Kompendium 2021 Forschung & Klinik
Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien; Leitung: o. Univ.-Prof. Dr. Reinhard Windhager www.meduniwien.ac.at/ortho-unfall www.unlimitedmedia.at/orthopaedie2021
Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien; Leitung: o. Univ.-Prof. Dr. Reinhard Windhager
www.meduniwien.ac.at/ortho-unfall
www.unlimitedmedia.at/orthopaedie2021
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<strong>Kompendium</strong> <strong>2021</strong><br />
<strong>Forschung</strong> & <strong>Klinik</strong><br />
Universitätsklinik für<br />
Orthopädie und Unfallchirurgie<br />
MedUni Wien und AKH Wien<br />
ISBN 978-3-200-08547-3<br />
www.meduniwien.ac.at/ortho-unfall
Kundenkompetenzzentrum mit<br />
Shop & Werkstätte:<br />
1210 Wien, Paukerwerkstraße 1c<br />
Tel.: 01/402 21 25-1000<br />
Email: office@ortoproban.at<br />
www.ortoproban.at<br />
1040 Wien, Wiedner Hauptstraße 76 Tel.: 01/402 21 25-3070<br />
1080 Wien, Josefstädter Straße 33 Tel.: 01/402 21 25-3010<br />
1110 Wien, Simmeringer Hauptstr 101-103 Tel.: 01/402 21 25-3080<br />
1130 Wien, St. Veit-Gasse 56 Tel.: 01/402 21 25-3040<br />
1130 Wien, Speisinger Straße 109 Tel.: 01/402 21 25-3090<br />
1160 Wien, Thaliastraße 45 Tel.: 01/402 21 25-3140<br />
1190 Wien, Heiligenstädter Straße 46-48 Tel.: 01/402 21 25-3060<br />
1210 Wien, Floridsdorfer Hauptstraße 45 Tel.: 01/402 21 25-3030<br />
1210 Wien, Brünner Straße 70 Tel.: 01/402 21 25-3100<br />
1230 Wien, Geßlgasse 5 Tel.: 01/402 21 25-3110<br />
1230 Wien, Anton-Baumgartner-Straße 44 Tel.: 01/402 21 25-3120<br />
2380 Perchtoldsdorf, Marktplatz 13 Tel.: 01/402 21 25-3130<br />
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Inhalt/Impressum<br />
3<br />
Die <strong>Klinik</strong><br />
4 Editorial<br />
6 Klinische Leistungen und Operationen<br />
9 Spezialambulanzen zunehmend gefragt<br />
10 Interview mit o. Univ.-Prof. Dr. Reinhard Windhager:<br />
„Unsere <strong>Forschung</strong> orientiert sich an den täglichen<br />
klinischen Problemen“<br />
14 Die Expertinnen und Experten auf einen Blick<br />
18 Ambulanzverzeichnis der Universitätsklinik<br />
für Orthopädie und Unfallchirurgie<br />
Impressum:<br />
Herausgeber:<br />
Universitätsklinik für<br />
Orthopädie und Unfallchirurgie<br />
MedUni Wien und AKH Wien<br />
o. Univ.-Prof. Dr. Reinhard<br />
Windhager<br />
Währinger Gürtel 18–20<br />
1090 Wien<br />
Redaktion & Gestaltung:<br />
Unlimited Media<br />
www.unlimitedmedia.at<br />
Lektorat: Sophie Hermann,<br />
BSc, Alexandra Lechner<br />
Fotos: iStock-458810669/<br />
SomkiatFakmee,<br />
Unlimited Media, MedUni<br />
Wien/Christian Houdek,<br />
Mark Glassner, Alexander<br />
Bumberger<br />
Druckerei: Copydruck KG<br />
Sandleitengasse 9–13<br />
1160 Wien<br />
Wien, Juli 2022<br />
ISBN 978-3-200-08547-3<br />
TOP-Studien<br />
22 Clinical Comparison of Four Different Graft Types in<br />
Matrix-Associated Autologous Chondrocyte transplantation<br />
26 Patient-Specific Implants for Pelvic Tumor Resections<br />
30 Size Matters as Critical Parameter for the Reliability<br />
of Spheroids in Drug Screening Applications<br />
34 Pseudotumors in Metal-on-Metal Total Hip Arthroplasty<br />
37 Safe Bone Block Harvesting for Quadriceps Tendon Autografts<br />
40 Semi-Quantitative and Quantitative MRI for the<br />
Assessment of Cartilage Repair and Intervertebral Discs<br />
43 Bone Mineral Density of the Thoracic Spine<br />
46 Asso ci a tion of Varus Deformity and Coronal<br />
Tibiofemoral Subluxation<br />
49 Outcome after Arthroscopically Assisted TFCC Refixation<br />
52 Osseointegration Can Be Improved by Conventionally Used<br />
Anti-Osteoporotic Drugs Proven in a Clinically Relevant<br />
Murine Implant Model<br />
56 Mimicking the Zonal Organization of Articular<br />
Cartilage in Vitro<br />
58 Relevance of Follow-up CCT in Patients on Intracranial<br />
Pressure Monitoring<br />
Publikationen<br />
62 Originalarbeiten <strong>2021</strong><br />
E-Book<br />
www.meduniwien.ac.at/ortho-unfall<br />
www.unlimitedmedia.at/orthopaedie<strong>2021</strong>
Editorial<br />
4<br />
Liebe Leserinnen und Leser!<br />
o. Univ.-Prof. Dr. Reinhard Windhager<br />
Ein Bild sagt mehr als tausend Worte. Wie Sie den Histogrammen<br />
entnehmen können, erzielte die Universitätsklinik für Orthopädie<br />
und Unfallchirurgie seit ihrer Zusammenlegung nicht nur eine<br />
Steigerung des gesamten wissenschaftlichen Outputs, sondern<br />
auch der Leistungen pro MitarbeiterIn. Besonders erfreulich ist,<br />
dass das Ranking der <strong>Klinik</strong> kontinuierlich verbessert werden<br />
konnte und dies vor dem Hintergrund, dass die Publikationsleistung<br />
universitätsweit unentwegt ansteigt. Da hier nicht der Platz<br />
ist, Ihnen alle Studien überblicksmäßig darzustellen, haben wir<br />
wie immer eine Auswahl von zehn wichtigen, in Top-Journalen publizierten<br />
Veröffentlichungen ausgewählt, die sowohl in der <strong>Klinik</strong><br />
als auch im Labor wesentliche Ergebnisse generieren konnten und<br />
international Beachtung gefunden haben. Nehmen Sie die Zusammenstellung<br />
nicht nur als Leistungsschau, sondern auch als Anregung,<br />
um in Zukunft weitere Kooperationen etablieren zu können.<br />
Ich wünsche Ihnen viel Vergnügen beim Studium dieser Lektüre.<br />
Ihr Reinhard Windhager<br />
Gesamtoutput<br />
245<br />
286<br />
199 193<br />
50<br />
83<br />
82<br />
104<br />
Output pro MitarbeiterIn<br />
1,84<br />
2,33<br />
1,72 1,67<br />
2,11<br />
2,43<br />
1,065<br />
0,65
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nach operativen Eingriffen an der Wirbelsäule<br />
• Zustand nach arthroskopischen Eingriffen<br />
an Gelenken<br />
• Zustand nach Gelenksersatz<br />
• Zustand nach offenen Operationen am<br />
Bewegungsapparat<br />
• orthopädisch-rehabilitative Schmerztherapie<br />
• Cerebrale Gefäßerkrankungen<br />
• Polyneuropathien<br />
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Zahlen und Fakten<br />
6<br />
Klinische Leistungen<br />
und Operationen<br />
Trotz der Einschränkungen durch die Corona-Pandemie im Jahr<br />
<strong>2021</strong> wurden an der Universitätsklinik für Orthopädie und<br />
Unfallchirurgie insgesamt 5.863 Operationen durchgeführt.<br />
Die Universitätsklinik für Orthopädie und Unfallchirurgie ist eine Groß klinik mit<br />
einem breitgefächerten Leistungsspektrum. Im Bereich der Orthopädie<br />
wurden insgesamt 2.413 Operationen durchgeführt. Dabei handelte es sich<br />
vielfach um hochspezifische Eingriffe, die oft an anderen Spitälern in Österreich<br />
nicht durchgeführt werden konnten: 293 Hüftendoprothesen, 265 Knieendoprothesen<br />
und 168 Fusionen der Wirbelsäule. Hinzu kamen 417 Arthroskopien,<br />
102 Fußoperationen, 298 Tumorresektionen und 83 Osteosynthesen.<br />
An der Klinischen Abteilung für Unfallchirurgie wurden im Jahr <strong>2021</strong><br />
insgesamt 3.450 Operationen vorgenommen.<br />
Klinische Leistung Orthopädie 2020 <strong>2021</strong><br />
Operationen gesamt 2.449 2.413<br />
unter anderem:<br />
Fusionen der Wirbelsäule 149 168<br />
Endoprothetische Versorgungen (gesamt) 653 621<br />
davon Hüftendoprothesen 315 293<br />
davon Knieendoprothesen 277 295<br />
Arthroskopien (alle Gelenke) 341 417<br />
Fußoperationen 78 102<br />
Tumorresektionen 286 298<br />
Osteosynthesen 83 83<br />
Klinische Leistung Unfallchirurgie<br />
Anzahl Operationen 3.265 3.450<br />
unter anderem:<br />
Endoprothetische Versorgungen (gesamt) 192 218<br />
Schädel-Hirn-Trauma 57 30<br />
Wirbelsäulen-OP 70 39<br />
Becken-/Acetabulum-Frakturen 32 33<br />
Knie-Binnenverletzungen 334 379<br />
Rekonstruktive Operationen an der Schulter 83 93<br />
Handverletzungen 329 427<br />
Thorax-/Abdomenverletzungen 24 32<br />
Periprothetische Frakturen 46 37<br />
Osteosynthesen 606 603<br />
Stationäre Aufnahmen 6.054 6.342
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Zahlen und Fakten<br />
9<br />
Spezialambulanzen<br />
zunehmend gefragt<br />
Die Diagnose, Therapie und Prävention von angeborenen und<br />
erworbenen Erkrankungen des Bewegungsapparates sind die<br />
zentrale Ausrichtung der Universitätsklinik für Orthopädie und<br />
Unfallchirur gie im AKH Wien. Die hochgradige Spezialisierung<br />
auf bestimmte Fachgebiete hat dazu geführt, dass die mittlerweile<br />
22 Spezial ambulanzen im vergangenen Jahr eine<br />
steigende Frequenz aufweisen konnten.<br />
Im Vergleich zum Jahr 2020 wurden in allen Ambulanzen im Jahr <strong>2021</strong><br />
höhere Frequenzen verzeichnet. So kam es im Jahr <strong>2021</strong> zu 24.993<br />
Ambulanzbesuchen (im Vergleich zu 23.306 im Jahre 2020). Die höchsten<br />
Frequenzen wiesen folgende Ambulanzen auf: Schmerztherapie (2.047),<br />
Tumororthopädie (3.192), Rheumaorthopädie (2.364), Kinderorthopädie<br />
(2.138), Wirbelsäule (1.578), Sportorthopädie (1.486), Endoprothetik (1.046),<br />
Sarkome (666) und die Fußambulanz (581).<br />
Die ambulanten Frequenzen der Klinischen Abteilung für Unfallchirurgie<br />
lagen ebenfalls über den Vorjahreszahlen. So wurden <strong>2021</strong> insgesamt<br />
51.293 ambulante Besuche in der Erstversorgung verzeichnet<br />
(2020: 49.342) und auch die ambulanten Kontrollen bei den Nachbehandlungen<br />
lagen mit 36.476 höher als im Jahr davor (2020: 34.704).<br />
2020 <strong>2021</strong><br />
Ambulante Frequenzen Orthopädie (gesamt) 23.306 24.993<br />
Schmerztherapie 2.343 2.047<br />
Tumororthopädie 2.872 3.192<br />
Rheumaorthopädie 2.468 2.364<br />
Kinderorthopädie 1.805 2.138<br />
Wirbelsäule 1.550 1.578<br />
Sportorthopädie 1.512 1.486<br />
Endoprothetik 1.133 1.046<br />
Sarkome 852 666<br />
Fußambulanz 403 581<br />
Ambulante Frequenzen Unfallchirurgie<br />
Ambulante Frequenzen (ABF) Erstversorgung 49.342 51.293<br />
Ambulante Kontrollen (ABK) Nachbehandlung 34.704 36.476<br />
SchockraumpatientInnen 507 566<br />
Eingriffe in der Wundversorgung 3.616 3.872<br />
Versorgungen im Gipszimmer 19.579 21.017
<strong>Klinik</strong><br />
10<br />
Unsere <strong>Forschung</strong> orientiert<br />
sich an den täglichen<br />
klinischen Problemen<br />
Die Universitätsklinik für Orthopädie und Unfallchirurgie ist<br />
eine der größten im AKH Wien und der MedUni Wien und genießt<br />
vor allem im Bereich der hochspezialisierten Operationen<br />
interna tionalen Ruhm. Die Corona-Pandemie hat aber bei der<br />
Behandlung der Patientinnen und Patienten massive Probleme<br />
bereitet und zu Rückgängen der über die letzten Jahre steigenden<br />
Operations fallzahlen geführt. Die Auswirkungen im Bereich der<br />
<strong>Forschung</strong> und Lehre waren unterschiedlich.<br />
o. Univ.-Prof. Dr. Reinhard Windhager<br />
Für welche hochspezialisierten Operationen, die sonst kaum in Österreich<br />
gemacht werden, ist die Universitätsklinik für Orthopädie und Unfallchirurgie<br />
bekannt?<br />
Hierzu zählt in erster Linie die Tumororthopädie mit allen ihren Facetten und<br />
Detailbereichen. So wurden an der Universitätsklinik für Orthopädie und<br />
Unfallchirurgie En-Block-Resektionen bei hochmalignen Knochentumoren<br />
der Wirbelsäule bereits vor 30 Jahren als weltweit führende <strong>Klinik</strong> begonnen<br />
und in weiterer Folge perfektioniert, sodass diese heutzutage Routineoperationen<br />
darstellen, die aber kaum anderswo durchgeführt werden.<br />
Weiters zu erwähnen sind komplexe Eingriffe bei Infektionen des Knochens<br />
in verschiedenen Lokalisationen und vor allem der Wirbelsäule, die ein interdisziplinäres<br />
Management voraussetzen, ebenso wie eine hohe Expertise in<br />
Bezug auf Planung der Operationsabfolgen und Umsetzung derselben.<br />
Ein weiterer herausragender Schwerpunkt ist die Deformitätenkorrektur nicht<br />
nur im Bereich der Extremitäten, die häufig interdisziplinär mit der plastischen<br />
Chirurgie durchgeführt wird, sondern auch im Bereich der Wirbelsäule. Ein<br />
weiterer Spezialbereich ist die moderne Amputationschirurgie mit direkter<br />
Verbindung der Exoprothesen an den Knochen, wodurch vor allem im Oberschenkelbereich<br />
enorme Funktionsvorteile zu registrieren sind.<br />
Schließlich ist noch das hochspezialisierte Polytraumamanagement zu<br />
erwähnen, welches aufgrund der hohen Frequenz und der Schwere der<br />
Fälle nicht nur im nationalen, sondern im internationalen Vergleich hervorragend<br />
repräsentiert ist.<br />
Die Zuweisungen für diese Spezialeingriffe erfolgen nicht nur aus den umgebenden<br />
Bundesländern und Gesamtösterreich, sondern sehr häufig auch<br />
aus dem benachbarten, aber auch fernen Ausland.
<strong>Klinik</strong><br />
11<br />
Über 20 Spezialambulanzen werden von der Universitätsklinik für<br />
Orthopädie und Unfallchirurgie angeboten. Wie wichtig sind diese für<br />
die Versorgung der Patientinnen und Patienten?<br />
Die hohe Zahl an Spezialambulanzen repräsentiert die Differenziertheit in<br />
der Behandlung und die zunehmende Spezialisierung dieses umfangreichen<br />
Faches. Diese Spezialambulanzen werden von hochengagierten Kolleginnen<br />
und Kollegen betrieben, die aufgrund ihrer Expertise und Hingebung an diese<br />
spezielle Tätigkeit eine enorme Attraktion für die PatientInnen darstellen.<br />
Wie überlastet sind diese Ambulanzen?<br />
Alle Spezialambulanzen werden als Terminambulanzen geführt, sodass eine<br />
Überlastung regulierbar ist. Allerdings entstehen in einzelnen Bereichen sehr<br />
lange Vormerkzeiten, sodass zu Alternativen, wie telemedizinische Beratung,<br />
gegriffen werden musste.<br />
Wie funktioniert die Zusammenarbeit mit den niedergelassenen<br />
ÄrztInnen – bei der Zuweisung und auch Nachsorge?<br />
Die Kooperation mit dem niedergelassenen Bereich ist hervorragend und<br />
hat sich in der Vergangenheit in erster Linie auf die Nachsorge beschränkt.<br />
Neuerdings werden auch telemedizinische Beratungen angeboten, wodurch<br />
einerseits die Wartezeiten verkürzt werden können, andererseits eine bessere<br />
Vorbereitung der Patienten auf die Erstvorstellung gewährleistet wird.<br />
„Die Zuweisungen für die hochspezialisierten<br />
Operationen erfolgen nicht nur<br />
aus den umgebenden Bundesländern<br />
und Gesamtösterreich, sondern sehr<br />
häufig auch aus dem benachbarten, aber<br />
auch fernen Ausland.“<br />
Reinhard Windhager<br />
Welche Leistungen bietet die neue Patellofemoral-Spezialambulanz an?<br />
Der Fokus dieser Ambulanz liegt auf dem Patellofemoralgelenk, welches<br />
einen Teilbereich des Kniegelenkes darstellt. Probleme mit dem Patellofemoralgelenk<br />
sind extrem häufig und betreffen funktionelle Dysbalancen, die angeboren<br />
sein oder nach Unfällen auftreten und zu dauerhaften Belastungen<br />
der Patientinnen und Patienten führen können. Das Wissen in diesem Spezialbereich<br />
hat sich in den letzten 30 Jahren enorm ausgeweitet und bedingt,<br />
dass eine multimodale Abklärung zur Analyse der Probleme erforderlich ist,<br />
um eine patientenspezifische Behandlung und Korrektur dieser Problematik<br />
gewährleisten zu können.<br />
Welche Neuentwicklungen gibt es bei den einzelnen Operationen und<br />
Behandlungen – Knie, Hüfte, Wirbelsäule, Endoprothetik …?<br />
Bei dem heutigen Wissensstand ist es schwer, von reinen Neuentwicklungen<br />
zu sprechen, da viele diagnostische und therapeutische Ansätze bereits<br />
versucht worden sind, allerdings heutzutage mit neuen Methoden andere<br />
Zugänge ermöglichen und auch bessere Ergebnisse erwarten lassen.<br />
Im Kniegelenksbereich ist sicherlich die kinematische Ausrichtung der<br />
Gelenkachsen bei Implantationen der totalen Endoprothese ein Ansatz,<br />
der neuerdings weitere Verbreitung findet. Dabei wird versucht, die individuellen<br />
Achsverhältnisse mehr zu berücksichtigen und nicht alle Kniegelenke<br />
einheitlich auf die gleichen Maße einzustellen.<br />
Im Bereich der Hüftendo prothetik ist es vor allem die verbesserte Ausrichtung<br />
der Gelenke unter Einbeziehung der Stellung zwischen Becken und<br />
Wirbelsäule, bei welchen große individuelle Unterschiede bestehen. Verbesserungen<br />
und Innovationen sind auch im Bereich Navigation und vor allem<br />
Robotik zu verzeichnen, sowohl was die Endoprothetik betrifft als auch die<br />
Wirbelsäulenchirurgie. Inwieweit diese Neuentwicklungen zu dauerhaften<br />
Verbesserungen führen, bleibt momentan Gegenstand intensiver <strong>Forschung</strong>.
<strong>Klinik</strong><br />
12<br />
Welche <strong>Forschung</strong>sthemen sind in naher Zukunft zu erwarten?<br />
Da sich aus einer interessanten Studie immer neue Fragen ergeben, ist<br />
eine Auflistung interessanter <strong>Forschung</strong>sthemen in der Zukunft hier nicht<br />
abzuhandeln. Die <strong>Forschung</strong> bleibt weiterhin ausgerichtet auf die Individualisierung<br />
therapeutischer Konzepte, Charakterisierung von Patientenansprüchen<br />
auf Basis von PROMS (patient related outcome measures), wofür große<br />
Datenmengen herangezogen werden müssen, Analyse von Dispositionen einzelner<br />
Patienten für unerwünschte Krankheitsverläufe und Verhinderung von<br />
Infektionen als schwerwiegendste Komplikation bei Operationen, vor allem<br />
bei multimorbiden Patienten. Bei Durchsicht der ausgewählten Top-Publikationen<br />
lassen sich unschwer wichtige Themen für die Zukunft erkennen.<br />
Welches Standing hat die Wiener Universitätsklinik international?<br />
Das Universitätsklinikum AKH Wien ist Teil der sogenannten European<br />
University Hospital Alliance, in der sieben renommierte <strong>Klinik</strong>en Europas im<br />
ständigen Austausch und Vergleich stehen. Somit ist ein direktes Benchmarking<br />
gewährleistet und auch durch direkte Kooperationen die Möglichkeit<br />
gegeben, Optimierungen in einzelnen Bereichen rasch herbeizuführen.<br />
„Unsere <strong>Forschung</strong>sansätze sind translational,<br />
das heißt, dass <strong>Forschung</strong>sthemen<br />
aus der <strong>Klinik</strong> und von klinischen<br />
Problemen generiert werden und<br />
durch Entwicklungen im Labor mit den<br />
entsprechenden Ergebnissen wieder<br />
Eingang in die <strong>Klinik</strong> finden und damit<br />
den Patientinnen und Patienten zugutekommen.“<br />
Reinhard Windhager<br />
Wie wichtig sind für Sie Kooperationen mit Firmen bzw. anderen <strong>Klinik</strong>en?<br />
Was erwarten Sie sich davon?<br />
Die Kooperation mit anderen <strong>Klinik</strong>en ist im <strong>Forschung</strong>sbereich zur Generierung<br />
größerer Fallzahlen unabdingbar, um international mit größten Institutionen,<br />
vor allem im asiatischen Bereich, mithalten zu können. Kooperationen<br />
mit Firmen sind in Bezug auf Produktentwicklungen interessant, um durch<br />
komplementäre Vermengung verschiedener Expertisen rascher zu Ergebnissen<br />
und Produktentwicklungen zu kommen. Die Abteilung Technologie Transfer<br />
der Medizinischen Universität Wien bietet hierfür eine ausgezeichnete<br />
Plattform und unterstützt unsere Forscherinnen und Forscher bei Patentanmeldungen<br />
und weiteren Entwicklungen.<br />
Wie wirkt sich die laufende <strong>Forschung</strong>stätigkeit auf die tägliche Arbeit<br />
für die Patientinnen und Patienten aus?<br />
Unsere <strong>Forschung</strong>sansätze sind in erster Linie translational, das heißt, dass<br />
<strong>Forschung</strong>sthemen aus der <strong>Klinik</strong> und von klinischen Problemen generiert<br />
werden und durch Entwicklungen im Labor mit den entsprechenden Ergebnissen<br />
wieder Eingang in die <strong>Klinik</strong> finden und damit den Patientinnen und<br />
Patienten zugutekommen.<br />
Wie wirkt sich die Coronakrise derzeit noch auf die <strong>Klinik</strong> aus?<br />
Die früher noch aufwendigen organisatorischen Änderungen haben sich<br />
gut eingespielt und in den Alltag integrieren lassen, allerdings sind wegen<br />
Corona-bedingter Personalausfälle noch Engpässe zu verzeichnen gewesen.<br />
Auch wenn die Situation derzeit als stabil gewertet werden kann, ist nicht<br />
abzu sehen, was an weiteren Änderungen auf uns zukommen wird. Wichtig ist<br />
hierbei, die Motivation der Mitarbeiterinnen und Mitarbeiter hochzuhalten<br />
und zu bündeln, da sich dauerhafte Restriktionen negativ auf das Gesamtergebnis<br />
der Leistung sowohl im klinischen als auch im wissenschaftlichen<br />
Bereich auswirken können. Überraschend ist immer noch die gelegentlich<br />
hohe Kumulation von Ereignissen, wie die positive Covid-19-Testung von<br />
Mitarbeiterinnen und Mitarbeitern oder aber Patientinnen und Patienten,<br />
die vereinzelt zu plötzlichen Ausfällen führen können, die nicht aufgefüllt<br />
werden können, und somit kostbare Behandlungsressourcen verloren gehen.
Comparative 3 Year<br />
ACTIS Stem data<br />
Survival analysis for all-cause<br />
revision following primary total hip<br />
arthroplasty with a medial collared,<br />
triple-tapered primary hip stem versus<br />
other implants in real-world settings.<br />
Chitnis A, Mantel J, Ruppenkamp J, Bourcet A, Holy C<br />
Current Medical Research Opinion. 2020 Sep 22:1-7.<br />
• A retrospective cohort study identified 1,213 patients who received the<br />
ACTIS Total Hip. This group was compared to 6,916 patients who<br />
received other THA implants.<br />
• Data was drawn from the Mercy Healthcare Systems Orthopedics<br />
Database, a large US based multi-state database.<br />
• Kaplan-Meier survival curves were generated, and a multivariable<br />
Cox proportional hazard model was used to compare the relative risk<br />
of revision.<br />
57% lower risk of revisions<br />
Adjusted Hazard Ratio 0.43 ((0.19-0.97) p=0.042)<br />
3<br />
ACTIS Stem revision rate estimated<br />
at 1.08% at years 2 and 3<br />
2.63%<br />
(2.19%-3.16%)<br />
2<br />
1.9%<br />
(1.57%-2.29%)<br />
2.29%<br />
(1.91%-2.74%)<br />
2.63%<br />
(2.19%-3.16%)<br />
1.08%<br />
(0.43%-2.72%)<br />
ALL-CAUSE REVISION RATE AT 3 YEARS<br />
1<br />
0<br />
0.64%<br />
(0.28%-1.43%)<br />
1.08%<br />
(0.43%-2.72%)<br />
1.08%<br />
(0.43%-2.72%)<br />
YR 1 YR 2 YR 3<br />
ACTIS STEM<br />
OTHER THA IMPLANTS<br />
57% Reduced Risk of Revision when<br />
Compared to Other THA Implants<br />
Please refer to the instructions for use for a complete list of indications, contraindications, warnings and precautions.<br />
Johnson & Johnson Medical Limited. Baird House, 4 Lower Gilmore Bank, Edinburgh, EH3 9QP, United Kingdom.<br />
Incorporated and registered in Scotland under company number SC132162.<br />
www.jnjmedicaldevices.com<br />
© DePuy Synthes 2020. All Rights Reserved.<br />
155950-201015 DSUS/EMEA
Das ÄrztInnenteam<br />
14<br />
Die Expertinnen und<br />
Experten auf einen Blick<br />
Neben dem Fortschritt in der Medizintechnik und innovativen<br />
Medikamenten sind vor allem die Mitarbeiterinnen und Mitarbeiter<br />
ein essenzieller Garant für den optimalen medizinischen<br />
Erfolg. Die rund 100 ÄrztInnen der Universitätsklinik für<br />
Orthopädie und Unfallchirurgie von MedUni Wien und AKH<br />
Wien profitieren dabei auch vom exzellenten Netzwerk, dem<br />
wertschätzenden Umgang miteinander und der zielorientierten,<br />
individuellen Fort- und Weiterbildung.
