager R
Block I: OP Technik und die schwierige primäre TKA
AE-Masterkurs „Knie“, Arbeitsgemeinschaft Endoprothetik
GmbH Linz, 1.10.2021
ASG-Fellows: Hüftgelenk – von der Säuglingshüfte
bis zum Hüft-TEP-Wechsel, DKOU 2021, Berlin,
28.10.2021
Wissenschaftliche Leitung 2021
Negrin L
Wissenschaftliche Leitung: 23. GOTS Wintertreffen
– Stabil und Mobil – Vom Rumpf bis zur Extremität,
Online, 26. – 27.3.2021 Österreich
Leiter des Organisationskomitees: 4. Interdisziplinäres
Polytraumasymposium – Aktuelle Herausforderungen
in der Schwerstverletztenversorgung,
Online, 7.5.2021 Österreich
Wissenschaftliche Leitung: Beckenkurs – Osteosynthese
bei Beckenfrakturen am Humanpräparat,
Salzburg, 6. 10.2021 Österreich
Windhager R
Wissenschaftliche Leitung: Online Ausbildungskurs
„Tumororthopädie“ ÖGO, 12.3.2021
Wissenschaftliche Leitung: Medacta Surgical Days,
15. – 18. 6.2021, Graz
Wissenschaftliche Leitung: AE-Masterkurs „Knie“,
Arbeitsgemeinschaft Endoprothetik GmbH Linz,
1. – 2.10.2021

Publikationen
82
Präsidentschaften und
Funktionen bei Journalen 2021
Antoni A
Vorstandsmitglied der ADNANI (Interdisziplinäre
Arbeitsgemeinschaft Neuromedizin)
Döring K
Reviewer
World Journal of Surgical Oncology
Frenzel S
Reviewer
PLOS ONE
Giurea A
Guest Editor. Acta Chirurgica Austriaca
Wissenschaftlicher Beirat bei IATROS
Kolumne in: Sport in Wien, Echo Verlag Wien
Kolumne in: Running, Echo Verlag Wien
Grohs J
Corresponding Member, North American Spine
Society (NASS)
Reviewer Wiener Medizinische Wochenschrift
Beirat der Österreichischen Gesellschaft für
Wirbelsäulenchirurgie
Preiskommittee Otto Kraupp Preis
26.10.2021
Haider T
Reviewer
British Medical Journal (BMJ) Open
Injury – International Journal of the Care
of the Injured
European Journal of Trauma and Emergency
Surgery
Scientific Reports
BMC Musculoskeletal Disorders
Hajdu S
Preiskommission für den Günther-Schlag
Abstractpreis für junge Forscher*innen
Holzer S
Präsidiumsmitglied der Österreichische Gesellschaft
für Musik und Medizin (ÖGfMM) Leitung der
AG Musikermedizin 2020 – 2022
Kdolsky R
Section Chair
ESTES: skeletal trauma and sports medicine
Reviewer
International Journal of Environmental Research
and Public Health
Medicina
World Journal of Orthopedics
Medicines
Lass R
Editorial Boards
Austin Journal of Orthopedics & Rheumatology
World Journal of Orthopedics
Reviewer
Journal of Orthopedic Research
Bone & Joint Research
BMC Muskuloskeletal Disorders
Diagnostic Microbiology
European Journal of Clinical Microbiology & Infectious
Diseases
Expert Reviews
Journal of Functional Biomaterials
Negrin L
Editorial Board Member
Journal of Clinical Trials
Journal of Trauma & Treatment
Nürnberger S
Reviewer
Acta Biomaterialia
EBiomed
Ticks and Tick born deseases
Payr S
Reviewer
Journal of Orthopaedic Surgery and Research
Journal of Clinical Medicine
International Journal of Environmental Research
and Public Health
Children
Rothbauer M
Reviewer
RSC Lab on a chip, Acta Biomat, Small, Anal Chem,
Adv Science, Adv Materials, Adv functional mat,
Nature sci rep, Nature comms, World J Surg Onc,

Publikationen
83
Molecules, Micromachines, E&I Elektrotechnik,
Biophys rev, Biology, Adv mat techn, ACS biomat
sci eng, ACS appl bio mat, Biosensors, Methods
Biomech Bioeng, Life, Cell Biol Int, Pharmaceutics,
Vet Med, Appl Sci, Expert Opin Drug Deliv, Nanomaterials,
Eng rep, IJMS, J TERM, Electronics,
BioTechniques
Scientific Evaluator
The Dutch Cancer Society (KWF)/The Netherlands
Fundação para a Ciência e a Tecnologia, I. P. (FCT) –
the Portuguese public funding agency for R&D/
Portugal
The Dutch Research Council/The Netherlands
The Swiss National Science Foundation
Switzerland
Editorial and Board Positions
Reviewing Editor, Frontiers in Biotechnology
and Bioengineering
Reviewing Editor, MDPI Sensors
Editorial Board Member, Organs-on-a-Chip
(Elsevier)
Financial auditor for the EUSAAT
Salzmann S
Reviewer
Spine (Phila Pa 1976), World Neurosurgery
Current Sports Medicine Reports
Osteoporosis International
Sigmund IK
Ordinary Member of the Executive Committee
of the European Bone & Joint Infection Society
(EBJIS)
Associate Editor Journal of Bone and Joint Infection
(JBJI)
Reviewer
Bone & Joint Research (BJR)
Journal of Bone and Joint Infection (JBJI)
Archives of Orthopaedic and Trauma Surgery (AOTS)
Stelzeneder B
Reviewer
European Radiology
Thalhammer G
Reviewer
Journal of Plastic Surgery and Hand Surgery
Arthroscopy - the Journal of Arthroscopic and
Related Surgery
Tiefenböck T
Guest-Editor
Children – Special Issue ‚Frontier Research of
Orthopedic Trauma Surgery‘
Reviewer
Journal of Orthopaedic Surgery and Research
Journal of Clinical Medicine
International Journal of Environmental Research
and Public Health
Biomechanics
Plos ONE
Children
Toegel S
Reviewer
Arthritis Research & Therapy
Biochemical and Molecular Toxicology
Journal of Orthopecis Research
Osteoarthritis and Cartilage
Proteomics Clinical Application
Wiener Klinische Wochenschrift
Experimental and Molecular Pathology
Member of the Editorial Academy. ‚International Journal
of Molecular Medicine‘, Spandidos Publications.