Das ÄrztInnenteam<br />
15<br />
Universitätsklinik für Orthopädie und Unfallchirurgie<br />
Leiter: o. Univ.-Prof. Dr. Reinhard WINDHAGER<br />
Klinische Abteilung für Orthopädie<br />
o. Univ.-Prof. Dr. Reinhard WINDHAGER<br />
ao. Univ.-Prof. in Dr. in Catharina CHIARI, MSc<br />
Univ.-Prof. Dr. Alexander GIUREA<br />
Klinische Abteilung für Unfallchirurgie<br />
Assoz. Prof. Priv.-Doz. Dr. Stefan HAJDU, MBA<br />
Assoz. Prof. in Priv.-Doz. in Dr. in Silke ALDRIAN<br />
Mitarbeiterinnen und Mitarbeiter<br />
(in alphabetischer Reihenfolge):<br />
Dr. Jürgen ALPHONSUS<br />
Dr. in Anna ANTONI<br />
Dr. Sebastian APPRICH<br />
Univ.-Prof. in Dr. in Michaela AUER-GRUMBACH<br />
Mag. a Dr. in Rita BABELUK<br />
Dr. Oskar BAMER<br />
Dr. in Elena BATRINA<br />
Dr. Harald BINDER, MSc<br />
Priv.-Doz. DDr. Christoph BÖHLER<br />
Dr. Robert BREUER (karenziert)<br />
Dr. Alexander BUMBERGER<br />
Dr. in Alexandra CHRIST<br />
Dr. in Britta CHOCHOLKA<br />
Dr. in Theresia DANGL<br />
Dr. Michél DEDEYAN<br />
Dr. in Danielle DIARRA<br />
Dr. Kevin DÖRING<br />
Dr. in Nevenka DRMIC<br />
Dr. in Larissa EGKHER<br />
Dr. Alexander EGKHER<br />
Dr. Lukas EICHELBERGER<br />
Dr. in Emilia EREDANSKY<br />
Dr. Jozsef-Tibor ERDÖS<br />
Mag. a Seyma ERGÜN<br />
Assoz. Prof. Priv.-Doz. Dr. Philipp FUNOVICS, MSc<br />
Mag. Dr. Georg FRABERGER<br />
Dr. Stephan FRENZEL<br />
Dr. in Nina JANJIC<br />
Ass.-Prof. Dr. Martin FROSSARD<br />
Dr. Bernhard GASSER<br />
Mag. a Andrea GAVENDOVA<br />
Dr. Markus GREGORI<br />
Dr. Fabian GREINER<br />
Ass.-Prof. Dr. Manfred GREITBAUER<br />
ao. Univ.-Prof. Dr. Josef GROHS<br />
Dr. in Luiza GRÜNBERG<br />
Priv.-Doz. Thomas HAIDER, MBA (karenziert)<br />
DDr. Gabriel HALAT<br />
ao. Univ.-Prof. Dr. Thomas HEINZ<br />
Dr. Stephan HEISINGER<br />
Priv.-Doz. Dr. Gerhard HOBUSCH, MSc<br />
Assoz. Prof. Priv.-Doz. Dr. Marcus HOFBAUER<br />
Dr. Christoph HOFER<br />
Dr. Florian HOFMANN<br />
Dr. in Anna HOHENSTEINER<br />
Dr. in Katharina HOHENSTEIN-SCHEIBENECKER<br />
Dr. in Sabrina HOLZER (karenziert)<br />
Dr. in Laura HRUBY, PhD<br />
Dr. Florian HRUSKA<br />
Dr. Zhaohui HU<br />
Dr. Michael HUMENBERGER<br />
Dr. in Manuela JAINDL<br />
Dr. Nikolaus JANTSCH<br />
Dr. Fatmir KABASHI<br />
Dr. Georg KAISER<br />
ao. Univ.-Prof. Dr. Richard KDOLSKY<br />
Dr. Maximilian KEINTZEL<br />
Dr. in Ahkin KEIZER<br />
Dr. in Anne KLEINER<br />
Priv.-Doz. Dr. Alexander KOLB<br />
Dr. Paul KOLBITSCH (karenziert)<br />
Priv.-Doz. Dr. Ulrich KOLLER, MSc<br />
Dr. in Irena KRUSCHE-MANDL<br />
Assoz. Prof. Priv.-Doz. Dr. Bernd KUBISTA, MSc<br />
Priv.-Doz. Dr. Nikolaus LANG, MSc<br />
Dr. in Roberta LAGGNER<br />
Assoz. Prof. Priv.-Doz. Dr. Richard LASS, MSc<br />
Assoz. Prof. Priv.-Doz. Dr. Johannes LEITGEB, PhD<br />
Dr. in Marie-Christine LUTSCHOUNIG<br />
Dr. in Monika LUXL<br />
Ass.-Prof. Dr. Wolfgang MACHOLD<br />
Dr. Bernhard MAIER
Das ÄrztInnenteam<br />
16<br />
Dr. in Ulrike MARQUART<br />
Dr. Michael MATZNER<br />
Dr. Timon MOFTAKHAR<br />
Dr. in Raffaela MORGENBESSER<br />
Dr. Arastoo NIA (karenziert)<br />
Ap. Prof. Priv.-Doz. Dr. Lukas NEGRIN, PhD, MMSc<br />
Ass.-Prof. Dr. Gholam PAJENDA<br />
Dr. in Karin PAGANO-BRAUN<br />
Assoz. Prof. Priv.-Doz. Dr. Joannis PANOTOPOULOS<br />
DDr. Stephan PAYR, PhD<br />
Dr. Lorenz PICHLER<br />
Dr. Stefan PLESSER (karenziert)<br />
Dr. in Sigrid POLZER<br />
Dr. Domenik POPP (karenziert)<br />
Priv.-Doz. Dr. Stephan PUCHNER, MSc<br />
Dr. in Colleen RENTENBERGER<br />
Dr. Gregor RETTL<br />
DI in Dr. in Anna RIENMÜLLER<br />
Dr. Stephan SALZMANN<br />
Dr. Paul SCHADLER<br />
Ass.-Prof. Dr. Klaus-Dieter SCHATZ<br />
Dr. Philipp SCHEIDER<br />
Dr. in Eleonora SCHNEIDER<br />
Dr. Markus SCHREINER<br />
Dr. Rupert SCHUSTER<br />
Dr. Gilbert SCHWARZ (karenziert)<br />
Ass.-Prof. in Dr. in Elisabeth SCHWENDENWEIN<br />
Priv.-Doz. in DDr. in Irene SIGMUND<br />
Ass.-Prof. Dr. Gobert SKRBENSKY<br />
Dr. Bernhard SPRINGER<br />
Dr. Kevin STAATS<br />
Priv.-Doz. in Dr. in Julia STARLINGER, LL.M, FEBOT,<br />
PhD (karenziert)<br />
Dr. in Beate STELZENEDER (karenziert)<br />
Dr. in Sandra STENICKA (karenziert)<br />
Priv.-Doz. Dr. Christoph STIHSEN<br />
Dr. in Geraldine STURZ<br />
Dr. in Gerhild THALHAMMER<br />
Priv.-Doz. Dr. Thomas TIEFENBÖCK, MSc<br />
Dr. Klemens VERTESICH<br />
Dr. Rainer WAGNER<br />
Dr. in Rebecca WAGNER<br />
Ap. Prof. Priv.-Doz. Dr. Wenzel WALDSTEIN-<br />
WARTENBERG<br />
Dr. in Valerie WEIHS<br />
Ap. Prof. Priv.-Doz. Dr. Harald WIDHALM, MBA<br />
Priv.-Doz. in Dr. in Madeleine WILLEGGER, FEBOT<br />
Dr. Gregor WOLLNER<br />
ao. Univ.-Prof. Dr. Gerald E. WOZASEK<br />
Priv.-Doz. Dr. Lukas ZAK<br />
Dr. in Cornelia ZEITLER (karenziert)<br />
Mitarbeiterinnen und Mitarbeiter in <strong>Forschung</strong>slabors<br />
(in alphabetischer Reihenfolge):<br />
Melanie ACOSTA, BSc<br />
Ana BREIL<br />
Isabel CASADO LOSADA, MU<br />
Marian FÜRSATZ, MSc MMSc<br />
Dr. in scient. med. Verena KOPATZ, MSc<br />
Priv.-Doz. in Dr. in rer. nat Sylvia NÜRNBERGER<br />
Dr. Emir BENCA<br />
Dr. Mario ROTHBAUER<br />
Dr. in Anita FISCHER<br />
Dr. in Katharina PICHLER (Karenz)<br />
Melanie CEZANNE, BMA<br />
Ruth GRÜBL-BARABAS, BMA<br />
Alexander STÖGNER, BMA<br />
Bettina RODRIGUEZ-MOLINA, BMA (Karenz)<br />
Dr. Jürgen ALPHONSUS<br />
Ingeborg Eva REIHS, MSc<br />
Tamara COLOVIC<br />
Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan TÖGEL<br />
Mitarbeiterinnen des Studiensekretariats<br />
(in alphabetischer Reihenfolge):<br />
Sandra HACKER, MSc<br />
Anna-Theresia KOURIMSKY, BSc<br />
Anja LANGER<br />
Carmen TROST, BA MA
COPAL ® – ERFOLGREICH GEGEN INFEKTIONEN<br />
COPAL<br />
Bei infektionsgefährdeten Patienten & Revisionseingriffen<br />
® G+C<br />
Heraeus unterstützt Die Wahl des richtigen Behandlungsalgorithmus ist ein<br />
bei COPAL der Therapie knee moulds mit COPAL Formen ® für temporäre Knie Spacer<br />
Knochenzement gesteigert. (1) PALAMIX ® duo<br />
Vakuummischsystem mit Sammeln<br />
essenzieller Erfolgsfaktor zur Prävention und Reduktion von<br />
periprothetischen Infektionen. Bei Revisionen – ob einzeitig<br />
bei guten Weichteilverhältnissen und bekannten sensiblen<br />
Erregern oder zweizeitig bei prekären Weichteilverhältnissen<br />
und unbekannten resistenten Pathogenen – wird die Effektivität<br />
Knochenzement sowie den COPAL ® knee moulds zur<br />
He rstellung artikulierender Knie-Spacer. Auch bei Primäreingriffen<br />
mit er höhtem Infektionsrisiko aufgrund von<br />
Komorbidiäten oder durch eine Schenkel hals fraktur als<br />
Traumafall unterstützen PALAMIX COPAL ® - Knochenzemente. Beschreibung<br />
(2)<br />
der Therapie durch den Einsatz von antibiotikahaltigem<br />
PALAMIX ® uno<br />
Vakuummischsystem mit Sammeln<br />
(bis 160 g Zement)<br />
COPAL ® Knochenzemente bieten:<br />
COPAL ®<br />
COPAL ® G+V<br />
COPAL ® spacem<br />
PALAMIX ® Schnorchel Slim<br />
PALAMIX ® Schnorchel<br />
Medium<br />
PALAMIX ® Zementpistole<br />
PALAMIX ® Vakuumpumpe<br />
Beschreibung<br />
Hochviskoser, röntgenpositiver Kno<br />
Hochviskoser, röntgenpositiver Kno<br />
Hochviskoser, röntgenpositiver Spe<br />
Schnorchel zur Applikation niedrig<br />
biegsamer, konischer Schnorchel;<br />
wiederverwendbare Applikationspis<br />
wiederverwendbare Vakuumpumpe<br />
Zweifach antibiotikahaltiger<br />
Knochenzement<br />
Implantatfixierung<br />
Effektiv auch gegen<br />
Anaerobier<br />
Breites Wirkspektrum gegen die<br />
für PPI klinisch relevanten Keime<br />
Infektions-Prävention bei<br />
Revisionseingriffen<br />
Hoher lokaler Wirkspiegel bei<br />
niedriger systemischer<br />
Belastung<br />
Effektiv auch gegen<br />
MRSA / MRSE<br />
Bestellen Sie einfach bei Heraeus.<br />
Deutschland:<br />
Tel.: + 49 (0) 6181 35 30 00<br />
Fax: + 49 (0) 6181 35 33 66<br />
Österreich:<br />
Tel.: + 43 (0) 1 5 22 25 80<br />
Fax: + 43 (0) 1 5 22 25 81<br />
(10) (1)<br />
Sprowson AP. et al. Bone Joint J. 2016.<br />
(11) (2)<br />
Engesaeter in Wahlenkamp. Local Antibiotics in arthroplasty.<br />
2007, p. 152.<br />
www.heraeus-medical.com<br />
Heraeus Medical GmbH<br />
Philipp-Reis-Str. 8/13<br />
61273 Wehrheim<br />
Germany<br />
Heraeus Medical Schweiz AG<br />
Mühlebachstrasse 72<br />
8008 Zürich<br />
Switzerland
Das ÄrztInnenteam<br />
18<br />
Wiener Gesundheitsverbund<br />
Teilunternehmung AKH Wien<br />
Universitätsklinik für<br />
Klinische Abteilung für Orthopädie<br />
PatientInnenversorgung<br />
<strong>Forschung</strong><br />
Spezialambulanzen<br />
Schulter und Ellbogen<br />
Sportchirurgie Knie<br />
Hand<br />
Fuß<br />
Orthopädische<br />
Schmerzambulanz<br />
Hüfte<br />
Knie<br />
Knorpelschäden<br />
Neuromuskuläre<br />
Fußamb.<br />
Patellofemoral<br />
Knochen- und<br />
Weichteilsarkome<br />
Klumpfuß<br />
Extremitätendeformität<br />
Spezialteams<br />
Sportorthopädie<br />
Rheumaorthopädie<br />
Rehabilitation<br />
und Prothetik<br />
Komplexe Revision und<br />
Extremitätenrekonstruktionen<br />
Endoprothetik<br />
Kinderorthopädie<br />
Tumororthopädie<br />
<strong>Forschung</strong>scluster<br />
Arthrose und<br />
Geweberegeneration<br />
Deformitäten und<br />
Frakturheilung<br />
Endoprothetik<br />
Hand<br />
Infektionen<br />
Kinder<br />
Neuropathien<br />
Poly- und Schädelhirntrauma<br />
Sport und Gelenkserhaltung<br />
Tumor<br />
Spezielle<br />
biomedizinischtechnische<br />
Verfahren<br />
3D OP<br />
Ganganalyse<br />
MRT und biochemische<br />
Bilddiagnostik<br />
PROMS/RDA<br />
Rapid Prototyping<br />
RSA<br />
Skoliose und WS-<br />
Deformitäten<br />
Wirbelsäule<br />
Wirbelsäule
Das ÄrztInnenteam<br />
19<br />
Medizinische Universität Wien<br />
Orthopädie und Unfallchirurgie<br />
Klinische Abteilung für Unfallchirurgie<br />
Lehre<br />
PatientInnenversorgung<br />
Orthopädie<br />
Diplom- und<br />
Doktoratsstudium<br />
Unfallchirurgie<br />
Diplom- und<br />
Doktoratsstudium<br />
Erstbehandlungsambulanz<br />
+<br />
Nachbehandlungsambulanz<br />
Spezialambulanzen<br />
Postgraduelle Aus-/<br />
Weiterbildung<br />
inkl. PhD<br />
Facharztausbildung<br />
Postgraduelle Aus-/<br />
Weiterbildung<br />
inkl. PhD<br />
Facharztausbildung<br />
Wirbelsäulenverletzungen<br />
Traumatische Knorpelschäden<br />
Posttraumat. Deformitäten<br />
und Gliedmaßenrekonstruktion<br />
Kindertraumatologie<br />
Sportambulanz<br />
Handambulanz<br />
Schulterambulanz<br />
Hüftambulanz
Ambulanzen<br />
20<br />
Ambulanzverzeichnis der<br />
Universitätsklinik für<br />
Orthopädie und Unfallchirurgie<br />
Die Spezialambulanzen der Klinischen Abteilung für Ortho pädie<br />
befinden sich im AKH Wien auf Ebene 7D unter dem grünen<br />
Betten haus. Für diese Bestellambulanzen sind telefonische Terminvereinbarungen<br />
unter der Telefonnummer +43/1/404 00-40800<br />
erforderlich. Zuweisungen erfolgen jeweils durch die niedergelassenen<br />
Fachärztinnen und -ärzte für Orthopädie.<br />
Die Spezialambulanzen der Klinischen Abteilung für Unfallchirurgie<br />
und die Nachbehandlung in der Unfallambulanz<br />
befinden sich auf Ebene 6B und sind unter der Telefonnummer<br />
+43/1/404 00-59380 zu kontaktieren.
Ambulanzen<br />
21<br />
Spezialambulanzen Klinische Abteilung für Orthopädie<br />
Spezialambulanz für orthopädische Schmerztherapie<br />
Endoprothesenzentrum der Maximalversorgung<br />
• Spezialambulanz für Endoprothetik<br />
• Spezialambulanz für Knie<br />
• Spezialambulanz für Hüfte<br />
• Spezialambulanz für komplexe Revisionen und Extremitätenrekonstruktionen<br />
• Patellofemoral-Spezialambulanz<br />
Tumororthopädie<br />
• Spezialambulanz für Tumororthopädie<br />
• Spezialambulanz für Knochen- und Weichteilsarkome<br />
• Spezialambulanz für Rehabilitation und Prothetik<br />
Wirbelsäulenorthopädie<br />
• Spezialambulanz für Wirbelsäule<br />
• Spezialambulanz für Skoliose und Wirbelsäulendeformitäten<br />
Kinderorthopädie<br />
• Spezialambulanz für Kinderorthopädie<br />
• Spezialambulanz für Knorpelschäden<br />
• Spezialambulanz für Klumpfuß<br />
• Spezialambulanz für Extremitätendeformitäten<br />
• Neuromuskuläre Fußambulanz<br />
Rheumaorthopädie<br />
• Spezialambulanz für Rheumaorthopädie<br />
• Spezialambulanz für Fuß<br />
• Spezialambulanz für Hand<br />
Sportorthopädie<br />
• Spezialambulanz für Sportorthopädie<br />
• Spezialambulanz für Sportchirurgie Knie<br />
• Spezialambulanz für Schulter und Ellbogen<br />
Spezialambulanzen Klinische Abteilung für Unfallchirurgie<br />
• Allgemeine Unfallambulanz – Erstversorgung<br />
• Allgemeine Unfallambulanz – Nachbehandlung<br />
• Ambulanz für Kindertraumatologie<br />
• Ambulanz für Handchirurgie<br />
• Ambulanz für Hüftverletzungen und posttraumatische Hüftbeschwerden<br />
• Schulterambulanz<br />
• Ambulanz für traumatische Knorpelschäden<br />
• Ambulanz für posttraumatische Deformitäten und Gliedmaßenrekonstruktion<br />
• Ambulanz für Sportverletzungen<br />
• Ambulanz für posttraumatische Wirbelsäulenbeschwerden
TOP-Studien<br />
22<br />
Clinical Comparison of Four<br />
Different Graft Types in<br />
Matrix-Associated Autologous<br />
Chondrocyte transplantation<br />
Articular cartilage lesions are one of the most frequent types of<br />
injuries encountered in orthopaedic practice: They show no<br />
spontaneous healing response and often lead to unicompartmental<br />
osteoarthritis (OA), which is a common problem among<br />
young and active people. Focal defects to the cartilage lead to<br />
progredient cartilage self-destruction and joint pain, ultimately<br />
resulting in secondary OA.<br />
Because of improvements and developments in cartilage repair, autologous<br />
chon-drocyte transplantation (ACT) has become an increasingly popular<br />
treatment method. The most common techniques are third-generation<br />
matrix-associated autologous chondrocyte transplantation (MACT) procedures,<br />
which follow a two-step surgical approach: First, a three-dimensional<br />
biocompatible scaffold serving as cell growth carrier is seeded with<br />
chondrocytes from an initial arthroscopy, to be then implanted in the patient<br />
during a subsequent mini-arthrotomy.<br />
Study:<br />
Binder H, Hoffman L, Zak L,<br />
Tiefenboeck T, Aldrian S,<br />
Albrecht C.<br />
Clinical evaluation after<br />
matrix-associated autologous<br />
chondrocyte transplantation:<br />
A comparison of four different<br />
graft types.<br />
Bone Joint Res. <strong>2021</strong><br />
Jul;10(7):370-379. doi:<br />
10.1302/2046-3758.107.<br />
BJR-2020-0370.R1.<br />
This scaffold is composed of cartilage extracellular matrix molecules or biopolymers,<br />
forming a biological matrix leading to more hyaline-like repair tissue<br />
in articular cartilage defects. The matrix traps the cells in the chondral defect<br />
and provides cell-matrix interactions, stimulating differentiation into articular<br />
chondrocytes and the production of a hyaline-like extracellular matrix.<br />
Compared to bone marrow-stimulating techniques such as MFX, MACT<br />
provides the possibility of differentiation of the cartilage repair tissue, leading<br />
to the reformation of hyaline or hyaline-like cartilage. It has also been<br />
shown that MACT consistently improves patient-reported functional outcomes<br />
compared with microfracture.<br />
However, comparisons between different types of MACT grafts are lacking<br />
in the literature. The four most common ones are Hyalograft ® C autografts<br />
(Fidia Advanced Biomaterials, Italy), MACI ® (Genzyme, USA, former Verigen,<br />
Germany), CaReS ® (Arthro Kinetics Biotechnology GmbH; Krems, Austria),<br />
and Novocart ® 3D (TeTeC, Reutlingen, Germany).
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23<br />
A B C<br />
Figure 1: Preoperative (A) and follow-up MRI after one year (B) and two years (C) of a 25-year-old female patient after matrix-associated autologous<br />
chondrocyte transplantation procedure with the Hyalograft®C Transplantation system.<br />
„Our data demonstrated that MACT<br />
resulted in good clinical improvement<br />
for tibio-femoral defects two years<br />
after transplantation, regardless of<br />
the graft type used.“<br />
Harald Binder<br />
Hyalograft ® C consists of a hyaluronan web seeded with previously obtained<br />
cells that are cultivated in 2D for at least two weeks. MACI ® is a collagen<br />
type I/III membrane seeded with Chondrocytes that are cultivated in 3D for<br />
one week. CaReS ® is composed of a collagen type I gel, the obtained cells are<br />
mixed with the gel directly without monolayer cultivation, instead, a three<br />
weeklong 3D-cultivation is performed. Novocart ® 3D is a bilayered collagen<br />
type I sponge, containing chondroitin-sulphate. The cells are isolated from<br />
full depth cartilage cylinders, multiplied in monolayers, and seeded onto the<br />
scaffold. Cultivation lasts for two days and is performed in 3D.<br />
Aim and Methods<br />
This retrospective study aims to determine the possible differences in shortterm<br />
clinical outcome among these four different types of MACT, since up to<br />
now, no comparison of these four commonly used transplant types has been<br />
documented.<br />
This case control study includes 88 patients (mean age: 34 years, mean<br />
BMI: 25) with full-thickness chondral lesions of the tibiofemoral joint who<br />
underwent MACT. Clinical examinations were performed preoperatively, and<br />
24 months after transplantation. Clinical outcomes were evaluated using the<br />
International Knee Documentation Committee (IKDC), the Brittberg score,<br />
the Tegner Activity Scale, and the visual analog scale (VAS) for pain. The<br />
Kruskal-Wallis test by ranks was used to compare the clinical scores of the<br />
different transplant types.<br />
Results and Conclusion<br />
The average defect size of the tibiofemoral joint compartment was 4.28 cm 2 .<br />
Eleven patients (12.6 %) underwent transplantation with Chondro-Gide<br />
(MACI), 40 patients (46.0 %) with Hyalograft (HYAFF) (Figure 1), 21 patients<br />
(24.1 %) with CaReS and 15 patients (17.2 %) with Novocart 3D. The mean<br />
IKDC score improved from 35.71 (± 6,44) preoperatively to 75.26 (± 18.36)
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24<br />
after 24 months postoperatively in the Hyalograft group, from 35.94 (± 10.29)<br />
to 71.57 (± 16.31) in the Chondro-Gide (MACI) group, from 37.06 (± 5.42) to<br />
71.49 (± 6.76) in the Novocart 3D group and from 45.05 (± 15.83) to 70.33<br />
(± 19.65) in the CaReS group. Similar improvements were observed in the VAS<br />
and Brittberg scores.<br />
Our data demonstrated that MACT resulted in good clinical improvement for<br />
tibiofemoral defects two years after transplantation, regardless of the graft<br />
type used. Different transplant composition and architecture did not significantly<br />
influence clinical outcomes in our study population.<br />
Resume<br />
The novelty of the herein presented study is the comparison of four different<br />
graft types among their clinical results in human. Published studies<br />
have varied in terms of their quality and which techniques have been compared<br />
with one another. To our knowledge, there are no studies comparing<br />
more than two different matrices in a clinical trial. Therefore, this is the<br />
first study comparing 2-year clinical outcomes of patients treated with different<br />
graft types for symptomatic, traumatic chondral defects restricted<br />
to the tibiofemoral joint area. The major finding of this study was that our<br />
data showed no significant differences in the clinical outcomes regarding<br />
the graft types used.<br />
References:<br />
[1] Curl, W.W., et al., Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy, 1997.<br />
13(4): p. 456-60.<br />
Dr. Harald Binder, MSc<br />
Author:<br />
As a member of the outpatient’s<br />
clinic for traumatic cartilage<br />
defects and shoulder surgery<br />
of the AKH Vienna, Harald<br />
Binder specialises in trauma<br />
surgery and orthopaedics. His<br />
clinical and scientific<br />
focus includes shoulder surgery,<br />
cartilage trauma, traumatic<br />
brain injuries, clinical<br />
paediatric traumatology, and<br />
sports medicine.<br />
[2] Hunziker, E.B., Articular cartilage repair: basic science and clinical progress. A review of the<br />
current status and prospects. Osteoarthritis Cartilage, 2002. 10(6): p. 432-63.<br />
[3] Schinhan, M., et al., Critical-size defect induces unicompartmental osteoar-thritis in a stable<br />
ovine knee. J Orthop Res, 2012. 30(2): p. 214-20.<br />
[4] Schulze-Tanzil, G., Activation and dedifferentiation of chondrocytes: implica-tions in<br />
[5] Brittberg, M., Autologous chondrocyte transplantation. Clin Orthop Relat Res, 1999(367 Suppl):<br />
p. S147-55.<br />
[6] Marlovits, S., et al., Cartilage repair: generations of autologous chondrocyte transplantation. Eur<br />
J Radiol, 2006. 57(1): p. 24-31.<br />
[7] Bartlett, W., et al., Autologous chondrocyte implantation versus matrix-induced autologous<br />
chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised<br />
study. J Bone Joint Surg Br, 2005. 87(5): p. 640-5.<br />
[8] Knutsen, G., et al., Autologous chondrocyte implantation compared with mi-crofracture in the<br />
knee. A randomized trial. J Bone Joint Surg Am, 2004. 86(3): p. 455-64.<br />
[9] Wondrasch, B., et al., Effect of accelerated weightbearing after matrix-associated autologous<br />
chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after<br />
2 years: a prospective, randomized controlled pilot study. Am J Sports Med, 2009. 37 Suppl 1: p.<br />
88s-96s.<br />
[10] Albrecht, C., et al., Gene expression and cell differentiation in matrix-associated chondrocyte<br />
transplantation grafts: a comparative study. Osteoar-thritis Cartilage, 2011. 19(10): p. 1<br />
219-27.
Integriertes Patientenversorgungskonzept zur MACT-<br />
Gelenksknorpelrekonstruktion<br />
Exakte Indikationsstellung<br />
Indikations- und Durchführungs empfehlungen<br />
der Arbeits gemeinschaft „Geweberegeneration<br />
und Gewebe ersatz“ zur Autologen<br />
Chondrozyten-Transplanta tion (ACT). Behrens<br />
P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier<br />
C, Krackhardt T, Löhnert J, Marlovits S, Meenen NM,<br />
Mollenhauer J, Nehrer S, Niethard FU, Nöth U, Perka C,<br />
Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K<br />
(2004). Z Orthop 142: 529-539<br />
Hohe Zelldichte und hohe Zellvitalität<br />
des Implantats<br />
Effect of cell seeding concentration on the quality<br />
of tissue engineered constructs loaded with adult<br />
human articular chondrocytes. Concaro S, Nick lasson E,<br />
Ellowsson L, Lindahl A, Brittberg M, Gatenholm P (2008).<br />
J Tissue Eng Regen Med<br />
Flexible Anpassung des Implantats bei<br />
der Trans plantation und Wahrung einer<br />
homogenen Zellmatrix<br />
Stabilization of fibrin-chondrocyte constructs for<br />
cartilage reconstruction. Meinhart J, Fussenegger M, Höbling W<br />
(1999), Ann Plast Surg 42(6): 673-678<br />
KnorpelbiobsatEntnahme<br />
Zellkultur züchten<br />
MACTTransplantation<br />
Seit 2001 züchtet das Institut<br />
für Gewebe- und Organrekonstruk<br />
tion, kurz igo®,<br />
autologe Zell kul turen für die<br />
Knorpel zell rekon struk tion für mehr als 1.500 Patienten<br />
erfolgreich an.<br />
igo® ist ein privates biopharmazeutisches Unternehmen<br />
und Pionier auf dem Gebiet der Zellkulturtechnik<br />
und des Tissue Engineerings und aktiv<br />
beteiligt an Entwicklung neuer Heilmethoden. Als<br />
österreichisches Unternehmen glänzen wir mit<br />
der besonderen räumlichen Nähe und dem direkten<br />
Kontakt zu unseren Kunden.<br />
Informieren Sie sich unter www.igor.at<br />
Hohe Compliance des Patienten: Die für<br />
die Nachtherapie verwendeten Geräte,<br />
CPM Schiene sowie HPM Gerät verfügen<br />
über eine ComplianceÜberwachung. Wenn<br />
der Patient hier compliant ist, kann man<br />
davon ausgehen, dass er auch bei der<br />
Physio therapie konsequent mitarbeitet, was<br />
für den Erfolg der Therapie wesentlich ist.<br />
Low frequency EMF regulates chondrocyte<br />
differentiation and expression of matrix proteins.<br />
Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002).<br />
J Orthop Res, Vol. 20(1): 40-50<br />
Postoperative Therapie<br />
Die Kontrollierte Nachtherapie: wird<br />
durch das Netz werk von geschulten Physiotherapeuten<br />
unterstützt<br />
MACTLangzeittherapie<br />
Autologous chondrocyte implantation postoperative<br />
care and rehabilitation. Hambly K, Bobic V, Wondrasch B,<br />
VanAssche D, Marlovits S (2006). Science and Practice.<br />
Am J Sports Med 34(6): 1020-1038<br />
A prospective, randomized comparison of traditional<br />
and accelerated approaches to postoperative<br />
rehabilitation following autologous chondrocyte<br />
implantation: 2-year clinical outcomes. Jay R. Ebert,<br />
William B. Robertson, David G. Lloyd, M.H. Zheng, David J. Wood,<br />
Timothy Ackland (2010). Catilage 1(3)180-187<br />
Wissenschaftliche Publikationen<br />
mit igor ChondroSystems<br />
Clinical experience with matrix associated<br />
autologous chondrocyte transplantation<br />
(MACT). Ramadani F, Orthner E, Kitzler B,<br />
Wallner B, Burghuber C, Fußenegger M, Meinhart J<br />
(2005). Revista de ortopedie si traumatologie 1(6):<br />
106-110<br />
Transplantation of chondrocytes – longtime<br />
experiments. Prof. Dr. Lars Peterson (2006)<br />
Ergebnis nach ca. 18 Monaten<br />
Quelle:<br />
<strong>Klinik</strong> Diakonissen<br />
Schladming<br />
Seit 2006 läuft das Koopera ti onsprojekt Leomed/<br />
Igor der integrierten Patientenver sorgung für<br />
Knor pel rekon struktion.<br />
Nach Implantation unterstützt Leomed die<br />
Patienten bei der Organisation der Nachtherapie.<br />
Informieren Sie sich unter www.leomed.at
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26<br />
Patient-Specific Implants<br />
for Pelvic Tumor Resections<br />
„Internal hemipelvectomy and<br />
reconstruction using custom-made<br />
implants comes with a high risk for<br />
postoperative complications. However,<br />
good functional outcomes can be<br />
regularly achieved.“<br />
Kevin Döring<br />
Limb-sparing surgery of primary malignant pelvic tumors has<br />
become the treatment of choice over the last decade, mainly due<br />
to improvement in surgical technique, imaging, and perioperative<br />
management. However, limb-sparing surgery remains challenging<br />
with respect to defect reconstruction and management of complications.<br />
Several methods have been applied for reconstruction<br />
after periacetabular tumor resections, such as iliofemoral arthrodesis,<br />
allograft reconstruction, irradiated, autoclaved or frozen<br />
autografts, and allograft-prosthetic composites.<br />
Endo prosthetic replacement bears the advantage of immediate stability and<br />
allows early weight bearing, which is of utmost importance in this mainly<br />
young patient group. Among the endoprosthetic replacements, custom-made<br />
endoprostheses have been used in the last three decades and still represent<br />
the technique of choice due to high variability in pelvic anatomy (Figure 1).<br />
However, as pelvic reconstruction using custom-made implants is only rarely<br />
necessary, follow up data on this type of reconstruction are rare. Thus, we<br />
conducted this study to analyse the outcome of custom-made prostheses in<br />
a single centre setting over a follow-up period of three decades.<br />
Patients and Methods<br />
Between 1990 and 2000, 26 patients underwent resection of pelvic malign<br />
bone tumors at the orthopaedic department of the Medical University of<br />
Vienna and received reconstruction using custom made pelvic prostheses<br />
(Howmedica, Kiel, Germany). Except of oncological survival analyses, 6 of<br />
these 26 patients were excluded due to a follow up below one year and, thus,<br />
no possibility of an adequate prosthesis assessment regarding function and<br />
complications. The median (range) age at surgery was 25 (13–63) years, the<br />
median follow-up after surgery was 5 (1–17) years.<br />
Study:<br />
Döring K, Staats K, Puchner S,<br />
Windhager R.<br />
Patient-Specific Implants for<br />
Pelvic Tumor Resections.<br />
J Pers Med. <strong>2021</strong> Jul<br />
21;11(8):683.<br />
Results<br />
At the time of last follow up, four patients had no surgical revision after prosthesis<br />
implantation, while 16 patients had at least one revision. The median<br />
number of revision surgeries per patient was 1.5 (0–7). The first surgical<br />
revision was performed with a median of 27 (0 days – 6 years) days after surgery.<br />
Regarding type I complications according to the ISOLS classification by<br />
Henderson et al., we found a revision free survival of 90 % after one year and<br />
84 % after two and five years. Type I complications occurred in three patients<br />
suffering from dislocation of their pelvic prosthesis, which required surgical<br />
revision after a median of five months (14 days – 20 months) after surgery.<br />
Type II complications or aseptic loosening showed a revision free survival of
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27<br />
Figure 1: Real-size planning model for preoperative prosthesis and osteotomy planning.<br />
95 % after one year, 89 % after two years and 78 % after five years. Aseptic<br />
loosening occurred in four patients after a median of 38.5 (10–80) months.<br />
Type IV complications or deep infections were the most prevalent surgical<br />
complications, with 9 out of 20 patients suffering from infections which<br />
needed surgical revision after a median of 86 days (13 days – 5 years) after<br />
primary prosthesis implantation. Although most of these infections could<br />
be treated with debridement and antibiotic therapy, three patients required<br />
implant removal due to otherwise uncontrollable infections after a median of<br />
15 months (95 days – 16 years) after surgery. There were no revisions due to<br />
type III complications or periprosthetic fractures, as well as type V complications<br />
or tumor progression in this study.<br />
Four patients suffered from sciatic nerve lesions, of whom 2 patients received<br />
singular surgical neurolysis with a median of 26 (24–28) months after<br />
surgery. Thromboembolic events were frequently observed after surgery,<br />
with 5 out of 20 patients suffering from thromboses. Three of these patients<br />
required immediate revision surgery at the day of prosthesis implantation,<br />
while two patients were successfully treated conservatively.<br />
15 patients with a minimum follow up of one year could be functionally<br />
assessed, while a complete Harris Hip Score (HHS) could be retrieved in<br />
eleven patients, showing good results with a median score of 81 (37–92)<br />
points at time of last follow up visit at the outpatient clinic. Six patients were<br />
able to walk without walking aid and six patients needed one walking stick,<br />
while three patients were mobilized with two crutches. No information regarding<br />
walking limitations could be assessed in five patients.
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28<br />
Figure 2: Left: Twenty-four-year-old patient with pelvic osteosarcoma. Middle: Same patient after receiving a modern 3D-printed custom-made prosthesis<br />
(Materialise, Gilching, GER), with a cemented Durasul inlay (Zimmer Biomet, Warsaw, IN, USA) articulating with an Actis femoral stem (DePuy<br />
Synthes, Raynham, MA, USA). Right: Two years after the surgery, the patient is pain free and has a moderately limb walk with no walking aid required.<br />
Discussion<br />
Although the use of custom-made prostheses led to primary stable reconstructions,<br />
complications were common at medium- to long-term follow ups.<br />
Especially in reflection of a high postoperative prosthesis morbidity with<br />
potentially devastating complications, patients need to be carefully selected,<br />
thoroughly educated, and integrated into the decision-making process.<br />
At our institution, these high complication numbers led to a diminished use<br />
of custom-made endoprostheses at the expense of saddle endoprostheses<br />
or ice-cone shaped endoprostheses in the last decade.<br />
However, not all types of periacetabular tumors may be addressed with<br />
saddle- or ice-cone shaped endoprostheses, as enough iliac bone is required<br />
for implant fixation. We believe that emerging 3D-printed custom-made<br />
prostheses show great promise in reconstruction of extensive periacetabular<br />
tumors, due to a potential reduction of duration of surgery and thus<br />
postoperative complications, a higher prosthesis survival and stability, and<br />
better availability due to a fast 3D-printing process (Figure 2).<br />
Dr. Kevin Döring<br />
Author:<br />
Kevin Döring has been a<br />
resident at the Department<br />
of Orthopedics and Trauma<br />
Surgery at the Medical University<br />
of Vienna since 2018.<br />
His research focuses on the<br />
promotion of patient-centered<br />
implant solutions in foot surgery,<br />
tumor orthopaedics and<br />
arthroplasty.<br />
In frontiers of limb salvage surgery, functional outcomes are of particular importance<br />
to justify invasive and complication-ridden procedures. This study<br />
showed good functional results, with a median HHS of 81 (37–92) points at<br />
time of last follow up. More than half of all patients showed a high weight<br />
bearing capability, as six patients walked without walking aid and six other<br />
patients only needed one walking stick.<br />
Conclusion<br />
Internal hemipelvectomy and reconstruction using custom-made implants<br />
comes with a high risk for postoperative complications. However, good<br />
functional outcomes can be regularly achieved. This information may help<br />
treating surgeons to find adequate indications, as eligible patients need<br />
to be critically selected. Future studies evaluating new generations of<br />
3D-printed custom-made pelvic implants are needed to determine their<br />
clinical value.