Waldstein W
Reviewer
Archives of Orthopaedic and Trauma Surgery (AOTS)
Widhalm H
Reviewer
Orthopaedic Journal of Sports Medicine
Wiener Klinische Wochenschrift
Obesity Surgery
Neurosurgical Review
Knee Surgery Sports Traumatology Arthroscopy
American Journal of Sports Medicine
Journal of Clinical Medicine
Willegger M
Generalsekretärin – Österreichische Gesellschaft
für Fußchirurgie
Genderbeauftrage – Österreichische Gesellschaft
für Orthopädie
Vollmitglied – AGA Fuss- und Sprunggelenk Komitee
Reviewer
Arthroscopy
Clinical Orthopaedics and Related Research –
Journal of Orthopaedic Research

Publikationen
84
International Orthopaedics
Journal of Pediatric infectious diseases
BMC Musculoskeletal Disorders
Journal of Oncology
Windhager R
Section-Editor, Wiener Klinische Wochenschrift
(seit Juli 2021)
Mitherausgeber von Journal of Ortopaedic
and Traumatology (SIOT)
Mitglied des Redaktionsrates des JOT, Journal
of Othopaedic Translation (seit Sept. 2018)
Mitherausgeber der Z ORTHOP (2003 bis dato)
Jubiläumsfonds der Österreichischen Nationalbank
(OeNB)
Medizinisch wissenschaftlicher Fonds des
Bürgermeisters der Bundeshauptstadt Wien,
Mitglied des wissenschaftlichen Beirates der
Zeitschrift „Der Orthopäde“
Mitglied des wissenschaftlichen Beirates der
Zeitschrift „Arzt + Patient“
Reviewer
EFORT Open Reviews
Clinical Orthopaedics and Related Research
Journal of Clinical Medicine
Journal of Orthopaedics and Traumatolog
Zak L
Guest Editor
Journal of Clinical Medicine - Special Issue: Deformity
Correction, Bone Lengthening and Correction
Osteotomies of the Lower Limb
Reviewer
Medicina
World Journal Orthopaedics
Besuchte Kurse und Kongresse
Antoni A
14. Endoprothetikkongress, 25. – 27.2.2021 (online)
Arbeitsgemeinschaft Endoprothetik „Master kurs
Hüfte“ 25. – 26.3.2021 (online)
21. European Congress of Trauma & Emergency
Surgery, 25. – 30.4.2021 (online)
Virtual Instructional Pelvic (VIP) Course,
2.9.2021 (online)
57. ÖGU & 2. ÖGOuT Jahrestagung „Minimalinvasive
Unfallchirugie & Orthopädie”, 7. – 9.10.2021
(online)
34. Wissenschaftliche Sitzung der ADNANI
„Neuro-Radiologie eine Erfolgsgeschichte“
15. – 16.10.2021 Hannover/Deutschland
AE-Online-Kompaktkurs Spezial: Periprothetische
Frakturen, 10. – 11.11.2021 (online)
Trauma Oggi, 25.11.2021, Rom/Italien (online)
Aldrian S
ÖGU: Öffentliche Sitzung des Arbeitskreises Knie –
15.1.2021 (online)
70. ÖGU Fortbildung/„Alterstraumatologie – Frakturversorgung
bei Osteoporose und perioperatives
Management“ – 19.3.2021 und 20.3.2021
(online)
57. Jahrestagung der ÖGU und 2. Jahrestagung
der ÖGOuT – Minimalinvasive Unfallchirurgie &
Orthopädie, 7. – 9.10.2021
ÖGU öffentliche Sitzung des Arbeitskreises
Knorpel, 26.11.2021, (online)
2. Tiroler Osteotomie Kurs, Rum, Austria,
18.6.2021
Benca E
Thermal effects during bone preparation for- and
during insertion of osseointegrated transfemoral
implants 26. Congress of the European Society of
Biomechanics (online). 14.7.2021
Bumberger A
7. Master Class Symposium: Funktionelle Anatomie
und periphere Ligamentrekonstruktion des
Kniegelenks. Münster November 2021
Chiari C
34. Jahrestag und der Vereinigung der Kinderorthopädie
e.V., 30.9. – 2.10.2021, Graz.
AGA Akademie Kurs, Arthroskopie des Hüftgelenks
Würzburg, 5. – 6.11.2021
ÖGO Ausbildungsseminar Kinderorthopädie
18.11.2021, OSS Wien
ÖGO/BVDO Tagung, 20.11.2021 Wien
„Advanced Orthopedics and Traumatology – Aktuelle
Konzepte der Orthopädie und Traumatologie
(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-
und traumatologie, Osteotomien“,
25. – 27.11.2021

Publikationen
85
Döring K
Wiener Handkurs – Basiskurs, 17. – 21.5.2021, Wien
Sharkscrew – Operationskurs Fuß, 30.9. – 1.10.2021,
Oberösterreich
Frenzel S
70. ÖGU Fortbildung „Alterstraumatologie –
Fraktur versorgung bei Osteoporose und perioperatives
Management“ (19.3.2021, online)
71. ÖGU Fortbildung „Der Fuß das unbekannte Wesen
– Diagnostik und Therapie der akuten Verletzung
und Möglichkeiten der späteren Korrektur“
(28. – 29.5.2021, online)
41. SICOT Orthopaedic World Congress, Budapest,
Ungarn; 15. – 18.9.2021
57. Jahrestagung der Österreichischen Gesellschaft
für Unfallchirurgie, 7. – 9.10.2021
72. ÖGU Fortbildung „Das Hüftgelenk – Von der Rekonstruktion
bis zum Gelenksersatz“, 12.11.2021,
(online)
IRCAD- Wrist Surgery Course, 10. – 11.12.2021;
Strasbourg, Frankreich
4. interdisziplinäre Polytraumasymposium, „Aktuelle
Herausforderungen in der Schwerstverletztenversorgung“,
7.5.2021
Grohs J
22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.