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30<br />
Size Matters as Critical<br />
Parameter for the Reliability<br />
of Spheroids in Drug Screening<br />
Applications<br />
Study:<br />
Eilenberger C, Rothbauer M,<br />
Selinger F, Gerhartl A, Neuhaus<br />
W, Jordan C, Harasek M,<br />
Schädl B, Grillari J, Küpcü S,<br />
Weghuber J, Ertl P, A microfluidic<br />
multi-size spheroid array<br />
for multi-parametric screening<br />
of anti-cancer drugs and<br />
blood-brain barrier transport<br />
properties, Advanced Science,<br />
<strong>2021</strong>, 2004856, 4. (16,806)<br />
In <strong>2021</strong>, a cooperative project of researchers of the ‚Karl Chiari<br />
Lab for Orthopaedic Biology‘ in collaboration with partners at<br />
the Vienna University of Technology, the University of Natural<br />
Resources and Life Sciences Vienna (BOKU), the Austrian Institute<br />
of Technology GmbH, the Ludwig-Boltzmann-Institute for<br />
Experimen tal and Clinical Traumatology, and the University of Applied<br />
Sciences Upper Austria developed a microfluidic multi-size<br />
spheroid array platform to standardize and validate spheroid<br />
tissue models for drug screening. The study resulted in the article<br />
entitled ‘A Microfluidic Multisize Spheroid Array for Multiparametric<br />
Screening of Anticancer Drugs and Blood–Brain Barrier<br />
Transport Properties’ in Wiley Advanced Science (IF 16.8). The<br />
work is a result of years of interdisciplinary research at the interface<br />
of basic biological research, engineering, and bioengineering.
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31<br />
„This study overall proves that size is<br />
a vital parameter that needs to be<br />
considered in the future to allow<br />
validation and standardization of<br />
organotypic spheroid-based models for<br />
pharmaceutical research, because<br />
it severely affects study outcome.“<br />
Mario Rothbauer<br />
The disadvantages associated with the development of novel drugs include<br />
the high costs for development, regulatory approval, and market introduction.<br />
Even though remaining the golden standard for clinical trials to this day, animal<br />
testing does not reflect what happens in the human body. Consequently, most<br />
drug candidates fail during development, with approx. 1 out of 20 successful<br />
drug candidates entering the market. Over the last two decades, in vitro assays<br />
based on artificial human tissues as three-dimensional cultures have gained<br />
momentum in pharmaceutical development, toxicology, and biomedicine.<br />
These complex three-dimensional tissue-like structures are not only<br />
intended to circumvent expensive animal experiments, but also to replace<br />
the currently existing and inadequate in vitro models, because both approaches<br />
that fail to resemble human tissue architecture and function. Thus,<br />
various culture techniques have been established over the years (e.g., pellet<br />
cultures, micro masses, Trans-wells, etc.) that aim to resemble function of<br />
human tissues on architectural down to molecular levels. The undisputed<br />
most promising technology for drug screening, allowing for the high scalability<br />
requirements of pharmaceutical industry, are multi-cellular organotypic<br />
spheroids, which create complex tissue structures based on the proficiency<br />
of primary cells to form tissue-like structures when being joined together as<br />
heterogenous aggregates.<br />
Even though the research community has promised that such next-generation<br />
models are of physiological relevance and ideal for improving the efficiency<br />
of drug screening during clinical studies, so far artificial human tissue<br />
technologies still severely lack the proper validation necessary for integration<br />
into development and production pipelines and certification procedures.<br />
Furthermore, not a single well-plate derived solution can maintain cells under<br />
the dynamic and perfused conditions needed to create a tissue-like microenvironment.<br />
Aside from variations in donor tissue and consequently cell<br />
function, the most significant drawback to use organ-like spheroids is simple:<br />
Every laboratory – be it academic or industrial – has its own protocol and<br />
recipe how to fabricate organotypic spheroids including variations in initial<br />
cell density, cell mixture ratios, spheroid size, culture duration as well as the<br />
utilization of medium composition and supplements. These simple facts lead<br />
to the nearly impossible task of comparing different study outcomes.<br />
Since 2019, tissue modelling with microfluidic biochips has been a new additional<br />
research focus of bioengineer Dr. Mario Rothbauer at the ‚Karl Chiari<br />
Lab for Orthopaedic Biology‘ (KCLOB) of the Department of Orthopaedics and<br />
Trauma Surgery. His microsystems team wants to use organotypic tissue-like<br />
microsystems as three-dimensional disease models for basic science and<br />
drug screening applications.<br />
As vice president of the European Society for Alternatives to Animal Experiments<br />
(EUSAAT), Dr. Rothbauer aims at a patient-derived approach, focusing<br />
on animal-free methods and approaches as complimentary tools to animal<br />
experiments.<br />
Aim and Methods<br />
Due to the current shortcomings of spheroid model validation and comparability,<br />
in the current study the team developed a scalable microfluidic biochip<br />
tool that can create multiple differently sized spheroids within a micro-
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32<br />
fluidic biochip-plate using a single step injection. The tool is compatible with<br />
multi-pipetting and pipetting robots and allows to reproducibly produce 360<br />
spheroids of five sizes on a single well plate by minimal user interaction of<br />
six cell suspension injections per plate. To demonstrate the broad applicability<br />
and effectiveness of our multi-spheroid array, we investigated the most<br />
common microwell shapes against our new hemispherical microwells that<br />
are replicated from optical micro lens-like shapes, hoping to prove that size<br />
control as well as placement accuracy of our approach outperforms standard<br />
elliptical as well as spherical and cylindrical approaches.<br />
To create a scalable model that facilitates perfused culture of multiple sizes<br />
of organoids under controllable flow profiles, liquids in our multi-tissue<br />
spheroid arrays are driven by hydrostatic pressure on a simple tilting plate<br />
that can hold multi-spheroid arrays. As initial screening demonstration we<br />
identified the best initial seeding densities for a pool of human cancer and<br />
primary cells frequently used in drug screening (e.g., liver cancer, intestinal<br />
cancer, lung cancer, dermal fibroblasts, and brain endothelial cells). As more<br />
practical demonstration, the team decided to investigate the anti-cancer effect<br />
of combinatorial drug screening on lung cancer spheroids, as well as the<br />
pharmaceutical function and barrier properties of a complex triple-co-culture<br />
model of the human blood brain barrier.<br />
Results and Conclusion<br />
The first demonstration on combinatorial drug treatment demonstrated<br />
that the most effective concentration against A549 lung cancer spheroids<br />
is 50 µM Doxorubicin with 5µM CIS-Platin independently of cancer spheroid<br />
size. In the latter demonstration, for the first time we investigated transport<br />
properties of a human blood-brain barrier (BBB) triple-coculture spheroids<br />
of brain endothelial with astrocytes and pericytes in a microfluidic environment,<br />
optimized seeding densities as well as cell ratios to identify the<br />
healthiest barriers, and tested the effect of mannitol as well as verapamil on<br />
paracellular transport of molecules through the BBB. This study overall proves<br />
that size is a vital parameter that needs to be considered in the future to<br />
allow validation and standardization of organotypic spheroid-based models<br />
for pharmaceutical research, because it severely affects study outcome.<br />
Dr. Mario Rothbauer, MSc<br />
Author:<br />
Mario Rothbauer is currently<br />
working on the bioengineering<br />
of human disease models<br />
using organ- and lab-on-a-chip<br />
technologies as University<br />
Assistant and group leader at<br />
the „Karl Chiari Lab for Orthopaedic<br />
Biology“. In 2015, he<br />
received his doctorate in biotechnology<br />
from the University<br />
of Natural Resources and Life<br />
Sciences Vienna (BOKU).<br />
This technology, which was awarded with the 2022 state award for alternative<br />
methods to animal tests of the Austrian Ministry of Science (BMBWF)<br />
to collaborator Prof. Ertl, will be used in the future to demonstrate that the<br />
size of the tissue models also affects the performance and reproducibility of<br />
musculoskeletal tissue models in the orthopaedic drug screening sector.<br />
References:<br />
[1] A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status<br />
Report on Progress in Toxicology and Pharmacology“ Micromachines <strong>2021</strong>, 12 (5), 470, M Rothbauer,<br />
BEM Bachmann, C Eilenberger, SRA Kratz, S Spitz, G Höll, and P Ertl.<br />
[2] Recent Advances in Additive Manufacturing and 3D Bioprinting for Organs-On-A-Chip and Microphysiological<br />
Systems. Frontiers in Bioengineering and Biotechnology 2022, 10. M Rothbauer, C<br />
Eilenberger, S Spitz, BEM Bachmann, SRA Kratz, EI Reihs, R Windhager, S Toegel and P Ertl.<br />
[3] A microfluidic multi-size spheroid array for multi-parametric screening of anti-cancer drugs<br />
and blood-brain barrier transport properties, Advanced Science, <strong>2021</strong>, 2004856, 4. C Eilenberger,<br />
M Rothbauer, F Selinger, A Gerhartl, W Neuhaus, C Jordan, M Harasek, B Schädl, J Grillari, S<br />
Küpcü, J Weghuber and P Ertl.<br />
[4] https://www.bmbwf.gv.at/Ministerium/Presse/20220413.html
Der Weg der Shark Screw®<br />
Vom Spenderknochen zu<br />
Patientenknochen<br />
Die Spenderauswahl<br />
Bevor der für die Produktion der Shark Screw® verwendete kortikale<br />
Spenderknochen für den weiteren Herstellungsprozess in Österreich<br />
und Deutschland freigegeben wird, werden zahlreiche Tests<br />
durchgeführt, Proben entnommen und der serologische Status<br />
erhoben. Dadurch kann maximale Sicherheit für Arzt und Patient<br />
gewährleistet werden. Die Wahrscheinlichkeit einer<br />
Krankheitsübertragung mit einem solchen Allograft liegt dabei bei<br />
1<br />
1:10.000.000.000.000.000.<br />
Der Herstellungsprozess<br />
Die Formgebung von Shark Screw® erfolgt in Linz, Oberösterreich.<br />
Damit aus kortikalem Knochen schlussendlich eine einwandfreie<br />
Shark Screw® wird, durchläuft jede Schraube eine aufwendige<br />
Qualitätskontrolle, bevor diese einen seit Jahrzehnten erprobten<br />
Sterilisationsprozess durchlaufen. Schrauben, welche die<br />
Qualitätskontrolle nicht bestanden haben, werden für die klinische<br />
Anwendung ausgeschlossen. Diese Schrauben stehen jedoch den<br />
ChirurgInnen bei Shark Screw® Wet-Labs zur Verfügung.<br />
Mission 2030<br />
surgebright ist die österreichische<br />
Gewebebank für Spitäler und Ihre<br />
Ansprechperson für Knochen- und<br />
Gewebeersatz sowie biointelligente<br />
Osteosynthesen. Gemeinsam mit Shark<br />
Screw® Chirurgen möchten wir durch den<br />
Einsatz von Shark Screw® bis 2030,<br />
500.000 Patienten das Risiko einer zweiten<br />
Operation zur Metallentfernung ersparen.<br />
In Shark Screw® Workshops sollen 5.000<br />
ChirurgInnen die Verwendung von Shark<br />
Screw trainieren können. Werden Sie jetzt<br />
Teil der Shark Screw® Peer Group auf:<br />
www.surgebright.com<br />
Der erste klinische Einsatz der<br />
Shark Screw®<br />
Nach dem erfolgreich absolvierten Shark Screw® Workshop<br />
können die ersten Operationen mit der allogenen<br />
Knochenschraube durchgeführt werden und die Shark<br />
Screw® in die klinische Routine implementiert werden.<br />
OP-Videos und Betreuung vor Ort werden hierbei als<br />
Unterstützung angeboten.<br />
Remodeling & Integration in<br />
Knochenstoffwechsel<br />
Nach und nach wird Shark Screw® von<br />
Stammzellen, Osteoblasten, Osteoklasten,<br />
und Osteozyten besiedelt und in<br />
Patientenknochen remodelt. Dabei löst<br />
sich Shark Screw® nicht auf, sondern wird<br />
narbenlos ein und umgebaut. Bereits<br />
nach wenigen Monaten ist die humane<br />
Knochenschraube gänzlich remodelt.²<br />
1 J. Brune, Update: Allogene Gewebetransplantation in Deutschland, AFRO Expertengremium Pontresina 2019 | Association for Orthopaedic Research<br />
2 I. Brcic, K. Pastl, H. Plank, J. Igrec, J. E. Schanda, E. Pastl, M. Werner. Incorporation of an Allogenic Cortical Bone Graft Following Arthrodesis of the First<br />
Metatarsophalangeal Joint in a Patient with Hallux Rigidus Life (<strong>2021</strong>)<br />
Mehr Infos unter:<br />
www.surgebright.com
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34<br />
Figure 1: Transversal T1-TSE MRI with arrows showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3<br />
Pseudotumors in Metal-on-Metal<br />
Total Hip Arthroplasty<br />
Study:<br />
Kolbitsch P, Noebauer-<br />
Huhmann IM, Giurea A,<br />
Kubista B, Windhager R,<br />
Lass R. Pseudotumors in<br />
Small-Head Metal-on-Metal<br />
Total Hip Arthroplasties at<br />
a Minimum Follow-Up of 20<br />
Years. J Arthroplasty. <strong>2021</strong><br />
Aug;36(8):2871-2877. doi:<br />
10.1016/j.arth.<strong>2021</strong>.03.022.<br />
Epub <strong>2021</strong> Mar 10. (4,757)<br />
Total hip arthroplasty (THA) is one of the most successful<br />
surgeries nowadays and the method of choice for end stage<br />
osteo arthritis (OA) of the hip joint with good clinical results and<br />
long survivorship of implants. Metal-on-metal (MOM) surfaces<br />
have been used for a long time and are still used nowadays in<br />
some young and active patients, because of their hardness and<br />
their reduced risk of wear. These bearings have shown high<br />
survival rates and very satisfying clinical results, but there is the<br />
risk of metal ion release and systemic accumulation. Consequently,<br />
carcinogenicity, neurological, cardiovascular, and endocrine<br />
deficits can result. Adverse reactions to metal debris (ARMD) and<br />
pseudotumors are possible complications in MOM THAs. Literature<br />
shows rates of up to 69 % of pseudotumors in symptomatic<br />
patients, and up to 61 % in asymptomatic patients.
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35<br />
Figure 2: Transversal T1-TIRM MRI with arrow showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3<br />
Serum Cobalt and Chromium levels are recommended as monitoring tool for<br />
the detection of elevated metal ion levels. For evaluating pseudotumors in<br />
symptomatic or asymptomatic patients, either magnetic resonance imaging<br />
or ultrasound is preferred. The data of this cohort have already been published<br />
at the follow-up period of 10, 17 and 18 years.<br />
„The most important finding of our<br />
study is the presence of pseudotumors<br />
also in asymptomatic patients, along<br />
with the conclusion that serum metal<br />
ion levels alone were not enough for<br />
following-up metal-on-metal THAs […].“<br />
Paul Kolbitsch<br />
These prior publications resulted in our recent publication with the title<br />
„Pseudotumors in Small-Head Metal-on-Metal Total Hip Arthroplasties at a<br />
Minimum Follow-Up of 20 Years.“ in the Journal of Arthroplasty (IF 4.757).<br />
The purpose of this study was to detect pseudotumors in patients with<br />
28mm-head MOM-THA using MRI at a minimum follow-up of 20 years. In<br />
addition, we analysed the correlation between serum metal levels, clinical<br />
outcome scores, activity scores and pseudotumors. For conducting our study<br />
we were supported by the „Medizinisch-Wissenschaftliche Fonds des Bürgermeisters<br />
der Bundeshauptstadt Wien“ in 2017.<br />
Methods<br />
We were able to recruit 26 patients with 29 THAs for the follow-up investigation<br />
at a minimum of 20 years after initial surgery with a mean age of 72.2<br />
years (range, 51–87 years) and a mean body-mass-index (BMI) of 28.5 (range,<br />
15.9–38.3). In all cases cementless tapered stems (Alloclassic ® Zweymüller ® ,<br />
Zimmer GmbH, Winterthur, Switzerland) with 28mm high-carbide-concentration<br />
metal-on-metal surfaces (Metasul ® , Zimmer GmbH) and a titanium made<br />
conical screw cup (CSF ® , Zimmer GmbH) were used. For the clinical investigation<br />
several scores were evaluated, including Harris Hip Score, University of<br />
California Los Angeles (UCLA) activity score, Western Ontario and McMaster<br />
Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS).
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36<br />
For radiologic follow-up standard X-rays as well as metal artifact reduction<br />
sequence (MARS) magnetic resonance imaging (MRI) were used (Figure 1).<br />
The detected pseudotumors were classified using a grading system described<br />
by Hauptfleisch et al. in 2012. It describes four different subtypes of<br />
pseudotumors regarding its walls, shape, and fluid or solid behaviour.<br />
The systemic blood metal ion levels of Cobalt and Chromium were evaluated<br />
using atomic absorption spectrometer.<br />
Of the initially included 98 patients and 105 hips included between November<br />
1992 and May 1994, 43 patients have died, 14 patients remained lost<br />
to follow-up, 6 patients could only be contacted via phone and 9 patients<br />
underwent revision surgery.<br />
Blood metal ion levels showed a mean serum cobalt level of 1.87μg/L (± 3.44)<br />
and mean chromium level of 2.23μg/L (± 2.96). For further analysis patients<br />
were divided in in a „single-metal“, and „multi-metal“ group, showing significantly<br />
higher levels in the second group (p = 0.018 for cobalt levels and<br />
p = 0.020 for chromium levels).<br />
The clinical scores showed good results in both groups. Mean HHS was 88.6<br />
(range, 62.0–100), UCLA 6.4 (range 3–10 points), VAS 0.76 (range, 0–5) and WO-<br />
MAC was at 1.66 (range 0–5.75 points). No significant differences were found<br />
between patients with pseudotumors in MRI and those with no alterations.<br />
MRI showed pseudotumors in 21 of 29 investigated hips (72 %). Comparing<br />
the serum metal ion levels showed mean cobalt and chromium of 2.2μg/L<br />
(± 3.98) and 2.39μg/L (± 3.41) in the pseudotumor group and 0.88μg/L (± 0.64)<br />
and 1.80μg/L (± 1.23) in the other group. Though levels were clearly higher<br />
in pseudotumor group, no statistically significant difference was found<br />
(p = 0.139 for cobalt and p = 0.504 for chromium). We found a cumulative rate<br />
of survival counting revision with aseptic loosening as the end point of 91.4 %<br />
at 22.8 years (95 % confidence interval).<br />
Dr. Paul Kolbitsch<br />
Author:<br />
Paul Kolbitsch is currently a<br />
resident at the Department<br />
of Orthopaedics and Trauma<br />
Surgery at the Medical University<br />
of Vienna. Since his time<br />
as student, he has actively<br />
participated in several studies<br />
of the adult reconstruction<br />
team of the Division of Orthopaedics.<br />
He has finished his<br />
medical school in 2017.<br />
Results<br />
The most important finding of our study is the presence of pseudotumors<br />
also in asymptomatic patients, along with the conclusion that serum metal<br />
ion levels alone were not enough for following-up metal-on-metal THAs,<br />
as most of our patients with pseudotumor were below the recommended<br />
threshold of 7μg/L. In addition, we could show that 28mm metal-on-metal<br />
bearings have a high incidence of pseudotumors in long term follow-up. The<br />
consequences that should be taken in cases of asymptomatic pseudotumor<br />
patients have not yet been clearly stated and will need further investigations.<br />
References:<br />
[1] Kolb A, Schneckener CD, Chiari C, et al. Cementless total hip arthroplasty with the rectangular<br />
titanium Zweymüller stem: a concise follow-up, at a minimum of twenty years, of previous<br />
reports. J Bone Joint Surg Am. 2012;94(18):1681-1684. doi:10.2106/JBJS.K.01574<br />
[2] Kolbitsch P, Noebauer-Huhmann IM, Giurea A, Kubista B, Windhager R, Lass R. Pseudotumors<br />
in Small-Head Metal-on-Metal Total Hip Arthroplasties at a Minimum Follow-Up of 20 Years. J<br />
Arthroplasty. <strong>2021</strong>;36(8):2871-2877. doi:10.1016/J.ARTH.<strong>2021</strong>.03.022<br />
[3] Hauptfleisch J, Pandit H, Grammatopoulos G, Gill HS, Murray DW, Ostlere S. A MRI classification<br />
of periprosthetic soft tissue masses (pseudotumours) associated with metal-on-metal resurfacing<br />
hip arthroplasty. Skeletal Radiol. 2012;41(2):149-155. doi:10.1007/S00256-011-1329-6
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Safe Bone Block Harvesting for<br />
Quadriceps Tendon Autografts<br />
37<br />
Quadriceps tendon (QT) autografts with and without a bone<br />
block have gained popularity in recent years for both primary<br />
and revision anterior cruciate ligament reconstruction due to<br />
the shortcomings of other graft choices. A bone block facilitates<br />
length and can also be used for tibial bone defects in revision<br />
surgery if necessary. However, the main advantage of an<br />
autograft with a bone block lies in quicker bone-to-bone healing.<br />
Unfortunately, it is associated with a potential risk for intra- and<br />
postoperative patellar fractures.<br />
Study:<br />
Negrin LL, Zeitler C, Hofbauer<br />
M. Patellar Size Variation at<br />
the Quadriceps Tendon-Bone<br />
Block Harvest Site: A Magnetic<br />
Resonance Imaging Study<br />
to Evaluate the Safe Zone for<br />
Harvesting a Sufficient Bone<br />
Block. Am J Sports Med. <strong>2021</strong><br />
Dec;49(14):3850-3858. doi:<br />
10.1177/03635465211049226.<br />
Epub <strong>2021</strong> Oct 21. (6,202)<br />
Aim and Methods<br />
The objective of this study was to assess the maximum individual-related<br />
patellar bone block depth and length and to identify the location and the<br />
dimensions of the bone block (in mm), which can be safely excised in most<br />
individuals with high success probability, by performing measurements on<br />
patellar geometry. Since guidelines for patellar bone block harvesting have<br />
been based solely on personal experience, we intended to derive recommendations<br />
from physical regularities and objective criteria. Our study population<br />
of 50 males and 50 females, all Caucasians and aged ≥ 18 years, underwent<br />
3.0-T magnetic resonance imaging of their knees at our institution.<br />
Figure 1A presents the patella in coronal view. The length of the centerline<br />
corresponds to the superoinferior height of the patella, the medial (lateral)<br />
Figure 1: Patella in coronal (A) and axial (B) views. C: Harvest site of BBmedial (open box in white) and subjacent bone bridge (closed box in dotted lines).<br />
D: Safe harvesting of a QT bone block (open box in white). The central area of the patella is shaded. The medial endpoint represents the suggested starting<br />
point for initial saw placement.
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38<br />
Figure 2: Frequency distributions of<br />
patients providing/not providing<br />
bone blocks with a depth<br />
of 8mm and a length of 15mm.<br />
„The objective of this study was to assess<br />
the maximum individual-related patellar<br />
bone block depth and length and to<br />
identify the location and the dimensions<br />
of the bone block (in mm), which can be<br />
safely excised in most individuals with<br />
high success probability, by performing<br />
measurements on patellar geometry.“<br />
Lukas Negrin<br />
patellar height is defined by the length of the medial (lateral) line. The medial<br />
and lateral lines border the central area (shaded). The medial, central, and<br />
lateral thickness of the patella was measured at the height of each of the<br />
three midpoints in the axial view (Figure 1B).<br />
Our patients (mean age, 29.4 ± 7.9 years; mean height 174.4 ± 10.3cm) provided<br />
a mean QT width and thickness of 49.0 ± 7.6mm and 7.3 ± 1.0mm, respectively.<br />
The mean patellar thickness in reference to the medial endpoint, the center,<br />
and the lateral endpoint was 18.3 ± 2.4mm, 17.9 ± 2.3mm, and 15.1 ± 2.3mm,<br />
respectively, whereas the mean patellar height was 35.1 ± 4.1mm,<br />
36.7 ± 4.2mm, and 35.1 ± 3.9mm. As expected, the tendon and patellar<br />
dimensions were significantly larger in males than in females (p ≤ 0.016).<br />
We focused on physical modeling to provide limits for the bone block dimensions.<br />
In general, the 3-point bending force in knee flexion or a direct blow to<br />
the knee is believed to cause patellar fractures.
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39<br />
After bone block harvesting, these forces act directly on the bone bridge,<br />
which is defined as the remaining bone posterior to the harvest site, and<br />
may lead to its fracture. The maximum bending stress turned out to be<br />
inversely proportional to the squared depth of the bone bridge, indicating<br />
that the risk for a patellar fracture increases with increasing bone block<br />
depth. On one hand, the bone block should be deep enough to enable standard<br />
interference screw fixation techniques, on the other hand, the bone<br />
bridge depth should be sufficient to minimize fracture risk. To satisfy both<br />
prerequisites, we restricted the bone block depth to 50 % of the patellar<br />
thickness at the harvest site. Because the patella is asymmetrically thickest<br />
in its proximal half, we limited the bone block length to 50 % of the patellar<br />
height measured at its harvest site.<br />
Ap. Prof. Priv.-Doz. Dr. Lukas Negrin, PhD, MMSc<br />
Author:<br />
Lukas Negrin has devoted<br />
most of his research work to<br />
severely injured and multipletraumatized<br />
patients from<br />
the beginning of his scientific<br />
career. Currently, he leads<br />
the interdisciplinary working<br />
group „Biomarkers in polytrauma“,<br />
and the research cluster<br />
„Polytrauma and traumatic<br />
brain injury“. Moreover, he is<br />
the head of the working group<br />
„Polytrauma“ and the task<br />
force „Special trauma surgery“<br />
of the Austrian Society for<br />
Trauma Surgery (ÖGU). Additionally,<br />
he has already drawn<br />
his interest to knee injuries<br />
early during his career. During<br />
his work as team doctor of the<br />
Austrian alpine skiing world<br />
cup team and the Austrian<br />
Olympic Committee, he<br />
rediscovered his passion for<br />
research in sports injuries.<br />
After setting the maximal dimensions of the bone block, its exact location<br />
had to be analyzed. Inherently, it has to be attached to the graft, which is<br />
commonly excised from the middle third of the QT, as it primarily consists of<br />
fibers from the rectus femoris and vastus intermedius, resulting in a natural<br />
plane. Following these fibers roughly indicates the bone block harvest<br />
site on the superior pole of the patella. To highlight the effect of the patellar<br />
geometry on osseous graft volume, we created three virtual bone blocks –<br />
BBlateral , BBcentral, and BBmedial – following our specifications within the<br />
central area in all patient knees, each with a given width of 10mm. BBmedial<br />
represented the outermost region of safe graft harvesting medially. Its length<br />
was 50 % of the medial patellar height, and its depth was 50 % of the patellar<br />
thickness at the medial midpoint (Figure 1C). BBlateral was characterized<br />
analogously. BBcentral was symmetrical to the centerline with a length of<br />
50 % of the patellar length and a depth of 50 % of the patellar thickness at<br />
the central midpoint.<br />
Results and Conclusion<br />
Pair-by-pair comparisons of the three bone block depths revealed significant<br />
differences in all cases (BBmedial, 9.2 ± 1.1mm, BBcentral, 8.9 ± 1.1mm;<br />
BBlateral, 7.6 ± 1.1mm; p < 0001). Whereas the mean length of BBcentral<br />
was significantly larger than the lengths of both BBmedial and BBlateral<br />
(18.4 ± 2.1mm versus 17.6 ± 2.0mm and 17.6 ± 1.9; p < 0.0001), there was no<br />
significant difference between the mean lengths of BBmedial and BBlateral<br />
(p = 0.887).<br />
As the patella is more shallow at the lateral side than at the center or the<br />
medial side, harvesting BBlateral should be avoided. Unfortunately, both<br />
maximal graft length and depth can neither be provided by BBcentral nor<br />
by BBmedial. Since the squared depth of the bone bridge is included in the<br />
formula of the maximum bending stress, the bone block depth has to be<br />
considered the determining factor of patellar fracture risk. Consequently, we<br />
gave particular emphasis to the patellar thickness.<br />
Bone block harvesting, with its depth not exceeding 50 % of the patellar<br />
thickness and its length accounting for < 50 % of the patellar height, poses<br />
the least risk for a patellar fracture when the bone block is excised from<br />
the medial half of the central area, with the outer edge of the saw positioned<br />
at the medial border of the central area (Figure 1 D). In almost all of our<br />
patients, a bone block of 15mm length, 10mm width, and 8mm depth could<br />
be safely harvested (Figure 2). Only in five females the depth and length of<br />
BBmedial did not reach 8mm and 15mm, respectively.