Wirbelsäule mit Abstand, Wien 30.1.2021
Nextar Kurs Luzern 22. – 23.6.2021
Haider T
Deutscher Kongress für Orthopädie und Unfallchirurgie
(DKOU 2021), 26. – 29.10.2021, Berlin
Halát G
4. Interdisziplinäres Polytraumasymposium „Aktuelle
Herausforderungen in der Schwerstverletztenversorgung“,
7.5.2021, Wien
Symposium der Deutschsprachigen Arbeitsgemeinschaft
für Handchirurgie (DAH)
Rhizarthrose, Radius, PIP Gelenk und 3-D Planung,
7. – 8.5.2021(online)
Ehrensymposium für Prof. Dr. Leixnering, Der
Aufstieg der Handchirurgie in Österreich,
1.10.2021, Wien
Rheumahandkurs (Wiener Handkurse),
10. – 12.11.2021, Wien
IRCAD – Wrist Surgery Course „All around the Scaphoid“,
10. – 11.12.2021, Strasbourg, Frankreich
Hruby L
81. Jahreskongress swiss orthopaedics 2021 online
AGA Kongress September 2021 Innsbruck
Kolb A
34. Jahrestag und der Vereinigung der Kinderorthopädie
e.V., 30.9. – 2.10.2021, Graz
Negrin L
Minimal invasive Hüfttotalendoprothetik, Salzburg,
4. – 5.11.2021
ITS-Beckenkurs, Salzburg, 6.10.2021
Master Knee Course 2021, Hochrum, 23. – 24. 9.2021
IOC World Conference on Prevention of Injury & Illness
in Sport, Monaco, 25. – 27.11.2021
12 th IOC Advanced Team Physician Course, Istanbul,
1. – 3.11.2021
Deutscher Kongress für Orthopädie und Unfallchirurgie,
Berlin, 27. – 28.10.2021
57. Jahrestagung der ÖGU und 2. Jahrestagung der
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,
(online), 7. – 9.10.2021
36. Jahreskongress der der Gesellschaft für
Orthopädisch-Traumatologische Sportmedizin,
1. – 2.7.2021 (online),
Virtual EFFORT Congress – VEChybrid, Online,
30.6.2021
SPORTMED GRAZ 21 – Spitzensport braucht
Spitzenbehandlung, Graz, 11.6.2021
Payr S
57. ÖGU & 2. ÖGOuT Jahrestagung (online)
„Minimal invasive Unfallchirurgie und Orthopädie“,
7. – 9.10.2021, Wien
Hüftsonographie bei Säuglingen (Stolzalpe)
Rentenberger C
Wiener Handkurs – Basiskurs, 7. – 11.6.2021, Wien
57. Jahrestagung der Österreichischen Gesellschaft
für Unfallchirurgie (07. – 09.10.2021, online)
Deutscher Kongress für Orthopädie und Unfallchirurgie
(Berlin 26. – 29.10.2021, online)

Publikationen
86
Salzmann S
ORS (Orthopaedic Research Society) 2021 Annual
Meeting, 12. – 15.2.2021
International Society for the Study of the Lumbar
Spine (ISSLS) Virtual Annual meeting
31.5. – 4.6.2021
AO Spine Basis Kurs–Notfälle und Degeneration in
der Wirbelsäulenchirurgie
10. – 11.9.2021, Anatomischen Institut der Paracelsus
Medizinische Universität Salzburg
North American Spine Society 36. Annual Meeting
29.9. – 2.10.2021, Boston, MA
Global Spine Congress, 3. – 6.11.2021
Scheider P
Wiener Handkurs (Basis) Nr. 167/2 (12. – 16.04.2021)
Virtual EFORT Congress 2021 (30.6. – 2.7.2021)
34. Jahrestagung der VKO in Graz mit Operationskurs
(30.9. – 2.10.2021)
Sigmund IK
EBJIS (Webinar) 18.5.2021 Infection after
arthroscopy & sport-orthopaedic procedures
AE Masterkurs Knie, Linz 1. – 2.10.2021
39. EBJIS annual meeting Ljubljana, Slovenia,
7. – 9.10.2021
DKOU Berlin, 26. – 29.10.2021
Springer B
57. Jahrestagung der ÖGU und 2. Jahrestagung der
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,
7. – 9.10.2021 (online)
Stelzeneder B
ÖGU: Öffentliche Sitzung des Arbeitskreises Knie -
15.1.2021 (online)
70. ÖGU Fortbildung / „Alterstraumatologie - Frakturversorgung
bei Osteoporose und perioperatives
Management“, 19.03.2021 und 20.03.2021 (online)
4. Interdisziplinäres Polytraumasymposium „Aktuelle
Herausforderungen in der Schwerstverletztenversorgung“,
7.5.2021 (online)
71. ÖGU Fortbildung „Der Fuß – das unbekannte
Wesen – Diagnostik und Therapie der akuten Verletzung
und Möglichkeiten der späteren Korrektur-
28. – 29.5.2021 (online)
57. Jahrestagung der ÖGU und 2. Jahrestagung der
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,
7. – 9.10.2021 (online)
72. Fortbildung „Das Hüftgelenk - Von der Rekonstruktion
bis zum Gelenksersatz“, 12. – 13.11.2021
(online)
Sportmedizin Leistungsphysiologisch-Internistisch-Pädiatrischer
Grundkurs IV + Traumatologisch-Pädiatrischer
Grundkurs III + Praxisseminar
+ Ärztesport, 18. – 21.11.2021, St. Pölten
ÖGU öffentliche Sitzung des Arbeitskreises Knorpel,
26.11.2021, (online)
Thalhammer G
Surgery of the Spastic Upper Limb, 16.4.2021
4. Interdisziplinäres Polytraumasymposium „Aktuelle
Herausforderungen in der Schwerstverletztenversorgung“,
7.5.2021
Virtuelles DAH Symposium, „Rhizarthrose, Radius,
PIP Gelenk und 3-D Planung“, 7. – 8.5.2021
71. Fortbildung ÖGU: „Der Fuß das unbekannte Wesen
– Diagnostik und Therapie der akuten Verletzung
und Möglichkeiten der späteren Korrektur“,
28. – 29.5.2021
„Operationskurs Hand - Osteosynthese mit humanbiologischem
Gewebe“ 7. – 8.6.2021
ISAKOS Innovative Techniques in Elbow Arthroscopy,
17.6.2021
57. ÖGU & 2. ÖGOuT Jahrestagung (online) „Minimalinvasive
Unfallchirurgie und Orthopädie“,
7. – 9.10.2021, Wien
72. Fortbildung ÖGU: „Das Hüftgelenk – Von der Rekonstruktion
bis zum Gelenksersatz, 12.11.2021
IRCAD - Wrist Surgery Course / Open Wrist Surgery
Workshop, 10. – 11.12.2021, Strasbourg, Frankreich
Tiefenböck T
ÖGU Jahrestagung
AGA Jahrestagung
ÖÄK ärztliche Wundbehandlung
Toegel S
2021 OARSI Virtual World Congress on Osteoarthritis,
29.4. – 1.5.2021
Scientific Advisory board meeting 2021 of the Ludwig
Boltzmann Institute for Arthritis and Rehabilitation.
7.5.2021 ( online).
Waldstein W
DKOU Berlin 26. – 29.10.2021

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Weihs V
Wiener Handkurse - Rheuma Handkurs
10. – 12.11.2021
ESICM 34 th ESICM LIVES Digital Annual Congress
2021, 3. – 6.10.2021
SICOT 41.SICOT Orthopaedic World Congress,
Budapest 15. – 18.9.2021
Jahrestagung 2021 Österreichische Kardiologische
Gesellschaft 27. – 28.5.2021
DAH Symposium 2021, 8.5.2021 (online)
4. Interdisziplinäres Polytrauma Symposium
„Akutelle Herausforderungen in der Schwerverletztenversorgung“,
7.5.2021
Widhalm HK
Knie Konsensus Meeting – Update Kreuzband –
Transplantatwahl und extraartikuläre Zusatzeingriffe,
15.1.2021, (online)
The Meniscus – Webinar NEWS – ESSKA,
30.1.2021
Modern Trauma Care – Expertenforum zur Zukunft
der Orthopädie und Traumatologie, AUVA
Webinar, 25. – 26.2.2021
Orthopädisch-Traumatologisch-Physikalischer
Grundkurs II – Ärztekammer, 27. – 28.2.2021 (online)
ÖGO-Ausbildungsseminar: Tumor-Orthopädie,
12.3.2021 (online)
70. ÖGU-Fortbildungsveranstaltung: „Alterstraumatologie
– Frakturversorgung bei Osteoporose
und perioperatives Management“ ONLINE,
19. – 20.3.2021
4.Interdisziplinäres Traumasymposium – MUW
Unfall, Wien, Online, 7.5.2021
GOTS-Webinar, 29.6.2021
AGA-Jahrestagung, Innsbruck – Hybrid Online,
9. – 11.09.2021
Fusskurs – Fußchirurgie in der Orthopädie – ÖGO
Ausbildungsseminar – Speising, 10. – 11.9.2021
TNT-Traumaregister-Jahrestreffen-Meeting, Salzburg
(Hybrid & Online), 17.9.2021
Mathys Hüfte – optimys / RM Pressfit, Salzburg –
Paracelsus Privatuniversität Salzburg (PMU), 29.-
30.9.2021
57. ÖGU & 2. ÖGOuT Jahrestagung (Online) „Minimalinvasive
Unfallchirurgie und Orthopädie“ vom
7. – 9.10.2021, Wien
5. Österr. Symposium für Perioperative Medizin –
Hybridveranstaltung, MUW, 29. – 30.10.2021
Behandlung von Wirbelkörperfrakturen - Hands-
On Training, Düsseldorf – Stryker, 2. – 3.11.2021
72.ÖGU Fortbildung - Das Hüftgelenk –Von der Rekonstruktion
bis zum Gelenksersatz, AUVA Online,
12. – 13.11.2021
Öffentliche Sitzung des Arbeitskreises Knorpel der
österreichischen Gesellschaft für Unfallchirurgie –
Update in der Knorpelchirurgie, 26.11.2021 (online)
Willegger M
IPOS – International Paediatric Orthopaedic Symposium
2021 – 7. – 11.12.2021, Orlando, FL, USA
Vorträge
Aldrian S
Eingeladender Vortrag: Update in der Knorpelchirurgie
Sitzung des Arbeitskreis Knorpel der ÖGU
Österreich
Eingeladender Vortrag: State of the Art der Knorpelchirurgie
Fachgruppensitzung der Ärztekammer
Österreich
Eingeladender Vortrag: Kniegelenksarthroskopie –
Grundlagen und Expertentipps 57. ÖGU & 2. ÖGOuT
Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie
und Orthopädie‘ vom 7. – 9.10.2021 Österreich
Eingeladender Vortrag: Das Polytrauma aus unfallchirurgischer
Sicht (Thorax, Abdomen, Becken)
1. Notarztkurs der Univ. Klinik für Anästhesie, Allg.
Intensivmedizin & Schmerztherapie in Kooperation
mit der Univ. Klinik für Notfallmedizin und dem
WIGEV Österreich
Antoni A
Eingeladender Vortrag: Diagnostik & Management
des leichten Schädel-Hirn Traumas bei antithrombotischer
Therapie 34. Wissenschaftliche Sitzung
der ADNANI, 16.10.2021, Hannover/Deutschland
Deutschland
Complex Pelvic Trauma: A territory disputed by
orthopedics and trauma surgeons Trauma Oggi,
25.11.2021, Rom/Italien (online)
Casado-Losada I
Técnicas de descelularización para regeneración
de cartílago (translation: decellularization

Publikationen
88
techniques for cartilage regeneration III Congreso
Internacional de Tecnología Médica – EAP Tecnología
Médica. Universidad Norbert Wiener, Perú.