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40<br />
Semi-Quantitative and<br />
Quantitative MRI for the<br />
Assessment of Cartilage Repair<br />
and Intervertebral Discs<br />
Studies:<br />
Schreiner MM, Raudner M,<br />
Marlovits S et al (<strong>2021</strong>) The<br />
MOCART (Magnetic Resonance<br />
Observation of Cartilage<br />
Repair Tissue) 2.0 Knee Score<br />
and Atlas.<br />
Schreiner MM, Raudner M, Rohrich<br />
S et al (<strong>2021</strong>) Reliability of<br />
the MOCART (Magnetic Resonance<br />
Observation of Cartilage<br />
Repair Tissue) 2.0 knee score<br />
for different cartilage repair<br />
techniques-a retrospective observational<br />
study. Eur Radiol.<br />
Schreiner MM, Raudner M,<br />
Szomolanyi P et al (2020)<br />
Chondral and Osteochondral<br />
Femoral Cartilage Lesions,<br />
Treated with GelrinC: Significant<br />
Improvement of Radiological<br />
Outcome Over Time and<br />
Zonal Variation of the Repair<br />
Tissue Based on T2 Mapping<br />
at 24 Months.<br />
Raudner M, Toth DF, Schreiner<br />
MM et al (<strong>2021</strong>) Synthetic<br />
T2-weighted images of the<br />
lumbar spine derived from<br />
an accelerated T2 mapping<br />
sequence: Comparison to<br />
conventional T2w turbo spin<br />
echo. Magn Reson Imaging<br />
84:92-100<br />
Morphological MRI has become the method of choice for<br />
the assessment of cartilage lesions and repair as well as intervertebral<br />
discs. However, radiographic reports from morphological<br />
MRI are inherently subjective and not standardised.<br />
The ability to measure and accurately define the extent of<br />
pathology and outcome after surgical treatment is a prerequisite<br />
for high-quality studies that use a radiological endpoint.<br />
One solution could be the introduction of semi-quantitative<br />
scoring systems. Another possibility is the use of quantitative<br />
MRI techniques that promise correlation with the composition<br />
and ultrastructure of the tissues studied. With respect to articular<br />
cartilage and intervertebral discs, T2 mapping is the most widely<br />
used and extensively studied technique. However, multi-echo<br />
spin-echo T2 mapping is time-consuming and therefore rarely<br />
feasible in the clinical setting.<br />
It is challenges like these on which the biomedical MR-imaging Cluster of<br />
orthopaedic disorders focuses. This fruitful collaboration between the High<br />
field MR Centre (Prof. Siegfried Trattnig) and the Department of Orthopaedics<br />
and Trauma Surgery involves physicists, radiologists as well as orthopaedic<br />
surgeons with a special interest in MRI of the musculoskeletal system.<br />
The increasing number of different surgical repair techniques of articular<br />
cartilage lesions required a non-invasive and reproducible tool to evaluate<br />
the outcome. In this endeavour, the MOCART (Magnetic Resonance Observation<br />
of Cartilage Repair Tissue) score was developed in collaboration between<br />
radiologists and orthopaedic surgeons and was widely accepted.<br />
However, with advances in surgical techniques, MRI hardware, and software,<br />
the original MOCART score was overdue for an update. Therefore, the<br />
MOCART 2.0 Knee Score and Atlas was introduced. In addition to revising the<br />
scoring system, a comprehensive atlas was introduced to increase reproducibility<br />
by providing an example for each possible score on the MOCART 2.0<br />
Knee Score. The new MOCART 2.0 knee score was then used by two experi-
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41<br />
Figure 1:<br />
T2w turbo spin echo image witch CPMG overlay<br />
(left), on the right synthetic T2w image with<br />
GRAPPATINI overlay (right) – with courtesy of<br />
Marcus Raudner MD, PhD.<br />
„These developments of novel<br />
semi-quantitative and quantitative<br />
imaging techniques greatly increase<br />
the possibilities for reproducible<br />
non-invasive diagnosis, characterisation,<br />
and monitoring of both<br />
disease and surgical repair.“<br />
Markus Schreiner<br />
enced radiologists and two junior radiologists with little or no experience in<br />
musculoskeletal radiology to evaluate the MRI examination of 24 patients<br />
after MACI. To assess whether access to the atlas would improve reproducibility,<br />
the inexperienced readers performed a second examination after<br />
a four-week interval and were allowed to use the atlas. The expert readers<br />
demonstrated almost perfect overall intrarater (ICC = 0.88, p < 0.001) as well<br />
as the interrater (ICC = 0.84, p < 0.001) reliability. The overall interrater reliability<br />
of the inexperienced readers increased from poor (ICC = 0.34, p < 0.019)<br />
to moderate (ICC = 0.59, p = 0.001), with additional access to the atlas during<br />
assessment.<br />
A limitation of the study, in which the MOCART 2.0 knee score was introduced,<br />
was that only patients after MACI were included, leaving its application<br />
to other cartilage repair techniques or lesion types, i.e., chondral vs.<br />
osteochondral lesion, unclear. Therefore, another study was performed,<br />
showing similar reproducibility of the MOCART 2.0 knee score in patients<br />
after MACI, MFX as well as osteochondral repair techniques. Interestingly,<br />
we observed higher reproducibility in patients with osteochondral lesions
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42<br />
compared to chondral lesions.However, semi-quantitative and quantitative<br />
imaging techniques can also be used complementing each other as in the<br />
following study: „Chondral and Osteochondral Femoral Cartilage Lesions<br />
Treated with GelrinC: Significant Improvement of Radiological Outcome<br />
Over Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at<br />
24 Months“. In this prospective multicenter study, the MOCART score and<br />
multi-echo spin-echo (MESE) T2 mapping were used to assess the outcome<br />
of cartilage repair of femoral cartilage lesions using GelrinC at different time<br />
points with a maximum follow-up of 24 months. In this study, the MOCART<br />
score increased significantly during the follow-up period. In addition, based<br />
on T2 mapping, significant zonal variation was observed between the deep<br />
and superficial zones of cartilage repair, which is considered a hallmark of<br />
hyaline cartilage.<br />
Dr. Markus Schreiner<br />
Author:<br />
Since 2016, Markus Schreiner<br />
has been a resident at the<br />
Department of Orthopaedics<br />
and Trauma Surgery at the<br />
Medical University of Vienna<br />
and a member of the biomedical<br />
MR-imaging Cluster of orthopaedic<br />
disorders. Together<br />
with Sebastian Apprich M.D.,<br />
he coordinates the scientific<br />
collaborations between the<br />
Orthopaedic department and<br />
the High Field MR Centre (Prof.<br />
Siegfried Trattnig) at the Medical<br />
University of Vienna.<br />
Within the biomedical<br />
MR-imaging cluster, his research<br />
focuses on the development<br />
and implementation of<br />
MR-imaging techniques used<br />
for qualitative and quantitative<br />
assessment of cartilage,<br />
tendons, and intervertebral discs,<br />
as well as clinical projects<br />
on cartilage repair surgery.<br />
More possibilities for reproducible non-invasive diagnosis<br />
However, as mentioned above, T2 mapping with a classical multi-echo spinecho<br />
technique is time-consuming and therefore not commonly used in<br />
daily clinical routine. To overcome this limitation, GRAPPATINI was recently<br />
developed. GRAPPATINI is a novel MR sequence that combines „model-based<br />
accelerated relaxometry by iterative nonlinear inversion“ (MARTINI) and<br />
„generalized autocalibrated partial parallel acquisition“ (GRAPPA). It allows<br />
accelerated T2 mapping and additionally provides synthetic morphological<br />
images, which in theory significantly reduce scan time, as one acquisition<br />
should provide both the T2 map and the morphological images. While the<br />
quality of the T2 maps of the intervertebral discs generated with GRAPPATINI<br />
has already been evaluated and compared with MESE T2 mapping, the quality<br />
of the synthetic T2-weighted images has not been evaluated and compared<br />
with conventional T2w turbo spin echo (TSE) images. Therefore, we studied<br />
58 patients with both sequences. All images were assessed by two blinded<br />
readers who determined disc degeneration and the presence of herniation or<br />
annular tear. Interrater and intrarater agreement correlated significantly in<br />
both sequences, and the agreement was substantial to near perfect.<br />
Overall, these developments of novel semi-quantitative and quantitative<br />
imaging techniques greatly increase the possibilities for reproducible<br />
non-invasive diagnosis, characterisation, and monitoring of both disease<br />
and surgical repair. This, in turn, could accelerate the understanding of<br />
underlying pathological processes and drive the development of new<br />
therapeutics.<br />
References:<br />
[1] Schreiner MM, Raudner M, Marlovits S et al (<strong>2021</strong>) The MOCART (Magnetic Resonance Observation<br />
of Cartilage Repair Tissue) 2.0 Knee Score and Atlas. Cartilage 13:571S-587S<br />
[2] Schreiner MM, Raudner M, Rohrich S et al (<strong>2021</strong>) Reliability of the MOCART (Magnetic Resonance<br />
Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair<br />
techniques-a retrospective observational study. Eur Radiol. 10.1007/s00330-021-07688-1<br />
[3] Schreiner MM, Raudner M, Szomolanyi P et al (2020) Chondral and Osteochondral Femoral<br />
Cartilage Lesions Treated with GelrinC: Significant Improvement of Radiological Outcome Over<br />
Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at 24 Months. Cartilage. 10.<br />
1177/1947603520926702:1947603520926702<br />
[4] Raudner M, Toth DF, Schreiner MM et al (<strong>2021</strong>) Synthetic T2-weighted images of the lumbar spine<br />
derived from an accelerated T2 mapping sequence: Comparison to conventional T2w turbo<br />
spin echo. Magn Reson Imaging 84:92-100
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43<br />
Bone Mineral Density<br />
of the Thoracic Spine<br />
„From a purely BMD standpoint,<br />
choosing UIVs in the upper thoracic<br />
spine for long fusion constructs might<br />
enhance instrumentation performance,<br />
especially in patients with osteoporosis.“<br />
Stephan Salzmann<br />
The thoracic spine is commonly affected by osteoporotic vertebral<br />
fractures, which occur in a bimodal distribution. The peak<br />
frequencies are at the thoracolumbar junction and the midthoracic<br />
spine. Besides osteoporotic vertebral fractures, the thoracic<br />
spine is a typical location for instrumentation failure after long<br />
spinal fusion procedures. Patients undergoing surgery for adult<br />
spinal deformity with low local bone mineral density (BMD) at<br />
the upper instrumented vertebra (UIV) have a higher risk for<br />
complications including proximal junctional kyphosis.<br />
Regional BMD variation has already been described for the cervical, lumbar,<br />
and sacral regions of the spine and the association between BMD and postoperative<br />
complications is well established. Despite the clinical importance of<br />
osteoporotic vertebral fractures, as well as instrumentation failure after long<br />
spinal fusions, no prior studies have comprehensively assessed level-specific<br />
BMD of the entire thoracic spine in patient undergoing spine surgery.<br />
The current gold standard to assess BMD in the spine is thought to be dual<br />
energy x-ray absorptiometry (DXA). However, due to the projectional nature<br />
of DXA measurements, the overlying sternum and ribs interfere with thoracic<br />
DXA measurements in the clinical setting. Quantitative computed tomography<br />
(QCT) is one of the alternatives to assess spinal BMD, circumventing<br />
several limitations of DXA measurements allowing for level-specific BMD<br />
measurements of the entire thoracic spine.<br />
Study:<br />
Salzmann SN, Okano I, Jones<br />
C, Basile E, Iuso A, Zhu J,<br />
Reisener MJ, Chiapparelli E,<br />
Shue J, Carrino JA, Girardi FP,<br />
Cammisa FP, Sama AA, Hughes<br />
AP. Thoracic bone mineral<br />
density measured by quantitative<br />
computed tomography<br />
in patients undergoing<br />
spine surgery. Spine J. <strong>2021</strong><br />
Nov;21(11):1866-1872. (4,166)<br />
Aim<br />
This study was created not only to assess the reliability of newly described<br />
thoracic QCT measurement protocol, but also to quantify the level-specific<br />
BMD of the thoracic spine in patients undergoing spinal surgery and to examine<br />
the correlation between the BMDs of the thoracic levels T1–T12.<br />
Material and Methods<br />
The study was approved by the hospital institutional review board. Spine surgery<br />
patients from 2016–2020 at a single, academic institution with available<br />
preoperative thoracic spine CT imaging were included in this study. Exclusion<br />
criteria included previous instrumentation at any thoracic level, concurrent<br />
vertebral fractures, a Cobb angle of more than 20 degrees, or incomplete<br />
thoracic spine CT imaging. Quantitative computed tomography measurements<br />
of the thoracic vertebra T1 to T12 were performed using the previously<br />
described asynchronous QCT. The method for thoracic QCT bone mineral
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44<br />
Figure 2: T1aT12 mean quantitative computed tomography (QCT) bone mineral density (BMD)<br />
in mg/cm 3 with standard deviation (SD).<br />
Figure 1: Representative thoracic QCT<br />
measurement. Axial (top) and sagittal (bottom)<br />
view of the region of interest (ROI).<br />
density measurements was similar to the clinically established approach to<br />
lumbar spine QCT measurements using a commercially available software<br />
program (QCT Pro, Mindways Software, Inc., Austin, TX, USA). Since the thoracic<br />
vertebra are smaller compared to the lumbar vertebrae, the predefined<br />
height of the volume of interested was adjusted to 7mm (predefined to 9mm<br />
for lumbar QCT measurements). An elliptical region of interest was placed in<br />
the trabecular bone at mid-vertebral height and displaced from the vertebral<br />
cortex (Figure 1). Bone islands or sclerotic regions were avoided. However, if<br />
this was not possible due to the extent of the lesion, the vertebra had to be<br />
excluded from the analysis.<br />
To assess intra- and inter-observer reliability of the experimental thoracic<br />
QCT measurements, a validation study was performed. A subsample of 120<br />
vertebrae in ten randomly selected patients were remeasured by another<br />
independent rater. In addition, the same rater remeasured the selected<br />
subsample six weeks after the first measurements. To assess inter- and<br />
intra-observer reliability the interclass correlation coefficient (ICC) was<br />
calculated. The ICC cut-offs were defined as follows: Values below 0.70<br />
indicated poor, 0.70 – 0.80 acceptable, 0.80 – 0.90 good, and ≥ 0.90 excellent<br />
agreement. A pairwise comparison of BMD was performed using the paired<br />
t-test, and correlations between each spinal level were evaluated using the<br />
Pearson’s correlation coefficient. The statistical significance level was set at<br />
p < 0.05 and all analyses were performed in R software (R for 3.5.3 GUI 1.64).<br />
Results<br />
In all, 60 patients (men, 51.7 %) undergoing spine surgery met the inclusion<br />
criteria. The study population was 90 % Caucasian with a mean age of 62.2<br />
years and a mean BMI of 30.2 kg/m². The inter-observer (ICC of 0.97, 95 %<br />
confidence interval 0.86–0.99) and intra-observer (ICC of 0.97, 95 % confidence<br />
interval 0.88–0.99) reliability of the thoracic QCT measurements was excellent.<br />
The highest trabecular BMD was found in the upper thoracic spine and<br />
decreased in the caudal direction (T1 = 182.3 mg/cm³, T2 = 168.1 mg/cm³,<br />
T3 = 163.5 mg/cm³, T4 = 164.7 mg/cm³, T5 = 161.4 mg/cm³, T6 = 152.5 mg/cm³,<br />
T7 = 143.5 mg/cm³, T8 = 141.3 mg/cm³, T9 = 143.5 mg/cm³, T10 = 145.1 mg/cm³,
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45<br />
T11 = 145.3 mg/cm³, T12 = 133.6 mg/cm³) (Figure 2). The BMD of all thoracic<br />
levels caudal to T6 was statistically lower than the BMD of all levels cranial<br />
to T6 (p < 0.001). Nonetheless, there were significant correlations in BMDs<br />
among all measured thoracic levels. The Pearson’s correlation coefficient<br />
ranged from 0.74 to 0.97.<br />
Discussion<br />
The results of this study indicate significant regional BMD differences in the<br />
thoracic spine depending on spinal level. The variation in thoracic BMD might<br />
contribute to several clinically observed phenomena:<br />
Firstly, vertebral fractures have a bimodal distribution and occur most<br />
commonly at the thoracolumbar junction (T12-L1), followed by the midthoracic<br />
region (T7-T8) as the second most common site. Besides mechanical<br />
reasons, this could be partially attributed to the thoracic BMD, which has<br />
been shown to be lowest at the T12 level (133.6 mg/cm³), followed by the T8<br />
level (141.3 mg/cm³).<br />
Secondly, choosing the optimal upper instrumented vertebra for stopping<br />
long fusions to the sacrum and pelvis is controversial. In this study, surgically<br />
relevant upper thoracic stopping points (T2-T4) showed significantly higher<br />
BMDs than lower thoracic stopping points (T10-T12). In addition to stress<br />
concentration at the relatively mobile lower thoracic segments, the low BMD<br />
at these levels might contribute to previously suggested higher rates of junctional<br />
failures of fusion constructs with UIVs in the lower thoracic spine.<br />
Conclusion<br />
In conclusion, the BMD is not uniform across the entire thoracic spine. It<br />
significantly varies by spinal level with a higher BMD in the upper thoracic<br />
levels compared to the lower thoracic levels. The data of this study might be<br />
used as a reference for future investigations and aid surgical planning. From<br />
a purely BMD standpoint, choosing UIVs in the upper thoracic spine for long<br />
fusion constructs might enhance instrumentation performance, especially in<br />
patients with osteoporosis.<br />
References:<br />
Dr. Stephan Salzmann<br />
Author:<br />
Stephan Salzmann is an orthopaedic<br />
surgery resident. His<br />
research interests include<br />
novel clinical tools to assess<br />
bone quality. He completed<br />
a re search fellowship at the<br />
Hospital for Special Surgery<br />
(NY) and received the Austrian<br />
Ministry of Science Honorary<br />
Prize and the Lumbar Spine<br />
Research Society Best Paper<br />
Award.<br />
[1] Wasnich RD. Vertebral fracture epidemiology. Bone 1996;18:S179–83. https://doi.<br />
org/10.1016/8756-3282(95)00499-8.<br />
[2] Smith MW, Annis P, Lawrence BD, Daubs MD, Brodke DS. Acute proximal junctional failure in patients<br />
with preoperative sagittal imbalance. Spine J 2015;15:2142–8. https://doi.org/10.1016/j.<br />
spinee.2015.05.028.<br />
[3] Duan P-G, Mummaneni P V, Rivera J, Guinn JM V, Wang M, XiZ, et al. The association between<br />
lower Hounsfield units of the upper instrumented vertebra and proximal junctional kyphosis in<br />
adult spinal deformity surgery with a minimum 2-year follow-up. Neurosurg Focus 2020;49:E7.<br />
https://doi.org/10.3171/2020.5.FOCUS20192.<br />
[4] Salzmann SN, Okano I, Ortiz Miller C, Chiapparelli E, Reisener M-J, Winter F, et al. Regional<br />
bone mineral density differences measured by quantitative computed tomography in patients<br />
undergoing anterior cervical spine surgery. Spine J 2020;20:1056–64. https://doi.org/10.1016/j.<br />
spinee.2020.02.011.<br />
[5] Salzmann SN, Shirahata T, Yang J, Miller CO, Carlson BB, Rentenberger C, et al. Regional<br />
bone mineral density differences measured by quantitative computed tomography: does the<br />
standard clinically used L1-L2 average correlate with the entire lumbosacral spine? Spine J<br />
2019;19:695–702. https://doi.org/10.1016/j.spinee.2018.10.007.<br />
[6] Salzmann SN, Ortiz Miller C, Carrino JA, Yang J, Shue J, Sama AA, et al. BMI and gender increase<br />
risk of sacral fractures after multilevel instrumented spinal fusion compared with bone mineral<br />
density and pelvic parameters. Spine J 2018:1–8. https://doi.org/10.1016/j.spinee.2018.05.021.
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46<br />
Association of Varus<br />
Deformity and Coronal<br />
Tibiofemoral Subluxation<br />
Osteoarthritis (OA) of the knee is one of the most common orthopaedic<br />
disorders, a burden to health care systems, and a major<br />
reason for knee pain, with Varus OA of the knee occurring more<br />
frequently than valgus OA. Total knee arthroplasty (TKA) and<br />
unicompartmental knee arthroplasty (UKA) are two reliable and<br />
successful treatment options for patients with end- stage OA with<br />
benefits on patient’s quality of life. Before scheduling patients<br />
for TKA or UKA, a critical preoperative evaluation is crucial. For<br />
UKA, an unstable knee joint is problematic. A functionally insufficient<br />
anterior cruciate ligament (ACL) often induces meniscus<br />
lesions and ultimately medial compartment OA and varus<br />
deformity of the knee. The current literature only provides a few<br />
studies investigating combined UKA and ACL reconstruction.<br />
An additional radiographic finding that gained recognition over the last few<br />
years is coronal tibiofemoral subluxation (CTFS). It has been shown that CTFS<br />
already develops in early stages of joint degeneration and continuously contributes<br />
to varus OA of the knee. It was also associated with impingement of the<br />
medial aspect of the lateral femoral condyle on the tibial spine. Furthermore,<br />
CTFS was considered as a potential reason for unexplained knee pain following<br />
UKA. Even if CTFS is a well- recognized radiographic finding, its impact<br />
on biomechanics and clinical symptoms are still not clear. The current study<br />
evaluates the association of a functional status of the ACL and the overall varus<br />
deformity of the knee or CTFS.<br />
Study:<br />
Springer B*, Waldstein W*,<br />
Bechler U, Jungwirth-<br />
Weinberger A, Windhager R,<br />
Boettner F.<br />
J Arthroplasty. <strong>2021</strong><br />
Feb;36(2):501-506. doi:<br />
10.1016/j.arth.2020.08.049.<br />
*Both authors contributed equally<br />
Materials and Methods<br />
The current study prospectively enrolled 100 consecutive knees in 84 patients<br />
who underwent primary TKA for varus OA between July 2010 and January<br />
2012. A standardised radiological work-up was performed pre operatively<br />
including a hip-to- ankle AP standing radiograph, an AP standing knee<br />
radiograph, a lateral radiograph, a valgus stress radiograph, and a magnetic<br />
resonance imaging (MRI) of the affected knee. After exclusion, 79 knees in 63<br />
patients were available for evaluation. The study-cohort consisted of 29 men<br />
(46 %) and 34 women (54 %) with a mean age of 69 years (range 50 – 89 years)<br />
and a mean body mass index of 26.1 kg/m 2 (range 17 – 47). Hip-to-ankle AP<br />
standing radiographs were used to assess the alignment of the lower limb.<br />
Alignment (mechanical tibiofemoral angle, mFTA) was measured as the angle
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47<br />
11,0<br />
10,0<br />
∆ ACL –<br />
• ACL +<br />
Figure 1: Illustration of the distribution of<br />
CTFS and mTFA in the entire cohort.<br />
Most knees (98 %, 40/41) with
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48<br />
„A functionally intact anterior cruciate<br />
ligament (ACL) is essential for medial<br />
unicompartmental knee arthroplasty.<br />
The current study showed that varus<br />
alignment and coronal tibiofemoral<br />
subluxation are associated with ACLinsufficiency.<br />
It remains unknown if the<br />
functional insufficiency of the ACL is a<br />
result of end-stage arthritic changes, or<br />
if an insufficient ACL leads to accelerated<br />
degenerative changes in the medial<br />
compartment with higher degrees of<br />
varus deformity.“<br />
Bernhard Springer<br />
used to evaluate the degree of correctability of mTFA. Finally, an MRI was<br />
used to evaluate the structural integrity of the ACL. The categorisation used<br />
differed between three cases: intact, with degenerative changes, or completely<br />
torn. The grading was based on the report of a blinded board-certified<br />
radiologist.<br />
In addition, the amount of intact posterior tibial cartilage (TCPOST) in the<br />
medial compartment was evaluated on sagittal T1-weighted images. A previously<br />
published study showed that a functionally insufficient ACL is likely<br />
if the intact TCPOST is < 14 %. Two groups were formed based on ACL grading<br />
and proportion of intact TCPOST. The first group included patients that had<br />
an intact ACL or a degenerative altered ACL with < 14 % intact TCPOST. These<br />
patients were considered to have a functionally intact ACL (ACL+).<br />
On the other hand, patients with a torn ACL or a degenerative altered ACL<br />
with < 14 % intact TCPOST were considered to have a functionally insufficient<br />
ACL (ACL-).<br />
Results<br />
68 knees (86 %) of the included 79 knees were considered as ACL+. Regarding<br />
KL classification in the lateral compartment, there was no difference between<br />
knees with a functionally intact ACL and ACL- deficient knees (p = 0.116).<br />
ACL- deficient knees showed significantly more femoral and tibial osteophytes<br />
in the medial compartment compared to knees with a functionally<br />
intact ACL (p < .001). ACL-deficient knees also showed a significantly higher<br />
mTFA on hip- to-ankle AP standing radiographs (p < 0.001) and on valgus<br />
stress radiographs (p = 0.017) than knees with a functionally intact ACL.<br />
The performed measurements are summarised in Table 1.<br />
Dr. Bernhard Springer<br />
Author:<br />
Bernhard Springer has been a<br />
resident at the Department of<br />
Orthopaedics and Trauma Surgery<br />
at the Medical University<br />
of Vienna since 2020. His research<br />
is focused on the knee,<br />
specialising in injuries of the<br />
anterior cruciate ligament and<br />
consequences of ACL-injuries.<br />
Seventy-three per cent of the ACL- deficient knees and 24 % of the knees<br />
with a functionally intact ACL had a mechanical varus alignment of ≥ 10°<br />
(p = 0.001). The mTFA correlated significantly with the functional status of<br />
the ACL (rs = 0.362; p = 0.001). In 64 % of the knees with a functionally insufficient<br />
ACL and in 22 % of the knees with a functionally intact ACL, a CTFS<br />
≥ 6mm was observed (p = 0.004). The CTFS also correlated significantly with<br />
the functional status of the ACL (rs = 0.227; p = 0.044). Eight patients (10 %)<br />
had ≥ 10° of varus and ≥ 6mm CTFS on AP radiographs (Figure 1). 98 % of the<br />
knees with < 10° varus and < 6mm CTFS had a functionally intact ACL. There<br />
was only one single patient with a functionally insufficient ACL when a mechanical<br />
varus of
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Outcome after Arthroscopically<br />
Assisted TFCC Refixation<br />
49<br />
In 2011, Dr. Thalhammer was given the opportunity to complete<br />
a one-year hand surgery training programme in the private<br />
practice of Dr. Heinrich-Geert Tünnerhoff and Dr. Martin Lauffer,<br />
the former being a European pioneer of wrist arthroscopy and<br />
arthroscopic TFCC repair. Among other things, Dr. Thalhammer<br />
was able to expand her knowledge in this field and has since<br />
promoted the use of arthroscopic techniques at the Clinical<br />
Department of Trauma Surgery. The idea for this study also<br />
arose during this stay.<br />
Study:<br />
Thalhammer G, Haider T, Lauffer<br />
M, Tünnerhoff HG. Mid- and<br />
Long-Term Outcome After<br />
Arthros copically Assisted<br />
Trans osseous Triangular Fibrocartilage<br />
Complex Refixation-Good<br />
to Excellent Results<br />
in Spite of Some Loss of<br />
Stability of the Distal Radioulnar<br />
Joint. Arthroscopy. <strong>2021</strong><br />
May;37(5):1458-1466. doi:<br />
10.1016/j.arthro.<strong>2021</strong>.01.056.<br />
Epub <strong>2021</strong> Feb 6. (4,772)<br />
Ulnar-sided wrist pain is frequently caused by either degenerative or<br />
traumatic lesions of the triangular fibrocartilage complex (TFCC). Espe -<br />
cially a rupture of the deep part of the radioulnar ligaments (RUL), which<br />
are considered to be the primary stabilizers of the distal radioulnar joint<br />
(DRUJ) during forearm rotation, may cause pain and recognizable instability.<br />
Because clinical diagnosis of TFCC lesions remains difficult, and also<br />
magnetic resonance imaging does not provide clear answers in all cases,<br />
arthroscopy of the wrist is crucial to detect and localize tears of the superficial<br />
or deep parts of the RUL.<br />
Arthroscopy proves to be not only a diagnostic, but also a therapeutic procedure,<br />
with the advantage of small skin incisions, less destruction of the surrounding<br />
structures, and the possibility of precise reattachment of the deep fibers<br />
of the RUL at the ulnar fovea with transosseous sutures or suture anchors.<br />
Short- and mid-term outcome reports of these methods indicate favourable<br />
results, but data regarding long-term outcome remain scarce.<br />
a<br />
b<br />
Figure 1: (a) Schematic illustration of a rupture of the RUL (purple; superficial layer of TFCC in orange) with dorsal subluxation of the ulnar head,<br />
(b) and after transosseous reattachment running dorsally and palmarly of the PSU (ulnar styloid process) and through an transosseous channel created<br />
with a K-wire in the centre of the ulnar fovea (©Tünnerhoff).
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50<br />
100<br />
***<br />
*** **<br />
60<br />
***<br />
***<br />
Mayo Wrist Score<br />
80<br />
60<br />
40<br />
DASH<br />
40<br />
20<br />
0<br />
Preoperative<br />
1 st Follow-up<br />
2 nd Follow-up<br />
n=28 – 29 n=24 – 30<br />
Preoperative<br />
1 st Follow-up<br />
2 nd Follow-up<br />
Figure 2: Time course of the Modified Mayo Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and Hand (DASH) score. Squares<br />
and whiskers represent mean and SEM; **…p < 0.01, ***…p < 0.001.<br />
Aim and Method<br />
The surgical technique used in this study was developed by Heinrich-Geert<br />
Tünnerhoff: He adapted the principles of open reattachment and developed<br />
an arthroscopically assisted procedure. The aim of this study was to evaluate<br />
mid- and long-term outcome of this technique and to analyse the association<br />
of DRUJ stability with the clinical outcome.<br />
„[…] arthroscopically assisted<br />
reattachment of the RUL provides<br />
reliable and satisfying long-term<br />
results. All study participants achieved<br />
good to excellent clinical outcome, as<br />
indicated by the MMWS at a median<br />
follow-up of 106 months.“<br />
Gerhild Thalhammer<br />
Patients with ulnar-sided wrist pain who underwent diagnostic wrist arthroscopy<br />
and arthroscopically assisted transosseous reattachment of the<br />
TFCC to the fovea between 2000 and 2009 were retrospectively evaluated.<br />
Inclusion criteria were arthroscopically confirmed avulsion of the deep RUL<br />
classified as Palmer type 1B and a minimum of 12 months for mid-term and<br />
4-years for long-term follow-up. The indication for surgery was persistent<br />
pain after unsuccessful conservative treatment of acute or chronic traumatic<br />
TFCC lesions. All surgeries were performed by either one of the senior<br />
authors (ML and HGT).<br />
Patient surveys were obtained at three separate time points, including<br />
preoperative assessment and two follow-up examinations. To reduce possible<br />
bias, the two postoperative evaluations of all patients were performed by<br />
two experienced hand surgeons not involved in the primary treatment. These<br />
included measurements of functional and clinical outcome using the Mayo<br />
Modified Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and<br />
Hand (DASH) Score. At the third follow–up examination, the Patient Rated<br />
Wrist Evaluation (PRWE) score was surveyed additionally.<br />
Pain was assessed using a visual analogue scale (VAS). Physical examination<br />
included quantification of active range of motion (ROM), including flexion/<br />
extension, radial/ulnar abduction, forearm rotation, and grip strength of
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both wrist joints. The ballottement test was used to assess DRUJ instability<br />
pre- and postoperatively. The severity of the instability was graded as either<br />
dynamically unstable, statically unstable, or stable.<br />
Patients and Results<br />
A total of 30 patients were included in this study. Preoperatively, the median<br />
MMWS was 60 (50 – 75), the DASH score was at a median of 48.3 (25.0 – 56.7),<br />
and VAS scores ranged from 3 to 10 with a median of 7 (6.0 – 8.0). The first<br />
evaluation took place at a median of 30 months postoperatively (2.5 years,<br />
range 12 – 83 months). Stability assessment showed a stable DRUJ in 23<br />
(76.7 %) patients and a dynamic instability in 5 (16.7 %) patients. All collected<br />
scores demonstrated statistically significant improvements following<br />
TFCC-repair (preoperative vs. 1st follow-up; MMWS: 60 vs. 100, p < 0.001;<br />
DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1, p < 0.001).<br />
At a median of 106 months (8.83 years, range 52 – 215 months), the second<br />
clinical assessment was performed. Stability assessment showed a stable<br />
DRUJ in 19 patients (63.3 %), while nine patients (30 %) had a dynamically<br />
unstable DRUJ, and two patients (6.7 %) had a statically unstable DRUJ. At<br />
the final follow-up, the PRWE was additionally performed with a median<br />
score of 5 (0 – 18).<br />
When compared to preoperative measures, evaluated scores demonstrated<br />
persisting and significant improvement (preoperative vs. 2nd follow-up;<br />
MMWS: 60 vs. 90, p < 0.001; DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1.8,<br />
p < 0.001). Comparing patients with DRUJ instability to patients with stable<br />
DRUJ at final follow-up, no significant differences in evaluated scores between<br />
these two groups were found.<br />
Dr. in Gerhild Thalhammer<br />
Author:<br />
Gerhild Thalhammer is a certified<br />
hand surgeon and head<br />
of the outpatient hand clinic<br />
at the Department of Trauma<br />
Surgery. She has been a<br />
senior physician at the Clinical<br />
Department of Traumatology<br />
since 2013 and is specialist in<br />
Trauma Surgery and Orthopaedics<br />
and Traumatology.<br />
Her research focuses on new<br />
techniques in wrist arthroscopy<br />
and the treatment of distal<br />
radius fractures and scaphoid<br />
fractures.<br />
These results demonstrate that arthroscopically assisted reattachment<br />
of the RUL provides reliable and satisfying long-term results. All study<br />
partici pants achieved good to excellent clinical outcome, as indicated by<br />
the MMWS at a median follow-up of 106 months. DASH-score and VAS also<br />
showed a statistically significant improvement in all patients compared to<br />
preoperative findings. Moderate deterioration of MMWS and VAS was observed<br />
at the final examination compared to the mid-term results, whereas<br />
the DASH score remained unchanged and the more wrist-specific PRWE<br />
score showed an average of 5 points.<br />
Regarding the stability of the DRUJ, we found no difference in clinical outcome<br />
between patients with static or dynamic DRUJ instability preoperatively,<br />
neither in mid-term follow-up examinations, nor in the long-term<br />
follow-up. Comparing the mid-term and long-term results of our study population,<br />
we found loss of DRUJ stability in some cases. This loss of stability of<br />
the DRUJ did not correlate with any of the evaluated scores in our statistical<br />
analysis. Despite this increase of instability, overall satisfying results in clinical<br />
outcome and high rates of patient satisfaction were observed.<br />
Conclusion<br />
Arthroscopically assisted transosseous reattachment of the deep fibres<br />
of RUL leads to excellent and good clinical results in mid- and long-term<br />
follow-up. Loss of DRUJ stability during follow-up was not associated with<br />
deterioration of clinical parameters or diminution of patient satisfaction.
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Osseointegration Can Be<br />
Improved by Conventionally Used<br />
Anti-Osteoporotic Drugs Proven<br />
in a Clinically Relevant Murine<br />
Implant Model<br />
„This study reveals that post-operative,<br />
short-term bisphosphonate treatment<br />
enhances osseointegration by increasing<br />
bone quantity. Furthermore, the<br />
decrease in osteoclast number and<br />
activity caused by bisphosphonates<br />
does not adversely affect osteogenesis<br />
and angiogenesis. Taken these together,<br />
bisphosphonates are potential therapeutic<br />
candidates for patients with a<br />
high risk of aseptic loosening caused by<br />
the failure of initial osseointegration.“<br />
Klemens Vertesich<br />
Study:<br />
Vertesich K, Sosa BR, Niu Y, Ji G,<br />
Suhardi V, Turajane K, Mun S,<br />
Xu R, Windhager R, Park-Min<br />
KH, Greenblatt MB, Bostrom<br />
MP, Yang X. Alendronate enhances<br />
osseointegration<br />
in a murine implant model.<br />
J Orthop Res <strong>2021</strong><br />
Apr;39(4):719-726. doi:<br />
10.1002/jor.24853 (3.494)<br />
Reliable and stable fixation of implants in total joint arthroplasty<br />
represents a crucial factor for long-term survival after<br />
adult joint reconstruction. In this study, the Department of<br />
Orthopaedics in collaboration with the Arthroplasty Research<br />
Laboratory at the Hospital for Special Surgery investigated<br />
the impact of bisphosphonates on osseointegration of<br />
cementless titanium implants.<br />
The success and longevity of cementless total joint arthroplasties depends<br />
on sufficient osseointegration and the process of structural and functional<br />
attachment of implants to the surrounding bone. Early and excessive implant<br />
micromotion impairs bone formation and induces the formation of fibrotic<br />
tissue, which leads to aseptic loosening and further to expensive and complex<br />
revision surgery. Bisphosphonates represent the most frequently used<br />
agents to treat osteoporosis. Arthroplasty registry studies have demonstrated<br />
that bisphosphonate treatment before, during, or after total joint arthroplasty<br />
is beneficial for long term survival.<br />
However, these studies do not allow the assessment of the cellular mechanism<br />
of osseointegration and mechanical properties of the bone-implant<br />
interface. Therefore, a reliable murine implant model has been developed,<br />
that encompasses all critical factors of cementless arthroplasty: implant<br />
positioning in metaphyseal cancellous bone, intraarticular positioning of the<br />
implant, and the ability of postoperative physiological weight-bearing.<br />
This study aimed to assess the ability of bisphosphonates to promote peri-implant<br />
bone formation, the inhibition of osteoclastogenesis at the bone-implant<br />
interface, and the enhancement of osseointegration. The hypothesis was that<br />
postoperative, short-term bisphosphonate treatment improves mechanical<br />
stability of the implant by increasing peri‐ implant bone volume, decreasing<br />
peri‐implant osteoclasts without impairing osteoblasts or angiogenesis.