(Translation: III International Congress of Medical
Technology) 22. – 24.10.2021 Peru
Pitch talk: in vitro model of decellularized cartilage
scaffolds for articular cartilage regeneration 1st
Annual Retreat of the Ludwig Boltzmann Institut
für Traumatologie, das Forschungszentrum in Kooperation
mit der AUVA. 22. – 24.9.2021 Österreich
It’s the stiffness not the density – decellularized auricular
cartilage scaffold (AuriScaff) as a model for
migration research Annual Meeting of the Austrian
Cluster for Tissue Regeneration, 30. – 31.8.2021.
Veterinary Medicine of Vienna (Vetmed). Österreich
Laser-engraving auricular cartilage scaffolds
enhance scaffold recellularization TERMIS SYIS
Virtual Seminar Series (online) Österreich
Cartilage Regeneration Group presentation from
LBI Traumatology TERMIS-EU Virtual Lab Tour series
Österreich
Stiffness or GAGs, what counts? A story of cell infiltration
Lunch seminars from the Ludwig Boltzmann
Institut Traumatologie, das Forschungszentrum in
Kooperation mit der AUVA Österreich
Chiari C
Grundkonzept „FAI und Dysplasie“. AGA Akademie
Kurs, AGA Hüftkomitee, Arthroskopie des Hüftgelenks
Würzburg, 5. – 6.11.2021
Wichtige Zugangswege zum Hüftgelenk. AGA Akademie
Kurs, AGA Hüftkomitee, Arthroskopie des
Hüftgelenks Würzburg, 5. – 6.11.2021
Grenzen der Hüftarthroskopie. Welche offenen Verfahren
haben sich bewährt? AGA Akademie Kurs,
AGA Hüftkomitee, Arthroskopie des Hüftgelenks
Würzburg, 5. – 6.11.2021
Epiphysiolysis capitis femoris. ÖGO
Ausbildungsseminar Kinderorthopädie
18.11.2021, OSS Wien
Gutartige Knochentumore. ÖGO Ausbildungsseminar
Kinderorthopädie 18.11.2021, OSS Wien
Wachstum. „Advanced Orthopedics and Traumatology
– Aktuelle Konzepte der Orthopädie und Traumatologie
(MSc)“ Modul 11 „Extremitätenkorrektur,
Kinderorthopädie- und traumatologie, Osteotomien“
25. – 27.11.2021
Beinachsenvermessung, Deformitätenanalyse,
Wachstumsprognose. „Advanced Orthopedics and
Traumatology – Aktuelle Konzepte der Orthopädie
und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,
Kinderorthopädie- und traumatologie,
Osteotomien“ 25. – 27.11.2021
Behandlung der SCFE, spezielle Techniken und
Komplikationen: Pinning, Verschraubung, SH Osteotomie,
Trochanter-Flip. „Advanced Orthopedics
and Traumatology – Aktuelle Konzepte der Orthopädie
und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,
Kinderorthopädie- und traumatologie,
Osteotomien“ 25. – 27.11.2021
DDH: Epidemiologie, Screening, wissenschaftliche
Basis. „Advanced Orthopedics and Traumatology –
Aktuelle Konzepte der Orthopädie und Traumatologie
(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-
und traumatologie, Osteotomien“
25. – 27.11.2021
Overview of malignant bone tumors, 39 th EPOS Annual
Meeting, European Paediatric Orthopaedic
Society, 14.4.2021 (online)
Tumor und Hüfte: Reliabilität und Unterschiede verschiedener
Messmethoden der Fermoralen Torsion
im Rotations-MRT. 34. Jahrestag und der Vereinigung
der Kinderorthopädie e.V., 30.9. – 2.10.2021, Graz
3 beste Vorträge, 3 beste Poster: Die Verwendung
der BImalleolar-Methode zeigt die reliabelsten Ergebnisse
zur Vermessung der Tibialen Torsion im
MRT. 34. Jahrestag und der Vereinigung der Kinderorthopädie
e.V., 30.09. – 2.10.2021, Graz
Döring K
Klinikwissen 21.1.2021: Grundlagen in der Diagnostik
und Therapie des Hallux Valgus Results in
the surgical treatment of aneurysmal bone cysts,
EMSOS 2021, 1.12.2021
Frenzel S
Eingeladender Vortrag: Versorgungskonzepte bei
periprothetischen Frakturen 72. ÖGU Fortbildung
„Das Hüftgelenk – Von der Rekonstruktion bis zum
Gelenksersatz“ 12.11.2021 (online) Österreich
Compex pelvic fractures with soft tissue injuries:
What to treat first International Conference of the
„Kazakhstan Association of Traumatologists and
Orthopedists“ 29.9. – 1.10.2021 (online) Kasachstan
ORIF in Tibial Plateau Fractures- Planning and Strategy
International Conference of the „Kazakhstan
Association of Traumatologists and Orthopedists“
29.9. – 1.10.2021 (online) Kasachstan

Publikationen
89
Emergency room requirements- the Vienna experience
International Conference of the “Kazakhstan
Association of Traumatologists and Orthopedists”
29.9. – 1.10.2021 (online) Kasachstan
Compex pelvic fractures with soft tissue injuries:
What to treat first 41. SICOT Orthopaedic World
Congress (Budapest, Ungarn; 15. – 18.9.2021)
Ungarn
Funovics Ph
Eingeladender Vortrag: Tumoren am Fuß – mit welcher
Inzidenz muss ich rechnen? 16.KLAUSURTA-
GUNG ZUR KONSENSUSFINDUNG DER ÖSTERREI-
CHISCHEN GESELLSCHAFT FÜR FUSSCHIRURGIE
Fuss-Tumoren und „PROMINENZEN“. 25.6.2021.