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53<br />
Figure 1: (A) Lateral radiograph 28 days after proximal tibial implantation surgery. (B) Schematic overview on regions of interest for µCT measurements. (C)<br />
Biomechanical testing revealed a significant increase in maximum pull-out load in the alendronate group compared with the vehicle group. (D) Significant<br />
increase of bone volume over trabecular volume (BV/TV) in the peri-implant and distal to implant region in the alendronate group compared to vehicle.<br />
Methods<br />
In this study 44 female C57BL/6 mice at the age of 17-weeks underwent<br />
arthroplasty surgery of the right knee joint. Under isoflurane anaesthesia<br />
and sterile conditions, a 8mm midline incision was made over the right knee.<br />
A medial parapatellar approach was used to dislocate the patella. Menisci<br />
and anterior cruciate ligaments were resected. The articular cartilage of<br />
the tibia was removed and a 0.9mm diameter hole was drilled into the tibial<br />
medullary canal. A 3D-printed titanium implant, with a smooth oval formed<br />
articular surface (2.0mm x 1.5mm x 0.2mm) and with an intramedullary stem<br />
with rough surface (1.0mm in diameter and 2.0mm in length), was press-fitted<br />
into the hole (Figure 1A). Joint capsule and skin were closed in layers. The<br />
mice started to ambulate with full weight‐bearing on both knees immediately<br />
after recovery from anaesthesia.<br />
Postoperatively, the mice were randomly divided into two groups and injected<br />
with the bisphosphonate, alendronate (BioVision Inc.; n = 22, 73 μg/kg, i.p.), or<br />
vehicle (n = 22, 200 μl phosphate‐buffered saline, i.p.) 5 days a week starting<br />
from the day of surgery until the day of euthanasia. The animals were<br />
euthanized by CO2 for histological assessment on postoperative days 1, 3, 7,
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54<br />
Figure 2: (A) TRAP staining revealed a significant reduction of osteoclasts per bone perimeter (N.Oc/B.Pm) and a significant increase in bone area percent<br />
(BV/TV) with 14 days of alendronate treatment. (B) Immunofluorescence staining showed a reduction of peri-implant cathepsin K at 7-days post-implantation<br />
with alendronate treatment. (C) Immunofluorescent imaging of the proximal tibia and peri-implant region highlights a robust presence of endothelial<br />
cells and osteoblasts through endomucin (EMCN) and osteocalcin (OCN) staining, respectively.<br />
14, and 28, or microcomputed tomography (µCT) analysis and pull-out testing<br />
at day 28 after surgery. µCT was performed to assess bone volume fraction,<br />
trabecular number, trabecular thickness, and trabecular separation in two<br />
regions of interest: Peri-implant region (cancellous bone around the distal<br />
500µm of the stem) and distal to implant (cancellous bone 500µm distal<br />
from the tip of the stem) (Figure 1B). Pull-out tests were performed to assess<br />
the mechanical stability. Immunofluorescence staining was performed to<br />
assess the impact of bisphosphonates on osteogenesis, angiogenesis, and<br />
osteoclastogenesis. Antibodies for anti-Osteocalcin (OCN), anti-Endomucin<br />
(EMCN), and anti-cathepsin K (CTSK) were used. Further, frozen sections<br />
were stained for tartrate‐resistant acid phosphatase (TRAP), and histomorphometry<br />
according to recommendations of the Nomenclature Committee of<br />
the American Society for Bone and Mineral Research was performed.<br />
Results<br />
Short-term, postoperative bisphosphonate treatment ultimately increased<br />
implant stability. The maximum load of pull-out was significantly increased<br />
by 45 % (p < 0.001) (Figure 1C). µCT showed that alendronate increased both<br />
peri‐implant and distal‐to‐implant bone mass compared with the control<br />
group (Figure 1D). In the distal‐to‐implant region, the alendronate treatment<br />
increased bone volume fraction by 139 % (p < 0.001), trabecular number by<br />
31 % (p < 0.001), and trabecular thickness by 18 % (p < 0.01). In the peri‐implant<br />
region, alendronate treatment increased bone volume fraction by 60 %<br />
(p < 0.05), trabecular thickness by 7 % (p < 0 .05), and trabecular spacing by<br />
22 % (p < 0.001).<br />
Although peri‐implant bone formation increased over time in both the<br />
alendronate‐treated and control mice, alendronate accelerated the rate of<br />
peri‐implant ossification with increased peri‐implant bone mass at 7‐ and<br />
14‐day postoperative. Histology demonstrated that alendronate increased
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55<br />
the percent of the bone area in the total area from 12.7 ± 1.6 in the control<br />
group to 20.7 ± 0.9 in the alendronate group at 14 days after surgery (p < 0.05)<br />
(Figure 2A). Immunofluorescence imaging showed that short‐term, post-operative<br />
alendronate treatment did decrease the presence of osteoclasts<br />
marked by cathepsin K (CTSK) (Figure 2B) but did not attenuate peri‐implant<br />
EMCN‐positive endothelial cells or OCN‐positive osteoblasts after 7 and 14<br />
days of treatment (Figure 2C).<br />
Conclusion<br />
This study reveals that post-operative, short-term bisphosphonate<br />
treatment enhances osseointegration by increasing bone quantity.<br />
Furthermore, the decrease in osteoclast number and activity caused by<br />
bisphosphonates does not adversely affect osteogenesis and angiogenesis.<br />
Taken these together, bisphosphonates are potential therapeutic candidates<br />
for patients with a high risk of aseptic loosening caused by the failure of<br />
initial osseointegration.<br />
References:<br />
[1] Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated Titanium Implants:<br />
Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man. Acta<br />
Orthopaedica Scandinavica 52(2): 155, 2009<br />
[2] Bishop NE, Hohn JC, Rothstock S, Damm NB, Morlock MM. The influence of bone damage on<br />
press-fit mechanics. J Biomech 47(6): 1472, 2014<br />
Dr. Klemens Vertesich<br />
Author:<br />
Klemens Vertesich started his<br />
residency at the Department of<br />
Orthopaedics and Trauma Surgery<br />
at the Medical University<br />
of Vienna in 2018. His research<br />
interests are total joint arthroplasty<br />
and revision arthroplasty,<br />
osseointegration of implants<br />
as well as hip-preservation<br />
surgery. He was awarded the<br />
Ines Mandl Research Fellowship<br />
in 2018 and got the opportunity<br />
to conduct research on<br />
the impact of bone formation<br />
on implant osseointegration<br />
ant the Arthroplasty Research<br />
Laboratory at the Hospital for<br />
Special Surgery/Weill Cornell<br />
University, New York City.<br />
[3] Ollivere B, Wimhurst JA, Clark IM, Donell ST. Current concepts in osteolysis. J Bone Joint Surg Br<br />
94(1): 10, 2012<br />
[4] Mann KA, Miller MA, Costa PA, Race A, Izant TH. Interface micromotion of uncemented femoral<br />
components from postmortem retrieved total hip replacements. J Arthroplasty 27(2): 238, 2012<br />
[5] Fehring TK, Murphy JA, Hayes TD, Roberts DW, Pomeroy DL, Griffin WL. The Coventry Award<br />
Paper: Factors Influencing Wear and Osteolysis in Press-Fit Condylar Modular Total Knee Replacements.<br />
Clinical Orthopaedics and Related Research 428: 40, 2004<br />
[6] Favus MJ. Bisphosphonates for osteoporosis. The New England journal of medicine 363(21):<br />
2027, 2010<br />
[7] Russell RG. Bisphosphonates: the first 40 years. Bone 49(1): 2, 2011<br />
[8] Rogers MJ, Crockett JC, Coxon FP, Monkkonen J. Biochemical and molecular mechanisms of<br />
action of bisphosphonates. Bone 49(1): 34, 2011<br />
[9] Khatod M, Inacio MC, Dell RM, Bini SA, Paxton EW, Namba RS. Association of Bisphosphonate<br />
Use and Risk of Revision After THA: Outcomes From a US Total Joint Replacement Registry. Clin<br />
Orthop Relat Res 473(11): 3412, 2015<br />
[10] Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C, Arden NK. Association<br />
between bisphosphonate use and implant survival after primary total arthroplasty of the knee<br />
or hip: population based retrospective cohort study. BMJ 343: d7222, 2011<br />
[11] Prieto-Alhambra D, Lalmohamed A, Abrahamsen B, Arden NK, de Boer A, Vestergaard P, de<br />
Vries F. Oral bisphosphonate use and total knee/hip implant survival: validation of results in an<br />
external population-based cohort. Arthritis Rheumatol 66(11): 3233, 2014<br />
[12] Thillemann TM, Pedersen AB, Mehnert F, Johnsen SP, Soballe K. Postoperative use of bisphosphonates<br />
and risk of revision after primary total hip arthroplasty: a nationwide population-based<br />
study. Bone 46(4): 946, 2010<br />
[13] Yang X, Ricciardi BF, Dvorzhinskiy A, Brial C, Lane Z, Bhimani S, Burket JC, Hu B, Sarkisian<br />
AM, Ross FP, van der Meulen MC, Bostrom MP. Intermittent Parathyroid Hormone Enhances<br />
Cancellous Osseointegration of a Novel Murine Tibial Implant. J Bone Joint Surg Am 97(13):<br />
1074, 2015
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Figure 1: Fiber orientation in<br />
the collagen matrix of chondroprogenitor<br />
pellets. Birefringent<br />
collagen fibers show developing<br />
zonation in the newly formed<br />
hyaline matrix. (A) Horizontally<br />
arranged birefringent fibers<br />
parallel to the pellet surface (PS).<br />
(B) Randomly organized collagen<br />
fibers were found in the central<br />
area. (C) Perpendicularly oriented<br />
birefringent fibers were located<br />
in proximity to the pellet center<br />
(PC). Scale bar equals 30 µm,<br />
400× magnification.<br />
Mimicking the Zonal Organization<br />
of Articular Cartilage in Vitro<br />
In <strong>2021</strong>, the Karl Chiari Lab for Orthopaedic Biology described an in<br />
vitro based cell model comprising human chondroprogenitor cells<br />
that form zonally organized engineered hyaline tissue comparable<br />
to the three zones of native cartilage. The collaboration of the Department<br />
of Orthopedics and Trauma Surgery (MedUni Vienna and<br />
AKH Wien) with the Hospital Speising, the Medical University of<br />
Graz, and the Danube University Krems resulted in the publica tion<br />
of an article entitled „A 3-Dimensional In Vitro Model of Zonally<br />
Organized Extracellular Matrix“ in the scientific journal „Cartilage“.<br />
Study:<br />
Walzer SM, Toegel S, Chiari C,<br />
Farr S, Rinner B, Weinberg<br />
AM, Weinmann D, Fischer MB,<br />
Windhager R. A 3-Dimensional<br />
In Vitro Model of Zonally<br />
Organized Extracellular<br />
Matrix. Cartilage <strong>2021</strong>;13(2_<br />
suppl):336S-345S. (4,634)<br />
In articular joints, cartilage integrity is key for patients’ mobility and activity.<br />
The sophisticated architecture of the extracellular matrix (ECM), in particular<br />
regarding the zonal distribution of collagen fibers across the cross-section of<br />
cartilage, contributes to the unique properties of the tissue. Injuries or degenerative<br />
changes often result in cartilage lesions that cause tremendous burden<br />
for patients and healthcare systems worldwide. Numerous tissue engineering<br />
approaches aim to restore the functionality of damaged cartilage, but so far fail<br />
to reconstruct zonally organized hyaline tissue that might fulfil the expectations<br />
of long-term functionality. To study hyaline cartilage repair in vitro, endogenous<br />
stem cells of the mesenchymal lineage resident in growth plate tissue could<br />
represent a promising cell source. Previously, we showed that these human<br />
chondroprogenitors (CPs) can be isolated from polydactyl digits 2 . The hyaline<br />
cartilage formation of human CPs in vitro, however, as well as their ability to<br />
differentiate into the three mesenchymal linages remained largely unknown.
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57<br />
„To study hyaline cartilage repair<br />
in vitro, endogenous stem cells of<br />
the mesenchymal lineage resident in<br />
growth plate tissue could represent<br />
a promising cell source.“<br />
Stefan Toegel<br />
Methods<br />
Clinical specimens of the human growth plate were obtained from the supernumerary<br />
digits of eight different donors (age < 36 months) with polydactylism<br />
at the time of surgical excision. Isolated CPs were characterized by<br />
FACS analysis using specific antibodies (CD45−, CD34−, CD73+, CD90+, and<br />
CD105+). Three-dimensional cell constructs were prepared by centrifugation<br />
and cultured for up to five weeks. Constructs were processed for histology<br />
and stained with Alcian blue or Picrosirius red (PSR) and analysed using light<br />
microscopy and polarised light microscopy (PLM). In addition, deparaffinised<br />
sectiones were stained with antibodies against collagen I or collagen II and<br />
DAPI, prior to analysis with an LSM 700 confocal laser scanning microscope.<br />
In vitro osteogenic and adipogenic differentiation of CPs was confirmed<br />
using RT-qPCR of respective target genes as well as alkaline phosphatase<br />
(ALP) activity assay, Alizarin Red S (ARS) staining and oil red O staining.<br />
Results<br />
In presence of osteogenic medium, ALP staining as well as ARS quantification<br />
significantly increased over time for up to 21 days, as compared to<br />
undifferentiated controls. In agreement, mRNA levels of ALP, a marker for<br />
early osteogenesis, and BGLAP, a marker of late osteogenesis, were increased<br />
20.9 ± 25.2-fold and 6.7 ± 4.69-fold, respectively, while those for transcription<br />
factor RUNX2 were significantly upregulated 2.88 ± 1.04-fold, supporting the<br />
osteoinduction of CPs. Adipogenic differentiation of cultures stimulated with<br />
adipogenic medium was demonstrated by oil red O staining of lipid droplets,<br />
with simultaneous upregulation of mRNA levels of early (PPARG: 2.0 ± 0.6-<br />
fold) and late (LPL: 1054 ± 906-fold)) adipogenic markers. The chondrogenic<br />
phenotype of CPs was promoted in self-assembling pellet cultures.<br />
Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel<br />
After 21 days, histological analyses showed an augmented amount of glycosaminoglycans<br />
(Alcian blue) as well as column-like formations of cells.<br />
Collagen type II positivity was detected in the newly formed ECM around the<br />
centre of the pellet, whereas collagen type I immunostaining was mainly<br />
found in the superficial zone, with weak positivity in the central area of the<br />
CP pellet. PSR staining and PLM after five weeks of cultivation revealed<br />
horizontally arranged birefringent fibers, parallel to the pellet surface, as<br />
well as randomly organized collagen fibers, and perpendicularly oriented<br />
birefringent fibers in the central and deep areas of the cartilaginous matrix,<br />
respectively (Figure 1). Equally processed native articular cartilage indicated<br />
similar collagen fibril assembly.<br />
Author:<br />
Stefan Toegel is head of the Karl<br />
Chiari Lab for Orthopaedic<br />
Biology. In 2015, he became<br />
an Associate Professor at the<br />
Medical University of Vienna,<br />
and he obtained his habilitation<br />
in Cell Biology in 2018.<br />
The main focus of his research<br />
is on the pathomechanisms of<br />
osteoarthritis.<br />
Concluding remarks<br />
Confirming the trilineage potential of CPs, osteogenic and adipogenic differentiation<br />
was induced in monolayer cultures using differentiation media. Under<br />
conditions promoting the chondrogenic signature in 3D constructs, CPs formed<br />
an aligned extracellular matrix positive for glycosaminoglycans and collagen<br />
type II, showing developing zonation of birefringent collagen fibers along the<br />
cross section of pellets, which reflect the distribution of collagen fibers in hyaline<br />
cartilage.<br />
References:<br />
[1] Walzer S.M. et al. A 3-Dimensional In Vitro Model of Zonally Organized Extracellular Matrix.<br />
Cartilage <strong>2021</strong>;13:336S-345S.<br />
[2] Walzer S.M. et al. Vascularization of primary and secondary ossification centres in the human<br />
growth plate. BMC Dev Biol. 2014;14(1):36.
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Relevance of Follow-up CCT<br />
in Patients on Intracranial<br />
Pressure Monitoring<br />
„The standard of care in patients suffering from a severe<br />
traumatic brain injury (TBI) includes an invasive monitoring of<br />
the intra cranial pressure (ICP) via a probe that is surgically placed<br />
in the brain parenchyma. Based on the clinical observation that<br />
cranial computed-tomography (CCT) follow-ups are frequently<br />
performed even in patients on continuous ICP monitoring<br />
within physiological limits, the authors of our study questioned<br />
the clinical relevance and necessity of these scans.“<br />
Study:<br />
Bumberger A, Braunsteiner T,<br />
Leitgeb J, Haider T. Intracranial<br />
pressure monitoring following<br />
traumatic brain injury:<br />
evaluation of indications,<br />
complications, and significance<br />
of follow-up imaging-an<br />
exploratory, retrospective<br />
study of consecutive patients<br />
at a level I trauma center.<br />
Eur J Trauma Emerg Surg.<br />
2022 Apr;48(2):863-870.<br />
doi: 10.1007/s00068-020-<br />
01570-3. Epub 2020 Dec 22.<br />
PMID: 33351163; PMCID:<br />
PMC7754179.<br />
According to a recent meta-analysis the overall incidence of traumatic brain<br />
injury (TBI) in Europe is around 262/100.000 with considerable heterogeneity<br />
between the included studies. Cranial computed tomography (CCT) is<br />
the gold standard of imaging in these patients and can guide further treatment<br />
strategies. Furthermore, the Brain Trauma Foundation recommends<br />
ICP-monitoring for patients with severe TBI (Glasgow Coma Scale 3 – 8 after<br />
resuscitation). While ICP-monitoring can be associated with catheterrelated<br />
complications, such as focal haemorrhage and local infection in<br />
about 6 percent of the interventions, it is considered an essential monitoring<br />
tool in sedated patients following severe TBI. Neurological examination of intubated<br />
patients is limited, prompting frequent follow-up CCT examinations<br />
which require patient transportation and positioning, both potentially increasing<br />
ICP. Moreover, suspected compartmentalization and flawed ICP-monitoring<br />
due to technical issues can prompt physicians to perform follow-up CCT<br />
scans, even in patients under ICP monitoring.<br />
The aim of the present study was threefold: To evaluate indications for follow-up<br />
CCT imaging with respect to ICP-monitoring and clinical findings, to<br />
analyse frequency and findings of follow-up CCTs and their impact on clinical<br />
decision making, and to report on complications associated with invasive<br />
ICP-monitoring.<br />
Methods<br />
We performed a systematic database search for patients on ICP-monitoring<br />
between January 2007 and September 2017 at an urban level I trauma centre.<br />
Initial CCT scans as well as the first two follow-up CCT scans were reviewed<br />
regarding relevant features indicating TBI (intracranial haemorrhage, fracture,<br />
edema, and midline-shift) and their spatiotemporal characteristics. As
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„The aim of the present study was<br />
threefold: To evaluate indications for<br />
follow-up CCT imaging with respect to<br />
ICP-monitoring and clinical findings,<br />
to analyse frequency and findings of<br />
follow-up CCTs and their impact on<br />
clinical decision making, and to report<br />
on complications associated with<br />
invasive ICP-monitoring.“<br />
Alexander Bumberger<br />
follow-up scans were routinely performed after implantation of the ICP-probe,<br />
the third follow-up CT scan was considered the first „true“ follow-up scan.<br />
Indications for these scans were extracted from clinical records and stratified<br />
as „routine follow-up“ (without clinical deterioration or elevated ICP), „follow-up<br />
due to clinical deterioration“ (new onset of anisocoria, cardiovascular<br />
decompensation etc.), and „follow-up due to elevated ICP“ (> 20 mmHg).<br />
The physical and neurological status of patients was extracted from letters of<br />
discharge and then quantified according to the Glasgow Outcome Scale (GOS).<br />
In case of patient decease, time and cause of death were recorded. All statistical<br />
analyses were performed using SPSS Statistics 25.0 (IBM, Armonk, NY, USA).<br />
Results<br />
A total of 214 patients at a mean age of 44 (range 1–92) years were on ICP-monitoring<br />
at our department between January 2007 and September 2017. The<br />
overall in-hospital mortality was 21.6 %. There were 12 (5.6 %) complications<br />
associated with the ICP-probe leading to 5 cases of surgical revision. Altogether,<br />
there were no severe adverse events (major bleeding, death) directly related to<br />
the probe or its implantation, and no catheter-associated infections.<br />
There were 192 cases where at least one follow-up CCT was performed, with<br />
an average of 7 CCT scans per patient. Most scans were routine follow-up<br />
scans (n = 137, 64.3 %). One out of four follow-up scans (n = 55, 25.8 %) was<br />
performed due to either clinical deterioration or elevated ICP. The prevalence<br />
of bleeding progression on routinely performed follow-up CCTs was 16.1 %<br />
(22/137). In case of clinical deterioration or elevated ICP, deterioration of findings<br />
(i.e. bleeding progression, additional intracranial haemorrhage, and/or<br />
increase of cerebral edema) was observed in 50.0 % (6/12) and 55.8 % (24/43)<br />
of the cases, respectively. Follow-up scans performed due to clinical deteriora-
TOP-Studien<br />
60<br />
Figure 1: Side-by-side comparison<br />
of progression and non-progression<br />
of cranial computed tomography (CCT)<br />
findings grouped by indication of<br />
follow-up CCT.<br />
( intracranial pressure)<br />
tion or elevated ICP were both more frequently associated with a deterioration<br />
of CCT findings, as compared to routine follow-up scans (clinical deterioration:<br />
x2(1) = 8.94, p < 0.01, OR = 5.52, 95 % CI 1.63 – 18.77; elevated ICP: x2(1) = 28.61,<br />
p < 0.001, OR = 6.98, 95 % CI 3.26 – 14.93). Figure 1 demonstrates the prevalence<br />
of bleeding progression according to the indication of CCT.<br />
Dr. Alexander Bumberger<br />
Routine follow-up CCT did not prompt any intervention in 94.9 % (130/137)<br />
of the cases. In case of aggravation of findings, the percentage was 68.2 %<br />
(15/22). The most common clinical consequence was a delay of antithrombotic<br />
therapy in 18 % (4/22) of the cases. There was one case of surgical<br />
intervention with removal of a newly detected epidural hematoma on routine<br />
follow-up. When CCT was performed due to either clinical deterioration or<br />
elevated ICP, a deterioration of findings was detected in 54.5 % (30/55) of the<br />
cases. In most of these patients (76.7 %, 23/30), haemorrhage progression on<br />
CCT did not result in any clinical consequence regarding the further treatment.<br />
The most common consequence was a craniectomy in 10 % (3/30) of<br />
the cases. Overall, a total of six patients (3.1 %) underwent surgical intervention<br />
prompted by follow-up imaging.<br />
Author:<br />
Alexander Bumberger started<br />
his residency at the Department<br />
of Orthopaedics and<br />
Traumatology at the Medical<br />
University of Vienna in 2018<br />
and is currently working at the<br />
OCM Orthopaedic Surgery Munich.<br />
While his primary research<br />
interest and PhD project<br />
focus on reconstructive knee<br />
surgery and joint preservation,<br />
he has been working on various<br />
topics in the field of trauma<br />
surgery and orthopaedics.<br />
Conclusion<br />
The present data show a high number of CCT scans performed in patients on<br />
invasive ICP monitoring following severe TBI. The number of cases in which<br />
a deterioration of findings on follow-up scans prompted any clinical intervention<br />
was very low. Therefore, the necessity of CCT scans should be more<br />
critically evaluated in each individual case, with respect to potential clinical<br />
consequences.<br />
References:<br />
[1] Peeters W, van den Brande R, Polinder S, Brazinova A, Steyerberg EW, Lingsma HF, et al. Epidemiology<br />
of traumatic brain injury in Europe. Acta Neurochir (Wien). 2015 Oct;157(10):1683–96.<br />
[2] Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GWJ, Bell MJ, et al. Guidelines for the Management<br />
of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery. 2017 01;80(1):6–15.<br />
[3] Forsyth RJ, Raper J, Todhunter E. Routine intracranial pressure monitoring in acute coma.<br />
Cochrane Database Syst Rev. 2015 Nov 2;(11):CD002043.<br />
[4] Martin M, Cook F, Lobo D, Vermersch C, Attias A, Ait- Mamar B, et al. Secondary Insults and<br />
Adverse Events During Intrahospital Transport of Severe Traumatic Brain-Injured Patients.<br />
Neurocrit Care. 2017 Feb 1;26(1):87–95.
·
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Universitätsklinik für<br />
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C, Dragoi RG, Gäbler G, Lems W, Mosor E, Pais<br />
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J, Stamm TA. 2019 EULAR points to consider for<br />
non-physician health professionals to prevent and<br />
manage fragility fractures in adults 50 years or older.<br />
Ann Rheum Dis. <strong>2021</strong> Jan;80(1):57-64. doi: 10.1136/<br />
annrheumdis-2020-216931. (19.103)<br />
Agibetov A, Kammerlander A, Duca F, Nitsche C,<br />
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A, Schrutka L, Binder C, Kastner J, Agis H, Kain R,<br />
Auer-Grumbach M, Samwald M, Hengstenberg C,<br />
Dorffner G, Mascherbauer J, Bonderman D. Convolutional<br />
Neural Networks for Fully Automated<br />
Diagnosis of Cardiac Amyloidosis by Cardiac Magnetic<br />
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11(12):1268. (4.945)<br />
Binder H, Hoffman L, Zak L, Tiefenboeck T, Aldrian<br />
S, Albrecht C. Clinical evaluation after matrix-associated<br />
autologous chondrocyte transplantation:<br />
a comparison of four different graft<br />
types. Bone Joint Res. <strong>2021</strong> Jul;10(7):370-379.<br />
doi: 10.1302/2046-3758.107. BJR-2020-0370.R1<br />
(5.853)<br />
Borgen IMH, Røe C, Brunborg C, Tenovuo O, Azouvi<br />
P, Dawes H, Majdan M, Ranta J, Rusnak M, Wiegers<br />
EJA, CENTER-TBI participants investigators<br />
(Antoni A, Schwendenwein E). Care transitions in<br />
the first 6months following traumatic brain injury:<br />
Lessons from the CENTER-TBI study. Ann Phys<br />
Rehabil Med. <strong>2021</strong>;64(6):101458. (4.919)<br />
Citerio G, Robba C, Rebora P, Petrosino M, Rossi<br />
E, Malgeri L, Stocchetti N, Galimberti S, Menon<br />
DK, Center-TBI participants and investigators<br />
(Antoni A, Schwendenwein E). Management of<br />
arterial partial pressure of carbon dioxide in the<br />
first week after traumatic brain injury: results<br />
from the CENTER-TBI study. Intensive Care Med.<br />
<strong>2021</strong>;47(9):961-973. (17.440)<br />
Döring K, Staats K, Puchner S, Windhager R.<br />
Patient-Specific Implants for Pelvic Tumor Resections.<br />
J Pers Med. <strong>2021</strong> Jul 21;11(8):683. (4.945)<br />
Döring K, Trost C, Hofer C, Salzer M, Kelaridis<br />
T, Windhager R, Hobusch G. How Common Are<br />
Chronic Residual Limb Pain, Phantom Pain, and<br />
Back Pain More Than 20 Years After Lower Limb Amputation<br />
for Malignant Tumors? Clin Orthop Relat<br />
Res. <strong>2021</strong> Sep 1;479(9):2036-2044. (4.291)<br />
Eilenberger C, Rothbauer M, Selinger F, Gerhartl<br />
A, Neuhaus W, Jordan C, Harasek M, Schädl B,<br />
Grillari J, Küpcü S, Weghuber J, Ertl P, A microfluidic<br />
multi-size spheroid array for multi-parametric<br />
screening of anti-cancer drugs and blood-brain
Publikationen<br />
63<br />
barrier transport properties, Advanced Science,<br />
<strong>2021</strong>, 2004856, 4. (16.806)<br />
Ferreira DA, Rothbauer M, Conde JP, Ertl P, Oliveira<br />
C, Grajana PL, A Fast Alternative to Soft Lithography<br />
for the Fabrication of Organ-on-a-Chip Elastomeric-Based<br />
Devices and Microactuators, Adv. Science,<br />
<strong>2021</strong> Feb 8;8(8):2003273. (16.806)<br />
Frank BJH, Aichmair A, Simon S, Schwarz GM,<br />
Dominkus M, Hofstaetter JG. Analysis of Culture<br />
Positive First and Second Stage Procedures in Periprosthetic<br />
Knee and Hip Joint Infections. J Arthroplasty.<br />
<strong>2021</strong> Jun;36(6):2158-2164. doi: 10.1016/j.<br />
arth.<strong>2021</strong>.01.074. Epub <strong>2021</strong> Feb 2. (4.757)<br />
Fürsatz M, Gerges P, Wolbank S, Nürnberger S. Autonomous<br />
spheroid formation by culture plate compartmentation.<br />
Biofabrication. <strong>2021</strong> Apr 7;13(3). doi:<br />
10.1088/1758-5090/abe186. (10.020)<br />
Hirtler L, Rath C, Kügler P, Reissig L, Willegger M.,<br />
Maximum ankle plantarflexion and dorsiflexion<br />
allow for optimal arthroscopic access to the talar<br />
dome: an anatomic 3D-radiography study. Arthroscopy.<br />
<strong>2021</strong> Apr;37(4):1245-1257. (4.325)<br />
Holzer G, Hobusch G, Hansen S, Fischer L, Patsch<br />
JM. Is There an Association Between Bone Microarchitecture<br />
and Fracture in Patients who were Treated<br />
for High-grade Osteosarcoma? A Controlled<br />
Study at Long-term Follow-up Using High-resolution<br />
Peripheral Quantitative CT. Clin Orthop Relat<br />
Res. <strong>2021</strong> Nov 1;479(11):2493-2501. doi: 10.1097/<br />
CORR.0000000000001842. (4.291)<br />
Horton L, Rhodes J, Menon DK, Maas AIR, Wilson<br />
L, Collaborative European NeuroTrauma Effectiveness<br />
Research in TBI (CENTER-TBI) Participants<br />
and Investigators (Antoni A, Schwendenwein E).<br />
Questionnaires vs Interviews for the Assessment of<br />
Global Functional Outcomes After Traumatic Brain<br />
Injury., JAMA Netw Open. <strong>2021</strong>;4(11): e2134121.<br />
(8.485)<br />
Huijben JA, Dixit A, Stocchetti N, Maas AIR, Lingsma<br />
HF, van der Jagt M, Nelson D, Citerio G, Wilson L, Menon<br />
DK CENTER-TBI investigators and participants<br />
(Antoni A, Schwenden wein E). Use and impact of<br />
high intensity treatments in patients with traumatic<br />
brain injury across Europe: a CENTER-TBI analysis.<br />
Crit Care. <strong>2021</strong>;25(1):78. (9.097)<br />
Jones C, Okano I, Salzmann SN, Reisener MJ,<br />
Chiapparelli E, Shue J, Sama AA, Cammisa FP,<br />
Girardi FP, Hughes AP. Endplate volumetric bone<br />
mineral density is a predictor for cage subsidence<br />
following lateral lumbar interbody fusion: a risk<br />
factor analysis. Spine J. <strong>2021</strong> Oct;21(10): 1729-1737.<br />
(4.166)<br />
Juras V, Szomolanyi P, Schreiner MM, Unterberger<br />
K, Kurekova A, Hager B, Laurent D, Raithel E, Meyer<br />
H, Trattnig S. Reproducibility of an Automated<br />
Quantitative MRI Assessment of Low-Grade Knee<br />
Articular Cartilage Lesions. Cartilage. <strong>2021</strong> Dec;13<br />
(1_suppl):646S-657S. (4.634)<br />
Kolbitsch P, Noebauer-Huhmann IM, Giurea A,<br />
Kubista B, Windhager R, Lass R. Pseudotumors in<br />
Small-Head Metal-on-Metal Total Hip Arthroplasties<br />
at a Minimum Follow-Up of 20 Years. J Arthroplasty.<br />
<strong>2021</strong> Aug;36(8):2871-2877. doi: 10.1016/j.<br />
arth.<strong>2021</strong>.03.022. Epub <strong>2021</strong> Mar 10. (4.757)<br />
Leister I, Linde LD, Vo AK, Haider T, Mattiassich<br />
G, Grassner L, Schaden W, Resch H, Jutzeler CR,<br />
Geisler FH, Kramer JLK, Aigner L. Routine Blood<br />
Chemistry Predicts Functional Recovery After<br />
Traumatic Spinal Cord Injury: A Post Hoc Analysis.<br />
Neurorehabil Neural Repair. <strong>2021</strong> Apr;35(4):321-<br />
333. doi: 10.1177/1545968321992328. Epub <strong>2021</strong><br />
Feb 22. (3.919)<br />
Negrin LL, Zeitler C, Hofbauer M. Patellar Size<br />
Variation at the Quadriceps Tendon-Bone Block<br />
Harvest Site: A Magnetic Resonance Imaging Study<br />
to Evaluate the Safe Zone for Harvesting a Sufficient<br />
Bone Block. Am J Sports Med. <strong>2021</strong> Dec;49(14):3850-<br />
3858. doi: 10.1177/03635465211049226. Epub<br />
<strong>2021</strong> Oct 21. (6.202)<br />
Nielsen CJ, Lewis SJ, Oitment C, Martin AR,<br />
Lenke LG, Qiu Y, Cheung KM, de Kleuver M, Polly DW,<br />
Shaffrey CI, Smith JS, Spruit M, Alanay A, Matsuyama<br />
Y, Jentzsch T, Rienmuller A, Shear-Yashuv H,<br />
Pellisé F, Kelly MP, Sembrano JN, Dahl BT, Berven SH,<br />
Forum Deformity ASK, Stratifying outcome based<br />
on the Oswestry Disability Index for operative treatment<br />
of adult spinal deformity on patients 60 years
Publikationen<br />
64<br />
of age or older: a multicenter, multi-continental study<br />
on Prospective Evaluation of Elderly Deformity<br />
Surgery (PEEDS). Spine J. <strong>2021</strong> Nov;21(11):1775-<br />