Fürsatz M
TERMIS SYIS Virtual Seminar Series, 29.6.2021
„Induction of spheroid-self assembly via growth
surface compartmentation“
Annual Meeting Austrian Cluster for Tissue Regeneration,
30. – 31.8.2021 „SpheroWell – a platform
technology for (cartilage) spheroids“
6 th World Congress of the Tissue Engineering and
Regenerative Medicine International Society (TER-
MIS 2021), Maastricht, 15. – 19.11.2021 „Self-assembly
of chondrogenic spheroids from cell-monolayers
via growth surface subdivision“
Haider T
Revisionsendoprothetik oder ORIF in Periprothetischen
Proximalen Femurfrakturen vom Typ Vancouver
B2 & B3: Systematischer Review und Meta-Analyse.
Deutscher Kongress für Orthopädie
und Unfallchirurgie (DKOU 2021), 26. – 29.10.2021,
Berlin
Halát G
Eingeladender Vortrag: Das Thoraxtrauma 32. NÖ
Notärztetagung der Ärztekammer Niederösterreich
am 30.5.2021 Österreich
Refixationstechniken bei Beugesehnenverletzungen
Arthrex Future Group Meeting – Distal Extremity
Österreich
Hobusch G
Eingeladender Vortrag: Functional Results after
Bone Sarcoma – Should we allow sports, virtual
EMSOS Graz 2021 (1. – 3.12.2021)
Expert Opinions about Sports Activity after Tumorendoprostheses-do
they differ in different parts of
the world? Virtual EMSOS Graz 2021(1. – 3.12.2021)
Functional Outcome and QOL after Sarcomas of the
Foot and Ankle Region-is early Amputation justified?
Virtual EMSOS Graz 2021 (1. – 3.12.2021)
Training day-Interactive Cases Soft tissue Sarcoma-Vienna
cases, virtual EMSOS Graz 2021
(1. – 3.12.2021), invited talk
Biopsy as the final point of staging, VEC (Virtual
EFORT Congress) Vienna 2021 (30.6.2021), invited
talk
Shall we improve sarcoma outcome and function
towards sporting activities? Functional Outcome in
Musculoskeletal Oncology, ISOLS Orthopedic Oncology
Webinar Series, 19.10.2021
Hruby L
Iatrogenic nerve injuries in primary and revision
reverse total shoulder arthroplasty Morgenfortbildung
Universitätsklinik für Orthopädie und Unfallchirurgie
Österreich
Bionische Rekonstruktion, Wiederherstellung an
der Grenze zwischen Mensch und Maschine Morgenfortbildung
Universitätsklinik für Orthopädie
und Unfallchirurgie Österreich
Iatrogenic nerve injury in primary and revision reverse
total shoulder arthroplasty 38. AGA Kongress,
9 – 11.9.2021, Innsbruck Österreich
Kdolsky R
Complications in pilon fractures. ESTES virtual
week: “Skeletal – Intraarticular fractures of the distal
tibia / Pilon tibiale” – 28.4.2021
Lass R
Senior Mentoring-Programm der MedUniWien im
Studienjahr 2020/21, 2021/22
Wahlpflichtfach Orthopädie-Konservativ-Operativ,
WS 21
Medacta Surgical Days, 15. – 18.6.2021, Graz
AE-Masterkurs Knie, 1. – 2.10.2021 Linz
11. Wiener Schmerztag, 8.10.2021 Rathaus Wien
DKOU 2021, 26. – 29.10.2021, Berlin
Negrin L
Serum Levels Of SRAGE Assessed AT Hospital Admission
may Provide Valuable Insights Regarding
The Appropriate Treatment Regimen in Polytrau-

Publikationen
90
matized Patients Virtual EFFORT Congress – VEC
hybrid, Online, 30.6.2021 Österreich
Morphologische MRT-Auswertungen liefern Größenvorgaben
für die adäquate Entnahme eines
Quadrizepssehnen-Knochenblocks 36. Jahreskongress
der der Gesellschaft für Orthopädisch-Traumatologische
Sportmedizin, Online, 1.7.2021 Österreich
Eingeladender Vortrag: Frakturversorgung 1. Notarztkurs
der Universitätsklinik für Anästhesie, Allgemeine
Intensivmedizin und Schmerztherapie
in Kooperation mit der Universitätsklinik für Notfallmedizin
und dem Wiener Gesundheitsverbund,
Wien, 9.2.2021 Österreich
Eingeladender Vortrag: Wintersport „Ski alpin“ Universitätslehrgang
‚Sportmedizin, MSc‘, Donauuniversität
Krems, 20.6.2021 Österreich
Nürnberger S
Eingeladender Vortrag: Cartilage for Cartilage Regeneration:
Development of a new scaffold generation.
Internationaler Tag der Frauen und Mädchen
in der Wissenschaft 11.2.2021 virtual
Scaffold based biological enhancement of cartilage
regeneration. EORS 15. – 17.9.2021 Rome Italy
Pajenda G
Konservative Behandlung der thorakolumbalen
Wirbelsäulenverletzungen AO Spine Kurs, Salzburg
September 2021 Österreich
Salzmann S
Thoracic Bone Mineral Density measured by Quantitative
Computed Tomography in Patients undergoing
Spine Surgery. International Society for the
Study of the Lumbar Spine (ISSLS) Virtual Annual
meeting May 4. Juni 2021
Preoperative MRI-based Vertebral Bone Quality
(VBQ) Score Assessment in Patients undergoing
Lumbar Spinal Fusion. North American Spine Society
36th Annual Meeting 29.9. – 2.10.2021 Boston, MA
Thoracic Bone Mineral Density measured by Quantitative
Computed Tomography in Patients undergoing
Spine Surgery. Global Spine Congress Paris,
France, (online) 3. – 6.11.2021
Preoperative MRI-based Vertebral Bone Quality
(VBQ) Score Assessment in Patients undergoing
Lumbar Spinal Fusion. Global Spine Congress Paris,
France, (online) 3. – 6.11.2021
Scheider P
Posttraumatischer Wachstumsfugenverschluss
an der kindlichen oberen Extremität Morgenfortbildung
Universitätsklinik für Orthopädie und Unfallchirurgie
Österreich
Schreiner MM
The influence of biologicals on aseptic arthroplasty
loosening, DKOU 2021, Berlin
Sigmund IK
Eingeladener Vortrag: Giftiger Dienstag, Wien –
Protheseninfektionen, 11.5.2021
(Ärztekammer, Wien) Webinar
Eingeladener Vortrag: AE Masterkurs Knie, Linz –
Infektdiagnostik bei PPI – Standardvorgehen ein
Muss! 2.10.2021
Eingeladener Vortrag: 39 th Annual Meeting of the
European Bone and Joint Infection society, Ljubljana
– The use of histology in the diagnosis of bone
and joint infections 7.10.2021
39 th Annual Meeting of the European Bone and Joint
Infection society, Ljubljana: Performance of routinely
available Serum Parameters in diagnosing periprosthetic
joint infections
DKOU Berlin 26. – 29.10.2021: Wilhelm- Roux-Preis-
Session: Der optimale Grenzwert der neutrophilen
Granulozyten in histologisch aufgearbeiteten Gewebeproben
zur Diagnostik von periprothetischen
Gelenksinfektionen
Block 21: Septische Arthritis und Osteomyelitis
Thalhammer G
Eingeladender Vortrag: Das instabile Handgelenk
Symposium Blickpunkt – Die instabile obere Extremität,
16.10.2021, Graz Österreich
Handgelenksarthroskopie – Grundlagen und Expertentipps
57. ÖGU & 2. ÖGOuT Jahrestagung
(Online) ‚Minimalinvasive Unfallchirurgie und Orthopädie‘,
07. – 09.10.2021 Österreich
Toegel S
Glycobiology: An emerging regulator of OA pathobiology.
Oral presentation at the 11 th Scientific Meeting
of the Ludwig Boltzmann Institute for Arthritis
and Rehabilitation. 24.3.2021.
Presentation of the Programme line „Chondrocyte
biology“. Oral presentation at the Online Evaluation
Meeting of the Ludwig Boltzmann Institute for Arthritis
and Rehabilitation. 5. – 6.10.2021

Publikationen
91
Waldstein W
VSOU 2021: Die radiologische Beurteilung der
Funktionalität des vorderen Kreuzbandes bei Patienten
mit Varusgonarthrose.
Weihs V
Comparison of characteristics of polytraumatized
patients with or without severe traumatic brain
injury and patients with isolated traumatic brain
injury 41 st SICOT Orthopaedic World Congress,
15.09. – 18.9.2021, Budapest Ungarn
Widhalm H
Polytrauma Strategies Weill Cornell Seminar:
Trauma & Emergency Surgery: Austrian American
Foundation (AAF), 12. – 18.12.2021, Salzburg Österreich
Traumatic Brain Injuries Weill Cornell Seminar:
Trauma & Emergency Surgery: Austrian American
Foundation (AAF), 12. – 18.12.2021, Salzburg Österreich
Windhager R
Eingeladener Vortrag: BMP signalling in Bone and
Cartilage Biology, 13.1.2021, BMP Virtual Forum
Eingeladender Vortrag: Therapie von Knochentumoren,
Online Ausbildungskurs „Tumororthopädie“
ÖGO, 12.3.2021
Eingeladener Vortrag: Spondylitis, Tumor und
Rheuma der Wirbelsäule, Lehrgang „Advanced Orthopedics
and Traumatology“, 19.3.2021, Zentrum
für Gesundheitswissenschaften und Medizin der
Donau-Universität Krems
Eingeladener Vortrag: Recombinant human BMP6
applied within Autologous Blood Coagulum accelerates
bone healing: Randomized controlled trials“,
14.4.2021, Salzburg
Eingeladener Vortrag: Reconstruction after tumor
resection in the extremities, OMI Hospital for Special
Surgery Seminar in Bone and Joint Surgery,
15.4.2021, Salzburg
Eingeladener Vortrag: Management of bone metastases,
OMI Hospital for Special Surgery Seminar in
Bone and Joint Surgery, 15.4.2021, Salzburg
„Survival of megaprostheses in oncology and revision“,
ISOLS Webinar, 20.4.2021, Houston, Texas
Keynote: Orthopädie 2030: Fokus Endoprothetik, 6.
Praevenire Gesundheitstage, 17. – 21.5.2021, Stift
Seitenstetten
Eingeladener Vortrag: „Kragen bei zementfreiem
Hüftschaft – hilfreich oder hinderlich?“ 26.5.2021,
Österreichischer Kongress für Orthopädie und
Traumatologie, Graz
Honorary Lecture: „Erwin Morscher Award”, EFORT
Annual Congress, 30.6. – 2.7.2021, Wien, Austria
Moderation: Blöcke Knie und Hüfte, Medacta Surgical
Days, 17.6.2021, Graz
„Der Kurzschaft in der Revisionsendoprothetik –
Was ist möglich?“, 1. Wiener Kurzschaftsymposium,
11.9.2021, Wien
Moderation: Functional Outcome in Musculoskeletal
Oncology, ISOLS Orthopedic Oncology Webinar
Series, 19.10.2021
Eingeladener Vortrag: „Hüftgelenknahe Tumoren:
Differentialdiagnostik und Therapie“, DKOU 2021,
Berlin, 28.10.2021
Eingeladener Vortrag: „Battle: Silver coating: Risk or
reason?“ 1.12.2021, 33 rd Annual Meeting of EMSOS
to take place on 1. – 3.12.2021, Graz Austria.