1783. (4.166)<br />
Nürnberger S, Schneider C, Keibl C, Schädl B, Heimel<br />
P, Monforte X, Teuschl AH, Nalbach M, Thurner PJ,<br />
Grillari J, Redl H, Wolbank S. Repopulation of decellularised<br />
articular cartilage by laser-based matrix<br />
engraving. EBioMedicine. <strong>2021</strong> Feb; 64:103196. doi:<br />
10.1016/j.ebiom.2020.103196. Epub <strong>2021</strong> Jan 19.<br />
(8.143)<br />
Oitment C, Bozzo A, Martin AR, Rienmuller A,<br />
Jentzsch T, Aoude A, Thornley P, Ghert M, Rampersaud<br />
R, Primary sarcomas of the spine: population-based<br />
demographic and survival data in 107<br />
spinal sarcomas over a 23-year period in Ontario,<br />
Canada. Spine J. <strong>2021</strong> Feb;21(2):296-301. (4.166)<br />
Plancikova D, Leitgeb J, Brazinova A, Melichova J,<br />
Sivco P, Nemcovska E, Pekarcikova J, Majdan M.<br />
Characteristics and outcome of severe traumatic<br />
brain injuries based on occupational status. Eur<br />
J Trauma Emerg Surg. <strong>2021</strong> Dec;47(6):2035-2041.<br />
doi: 10.1007/s00068-020-01372-7. Epub 2020 Apr<br />
18. (3.693)<br />
Raudner M, Schreiner MM, Hilbert T, Kober T,<br />
Weber M, Szelényi A, Windhager R, Juras V, Trattnig<br />
S. Clinical implementation of accelerated T 2 mapping:<br />
Quantitative magnetic resonance imaging as a<br />
biomarker for annular tear and lumbar disc herniation.<br />
Eur Radiol. <strong>2021</strong> Jun;31(6):3590-3599. (5.315)<br />
Röhrich S, Hofmanninger J, Negrin L, Langs G, Prosch<br />
H. Radiomics score predicts acute respiratory distress<br />
syndrome based on the initial CT scan after<br />
trauma. Eur Radiol. <strong>2021</strong> Aug;31(8):5443-5453. doi:<br />
10.1007/s00330-020-07635-6. Epub <strong>2021</strong> Mar 17.<br />
Erratum in: Eur Radiol. <strong>2021</strong> May 4. (5.315)<br />
Rothbauer M, Byrne RA, Schobesberger S,<br />
Olmos Calvo I, Fischer A, Reihs EI, Spitz S, Bachmann<br />
B, Sevelda F, Holinka J, Holnthoner W, Redl<br />
H, Toegel S, Windhager R, Kiener HP, Ertl P, Establishment<br />
of a human three-dimensional chipbased<br />
chondro- synovial co-culture joint model for<br />
reciprocal crosstalk studies in arthritis research,<br />
Lab on a Chip, <strong>2021</strong>, 21, 4128-4143. (6.799)<br />
Salzmann SN, Okano I, Jones C, Basile E, Iuso A,<br />
Zhu J, Reisener MJ, Chiapparelli E, Shue J, Carrino<br />
JA, Girardi FP, Cammisa FP, Sama AA, Hughes AP.<br />
Thoracic bone mineral density measured by quantitative<br />
computed tomography in patients undergoing<br />
spine surgery. Spine J. <strong>2021</strong> Nov;21(11):1866-1872.<br />
(4.166)<br />
Schneider C, Dungel P, Priglinger E, Danzer M,<br />
Schädl B, Nürnberger S. The impact of photobiomodulation<br />
on the chondrogenic potential of<br />
adipose-derived stromal/stem cells. J Photochem<br />
Photobiol B. <strong>2021</strong> Aug; 221:112243. doi: 10.1016/j.<br />
jphotobiol.<strong>2021</strong>.112243. Epub <strong>2021</strong> Jun 18.<br />
(6.252)<br />
Schreiner MM, Raudner M, Röhrich S, Zalaudek<br />
M, Weber M, Kaiser G, Aldrian S, Chiari C, Windhager<br />
R, Trattnig S. Reliability of the MOCART (Magnetic<br />
Resonance Observation of Cartilage Repair<br />
Tissue) 2.0 knee score for different cartilage<br />
repair techniques-a retrospective observational<br />
study. Eur Radiol. <strong>2021</strong> Aug;31(8):5734-5745. doi:<br />
10.1007/s00330-021-07688-1. Epub <strong>2021</strong> Jan 29.<br />
(5.315)<br />
Schreiner MM, Raudner M, Marlovits S, Bohndorf<br />
K, Weber M, Zalaudek M, Röhrich S, Szomolanyi P,<br />
Filardo G, Windhager R, Trattnig S. The MOCART<br />
(Magnetic Resonance Observation of Cartilage<br />
Repair Tissue) 2.0 Knee Score and Atlas. Cartilage.<br />
<strong>2021</strong> Dec;13 (1_suppl): 571S-587S. doi:<br />
10.1177/ 1947603519865308 (4.634)<br />
Schreiner MM, Raudner M, Szomolanyi P, Ohel K,<br />
Ben-Zur L, Juras V, Mlynarik V, Windhager R, Trattnig<br />
S. Chondral and Osteochondral Femoral Cartilage<br />
Lesions Treated with GelrinC: Significant<br />
Improvement of Radiological Outcome Over Time<br />
and Zonal Variation of the Repair Tissue Based on<br />
T2 Mapping at 24 Months. Cartilage. <strong>2021</strong> Dec;13<br />
(1_suppl):604S-616S. (4.634)<br />
Sigmund IK, McNally MA, Luger M, Böhler C,<br />
Windhager R, Sulzbacher I. Diagnostic accuracy of<br />
neutrophil counts in hisathological tissue analysis<br />
in periprosthetic joint infection using the ICM,<br />
IDSA, and EBJIS criteria. Bone Joint Res. <strong>2021</strong><br />
Aug;10(8):536-547. doi: 10.1302/2046-3758.108.<br />
BJR-<strong>2021</strong>-0058.R1. (5.853)
Publikationen<br />
65<br />
Smolle MA, Leithner A, Kapper M, Demmer G,<br />
Trost C, Bergovec M, Windhager R, Hobusch GM,<br />
Complications, mobility, and quality of life in<br />
ankle sarcoma patients. Bone Joint J. <strong>2021</strong><br />
Mar;103-B(3):553-561. (5.082)<br />
Smolle MA, van de Sande M, Hayes A, Bergovec M,<br />
Smith HG, Liegl-Atzwanger B, Tunn PU, Niethard M,<br />
Windhager R, Szkandera J, Leithner A. Comparison<br />
of the 7 th and 8 th version of the AJCC classifica tion<br />
system for soft tissue sarcomas of extremities<br />
and trunk in patients with localised, intermediate<br />
or high-grade disease treated at European<br />
tertiary sarcoma centres. Eur J Surg Oncol. <strong>2021</strong><br />
Aug;47(8):2182-2. (4.424)<br />
Springer B, Waldstein W, Bechler U, Jungwirth-Weinberger<br />
A, Windhager R, Boettner F.<br />
The Functional Status of the ACL in Varus OA of<br />
the Knee: The Association With Varus Deformity<br />
and Coronal Tibiofemoral Subluxation. J Arthroplasty.<br />
<strong>2021</strong> Feb;36(2):501-506. doi: 10.1016/<br />
j.arth.2020.08.049. (4.757)<br />
Thalhammer G, Haider T, Lauffer M, Tünnerhoff HG.<br />
Mid- and Long-Term Outcome After Arthroscopically<br />
Assisted Transosseous Triangular Fibrocartilage<br />
Complex Refixation-Good to Excellent Results<br />
in Spite of Some Loss of Stability of the Distal Radioulnar<br />
Joint. Arthroscopy. <strong>2021</strong> May;37(5):1458-<br />
1466. doi: 10.1016/j.arthro.<strong>2021</strong>.01.056. Epub <strong>2021</strong><br />
Feb 6. (4.772)<br />
Trummer M, Galardon E, Fischer A, Toegel S,<br />
Mayer BM, Steiner G, Kloesch B. Characterization of<br />
the inducible and slow-releasing hydrogen sulfide<br />
and persulfide donor P*: insights into hydrogen sulfide<br />
signaling. Antioxidants <strong>2021</strong>;10(7):1049. (6.313)<br />
Unterfrauner I, Hruby LA, Jans P, Steinwender L,<br />
Farshad M, Uçkay I. Impact of a total lockdown for<br />
pandemic SARS-CoV-2 (Covid-19) on deep surgical<br />
site infections and other complications after<br />
orthopedic surgery: a retrospective analysis. Antimicrobial<br />
Resistance and Infection Control. <strong>2021</strong> Jul<br />
31;10(1):112. doi: 10.1186/s13756-021-00982-z.<br />
(4.887)<br />
van Veen E, van der Jagt M, Citerio G, Stocchetti<br />
N, Gommers D, Burdorf A, Menon DK, Maas AIR,<br />
Kompanje EJO, Lingsma HF, CENTER-TBI investigators<br />
and participants (Antoni A, Schwendenwein<br />
E). Occurrence and timing of withdrawal of<br />
life-sustaining measures in traumatic brain injury<br />
patients: a CENTER-TBI study. Intensive Care Med.<br />
<strong>2021</strong>;47(10):1115-1129. (17.440)<br />
Vertesich K, Sosa BR, Niu Y, Ji G, Suhardi V, Turajane<br />
K, Mun S, Xu R, Windhager R, Park-Min KH, Greenblatt<br />
MB, Bostrom MP, Yang X. Alendronate enhances<br />
osseointegration in a murine implant model. J<br />
Orthop Res <strong>2021</strong> Apr;39(4):719-726. doi: 10.1002/<br />
jor.24853 (3.494)<br />
von Hertzberg-Boelch SP, Wagenbrenner M,<br />
Arnholdt J, Frenzel S, Holzapfel BM, Rudert M.<br />
Custom Made Monoflange Acetabular Components<br />
for the Treatment of Paprosky Type III Defects.<br />
J Pers Med. <strong>2021</strong> Apr 8;11(4):283. doi: 10.3390/<br />
jpm11040283. (4.945)<br />
Walzer SM, Toegel S, Chiari C, Farr S, Rinner B,<br />
Weinberg AM, Weinmann D, Fischer MB, Windhager<br />
R. A 3-Dimensional In Vitro Model of Zonally<br />
Organized Extracellular Matrix. Cartilage<br />
<strong>2021</strong>;13(2_suppl):336S-345S. (4.634)<br />
Weiss T, Taschner-Mandl S, Janker L, Bileck A, Rifatbegovic<br />
F, Kromp F, Sorger H, Kauer MO, Frech<br />
C, Windhager R, Gerner C, Ambros PF, Ambros IM.<br />
Schwann cell plasticity regulates neuroblastic<br />
tumor cell differentiation via epidermal growth<br />
factor-like protein 8. Nat Commun. <strong>2021</strong> Mar<br />
12;12(1):1624. (14.919)<br />
Wiegers EJA, Lingsma HF, Huijben JA, Cooper<br />
DJ, Citerio G, Frisvold S, Helbok R,<br />
Maas AIR, Menon DK, Moore EM, CEN-<br />
TER-TBI; OzENTER-TBI Collaboration Groups<br />
(Antoni A, Schwendenwein E). Fluid balance and<br />
outcome in critically ill patients with traumatic brain<br />
injury (CENTER-TBI and OzENTER-TBI): a prospective,<br />
multicentre, comparative effectiveness study.<br />
Lancet Neurol. <strong>2021</strong>;20(8):627-638. (44.182)<br />
Wiessner M, Maroofian R, Ni MY, Pedroni A, Müller<br />
JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM,<br />
Alfares AA, Zhu C, Uhrova Meszarosova A, Alehabib<br />
E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH,<br />
Peterson JT, Strom TM, De Jonghe P, Deconinck
Publikationen<br />
66<br />
T, De Ridder W, De Winter J, Pasquariello R, Ricca<br />
I, Alfadhel M, van de Warrenburg BP, Portier R,<br />
Bergmann C, Ghasemi Firouzabadi S, Jin SC,<br />
Bilguvar K, Hamed S, Abdelhameed M, Haridy NA,<br />
Maqbool S, Rahman F, Anwar N, Carmichael J,<br />
Pagnamenta A, Wood NW, Tran Mau-Them F,<br />
Haack T; Genomics England Research Consortium,<br />
PREPARE network, Di Rocco M, Ceccherini I,<br />
Iacomino M, Zara F, Salpietro V, Scala M, Rusmini<br />
M, Xu Y, Wang Y, Suzuki Y, Koh K, Nan H, Ishiura H,<br />
Tsuji S, Lambert L, Schmitt E, Lacaze E, Küpper<br />
H, Dredge D, Skraban C, Goldstein A, Willis MJH,<br />
Grand K, Graham JM, Lewis RA, Millan F, Duman<br />
Ö, Dündar N, Uyanik G, Schöls L, Nürnberg P,<br />
Nürnberg G, Catala Bordes A, Seeman P, Kuchar<br />
M, Darvish H, Rebelo A, Bouçanova F, Medard<br />
JJ, Chrast R, Auer-Grumbach M, Alkuraya FS,<br />
Shamseldin H, Al Tala S, Rezazadeh Varaghchi J,<br />
Najafi M, Deschner S, Gläser D, Hüttel W, Kruer<br />
MC, Kamsteeg EJ, Takiyama Y, Züchner S, Baets<br />
J, Synofzik M, Schüle R, Horvath R, Houlden H,<br />
Bartesaghi L, Lee HJ, Ampatzis K, Pierson TM,<br />
Senderek J. Biallelic variants in HPDL cause<br />
pure and complicated hereditary spastic paraplegia.<br />
Brain. <strong>2021</strong> Jun 22;144(5):1422-1434. doi:<br />
10.1093/brain/awab041. Erratum in: Brain. <strong>2021</strong><br />
Sep 4;144(8):e70. (13.501)<br />
Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR,<br />
Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT,<br />
TRACK-TBI Investigators for the CENTER-TBI Investigators<br />
(Antoni A, Schwendenwein E). Pathological<br />
Computed Tomography Features Associated<br />
With Adverse Outcomes After Mild Traumatic Brain<br />
Injury: A TRACK-TBI Study With External Valida tion<br />
in CENTER-TBI. JAMA Neurol. <strong>2021</strong>;78(9):1137-<br />
1148. (18.302)<br />
Zaric O, Juras V, Szomolanyi P, Schreiner M,<br />
Raudner M, Giraudo C, Trattnig S. Frontiers of<br />
Sodium MRI Revisited: From Cartilage to Brain<br />
Imaging. J Magn Reson Imaging. <strong>2021</strong> Jul;54(1):<br />
58-75. (4.813)<br />
Zirath H, Spitz S, Roth D, Schellhorn T, Rothbauer<br />
M, Müller B, Walch M, Kaur J, Wörle A, Kohl Y, Mayr<br />
T, Ertl P; Bridging the academic–industrial gap:<br />
application of an oxygen and pH sensor-inte grated<br />
lab-on-a-chip in nanotoxicology, RSC Lab on a<br />
Chip <strong>2021</strong>, 21, 21, 4237-4248 (6.799)<br />
Standard-Publikationen <strong>2021</strong><br />
Andelic N, Røe C, Brunborg C, Zeldovich M, Løvstad<br />
M, Løke D, Borgen IM, Voormolen DC, Howe EI,<br />
Forslund MV, CENTER-TBI participants investigators<br />
(Antoni A, Schwendenwein E). Frequency of fatigue<br />
and its changes in the first 6 months after traumatic<br />
brain injury: results from the CENTER-TBI study.<br />
J Neurol. <strong>2021</strong>;268(1):61-73. (4.849)<br />
Bechler U, Springer B, Rueckl K, Rolvien T, Boettner<br />
F. Can a simple iPad app improve C-arm based<br />
component position in anterior THA? Arch Orthop<br />
Trauma Surg. <strong>2021</strong> Aug;141(8):1401-1409. doi:<br />
10.1007/s00402-021-03807-1. (3.067)<br />
Beitzke D, Gremmel F, Senn D, Laggner R, Kammerlander<br />
A, Wielandner A, Nolz R, Hülsmann M, Loewe<br />
C. Effects of Levosimendan on cardiac function, size<br />
and strain in heart failure patients. Int J Cardiovasc<br />
Imaging. <strong>2021</strong> Mar;37(3):1063-1071. doi: 10.1007/<br />
s10554-020-02077-z. Epub 2020 Oct 24. (2.357)<br />
Bhaskara V, Leal MT, Seigner J, Friedrich T, Kreidl<br />
E, Gadermaier E, Tesarz M, Rogalli A, Stangl L,<br />
Wallwitz J, Hammel K, Rothbauer M, Moll H, Ertl P,<br />
Hahn R, Himmler G, Bauer A, Casanova E. Efficient<br />
production of recombinant secretory IgA against<br />
Clostridium difficile toxins in CHO-K1 cells. J Biotechnol.<br />
<strong>2021</strong> Apr 10; 331:1-13. (3.307)<br />
Benca E, Zderic I, Caspar J, Knegsel KV, Hirtler L,<br />
Gueorguiev B, Widhalm H, Windhager R, Varga P. On<br />
Measuring Implant Fixation Stability in ACL Reconstruction.<br />
Sensors (Basel). <strong>2021</strong> Oct 6;21(19):6632.<br />
doi: 10.3390/s21196632. (3.576)<br />
Benca E, Ferrante B, Zalaudek M, Hirtler L, Synek<br />
A, Kainberger FM, Windhager R, Brånemark R,<br />
Hobusch GM, Unger E. Thermal Effects during<br />
Bone Preparation and Insertion of Osseointegrated<br />
Transfemoral Implants. Sensors (Basel). <strong>2021</strong><br />
Sep18;21(18):6267. (3.576)<br />
Binder VE, Hofstoetter US, Rienmüller A, Száva Z,<br />
Krenn MJ, Minassian K, Danner SM. Influence of<br />
Spine Curvature on the Efficacy of Transcutaneous<br />
Lumbar Spinal Cord Stimulation. J Clin Med. <strong>2021</strong><br />
Nov 26;10(23):5543. (4.242)
Publikationen<br />
67<br />
Binder H, Majdan M, Leitgeb J, Payr S, Breuer R,<br />
Hajdu S, Tiefenboeck TM. Management and Outcome<br />
of Traumatic Intracerebral Hemorrhage in 79<br />
Infants and Children from a Single Level 1 Trauma<br />
Center. Children (Basel). <strong>2021</strong> Sep 26;8(10):854.<br />
doi: 10.3390/children8100854.PMID: 34682119<br />
(2.863)<br />
Böhm JK, Güting H, Thorn S, Schäfer N, Rambach V,<br />
Schöchl H, Grottke O, Rossaint R, Stanworth S, Curry N,<br />
Lefering R, Maegele M; CENTER-TBI Participants and<br />
Investigators (Antoni A, Schwendenwein E). Global<br />
Characterisation of Coagulopathy in Isolated Traumatic<br />
Brain Injury (iTBI): A CENTER-TBI Analysis.<br />
Neurocrit Care. <strong>2021</strong>;35(1):184-196 doi: 10.1007/<br />
s12028-020-01151-7. (2.720)<br />
Brenner TK, Posa-Markaryan K, Hercher D, Sperger<br />
S, Heimel P, Keibl C, Nürnberger S, Grillari J, Redl H,<br />
Hacobian A. Evaluation of BMP2/miRNA co-expression<br />
systems for potent therapeutic efficacy<br />
in bone-tissue regeneration. Eur Cell Mater. <strong>2021</strong><br />
Mar 3; 41:245-268. doi: 10.22203/eCM.v041a18<br />
(3.942)<br />
Cernakova M, Hobusch GM, Amann G, Funovics PT,<br />
Windhager R, Panotopoulos J. Diagnostic accuracy<br />
of ultrasound-guided core needle biopsy versus incisional<br />
biopsy in soft tissue sarcoma: an institutional<br />
experience. Sci Rep. <strong>2021</strong> Sep 8;11(1):17832.<br />
(4.380)<br />
Clauser P, Kapetas P, Stöttinger A, Bumberger A,<br />
Rudas M, Baltzer PAT. A risk stratification algorithm for<br />
lesions of uncertain malignant potential diagnosed by<br />
vacuum-assisted breast biopsy (VABB) of mammographic<br />
microcalcifications. Eur J Radiol. <strong>2021</strong> Feb;<br />
135:109479. doi: 10.1016/j.ejrad.2020.109479.<br />
Epub 2020 Dec 14. (3.528)<br />
Cuomo P, Scoccianti G, Schiavo A, Tortolini V,<br />
Wigley C, Muratori F, Matera D, Kukushkina M,<br />
Funovics PT, Lingitz MT, Windhager R, Dijkstra S,<br />
Jasper J, Müller DA, Kaiser D, Perlaky T, Leithner A,<br />
Smolle MA, Campanacci DA. Extra-abdominal desmoid<br />
tumor fibromatosis: a multicenter EMSOS<br />
study. BMC Cancer. <strong>2021</strong> Apr 20;21(1):437. (4.372)<br />
Davidovic K, Melnikov DV, Frank K, Gavril D, Green<br />
JB, Freytag DL, Heisinger S, Pavicic T, Gold MH,<br />
Cotofana S. To click or not to click - The importance<br />
of understanding the layers of the forehead when<br />
injecting neuromodulators - A clinical, prospective,<br />
interventional, split-face study. J Cosmet Dermatol.<br />
<strong>2021</strong> May;20(5):1385-1392. doi: 10.1111/<br />
jocd.13875. Epub 2020 Dec 8. (2.696)<br />
Döring K, Vertesich K, Martelanz L, Staats K,<br />
Böhler C, Hipfl C, Windhager R, Puchner S. Proximal<br />
femoral re con struction with modular megaprostheses<br />
in non-oncological patients. Int Orthop.<br />
<strong>2021</strong> Oct;45(10):2531-2542. (3.075)<br />
Engel B, Suppan J, Nürnberger S, Power AM,<br />
Marchetti-Deschmann M. Revisiting amino acid<br />
analyses for bioadhesives including a direct comparison<br />
of tick attachment cement (Dermacentor<br />
marginatus) and barnacle cement (Lepas anatifera).<br />
International Journal of Adhesion and Adhesives,<br />
Volume 105, <strong>2021</strong>. (3.189)<br />
Fuehrer J, Pichler KM, Fischer A, Giurea A,<br />
Weinmann D, Altmann F, Windhager R, Gabius HJ,<br />
Toegel S. N-Glycan profiling of chondrocytes and<br />
fibroblast-like synoviocytes: Towards functional<br />
glycomics in osteoarthritis. Proteomics Clin Appl<br />
<strong>2021</strong>: e2000057. (3.494)<br />
Greiner F, Trnka HJ, Chraim M, Neunteufel E, Bock<br />
P. Clinical and Radiological Outcomes of Operative<br />
Therapy in Insertional Achilles Tendinopathy<br />
With Debridement and Double-Row Refixation.<br />
Foot Ankle Int. <strong>2021</strong> Sep; 42(9):1115-1120. doi:<br />
10.1177/10711007211002814. Epub <strong>2021</strong> Apr 10.<br />
(2.827)<br />
Haider T, Seilern Und Aspang J, Gahleitner C, Plesser<br />
S, Hajdu S. Does patient positioning influence<br />
blood loss and transfusion rate in hip replacement<br />
for femoral neck fractures? A single-centre, retrospective<br />
chart review. BMC Musculoskelet Disord.<br />
<strong>2021</strong> May 8;22(1):496. doi: 10.1186/s12891-021-<br />
04375-6. (2.355)<br />
Hashemzadeh H, Shojaeilangari S, Allahverdi A,<br />
Rothbauer M, Ertl P, Naderi-Manesh H, A combined<br />
microfluidic deep learning approach for lung cancer<br />
cell high throughput screening toward automatic<br />
cancer screening applications” Scientific Reports<br />
11 (1), 9804 (4.380)
Publikationen<br />
68<br />
Heisinger S, Huber D, Matzner MP, Hasenoehrl<br />
T, Palma S, Sternik J, Trost C, Treiber M,<br />
Crevenna R, Grohs JG. Online Videos as a Source of<br />
Physio therapy Exercise Tutorials for Patients with<br />
Lumbar Disc Herniation-A Quality Assessment. Int J<br />
Environ Res Public Health. <strong>2021</strong> May 28;18(11):5815.<br />
doi: 10.3390/ijerph18115815. (3.390)<br />
Hosseini-Farid M, Schrier VJMM, Starlinger J, Amadio<br />
PC. Carpal Tunnel Syndrome Treatment and the Subsequent<br />
Alterations in Median Nerve Trans verse Mobility.<br />
J Ultrasound Med. <strong>2021</strong> Aug;40(8):1555-1568.<br />
doi: 10.1002/jum.15535. Epub 2020 Oct 19 (2.063)<br />
Huie JR, Mondello S, Lindsell CJ, Antiga L, Yuh EL,<br />
Zanier ER, Masson S, Rosario BL, Ferguson AR;<br />
The Transforming Research and Clinical Knowledge<br />
in Traumatic Brain Injury (TRACK-TBI) Investigators,<br />
Collaborative European NeuroTrauma<br />
Effective ness Research in Traumatic Brain Injury<br />
(CENTER-TBI) Participants and Investigators,<br />
Collaborative European NeuroTrauma Effectiveness<br />
Research in Traumatic Brain Injury (CEN-<br />
TER-TBI) Participants and Investigators (Antoni A,<br />
Schwenden wein E). Biomarkers for Traumatic Brain<br />
Injury: Data Standards and Statistical Considerations.<br />
J Neurotrauma. <strong>2021</strong> Sep 15;38(18):2514-<br />
2529 (5.269)<br />
Kampf S, Willegger M, Dawoud C, Fülöp G, Lirk P,<br />
Willfort-Ehringer A, Neumayer C, Gollackner B.<br />
Long-term outcome in pediatric surgical bypass<br />
grafting after traumatic injury and tumor resection:<br />
retrospective cohort analysis. Sci Rep. <strong>2021</strong><br />
Aug 11;11(1):16321. (4.380)<br />
Krassnig R, Hohenberger G, Schwarz A, Goessler W,<br />
Feierl G, Wildburger R, Windhager R. In vitro testing<br />
of silver-containing spacer in periprosthetic infection<br />
management. Sci Rep. <strong>2021</strong> Aug 26;11(1):17261.<br />
(4.380)<br />
Martin AR, Jentzsch T, Wilson JRF, Moghaddamjou<br />
A, Jiang F, Rienmueller A, Badhiwala JH, Akbar MA,<br />
Nater A, Oitment C, Ganau M, Massicotte EM, Fehlings<br />
MG. Inter-rater Reliability of the Modified Japanese<br />
Orthopedic Association Score in Degenerative<br />
Cervical Myelopathy: A Cross-sectional Study.<br />
Spine (Phila Pa 1976). <strong>2021</strong> Aug 15;46(16):1063-<br />
1069. (3.468)<br />
Martin AR, Kalsi-Ryan S, Akbar MA, Rienmueller AC,<br />
Badhiwala JH, Wilson JR, Tetreault LA, Nouri A,<br />
Massicotte EM, Fehlings MG. Clinical outcomes<br />
of nonoperatively managed degenerative cervical<br />
myelopathy: an ambispective longitudinal cohort<br />
study in 117 patients. J Neurosurg Spine. <strong>2021</strong><br />
Apr 9:1-9. (3.602)<br />
Mikolić A, Polinder S, Steyerberg EW, Retel Helmrich<br />
IRA, Giacino JT, Maas AIR, van der Naalt J, Voormolen<br />
DC, von Steinbüchel N, Wilson L, Colla borative<br />
European NeuroTrauma Effectiveness Research in<br />
Traumatic Brain Injury (CENTER-TBI) Study Participants<br />
and Investigators (Antoni A, Schwendenwein<br />
E). Prediction of Global Func tional Outcome<br />
and Post-Concussive Symptoms after Mild Traumatic<br />
Brain Injury: External Validation of Prognostic<br />
Models in the Collaborative European NeuroTrauma<br />
Effectiveness Research in Traumatic<br />
Brain Injury (CENTER-TBI) Study. J Neurotrauma.<br />
<strong>2021</strong>;38(2):196-209. (5.269)<br />
Mikolić A, van Klaveren D, Groeniger JO, Wiegers<br />
EJA, Lingsma HF, Zeldovich M, von Steinbüchel N,<br />
Maas AIR, Roeters van Lennep JE, CENTER-TBI Participants<br />
and Investigators (Antoni A, Schwendenwein<br />
E). Differences between Men and Women in<br />
Treatment and Outcome after Traumatic Brain Injury.<br />
J Neurotrauma. <strong>2021</strong>;38(2):235-251. (5.269)<br />
Moftakhar T, Wanzel M, Vojcsik A, Kralinger F,<br />
Mousavi M, Hajdu S, Aldrian S, Starlinger J. Incidence<br />
and severity of electric scooter related injuries<br />
after introduction of an urban rental programme<br />
in Vienna: a retrospective multicentre study. Arch<br />
Orthop Trauma Surg. <strong>2021</strong> Jul;141(7):1207-1213.<br />
doi: 10.1007/s00402-020-03589-y. Epub 2020 Aug<br />
27. (3.067)<br />
Nia A, Popp D, Thalmann G, Greiner F, Jeremic N,<br />
Rus R, Hajdu S, Widhalm HK. Predicting 30-Day and<br />
180-Day Mortality in Elderly Proximal Hip Fracture<br />
Patients: Evaluation of 4 Risk Prediction Scores at a<br />
Level I Trauma Center. Diagnostics (Basel). <strong>2021</strong> Mar<br />
11;11(3):497. doi: 10.3390/diagnostics11030497.<br />
(3.706)<br />
Nia A, Ungersboeck A, Uffmann M, Leaper D,<br />
Assadian O. Septic hip abscess due to Fusobacterium<br />
nucleatum and Actinomyces turicensis in an
Publikationen<br />
69<br />
immunocompetent SARS-CoV-2 positive patient.<br />
Anaerobe. <strong>2021</strong>; 71:102420. doi: 10.1016/j.anaerobe.<strong>2021</strong>.<br />
(3.331)<br />
Ostermann RC, Joestl J, Lang N, Tiefenboeck<br />
TM, Ohnesorg S, Platzer P, Hofbauer M. Thoracic<br />
Injuries in Pediatric Polytraumatized Patients:<br />
Epidemiology, Treatment and Outcome. Injury.<br />
<strong>2021</strong> Jun;52(6):1316-1320. doi: 10.1016/<br />
j.injury.<strong>2021</strong>.02.033. Epub <strong>2021</strong> Feb 17. (2.586)<br />
Paley D, Shannon CE, Nogueira M, Chiari C, Harris<br />
M, Can Adding BMP2 Improve Outcomes in Patients<br />
Undergoing the SUPERhip Procedure? Children (Basel).<br />
<strong>2021</strong>, Jun 10;8(6):495. (2.863)<br />
Payr S, Payr E, Chocholka B, Jaindl M, Luxl M,<br />
Schwendenwein E, Tiefenboeck T. Fractures of<br />
the trochanteric region in children and young adolescents-a<br />
treatment algorithm for a rare injury. Eur<br />
J Pediatr. <strong>2021</strong> Apr;180(4):1135-1143. (2.305)<br />
Payr S, Rosado-Balmayor E, Tiefenboeck T,<br />
Schuseil T, Unger M, Seeliger C, van Griensven M.<br />
Direct comparison of 3D and 2D cultivation reveals<br />
higher osteogenic capacity of elderly osteoblasts<br />
in 3D. J Orthop Surg Res. <strong>2021</strong> Jan 6;16(1):13. doi:<br />
10.1186/s13018-020-02153-z. (2.359)<br />
Payr S, Schuller A, Dangl T, Chocholka B, Binder H,<br />
Tiefenboeck TM. Spine Fractures in Children and<br />
Adolescents-Frequency, Causes, Diagnostics, Therapy<br />
and Outcome-A STROBE-Compliant Retrospective<br />
Study at a Level 1 Trauma Centre in Central<br />
Europe. Children (Basel). <strong>2021</strong> Dec 3;8(12):1127.<br />
(2.863)<br />
Payr S, Schuller A, Dangl T, Scheider P, Sator T,<br />
Cho cholka B, Jaindl M, Schwendenwein E, Tiefenboeck<br />
T. Maintaining Medical Resources to Treat<br />
Paediatric Injuries during COVID-19 Lockdown Is<br />
Essential-An Epidemiological Analysis of a Level<br />
1 Trauma Centre in Central Europe. Int J Environ<br />
Res Public Health <strong>2021</strong> May 28;18(11): 5829.doi:<br />
10.3390/ijerph18115829 (3.39)<br />
Pichler KM, Weinmann D, Schmidt S, Kubista<br />
B, Lass R, Martelanz L, Alphonsus J, Windhager<br />
R, Gabius HJ, Toegel S, The Dysregulated Galectin<br />
Network Activates NF-κB to Induce Disease<br />
Markers and Matrix Degeneration in 3D Pellet Cultures<br />
of Osteoarthritic Chondrocytes. Calcif Tissue<br />
Int. <strong>2021</strong> Mar;108(3):377-390. (4.33)<br />
Raudner M, Toth DF, Schreiner MM, Hilbert T,<br />
Kober T, Juras V, Windhager R, Trattnig S. Synthetic<br />
T2-weighted images of the lumbar spine derived<br />
from an accelerated T2 mapping sequence: Comparison<br />
to conventional T2 w turbo spin echo. Magn<br />
Reson Imaging. <strong>2021</strong> Dec;84:92-100. doi: 10.1016/j.<br />
mri.<strong>2021</strong>.09.011. (2.546)<br />
Reisener MJ, Okano I, Zhu J, Salzmann SN,<br />
Miller CO, Shue J, Sama AA, Cammisa FP, Girardi FP,<br />
Hughes AP. Workers’ Compensation Status in Association<br />
with a High NDI Score Negatively Impacts<br />
Post-Operative Dysphagia and Dysphonia Following<br />
Anterior Cervical Fusion. World Neurosurg.<br />
<strong>2021</strong> Oct;154:e39-e45. (2.104)<br />
Reisener MJ, Hughes AP, Okano I, Zhu J, Lu S, Salzmann<br />
SN, Shue J, Sama AA, Cammisa FP, Girardi FP,<br />
Soffin EM. The association of transversus abdominis<br />
plane block with length of stay, pain and opioid consumption<br />
after anterior or lateral lumbar fusion: a retrospective<br />
study. Eur Spine J. <strong>2021</strong> Dec;30 (12):3738-3745.<br />
doi: 10.1007/s00586-021-06855-8. (3.134)<br />
Rentenberger C, Haider T, Zak L, Wozasek GE.<br />
Implant failure after externally magnetic-controlled<br />
nail lengthening. Injury. <strong>2021</strong> Nov;52(11):3350-<br />
3354. doi: 10.1016/j.injury.<strong>2021</strong>.09.006. Epub <strong>2021</strong><br />
Sep 9. (2.586)<br />
Riemann L, Voormolen DC, Rauen K, Zweckberger<br />
K, Unterberg A, Younsi A, Collaborative European<br />
NeuroTrauma Effectiveness Research in Traumatic<br />
Brain Injury (CENTER-TBI) Investigators and Participants<br />
(Antoni A, Schwendenwein E). Persistent<br />
postconcussive symptoms in children and adolescents<br />
with mild traumatic brain injury receiving<br />
initial head computed tomography. J Neurosurg<br />
Pediatr. <strong>2021</strong>:1-10. (2.375)<br />
Rothbauer M, Bachmann BEM, Eilenberger C, Kratz<br />
SRA, Spitz S, Höll G, Ertl P. „A Decade of Organs-on-a-<br />
Chip Emulating Human Physiology at the Microscale:<br />
A Critical Status Report on Progress in Toxicology<br />
and Pharmacology,“ Micromachines <strong>2021</strong>, 12 (5), 470.<br />
(2.891)
Publikationen<br />
70<br />
Rueckl K, Runer A, Jungwirth-Weinberger A,<br />
Kasparek MF, Faschingbauer M, Boettner F.<br />
Severity of valgus knee osteoarthritis has no effect<br />
on clinical outcomes after total knee arthroplasty.<br />
Arch Orthop Trauma Surg. <strong>2021</strong>Aug; 141(8):<br />
1385-1391. doi: 10.1007/s00402-021-03785-4.<br />
(3.067)<br />
Salom M, Chiari C, Alessandri JMG, Willegger M,<br />
Windhager R, Sanpera I. Diagnosis and staging of<br />
malignant bone tumours in children: what is due<br />
and what is new? J Child Orthop. <strong>2021</strong> Aug 20;15(4):<br />
312-321. doi: 10.1302/1863-2548.15.210107.<br />
(1.548)<br />
Sánchez E, Schilling C, Grupp TM, Giurea A, Verdonschot<br />
N, Janssen D. No effect in primary stability<br />
after increasing interference fit in cementless TKA<br />
tibial components. J Mech Behav Biomed Mater.<br />
<strong>2021</strong> Jun; 118:104435. (3.902)<br />
Sauer A, Maas A, Ottawa S, Giurea A, Grupp TM,<br />
Towards a new pre-clinical, subject independent<br />
test model for kinematic analysis after total knee<br />
arthroplasty – influence of the proximo-distal<br />
patella position and patellar tendon stiffness. Appl<br />
Sci-1424572, 11, <strong>2021</strong>. (2.679)<br />
Sewalt CA, Gravesteijn BY, Menon D, Lingsma HF,<br />
Maas AIR, Stocchetti N, Venema E, Lecky FE, CEN-<br />
TER TBI Participants and Investigators (Antoni A,<br />
Schwendenwein E). Primary versus early secondary<br />
referral to a specialized neurotrauma center in patients<br />
with moderate/severe traumatic brain injury:<br />
a CENTER TBI study. Scand J Trauma Resusc Emerg<br />
Med. <strong>2021</strong>;29(1):113. (2.953)<br />
Sigmund IK, Holinka J, Staats K, Sevelda F,<br />
Lass R, Kubista B, Giurea A, Windhager R. Inferior<br />
performance of established and novel serum inflammatory<br />
markers in diagnosing periprosthetic<br />
joint infections. Int Orthop. <strong>2021</strong> Apr;45(4):837-<br />
846. doi: 10.1007/s00264-020-04889-z. Epub 2020<br />
Nov 27. (3.075)<br />
Sigmund IK, Puchner SE, Windhager R. Serum<br />
Inflammatory Biomarkers in the Diagnosis of Periprosthetic<br />
Joint Infections. Biomedicines. <strong>2021</strong> Sep<br />
1;9(9):1128. doi: 10.3390/biomedicines9091128.<br />
(6.081)<br />
Sigmund IK, Windhager R. Reply to the Letter to<br />
the Editor: Inferior performance of established and<br />
novel serum inflammatory markers in diagnosing<br />
periprosthetic joint infections. Int Orthop. <strong>2021</strong><br />
Apr;45(4):1117-1119. doi: 10.1007/s00264-021-<br />
04980-z. Epub <strong>2021</strong> Feb 12. (3.075)<br />
Springer B, Boettner F. Treatment of Unicompartmental<br />
Cartilage Defects of the Knee with Unicompartmental<br />
Knee Arthroplasty, Patellofemoral<br />
Partial Knee Arthroplasty or Focal Resurfacing.<br />
Life (Basel). <strong>2021</strong> Apr 27;11(5):394. doi: 10.3390/<br />
life11050394. (3.817)<br />
Starlinger J, Sarahrudi K, Kecht M, Koerbler F,<br />
Pietschmann P, Aharinejad S. The influence of M-CSF<br />
on fracture healing in a mouse model. Sci Rep. <strong>2021</strong><br />
Nov 16;11(1):22326. doi: 10.1038/s41598-021-<br />
01673-w. (4.380)<br />
Starlinger J, Schrier VJMM, Smith CY, Song J,<br />
Stewart EA, Gazzuola Rocca L, Amadio PC, Rocca<br />
WA. Risk of de novo severe carpal tunnel syndrome<br />
after bilateral oophorectomy: a population-based<br />
cohort study. Menopause. <strong>2021</strong> May 24;28(9):1026-<br />
1036. (2.953)<br />
Stelzeneder B, Trabauer BM, Aldrian S, Stelzeneder<br />
D, Juras V, Albrecht C, Hajdu S, Platzer P, Trattnig<br />
S. Evaluation of Meniscal Tissue after Meniscal<br />
Repair Using Ultrahigh Field MRI. J Knee Surg.<br />
<strong>2021</strong> Oct;34(12):1337-1348. doi: 10.1055/s-0040-<br />
1709135. Epub 2020 Apr 8. (2.757)<br />
Sturma A, Hruby LA, Boesendorfer A, Gstoettner<br />
C, Farina D, Aszmann OC. Therapy Interventions for<br />
Upper Limb Amputees Undergoing Selective Nerve<br />
Transfers. Journal of Visualized Experiments. <strong>2021</strong><br />
Oct 29;(176). doi: 10.3791/62896. (1.355)<br />
Sturma A, Hruby LA, Boesendorfer A, Pittermann<br />
A, Salminger S, Gstoettner C, Politikou O, Vujaklija<br />
I, Farina D, Aszmann OC. Prosthetic Embodiment<br />
and Body Image Changes in Patients Undergoing<br />
Bionic Reconstruction Following Brachial Plexus<br />
Injury. Front Neurorobot. <strong>2021</strong> Apr 30; 15:645261.<br />
doi: 10.3389/fnbot.<strong>2021</strong>.645261. (2.650)<br />
Waldstein W, Bouché PA, Pottmann C, Faschingbauer<br />
M, Aldinger PR, Windhager R, Merle C.
Publikationen<br />
71<br />
Quantitative and individualized assessment of<br />
the learning curve in preoperative planning of the<br />
acetabular cup size in primary total hip arthroplasty.<br />
Arch Orthop Trauma Surg. <strong>2021</strong> Sep;141(9):<br />
1601-1608. doi: 10.1007/s00402-021-03848-6.<br />
(3.067)<br />
Weihs V, Heel V, Dedeyan M, Lang NW, Frenzel S,<br />
Hajdu S, Heinz T. Age and traumatic brain injury<br />
as prognostic factors for late-phase mortality in<br />
patients defined as polytrauma according to the<br />
New Berlin Definition: experiences from a level<br />
I trauma center. Arch Orthop Trauma Surg. <strong>2021</strong><br />
Oct;141(10):1677-1681. (3.067)<br />
Wendt KW, Jaeger M, Verbruggen J, Nijs S, Oestern<br />
HJ, Kdolsky R, Komadina R. ESTES recommendations<br />
on proximal humerus fractures in the elderly.<br />
Eur J Trauma Emerg Surg. <strong>2021</strong> Apr;47(2):381-<br />
395. doi: 10.1007/s00068-020-01437-7. Epub<br />
2020 Aug 7. (2.139)<br />
Zak L, Arnhold R, Tiefenboeck TM, Wozasek GE.<br />
The influence of advanced age in bone healing after<br />
intramedullary limb lengthening. Orthop Traumatol<br />
Surg Res. <strong>2021</strong> Dec;107(8):103055. doi: 10.1016/j.<br />
otsr.<strong>2021</strong>.103055. Epub <strong>2021</strong> Sep 15. (2.265)<br />
Zak L, Tiefenboeck TM, Wozasek GE. Bone reconstruction:<br />
Subjective evaluation and objective<br />
analysis based on conventional digital X-rays - a<br />
retrospective evaluation. Orthop Traumatol Surg<br />
Res. <strong>2021</strong> Dec;107(8):103081. doi: 10.1016/j.<br />
otsr.<strong>2021</strong>.103081. Epub <strong>2021</strong> Sep 25. (2.265)<br />
Zak L, Kleiner A, Albrecht C, Tichy B, Aldrian S.<br />
Third-Generation Autologous Chondrocyte Implantation<br />
at the Knee Joint Using the Igor Scaffold: A<br />
Case Series With 2-Year Follow-up. Orthop J Sports<br />
Med. <strong>2021</strong> Jan 22;9(1):2325967120969237. doi:<br />
10.1177/2325967120969237. (2.727)<br />
Zak L, Tiefenboeck TM, Wozasek GE. Computed<br />
Tomography in Limb Salvage and Deformity Correction-3D<br />
Assessment, Indications, Radiation Exposure,<br />
and Safety Considerations. J Clin Med. <strong>2021</strong><br />
Aug 24;10(17):3781. doi: 10.3390/jcm10173781.<br />
(4.242)<br />
Supplement/Abstract <strong>2021</strong><br />
Casado Losada I, Schneider C, Fürsatz M, Schädl<br />
B, Monforte X, Teuschl A, Nürnberger S. Characterizing<br />
the chondrogenic niche in laser-engraved<br />
decellularized articular cartilage scaffolds. Abstracts<br />
from the Virtual <strong>2021</strong> OARSI World Congress<br />
on Osteoarthritis, 29. 4. – 1. 5.<strong>2021</strong> (online) Volume<br />
29, Supplement 1, Pages S196-S197 (April <strong>2021</strong>)<br />
(6.576)<br />
Casado-Losada I, Schneider C, Schädl B, Zehetner<br />
J, Nürnberger S. Laser-engraved auricular cartilage<br />
scaffolds: the next step on recellularization.<br />
6.World Congress of the Tissue Engineering and<br />
Regenerative Medicine International Society (TER-<br />
MIS), Maastricht, 15. – 19.11.<strong>2021</strong>, Abstract book<br />
Casado-Losada I, Schneider C, Schädl B, Zehetner J,<br />
Nürnberger S. Laser-engraving auricular cartilage<br />
scaffolds enhance scaffold recellularization. YSA<br />
Symposium 16. – 18.6. <strong>2021</strong> Abstract book.<br />
Cortese A, Dohrn M, Zhu Y, Rebelo A, Wang J, Danzi<br />
MC, Feely SME, Stojkovic T, Auer-Grumbach M,<br />
Hamed SA, Zhang R, Manganelli F, Taroni F, Pareyson<br />
D, Houlden H, Herrmann DN, Reilly MM, Shy<br />
M, Asian Oceanic Inherited Neuropathy Consortium,<br />
Inherited Neuropathy Consortium, Zuchner S.<br />
SORD NEUROPATHY: GENE IDENTIFICATION AND<br />
PROPOSAL FOR A FOLLOW UP MULTI-CENTRE NA-<br />
TURAL HISTORY STUDY (2706). 13.4.<strong>2021</strong>; 96 (15<br />
Supplement)<br />
Döring K, Puchner S, Vertesich K, Funovics PT,<br />
Hobusch GM, Sulzbacher I, Chiari C, Windhager R,<br />
Results in the surgical treatment of aneurysmal<br />
bone cysts – a retrospective data analysis. EMSOS,<br />
33. Annual Meeting, 1. – 3.12.<strong>2021</strong>, Austria<br />
Döring K, Stihsen C, Panotopoulos J, Kaider A,<br />
Windhager R, Funovics PT, The impact of surgical<br />
procedures on the outcome after resection of soft<br />
tissue Sarcoma. EMSOS, 33rd Annual Meeting,<br />
1. – 3.12.<strong>2021</strong>, Austria.<br />
Fürsatz M, Gerges P, Wolbank S, Nürnberger S.<br />
Spherowell, A Novel System Inducing Autonomous<br />
Spheroid Formation Of Cell Monolayers. Abstracts<br />
from the Virtual <strong>2021</strong> OARSI World Congress on
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Publikationen<br />
72<br />
Osteoarthritis, 29.4. – 1.5.<strong>2021</strong> • Virtual Event, Volume<br />
29, Supplement 1, Pages S407-S408 (April <strong>2021</strong>)<br />
(6.576)<br />
Funovics PT, Schreiner M, Staats K, Hobusch GM,<br />
Panotopoulos J, Windhager R, Computed tomography-guided<br />
navigation versus computer navigation-assisted<br />
surgery in the resection of musculoskeletal<br />
tumors. EMSOS, 33rd Annual Meeting,<br />
1. – 3.12.<strong>2021</strong>, Austria.<br />
Hacker S, Kourimsky AT, Trost C, Funovics PT,<br />
Panotopoulos J, Windhager R, Hobusch GM, Caring<br />
for patients with primary malignant bone and soft<br />
tissue tumors - a qualitative survey of their needs<br />
during and after inpatient treatment. EMSOS, 33rd<br />
Annual Meeting, 1. – 3.12.<strong>2021</strong>, Austria.<br />
Heisinger S, Huber D, Matzner M, Hasenörhl T,<br />
Palma S, Sternik J, Crevenna R, Grohs JG. YouTube<br />
As A Source Of Physiotherapy Tutorials For Lumbar<br />
Disc Herniation. 22. EFORT Annual Congress.<br />
Hirtler L, Czerny K, Schuh R, Willegger M, Accessibility<br />
of the metatarsal head comparing distraction<br />
and plantarflexion in a 2-portal technique for<br />
first metatarsophalangeal (MTP 1) joint arthroscopy,<br />
FASEB JOURNAL35(Suppl1), 10.1096/fasebj.<strong>2021</strong>.35.S1.00258<br />
Hofer C, Trost C, Panotopoulos J, Funovics PT,<br />
Windhager R, Hobusch GM, Using means of transport<br />
and walking aids after treatment for primary<br />
malignant bone tumors in the lower extremity - A<br />
minimum follow-up of 20 years. EMSOS, 33rd Annual<br />
Meeting, 1. – 3.12.<strong>2021</strong>, Austria.<br />
Hobusch GM, Smolle MA, Mrs. Trost C, Friesenbichler<br />
J, Bergovec M, Windhager R, Leithner A,<br />
Functional outcome and QOL after sarcomas of the<br />
foot and ankle region. Is early amputation justified?<br />
EMSOS, 33 rd Annual Meeting, 1. – 3.12.<strong>2021</strong>,<br />
Austria.<br />
Hobusch GM, Keusch F, Joyce M, Windhager R,<br />
Expert Opinions about sports activity after Tumorendoprostheses<br />
– Do they differ in different<br />
parts of the world? EMSOS, 33rd Annual Meeting,<br />
1. – 3.12.<strong>2021</strong>, Austria<br />
Hecker-Nolting S, Sorg B, Baumhoer D, Dürr HR, Von<br />
Eisenhart-Rothe R, Exner GU, Gosheger G, Hardes<br />
J, Heise U, Hillmann A, Kevric M, Krieg AH, Lehner<br />
B, Tunn PU, Windhager R, Wirth T, Bielack S, Does<br />
choice of surgical procedure correlate with survival<br />
in high-grade central osteosarcoma around<br />
the knee? - A report from the Cooperative Osteosarcoma<br />
Study Group (COSS). EMSOS, 33rd Annual<br />
Meeting, 1. – 3.12.<strong>2021</strong>, Austria.<br />
Laurent D, Scotti C, Schreiner M, Neubauer M, Muellner<br />
T, Zaric O, Juras V, Szomolanyi P, Goldhahn<br />
J, Praestgaard J, Gerwin N, Roubenoff R, Nehrer<br />
S, Schieker M, Trattnig S. „Regeneration of hyaline<br />
cartilage in response to a single injection of LNA043,<br />
an ANGPTL3 mimetic, in the knee of patients with<br />
a focal cartilage defect“, Abstracts / Osteoarthritis<br />
and Cartilage 29 (<strong>2021</strong>) S10eS432<br />
Lass R, Kolbitsch P, Nöbauer I, Giurea A, Kubista B,<br />
Windhager R, Pseudotumoren bei Metall-Hüftendoprothesen<br />
– Follow-up von mindestens 20 Jahren,<br />
Deutscher Kongress für Orthopädie und Unfallchirurgie<br />
(DKOU <strong>2021</strong>), 26. – 29.10.<strong>2021</strong>, Berlin<br />
Schreiner MM, Apprich S, Staats K, Aletaha D,<br />
Windhager R, Böhler C, The influence of biologicals<br />
on aseptic arthroplasty loosening, Deutscher Kongress<br />
für Orthopädie und Unfallchirurgie (DKOU<br />
<strong>2021</strong>), 26. – 29.10.<strong>2021</strong>, Berlin<br />
Sigmund IK, McNally M, Luger M, Böhler C, Windhager<br />
R, Sulzbacher I, Der optimale Grenzwert<br />
der neutrophilen Granulozyten in histologisch<br />
aufarbeiteten Gewebeproben zur Diagnostik von<br />
periprothetischen Gelenksinfektionen, Deutscher<br />
Kongress für Orthopädie und Unfallchirurgie (DKOU<br />
<strong>2021</strong>), 26. – 29.10.<strong>2021</strong>, Berlin<br />
Springer B, Stihsen C, Rienmüller A, Funovics P,<br />
Krepler P, Grohs J, Windhager R. Surgical Treatment<br />
of Spinal Metastases-Results of a Large<br />
Single Centre Study. 22nd EFORT Annual Congress<br />
30.6. – 2.7.<strong>2021</strong><br />
Springer B, Stihsen C, Rienmüller A, Funovics P,<br />
Krepler P, Grohs J, Windhager R. Surgical Treatment<br />
of Spinal Metastases – Results of a Large Single<br />
Centre Study. Eurospine <strong>2021</strong>
Publikationen<br />
74<br />
Trost C, Heisinger S, Funovics PT, Windhager R,<br />
Hobusch GM, Stamm T, Patients’ Perceptions of<br />
Changes and Consequences after Tumor Resection.<br />
A Qualitative Study in Austrian Patients with<br />
musculoskeletal Malignancies. EMSOS, 33. Annual<br />
Meeting, 1. - 3.12.<strong>2021</strong>, Austria.<br />
Vetchy V, Trost C, Funovics PT, Panotopoulos J,<br />
Windhager R, Hobusch GM, Secondary Amputation –<br />
A qualitative Study of Quality of Live in Patients<br />
after Primary Limb Salvage Surgery and after later<br />
Ablative Sarcoma Treatment”. EMSOS, 33. Annual<br />
Meeting, 1. – 3.12.<strong>2021</strong>, Austria.<br />
Sonstige Publikationen und Substandard <strong>2021</strong><br />
Alfertshofer M, Frank K, Melnikov DV, Möllhoff N,<br />
Gotkin RH, Freytag DL, Heisinger S, Giunta RE,<br />
Schenck TL, Cotofana S. Performing Distance Measurements<br />
in Curved Facial Regions: A Comparison<br />
between Three-Dimensional Surface Scanning<br />
and Ultrasound Imaging. Facial Plast Surg. <strong>2021</strong><br />
Jun;37(3):395-399. doi: 10.1055/s-0041-1725166.<br />
Epub 11.3.<strong>2021</strong>. (1.446)<br />
Apprich S, Nia A, Schreiner MM, Friedrich K, Windhager<br />
R, Trattnig S. The Vienna morphological Achilles<br />
tendon score-VIMATS : Description, reproducibility<br />
and initial clinical results. Wien Klin Wochenschr.<br />
<strong>2021</strong> Jun;133(11-12):560-7. Epub 6.4.<strong>2021</strong>. (1.704)<br />
Apprich SR, Nia A, Schreiner MM, Jesch M, Böhler<br />
C, Windhager R. Modular megaprostheses in the<br />
treatment of periprosthetic fractures of the femur.<br />
Wien Klin Wochenschr. <strong>2021</strong> Jun;133(11-12):550-<br />
9. Epub 14.4.<strong>2021</strong>. (1.704)<br />
Bumberger A, Borst K, Hobusch GM, Willegger M,<br />
Stelzeneder D, Windhager R, Domayer S, Waldstein<br />
W. Higher patient knowledge and resilience<br />
improve the functional outcome of primary total<br />
knee arthroplasty. Wien Klin Wochenschr. <strong>2021</strong><br />
Jun;133(11-12):543-549. (1.704)<br />
Casari FA, Navab N, Hruby LA, Kriechling P, Nakamura<br />
R, Tori R, de Lourdes Dos Santos Nunes F,<br />
Queiroz MC, Fürnstahl P, Farshad M. Augmented<br />
Reality in Orthopedic Surgery Is Emerging from<br />
Proof of Concept Towards Clinical Studies: a Literature<br />
Review Explaining the Technology and Current<br />
State of the Art. Curr Rev Musculoskelet Med.<br />
<strong>2021</strong> Apr;14(2):192-203. doi: 10.1007/s12178-<br />
021-09699-3. Epub 5.2.<strong>2021</strong><br />
Carlin GL, Baumgartner JS, Moftakhar T, König D,<br />
Negrin LL. Impact of COVID-19 lockdown on suicide<br />
attempts: A retrospective analysis of the springtime<br />
admissions to the trauma resuscitation room at<br />
the Medical University of Vienna from 2015-2020.<br />
Wien Klin Wochenschr. <strong>2021</strong> Sep;133(17-18):915-<br />
922. doi: 10.1007/s00508-021-01839-6. Epub<br />
31.3.<strong>2021</strong>. (1.704)<br />
Chiari C, Willegger M, Kolb A, Windhager R, Epiphysiolysis<br />
capitis femoris: Notfallversorgung Jatros<br />
Orthopädie und Traumatologie 1/21: S 12-15.<br />
Chiari C, Editorial Fokusthema Kinderorthopädie<br />
und Kindertraumatologie, Jatros Orhopädie und<br />
Traumatologie 4/21: S3.<br />
Dekhne MS, Thomas HM, Haider T, Mortensen S,<br />
Rodriguez EK, Weaver MJ, von Keudell A. Treatment<br />
and outcomes of basicervical femoral neck<br />
fractures: A systematic review. J Orthop Surg (Hong<br />
Kong). <strong>2021</strong> Jan – Apr;29(1):23094990211003344.<br />
doi: 10.1177/23094990211003344.<br />
Farr S, Scheider P. The Molding Hands of Time:<br />
Remodeling of Sagittal Plane Malunion After Pediatric<br />
Supracondylar Humerus Fractures. J Pediatr<br />
Orthop. <strong>2021</strong> Sep 1;41(8):e700.<br />
Haider T, Hanna P, Mohamadi A, Merchan N, McNichol<br />
M, Wixted JJ, Appleton PT, Nazarian A ,von Keudell AG,<br />
Rodriguez EK. Revision Arthroplasty Versus Open Reduction<br />
and Internal Fixation of Vancouver Type-B2<br />
and B3 Periprosthetic Femoral Fractures. JBJS Rev.<br />
20.8.<strong>2021</strong>, 9(8). doi: 10.2106/JBJS.RVW.21.00008.<br />
Haider T, Notter L. Das funktionelle Querschnittsyndrom<br />
– ein Fallbericht. Functional Para plegia –<br />
A Case Report. Neurologie Open Access Published:<br />
14.4.<strong>2021</strong> psychopraxis. neuropraxis volume 24,<br />
pages 178–181 (<strong>2021</strong>)
Publikationen<br />
75<br />
Lang NW, Kasparek MF, Synak L, Waldstein W,<br />
Funovics PT, Windhager R, Hobusch GM. What<br />
sports activity levels are achieved in long-term<br />
survivors with modular endoprosthetic humerus<br />
reconstruction following primary bone sarcoma<br />
resection? Wien Klin Wochenschr. <strong>2021</strong> Jan;133(1-<br />
2):14-20. (1.704)<br />
Negrin LL. Knieverletzungen im alpinen Skibreiten-<br />
und Skileistungssport – eine selektive Aufarbeitung<br />
der aktuellen Literatur. Sports Orthop<br />
Traumatol. <strong>2021</strong> 37: 313 -321. doi: org/10.1016/j.<br />
orthtr.<strong>2021</strong>.11.007.<br />
Negrin LL und Puchwein P. REBOA in der Polytraumaversorgung:<br />
State of the Art und Case Report.<br />
Jatros Orthopädie & Traumatologie Rheumatologie<br />
1/<strong>2021</strong><br />
Nia A, Popp D, Diendorfer C, Apprich S, Munteanu<br />
A, Hajdu S, Widhalm HK. Impact of lockdown during<br />
the COVID-19 pandemic on number of patients<br />
and patterns of injuries at a level I trauma center.<br />
Wien Klin Wochenschr. <strong>2021</strong> Apr;133(7-8):336-343.<br />
(1.704)<br />
Nürnberger S. Gewebekleber nach dem Vorbild der<br />
Natur. Jatros Orthopädie & Traumatologie Rheumatologie<br />
2/<strong>2021</strong><br />
Rentenberger C, Salzmann SN, Shue J, Hughes AP.<br />
Heel Lift for Skiing to Compensate for Corrected<br />
Sagittal Vertical Axis After Spinal Surgery: A Case<br />
Report. Int J Spine Surg. <strong>2021</strong> Feb;14(s4): S33-S36.<br />
doi: 10.14444/7162.<br />
Salom M, Chiari C, Alessandri JMG, Willegger M,<br />
Windhager R, Sanpera I. Diagnosis and staging<br />
of malignant bone tumours in children: what is<br />
due and what is new? J Child Orthop. <strong>2021</strong> Aug<br />
20;15(4):312-321. (1.548)<br />
Salzmann SN, Knochenqualität in der spinalen MRT<br />
sagt Fragilitätsfrakturen voraus. Die Wirbelsäule<br />
<strong>2021</strong>; 5: Seiten: 15 – 17, DOI: 10.1055/a-1222-6211<br />
Schitz F, Rilk, S, Schabus R. Arthroskopische Versorgung<br />
einer suprakondylären Femurfraktur bei<br />
einliegender Knietotalendoprothese mittels retrogradem<br />
Femurnagel. Arthroskopie 34, 74–79 (<strong>2021</strong>).<br />
https://doi.org/10.1007/s00142-020-00422-x<br />
Seilern Und Aspang J, Böckmann D, Erhart J,<br />
Haider T. Ossification of the pseudarthrosis following<br />
the Sauvé-Kapandji procedure: a case<br />
report and review of the literature. Case Reports<br />
Plast Surg Hand Surg. <strong>2021</strong> Apr 16;8(1):66-71. doi:<br />
10.1080/23320885.<strong>2021</strong>.1910040.<br />
Sigmund IK, Puchner SE, Windhager R. Serum<br />
Inflammatory Biomarkers in the Diagnosis of Periprosthetic<br />
Joint Infections. Review. Biomedicines<br />
<strong>2021</strong>, 9(9), 1128. (6.081)<br />
Sigmund IK, Windhager R, State of the Art: Behandlung<br />
von periprothetischen Gelenksinfektionen<br />
nach Implantation einer Hüft- bzw. Knietotalendoprothese.<br />
JATROS, Orthopädie & Traumatologie<br />
Rheumatologie 6/<strong>2021</strong>.<br />
Soffin EM, Reisener MJ, Padgett DE, Kelly BT, Sama<br />
AA, Zhu J, Salzmann SN, Chiapparelli E, Okano I,<br />
Oezel L, Miller AO, Cammisa FP, Girardi FP, Hughes<br />
AP. Coronavirus Disease 2019 Exposure in Surgeons<br />
and Anesthesiologists at a New York City Specialty<br />
Hospital: A Cross-Sectional Study of Symptoms<br />
and SARS-CoV-2 Antibody Status. J Occup Environ<br />
Med. <strong>2021</strong> Jun 1;63(6):521-527. doi: 10.1097/<br />
JOM.0000000000002182. PMID: 34048384; PM-<br />
CID: PMC8168673.<br />
Ternovoy S, Ustyuzhanin D, Shariya M, Shabanova<br />
M, Gaman S, Serova N, Mironov V, Merkulova I,<br />
Rienmueller A, Meyer EL, Rienmueler T. Reliability<br />
of coronary computed tomography angiography in<br />
acute coronary syndrome in an emergency setting.<br />
Heliyon. 1.2.<strong>2021</strong>;7(2):e06075<br />
Trost C, Hofer C, Stamm T, Windhager R, Hobusch<br />
GM, Cross-cultural adaption, translation and validation<br />
of the Toronto extremity salvage score (TESS)<br />
for patients in German-speaking countries; Wien<br />
Klin Wochenschr. <strong>2021</strong> Jun;133(11-12):536-542.<br />
Weihs V, Pogran E, Kunschitz E, Weihs W, Prinz E,<br />
Eichenberg C, Fiegl J, Friedrich O, Huber K.<br />
Psychocardiological assessment in the acute<br />
phase of the takotsubo syndrome: Somatic and de
Publikationen<br />
76<br />
pressive disorders, resilience and illness perception.<br />
Wien Klin Wochenschr. <strong>2021</strong> Oct 20. doi:<br />
10.1007/s00508-021-01957-1. Online ahead of<br />
print. (1,704)<br />
Willegger M, Schreiner M, Kolb A, Windhager R,<br />
Chiari C. Epiphysiodesis for the treatment of tall<br />
stature and leg length discrepancy. Wien Med Wochenschr.<br />
<strong>2021</strong> Apr;171(5-6):133-41.<br />
Willegger M, Hirtler L, Schwarz GM, Windhager<br />
RH, Chiari C. Peronealsehnenpathologien: Von der<br />
Diagnose bis zur Behandlung [Peroneal tendon pathologies:<br />
From the diagnosis to treatment]. Orthopade.<br />
<strong>2021</strong> Jul;50(7):589-604.<br />
Willegger M., Kolb A., Chiari C. Timing von Epi- und<br />
Hemiepiphysiodese an der unteren Extremität. Jatros<br />
Orthopädie & Traumatologie, Rheumatologie<br />
<strong>2021</strong>, 4:25-27<br />
Windhager R. Tumorendoprothetik [Tumour arthroplasty].<br />
Orthopade. <strong>2021</strong>Oct;50(10):839-842.<br />
Buchbeiträge <strong>2021</strong><br />
Bostrom MP, Sosa B, Staats K; „Trochanteric Osteotomy“,<br />
Advances in Specialist Hip Surgery, Seite:<br />
225-235; Verlag: Springer Medizin, ISBN: 978-<br />
3030618292<br />
Chiari C, Kainberger F. Gliederschmerzen, Arthralgie,<br />
Muskel- und Knochenschmerz, In Klinisches<br />
und Kritisches Denken. Manual klinischer Symptome,<br />
Syndrome und Risikofaktoren inklusive<br />
e-Learning-Plattform Taschenbuch Facultas,<br />
ISBN: 978-3-7089-2073-0; 2. Auflage <strong>2021</strong>, Kainberger<br />
F, Karanikas G, Schernthaner G, Szekeres T<br />
(Herausgeber)<br />
Grohs J, Kainberger F. Rückenbeschwerden. In Klinisches<br />
und Kritisches Denken. Manual klinischer Symptome,<br />
Syndrome und anderer Anlassfälle inklusive<br />
e-Learning-Plattform. Franz Kainberger, Georgios<br />
Karanikas, Gerit Schernthaner, Thomas Szekeres.<br />
ISBN: 978-3-7089-2073-0; 2. Auflage <strong>2021</strong>; 415-8<br />
Hager B, Raudner M, Juras V, Zaric O, Szomolanyi<br />
P, Schreiner M, Trattnig S. MRI of Early OA in: Early<br />
Osteoarthritis - State-of-the-Art Approaches to<br />
Diagnosis, Treatment and Controversies, Springer<br />
<strong>2021</strong>, pp. 17-26<br />
Hobusch GM, Windhager R, Chondrosarcoma of<br />
the Pelvis, Book chapter in Surgery of Pelvis Bone<br />
Tumors, Springer ISBN: 978-3-030-77007-5, Book<br />
chapter, Pages 55-62<br />
Hobusch GM et al, Implant Reconstruction of the<br />
Distal Femur: Expandable Prosthesis.in Orthopedic<br />
Surgical Oncology For Bone Tumors, A case Study<br />
Atlas, DOI 10.1007/978-3-030-73327-8_24 book<br />
Chapter<br />
Hruby LA, Mayer JA, Aszmann OC. Inner Amputations<br />
of the Upper Extremity. In: Bionic Limb Reconstruction,<br />
Oskar C. Aszmann and Dario Farina.<br />
<strong>2021</strong>, Springer<br />
Hruby LA. Deafferentation Pain Following Brachial<br />
Plexus Avulsion Injuries. In: Bionic Limb Reconstruction,<br />
Oskar C. Aszmann and Dario Farina. <strong>2021</strong>, Springer<br />
Hruby LA, Sturma A.Treatment Algorithm for Bionic<br />
Hand Reconstruction in Patients with Global Brachial<br />
Plexopathies. In: Bionic Limb Reconstruction,<br />
Oskar C. Aszmann and Dario Farina. <strong>2021</strong>, Springer<br />
Hruby LA, Sturma A, Pittermann A. Functional and<br />
Psychosocial Outcomes of Bionic Reconstruction<br />
and Impact on Quality of Life, Body Image Perception<br />
and Deafferentation Pain In: Bionic Limb Reconstruction,<br />
Oskar C. Aszmann and Dario Farina.<br />
<strong>2021</strong>, Springer<br />
Negrin LL: Epidemiology and Classification of Distal<br />
Femur Fractures. In: Knee Fractures. Marc Hanschen,<br />
Peter Biberthaler, James P. Waddell, Springer,<br />
ISBN 978-3-030-8175-6. 297 Seiten<br />
Pittermann A, Hruby LA, Sturma A, Aszmann OC.<br />
Psychosocial Importance of the Hand and Consequences<br />
of Severe Hand Trauma, Amputation and<br />
Complete Brachial Plexus Injury. In: Bionic Limb Reconstruction,<br />
Oskar C. Aszmann and Dario Farina.<br />
<strong>2021</strong>, Springer
Publikationen<br />
77<br />
Pittermann A, Hruby LA, Sturma A, Aszmann OC.<br />
Ethical Considerations and Psychosocial Evaluation<br />
in Elective Amputation for Brachial Plexus<br />
Injuries. In: Bionic Limb Reconstruction, Oskar C.<br />
Aszmann and Dario Farina. <strong>2021</strong>, Springer<br />
Staats K, Mokrusa, Sauer, Kainberger; Medizininformatik,<br />
Kritisches und Klinisches Denken, Seite:<br />
43 - 53; Verlag: Facultas ISBN: 978-3708920719<br />
Sturma A, Hruby LA, Diers M. Epidemiology and<br />
Mechanisms of Phantom Limb Pain. In: Bionic Limb<br />
Reconstruction, Oskar C. Aszmann and Dario Farina.<br />
<strong>2021</strong>, Springer<br />
Sturma A, Hruby LA, Vujakilija I, Østlie K, Farina<br />
D. Treatment Strategies for Phantom Limb Pain.<br />
In: Bionic Limb Reconstruction, Oskar C. Aszmann<br />
and Dario Farina. <strong>2021</strong>, Springer<br />
Diplomarbeiten/Dissertationen <strong>2021</strong><br />
Apprich S: Moritz Priol. Einfluss der medialen<br />
Menis kusextrusion auf den Knorpel der Belastungszone<br />
des femoromedialen Kompartiments im<br />
Kniegelenkretrospektive Evaluierung anhand von<br />
quantitativem T2 Mapping auf 3 Tesla<br />
Benca E: Beatrice Ferrante (Politecnico di Milano).<br />
Analysis of thermal effects in the bone cortex caused<br />
by the implantation of transfemoral osseointegrated<br />
prosthesis.<br />
Giurea A: Franz Xaver Feichtinger: Vergleich: Navigationsdaten<br />
und Röntgenanalyse<br />
Giurea A: Richard Koza. Outcome von Knierevisionsprothesen<br />
7 Jahresergebnisse<br />
Gregori M, Aldrian S: Anna Hohensteiner. Mittelfristige<br />
und Langzeitergebnisse nach operativer<br />
Refixation von chondralen und osteochondralen<br />
Abscherfrakturen im Kniegelenk (18.11.2020)<br />
Haider T, Negrin L: Philipp Pauli. The role of thrombocytes<br />
after severe thoracic trauma – a retrospective<br />
study (17.12.2020)<br />