Moderation: „New guidelines and studies in sarcoma“,
2.12.2021, 33 rd Annual Meeting of EMSOS to
take place on 1. – 3.12.2021, Graz Austria.
Willegger M
Rotations-MRT, Accessorische Knochen am Fußskelett
und deren Relevanz. 16. Klausurtagung
zur Konsensfindung der Österreichischen Gesellschaft
für Fußchirurgie 25.6.2021, Mondsee
Österreich
Poster
Casado-Losada I
An in vitro model to unravel the mysteries of the
chondrogenic niche.
Osteoarthritis Research Society International
(OARSI) Virtual World Congress on Osteoarthritis
Connect 21, 29.4. – 1.5.2021.
Laser-engraving auricular cartilage scaffolds enhance
scaffold recellularization.
Young Scientist Association (YSA) MUW Symposium,
Wien, 17. – 18.6.2021.
Laser-engraved auricular cartilage scaffolds: the
next step on recellularization.
6 th World Congress of the Tissue Engineering and

Publikationen
92
Regenerative Medicine International Society (TER-
MIS 2021), Maastricht, 15. – 19.11.2021.
Chiari C
Die Verwendung der Bimalleolar-Methode zeigt die
reliabelsten Ergebnisse zur Vermessung der Tibialen
Torsion im MRT. 34. Jahrestag und der Vereinigung
der Kinderorthopädie e.V., 30.9. – 2.10.2021, Graz
Use of the bimalleolar method for tibial torsion
measurement shows the most reliable results in
MRI of paediatric patients, 39 th EPOS Annual Meeting,
European Paediatric Orthopaedic Society,
14.4.2021 (online)
Hofer C
Using means of transport and walking aids after
treatment for primary malignant bone tumors in the
lower extremity – A minimum follow-up of 20 years.
EMSOS 2021, 1. – 3.12.2021, Graz, Austria
Funovics P
Do extended reconstructions compensate prognostically
unfavourable soft tissue sarcoma? Deutscher
Kongress für Orthopädie und Unfallchirurgie
(DKOU 2021), 26.. – 29.10.2021, Berlin
Kolb A
Entwicklung eines elektronischen Navigationssystems
zur Eliminierung untersucherabhängiger Faktoren
in der Säuglings-Hüftsonographie nach Graf:
Preliminary Results. 34. Jahrestag und der Vereinigung
der Kinderorthopädie e.V., 30.9. – 2.10.2021,
Graz
Morgenbesser R
Verbessert lokales Östrogen Prolaps-assoziierte
Beschwerden bei postmenopausalen Patientinnen
mit symptomatischem Beckenorganprolaps?
Jahrestagung der Österreichischen Arbeitsgemeinschaft
für Urogynäkologie und rekonstruktive
Beckenbodenchirurgie (AUB) 1. – 2.10.2021
Innsbruck
Salzmann S
A Comprehensive MRI Analysis of Paraspinal and
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration
in Patients undergoing Lumbar Spinal Fusion.
ORS (Orthopaedic Research Society) 2021 Annual
Meeting, 12. – 15.2.2021
Preoperative MRI-based Vertebral Bone Quality
(VBQ) Score Assessment in Patients undergoing
Lumbar Spinal Fusion. ORS (Orthopaedic Research
Society) 2021 Annual Meeting, 12. – 15.2.2021
Thoracic Bone Mineral Density measured by Quantitative
Computed Tomography in Patients undergoing
Spine Surgery. ORS (Orthopaedic Research
Society) 2021 Annual Meeting, 12. – 15.2.2021
A Comprehensive MRI Analysis of Paraspinal and
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration
in Patients undergoing Lumbar Spinal
Fusion. International Society for the Study of the
Lumbar Spine (ISSLS) Virtual Annual meeting
31.5. – 4.6.2021
Preoperative MRI-based Vertebral Bone Quality
(VBQ) Score Assessment in Patients undergoing
Lumbar Spinal Fusion. International Society for the
Study of the Lumbar Spine (ISSLS) Virtual Annual
meeting 31.5. – 4.6.2021
A Comprehensive MRI Analysis of Paraspinal and
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration
in Patients undergoing Lumbar Fusion. Global
Spine Congress Paris, France, 3. – 6.11.2021
Scheider P
Temporary epiphysiodesis in adolescent patients
with ulnocarpal impaction syndrome 22 nd EFORT
Congress 2021 in Wien Österreich
Temporary epiphysiodesis in adolescent patients
with ulnocarpal impaction syndrome 34. Jahrestagung
der Vereinigung für Kinderorthopädie, Graz
Staats K
Langzeituntersuchungen des Zweymüller-Alloclassic
Geradschaftes mit einem Minimum-follow-up
von 30 Jahren, Deutscher Kongress für
Orthopädie und Unfallchirurgie (DKOU 2021),
26. –29.10.2021, Berlin
Weihs V
Psychocardiological Assessment in the Acute Phase
of the Takotsubo Syndrome. Somatic and Depressive
Disorders, Resilience and Illness Perception Jahrestagung
2021 Österreichische Kardiologische
Gesellschaft 27. –28.5.2021, Österreich
Treatment of Polytraumatized Patients in a Level 1
Trauma center between 1995 and 2019. 25-Year Experience
– what has changed? 34 th ESICM LIVES Digital
Annual Congress 2021, 3. –6.10.2021 Österreich

Publikationen
93
Willegger M
Die Verwendung der Bimalleolar-Methode zeigt
die reliabelsten Ergebnisse zur Vermessung der
Tibialen Torsion im MRT. Jahrestagung Vereinigung
für Kinderorthopädie (VKO), Graz, Austria,
Oktober 2021
Accessibility of the metatarsal head comparing
distraction and plantarflexion in a 2-portal
technique for first metatarsophalangeal (MTP 1)
joint arthroscopy.
Annual Meeting American Association for Anatomy,
April 2021
Gastärzte/Beobachter
Zaur Mugutdinov, Russland, 6.9. – 29.10.2021

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