Haider T, Hajdu S: Melanie Winter. Kalkaneus<br />
Frakturen - Vergleich operativer und konservertiver<br />
Therapie - eine retrospektive Studie (21.12.2020)<br />
Hasenöhrl T, Widhalm H: Sebastian Rilk. Isokinetic<br />
and Isometric Biodex quadriceps strength<br />
testing following anterior cruciate ligament reconstruction:<br />
A systematic review and meta-analysis.<br />
(28.6.<strong>2021</strong>)<br />
Hofbauer M, Binder H: Maximilian Gruber. Management<br />
und Outcome der seltenen unteren Schulterluxation<br />
(Luxation Erecta): eine single-center Studie<br />
(8.10.2020)<br />
Hofbauer M, Ostermann R: Claus Derek Bukowsky.<br />
Ist der Discus acromioclavicularis durch eigene<br />
Schmerzfasern eine mögliche Ursache für Schulterschmerzen?<br />
(16.12.2020)<br />
Humenberger M, Hajdu S: Cornelia Naß. Inzidenz<br />
und Ursache der Peroneusläsion nach Verriegelungsnagelung<br />
bei Unterschenkelfrakturen - Eine<br />
retrospektive Studie (31.3.<strong>2021</strong>)<br />
Kdolsky R: Jakob Ulreich. Effektivität der radialen<br />
extrakorporalen Stoßwellentherapie im Vergleich<br />
zu anderen konservativen Therapien und Placebo<br />
für die laterale Epikondylitis des Ellenbogens.<br />
Eine systematische Literaturarbeit und Metaanalyse<br />
von randomisiert kontrollierten Studien<br />
(8.10.2020)<br />
Kdolsky R: Benjamin Nikolaus Janda. Die Rolle des<br />
operativen Eingriffs in der Behandlung des lateralen<br />
Bandapparates im oberen Sprunggelenk nach<br />
Supinationstrauma (24.2.<strong>2021</strong>)<br />
Lass R, Rentenberger C: Daniel Birgsteiner. Navigierte<br />
Hüftendoprothetik – Verlaufsbeobachtung<br />
einer prospektiv randomisierten Kontrollstudie.<br />
Lass R: Co-Betreuer: Lukas Rabitsch. 10-Jahres<br />
Untersuchung nach zementfreier Knietotalendoprothese.<br />
Maier B, Aldrian S: Julia Strasser. Funktioneller<br />
Outcome nach Therapie von Luxationen und Luxationsfrakturen<br />
der Mittelhand (21.4.<strong>2021</strong>)
Publikationen<br />
78<br />
Negrin L: Greta Carlin. Serum level alterations of<br />
matrix metalloproteinases (MMPs) and tissue<br />
inhibitors of metalloproteinases (TIMPs) in polytraumatised<br />
patients (24.2.<strong>2021</strong>)<br />
Payr S, Hofbauer M: Karin Valentina Leitner.<br />
Eine retrospektive und epidemiologische Datenanalyse<br />
von Übergangsfrakturen – Inzidenz,<br />
Ursachen, Diagnostik, Therapie und Outcome<br />
einer Verletzung im Kindes- und Jugendalter<br />
an einem Level I Trauma zentrum<br />
(27.5.<strong>2021</strong>)<br />
Payr S, Hofbauer M: Andrea Schuller. Spine injuries<br />
in children and adolescents - frequency, causes,<br />
diagnostics, therapy and outcome at a Level I<br />
trauma center a retrospective, epidemiological<br />
data analysis (29.9.<strong>2021</strong>)<br />
Sarahrudi K, Tiefenböck T: Christian Schützner.<br />
Die Inzidenz und Therapie von Frakturen nach<br />
Lungentransplantationen - Eine explorative Single<br />
Center Studie (4.12.2020)<br />
Schreiner M: Ina Bischofs, Beinlängenausgleich<br />
durch Epiphysiodese im Kindesalter – eine retrospektive<br />
Vergleichsstudie zwischen RigidTack und<br />
PETS (29.9.<strong>2021</strong>).<br />
Staats K: Alexander Banyai. Der Einfluss des<br />
Kragens auf das Prothesenüberleben bei zementfreien<br />
Hüfttotalendoprothesen, eine retrospektive<br />
Datenanalyse (21.4.<strong>2021</strong>).<br />
Tiefenböck T, Hofbauer M: Manuel Wildtgrube.<br />
The All-inside Anterior Cruciate Ligament Reconstruction<br />
Technique? A Gender-Based Difference<br />
in Results and Outcome After 2 Years of Experience<br />
(21.4.<strong>2021</strong>)<br />
Tiefenböck T: Thomas Sator. Surveillance von<br />
postoperativen Wundinfektionen nach operativer<br />
Versorgung pertrochantärer und subtrochantärer<br />
Frakturen? Eine retrospektive Datenauswertung<br />
(3.5.<strong>2021</strong>)<br />
Tiefenböck T, Sarahrudi K: Olga Bajenov. Die Anwendung<br />
von BMP-2 in der Therapie von Knochendefekten<br />
am Mausmodell (10.6.<strong>2021</strong>)<br />
Tiefenböck T: Thomas Böhm. Die Behandlung von<br />
diaphysären Femurfrakturen mittels Fixateur externe<br />
Versorgung bei PatientInnen im Alter von zwei<br />
bis 16 Jahren (10.6.<strong>2021</strong>)<br />
Tiefenböck T: Vinzenz Bussek. Sekundäre Nagelung<br />
nach primärer Versorgung mittels Externen<br />
Fixateur eine Single Center Studie (10.6.<strong>2021</strong>)<br />
Tiefenböck T: Silvina Elena Ohnesorg. Thoraxverletzungen<br />
bei polytraumatisierten Kindern und<br />
Jugendlichen Epidemiologie, Behandlung und Ergebnisse<br />
Eine retrospektive Studie (1.9.<strong>2021</strong>)<br />
Toegel S: Patrick Mannsberger. Biocompatibility of<br />
3D printed materials: Cytotoxicity tests with L929<br />
cells, primary chondrocytes and synovial fibroblasts.<br />
(4.5.<strong>2021</strong>)<br />
Waldstein W: Eugen Lacic. Präoperative Beurteilung<br />
der Meniskusrampe im MRT bei Patienten mit<br />
Ruptur des vorderen Kreuzbands.<br />
Walzer S, Toegel S: Christopher Bauer. Effects of<br />
BMP-6 and inflammatory cytokines in human fibroblast-like<br />
synoviocytes under mechanical stimulation.<br />
(27.7.<strong>2021</strong>)<br />
Widhalm H: Julia Elisabeth Zieger. Epidemiologische<br />
Aspekte von Frakturen im Kindes- und Jugendalter<br />
- Einfluss der Zunahme der Verwendung<br />
elektronischer Geräte. Eine retrospektive Studie an<br />
circa 5.000 Patienten. (7.7.<strong>2021</strong>)<br />
Preise <strong>2021</strong><br />
Casado Losada I: Best Poster Presentation 2. Prize,<br />
Young Scientist Association (YSA)<br />
Casado Losada I: Science Art contest,<br />
Young Scientist Association (YSA)<br />
Fürsatz M: Best Poster Chair Award, TERMIS <strong>2021</strong><br />
Hobusch GM: Austrian Musculo-Skeletal-Oncologic<br />
Society (AMSOS) Research Promotion Prize
Publikationen<br />
79<br />
2020/<strong>2021</strong>: Electronically Patient Reported Outcomes<br />
(EPROS) Analysis in Patients with Musculoskeletal<br />
Sarcomas.<br />
Morgenbesser R: AUB Wissenschafts-Posterpreis.<br />
Jahrestagung der Österreichischen Arbeitsgemeinschaft<br />
für Urogynäkologie und rekonstruktive<br />
Beckenbodenchirurgie (AUB)<br />
Nürnberger S: Battle for the topic „Scaffolds“ on<br />
EORS 15. – 17.9.<strong>2021</strong>, Rome/Italy<br />
Willegger M, Karin Hebenstreit, Martin Zalaudek, Alexander<br />
Kolb, Reinhard Windhager, Catharina Chiari,<br />
1. Poster Preis, Use of the bimalleolar method shows<br />
the highest reliability in measuring tibial torsion on<br />
paediatric rotational MRI, Vereinigung für Kinderorthopädie<br />
(VKO), Graz, Austria, Oktober <strong>2021</strong><br />
Zak L: 2. Platz des ÖGU Förderpreises für Open<br />
Access Publikationen “Third generation Autologous<br />
Chondrocyte Implantation at the knee joint using<br />
the Igo ® scaffold – a case series”<br />
Drittmittelfinanzierte Projekte <strong>2021</strong><br />
Projektleitung: Benca E<br />
Fixation of the ACL using an allograft osteosynthesis<br />
system. Surgebright GmbH (Industrie),<br />
Projektlaufzeit: 22.2.<strong>2021</strong> – 22.2.2022<br />
Laufzeit: 12 Monate<br />
Gesamtfördersumme: 6.000 €<br />
Projektleitung: Halát G<br />
Vorstellung einer innovativen, Anker-basierten<br />
Rekonstruktionstechnik in der chirurgischen<br />
Therapie der A2-Ringband Ruptur. Eine experimentelle<br />
Studie am humanen Kadavermodell.<br />
Medizinisch-Wissenschaftlichen Fonds des<br />
Bürgermeisters der Bundeshauptstadt Wien<br />
Projektnummer: 20029<br />
Zuteilungsdatum: Juni 2020<br />
Laufzeit: 18 Monate<br />
Fertigstellung des Projektes: November <strong>2021</strong><br />
Gesamtfördersumme 1.000 €<br />
Projektleitung: Maier B<br />
Beurteilung des Heilungsprozesses bei<br />
konservativ behandelten distalen Radiusfrakturen<br />
sowie Identifizierung osteoporotischer<br />
Frakturen bei postmenopausalen Frauen mittels<br />
HrPQCT (hochauflösende periphere quantitative<br />
Computertomographie)<br />
Medizinisch-Wissenschaftlicher Fonds des<br />
Bürgermeisters der Bundeshauptstadt Wien<br />
Projektnummer: 20043<br />
Zuteilungsdatum: 4.6.2020<br />
Laufzeit: 18 Monate bis Juni 2022<br />
Gesamtfördersumme 2.000 €<br />
Projektleitung: Negrin L<br />
Welche Schlussfolgerungen lässt der<br />
zeitliche Verlauf von Biomarkerspiegeln, die<br />
im Blut von Polytrauma-Patienten erhoben<br />
werden, zu? – Eine Pilotstudie<br />
Förderung der Österreichischen Gesellschaft<br />
für Unfallchirurgie<br />
Start: Jänner 2019<br />
Laufzeit: 48 Monate<br />
Projektlaufzeit: 01.2019 – 12.2022<br />
Gesamtfördersumme 10.000 €<br />
Projektleitung: Nürnberger S<br />
Cartilage for Cartilage regeneration: Laser engraved<br />
decellularized cartilage as biomaterial for<br />
defect treatment<br />
FFG Bridge 1 Projekt<br />
Projektnummer: 874759<br />
Bewilligung: Juni 2019<br />
Laufzeit: 36 Monate + 12 Monate<br />
Projektlaufzeit: 1.10.2019 – 30.9.2023<br />
Gesamtfördersumme 317.936 € (UCO 40.748 €)<br />
Projektleitung: Nürnberger S<br />
Laserbasierte Methode zur Wiederbesiedelung<br />
von dezellularisierter Knorpelmatrix<br />
(LaserScaffold) für die Knorpelregeneration<br />
Lorenz Böhler Fonds<br />
Projektnummer: 5/19<br />
Bewilligung: Mai 2019<br />
Laufzeit: 18 Monate + 10 Monate<br />
Projektlaufzeit: 1.9.2019 – 31.12.<strong>2021</strong><br />
Gesamtfördersumme 33.464 €
Publikationen<br />
80<br />
Projektleitung: Schwarz G<br />
Titel: Femorale Stabilität nach Marknagel-<br />
Entfernung – Anatomische und biomechanische<br />
Auswertung.<br />
Geldgeber: Medizinisch-wissenschaftlicher Fonds<br />
des Bürgermeisters der Bundeshauptstadt Wien<br />
Nummer des Projektes: 21072<br />
Zuteilungsdatum: 1.7.<strong>2021</strong><br />
Laufzeit: 12 Monate<br />
Voraussichtliche Fertigstellung: Juli 2022<br />
Gesamtfördersumme 13.500 €<br />
Projektleitung: Staats K<br />
Titel: Functionalization of Nanopatterned Titanium<br />
(Ti) for Biomedical Application (FTiBA)<br />
Geldgeber: CEST<br />
Zuteilungsdatum: 15.9.2020<br />
Laufzeit: 15,5 Monate<br />
Voraussichtliche Fertigstellung: 31.12.<strong>2021</strong><br />
Gesamtfördersumme 33.696 €<br />
Projektleitung: Toegel S.<br />
Titel: Identifizierung von Galektinrezeptoren in<br />
arthrotischen Knorpelzellen<br />
Geldgeber: Johnson&Johnson<br />
Zuteilungsdatum: 1.8.2019<br />
Laufzeit: 18 Monate<br />
Voraussichtliche Fertigstellung des Projekts:<br />
Ende <strong>2021</strong><br />
Gesamtfördersumme 75.000 €<br />
Projektleitung: Toegel S.<br />
Titel: AFOR Wissenschaftspreis 2020<br />
Geldgeber: Association for Orthopaedic Research<br />
Zuteilungsdatum: 1.11.2020<br />
Laufzeit: 23 Monate<br />
Voraussichtliche Fertigstellung des Projekts:<br />
Ende 2022<br />
Gesamtfördersumme 6.250 €<br />
Projektleitung: Widhalm HK<br />
The Clinical Relevance of micro RNAs in Mild<br />
Traumatic Brain Injury - A Pilot Study<br />
(Micro RNA Diagnostik bei Schädelhirntrauma)<br />
Medizinisch-Wissenschaftlichen Fonds des<br />
Bürgermeisters der Bundeshauptstadt Wien<br />
Zuteilungsnummer des Projekts: 15113<br />
Zuteilungsdatum: 1.12.2015<br />
Laufzeit: 60 Monate<br />
Fertigstellung des Projekts: Ende <strong>2021</strong><br />
Gesamtfördersumme 13.000 €<br />
Vorsitz bei Tagungen <strong>2021</strong><br />
Aldrian S<br />
Minimalinvasive Osteosynthesen II, 57. ÖGU &<br />
2. ÖGOuT Jahrestagung (Online) „Minimalinvasive<br />
Unfallchirurgie und Orthopädie“, 7. – 9.10.<strong>2021</strong>,<br />
Österreich<br />
Casado Losada I<br />
Mechanisms of action in skeletal biology and repair,<br />
6. World Congress of the Tissue Engineering and Regenerative<br />
Medicine International Society (TERMIS),<br />
Maastricht, 15. – 19.11.<strong>2021</strong> (online), Niederlande;<br />
Engineering extracellular matrices: fabrication methods,6.<br />
World Congress of the Tissue Engineering<br />
and Regenerative Medicine International Society<br />
(TERMIS), Maastricht, 15. – 19.11.<strong>2021</strong> (online)<br />
Chiari C<br />
Surgical Treatment: What is best for spine and pelvis?<br />
39. EPOS Annual Meeting, European Paediatric<br />
Orthopaedic Society, 14.4.<strong>2021</strong> (online)<br />
Deformitäten II, Trauma, Varia. 1.10.<strong>2021</strong>, 34. Jahrestag<br />
und der Vereinigung der Kinderorthopädie e.V.,<br />
30.9. – 2.10.<strong>2021</strong>, Graz<br />
Kursorganisation. Ausbildungskurs der Medizinischen<br />
Universität Wien - Sonografie der Säuglingshüfte<br />
nach Graf – 15. – 16.10.<strong>2021</strong><br />
Vortragsblock 4: Wirbelsäule operative, ÖGO/BVDO<br />
Tagung, 20.11.<strong>2021</strong> Wien<br />
Frenzel S<br />
Workshop des Jungen Forums der ÖGU – „Minimalinvasive<br />
Chirurgie“. 57. Jahrestagung der Österreichischen<br />
Gesellschaft für Unfallchirurgie,<br />
(7. – 9.10.<strong>2021</strong>): 7.10.<strong>2021</strong><br />
Fürsatz M<br />
Postersession: Use of bioelectronic, biomagnetic<br />
and biophysical approaches in Regenerative Medicine<br />
6. World Congress of the Tissue Engineering and<br />
Regenerative Medicine International Society (TER-<br />
MIS <strong>2021</strong>), Maastricht, 15. – 19.11.<strong>2021</strong> Niederlande
Publikationen<br />
81<br />
Grohs J<br />
22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.<br />
virtuelle Live Diskussion Wirbelsäule mit<br />
Abstand 20.2.<strong>2021</strong>. Wien, 30.1.<strong>2021</strong><br />
Halát G<br />
Aktuelle Herausforderungen in der Schwerstverletztenversorgung<br />
4. Interdisziplinären Polytraumasymposium<br />
Österreich<br />
Humenberger M<br />
Sitzung des Jungen Forums der ÖGU & Assistent*innenversammlung<br />
57. ÖGU & 2. ÖGOuT Jahrestagung<br />
(Online) ‚Minimalinvasive Unfallchirurgie<br />
und Orthopädie‘, 7. – 9.10.<strong>2021</strong> Österreich<br />
Kdolsky R<br />
ESTES webinar: „Management of periarticular injuries<br />
of the knee“, 22.3.<strong>2021</strong>,ESTES virtual week:<br />
„Recommendations on thoraco-lumbar fractures“,<br />
25.4.<strong>2021</strong><br />
Nürnberger S<br />
Knorpel-Session, „Annual Meeting Austrian Cluster<br />
for Tissue Regeneration“, 30. – 31.8.<strong>2021</strong>, Wien<br />
Pajenda G<br />
Postervorträge 57. ÖGU & 2. ÖGOuT Jahrestagung<br />
(Online) „Minimalinvasive Unfallchirurgie und<br />
Ortho pädie“, 7. – 9.10.<strong>2021</strong> Österreich<br />
Sigmund IK<br />
Best Paper Session. 39. Annual Meeting of the European<br />
Bone and Joint Infection Society. 7. – 9.10.<strong>2021</strong><br />
Ljubljana, Slovenia<br />
Springer B<br />
Workshop des Jungen Forums der ÖGU – „Minimalinvasive<br />
Chirurgie“, 57. ÖGU & 2. ÖGOuT Jahrestagung<br />
(Online) ‚Minimalinvasive Unfallchirurgie und<br />
Orthopädie‘, 7. – 9.10.<strong>2021</strong>, Österreich<br />
Thalhammer G<br />
Spezielle Fragestellungen 57. ÖGU & 2. ÖGOuT<br />
Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie<br />
und Orthopädie‘ vom 7. – 9.10.<strong>2021</strong>, Wien<br />
Widhalm H<br />
Interdisziplinäres Management 5. Österreichisches<br />
Symposium für Perioperative Medizin – Hybridveranstaltung,<br />
MUW, 01. Oktober <strong>2021</strong> Österreich<br />
Weill Cornell Seminar Weill Cornell Seminar: Trauma<br />
& Emergency Surgery: Austrian American Foundation<br />
(AAF), 12. – 18.12.<strong>2021</strong>, Salzburg Österreich<br />
Willegger M<br />
Ausbildungskurs der Medizinischen Universität<br />
Wien – Sonografie der Säuglingshüfte nach Graf, ao.<br />
Univ.-Prof. Dr. Catharina Chiari, MSc; OA Priv. Doz. Dr.<br />
Alexander Kolb, Priv. Doz. Dr. Madeleine Willegger<br />
FEBOT, Dr. Markus Schreiner<br />
Windhager R<br />
Block I: OP Technik und die schwierige primäre TKA<br />
AE-Masterkurs „Knie“, Arbeitsgemeinschaft Endoprothetik<br />
GmbH Linz, 1.10.<strong>2021</strong><br />
ASG-Fellows: Hüftgelenk – von der Säuglingshüfte<br />
bis zum Hüft-TEP-Wechsel, DKOU <strong>2021</strong>, Berlin,<br />
28.10.<strong>2021</strong><br />
Wissenschaftliche Leitung <strong>2021</strong><br />
Negrin L<br />
Wissenschaftliche Leitung: 23. GOTS Wintertreffen<br />
– Stabil und Mobil – Vom Rumpf bis zur Extremität,<br />
Online, 26. – 27.3.<strong>2021</strong> Österreich<br />
Leiter des Organisationskomitees: 4. Interdisziplinäres<br />
Polytraumasymposium – Aktuelle Herausforderungen<br />
in der Schwerstverletztenversorgung,<br />
Online, 7.5.<strong>2021</strong> Österreich<br />
Wissenschaftliche Leitung: Beckenkurs – Osteosynthese<br />
bei Beckenfrakturen am Humanpräparat,<br />
Salzburg, 6. 10.<strong>2021</strong> Österreich<br />
Windhager R<br />
Wissenschaftliche Leitung: Online Ausbildungskurs<br />
„Tumororthopädie“ ÖGO, 12.3.<strong>2021</strong><br />
Wissenschaftliche Leitung: Medacta Surgical Days,<br />
15. – 18. 6.<strong>2021</strong>, Graz<br />
Wissenschaftliche Leitung: AE-Masterkurs „Knie“,<br />
Arbeitsgemeinschaft Endoprothetik GmbH Linz,<br />
1. – 2.10.<strong>2021</strong>
Publikationen<br />
82<br />
Präsidentschaften und<br />
Funktionen bei Journalen <strong>2021</strong><br />
Antoni A<br />
Vorstandsmitglied der ADNANI (Interdisziplinäre<br />
Arbeitsgemeinschaft Neuromedizin)<br />
Döring K<br />
Reviewer<br />
World Journal of Surgical Oncology<br />
Frenzel S<br />
Reviewer<br />
PLOS ONE<br />
Giurea A<br />
Guest Editor. Acta Chirurgica Austriaca<br />
Wissenschaftlicher Beirat bei IATROS<br />
Kolumne in: Sport in Wien, Echo Verlag Wien<br />
Kolumne in: Running, Echo Verlag Wien<br />
Grohs J<br />
Corresponding Member, North American Spine<br />
Society (NASS)<br />
Reviewer Wiener Medizinische Wochenschrift<br />
Beirat der Österreichischen Gesellschaft für<br />
Wirbelsäulenchirurgie<br />
Preiskommittee Otto Kraupp Preis<br />
26.10.<strong>2021</strong><br />
Haider T<br />
Reviewer<br />
British Medical Journal (BMJ) Open<br />
Injury – International Journal of the Care<br />
of the Injured<br />
European Journal of Trauma and Emergency<br />
Surgery<br />
Scientific Reports<br />
BMC Musculoskeletal Disorders<br />
Hajdu S<br />
Preiskommission für den Günther-Schlag<br />
Abstractpreis für junge Forscher*innen<br />
Holzer S<br />
Präsidiumsmitglied der Österreichische Gesellschaft<br />
für Musik und Medizin (ÖGfMM) Leitung der<br />
AG Musikermedizin 2020 – 2022<br />
Kdolsky R<br />
Section Chair<br />
ESTES: skeletal trauma and sports medicine<br />
Reviewer<br />
International Journal of Environmental Research<br />
and Public Health<br />
Medicina<br />
World Journal of Orthopedics<br />
Medicines<br />
Lass R<br />
Editorial Boards<br />
Austin Journal of Orthopedics & Rheumatology<br />
World Journal of Orthopedics<br />
Reviewer<br />
Journal of Orthopedic Research<br />
Bone & Joint Research<br />
BMC Muskuloskeletal Disorders<br />
Diagnostic Microbiology<br />
European Journal of Clinical Microbiology & Infectious<br />
Diseases<br />
Expert Reviews<br />
Journal of Functional Biomaterials<br />
Negrin L<br />
Editorial Board Member<br />
Journal of Clinical Trials<br />
Journal of Trauma & Treatment<br />
Nürnberger S<br />
Reviewer<br />
Acta Biomaterialia<br />
EBiomed<br />
Ticks and Tick born deseases<br />
Payr S<br />
Reviewer<br />
Journal of Orthopaedic Surgery and Research<br />
Journal of Clinical Medicine<br />
International Journal of Environmental Research<br />
and Public Health<br />
Children<br />
Rothbauer M<br />
Reviewer<br />
RSC Lab on a chip, Acta Biomat, Small, Anal Chem,<br />
Adv Science, Adv Materials, Adv functional mat,<br />
Nature sci rep, Nature comms, World J Surg Onc,
Publikationen<br />
83<br />
Molecules, Micromachines, E&I Elektrotechnik,<br />
Biophys rev, Biology, Adv mat techn, ACS biomat<br />
sci eng, ACS appl bio mat, Biosensors, Methods<br />
Biomech Bioeng, Life, Cell Biol Int, Pharmaceutics,<br />
Vet Med, Appl Sci, Expert Opin Drug Deliv, Nanomaterials,<br />
Eng rep, IJMS, J TERM, Electronics,<br />
BioTechniques<br />
Scientific Evaluator<br />
The Dutch Cancer Society (KWF)/The Netherlands<br />
Fundação para a Ciência e a Tecnologia, I. P. (FCT) –<br />
the Portuguese public funding agency for R&D/<br />
Portugal<br />
The Dutch Research Council/The Netherlands<br />
The Swiss National Science Foundation<br />
Switzerland<br />
Editorial and Board Positions<br />
Reviewing Editor, Frontiers in Biotechnology<br />
and Bioengineering<br />
Reviewing Editor, MDPI Sensors<br />
Editorial Board Member, Organs-on-a-Chip<br />
(Elsevier)<br />
Financial auditor for the EUSAAT<br />
Salzmann S<br />
Reviewer<br />
Spine (Phila Pa 1976), World Neurosurgery<br />
Current Sports Medicine Reports<br />
Osteoporosis International<br />
Sigmund IK<br />
Ordinary Member of the Executive Committee<br />
of the European Bone & Joint Infection Society<br />
(EBJIS)<br />
Associate Editor Journal of Bone and Joint Infection<br />
(JBJI)<br />
Reviewer<br />
Bone & Joint Research (BJR)<br />
Journal of Bone and Joint Infection (JBJI)<br />
Archives of Orthopaedic and Trauma Surgery (AOTS)<br />
Stelzeneder B<br />
Reviewer<br />
European Radiology<br />
Thalhammer G<br />
Reviewer<br />
Journal of Plastic Surgery and Hand Surgery<br />
Arthroscopy - the Journal of Arthroscopic and<br />
Related Surgery<br />
Tiefenböck T<br />
Guest-Editor<br />
Children – Special Issue ‚Frontier Research of<br />
Orthopedic Trauma Surgery‘<br />
Reviewer<br />
Journal of Orthopaedic Surgery and Research<br />
Journal of Clinical Medicine<br />
International Journal of Environmental Research<br />
and Public Health<br />
Biomechanics<br />
Plos ONE<br />
Children<br />
Toegel S<br />
Reviewer<br />
Arthritis Research & Therapy<br />
Biochemical and Molecular Toxicology<br />
Journal of Orthopecis Research<br />
Osteoarthritis and Cartilage<br />
Proteomics Clinical Application<br />
Wiener Klinische Wochenschrift<br />
Experimental and Molecular Pathology<br />
Member of the Editorial Academy. ‚International Journal<br />
of Molecular Medicine‘, Spandidos Publications.<br />
Waldstein W<br />
Reviewer<br />
Archives of Orthopaedic and Trauma Surgery (AOTS)<br />
Widhalm H<br />
Reviewer<br />
Orthopaedic Journal of Sports Medicine<br />
Wiener Klinische Wochenschrift<br />
Obesity Surgery<br />
Neurosurgical Review<br />
Knee Surgery Sports Traumatology Arthroscopy<br />
American Journal of Sports Medicine<br />
Journal of Clinical Medicine<br />
Willegger M<br />
Generalsekretärin – Österreichische Gesellschaft<br />
für Fußchirurgie<br />
Genderbeauftrage – Österreichische Gesellschaft<br />
für Orthopädie<br />
Vollmitglied – AGA Fuss- und Sprunggelenk Komitee<br />
Reviewer<br />
Arthroscopy<br />
Clinical Orthopaedics and Related Research –<br />
Journal of Orthopaedic Research
Publikationen<br />
84<br />
International Orthopaedics<br />
Journal of Pediatric infectious diseases<br />
BMC Musculoskeletal Disorders<br />
Journal of Oncology<br />
Windhager R<br />
Section-Editor, Wiener Klinische Wochenschrift<br />
(seit Juli <strong>2021</strong>)<br />
Mitherausgeber von Journal of Ortopaedic<br />
and Traumatology (SIOT)<br />
Mitglied des Redaktionsrates des JOT, Journal<br />
of Othopaedic Translation (seit Sept. 2018)<br />
Mitherausgeber der Z ORTHOP (2003 bis dato)<br />
Jubiläumsfonds der Österreichischen Nationalbank<br />
(OeNB)<br />
Medizinisch wissenschaftlicher Fonds des<br />
Bürgermeisters der Bundeshauptstadt Wien,<br />
Mitglied des wissenschaftlichen Beirates der<br />
Zeitschrift „Der Orthopäde“<br />
Mitglied des wissenschaftlichen Beirates der<br />
Zeitschrift „Arzt + Patient“<br />
Reviewer<br />
EFORT Open Reviews<br />
Clinical Orthopaedics and Related Research<br />
Journal of Clinical Medicine<br />
Journal of Orthopaedics and Traumatolog<br />
Zak L<br />
Guest Editor<br />
Journal of Clinical Medicine - Special Issue: Deformity<br />
Correction, Bone Lengthening and Correction<br />
Osteotomies of the Lower Limb<br />
Reviewer<br />
Medicina<br />
World Journal Orthopaedics<br />
Besuchte Kurse und Kongresse<br />
Antoni A<br />
14. Endoprothetikkongress, 25. – 27.2.<strong>2021</strong> (online)<br />
Arbeitsgemeinschaft Endoprothetik „Master kurs<br />
Hüfte“ 25. – 26.3.<strong>2021</strong> (online)<br />
21. European Congress of Trauma & Emergency<br />
Surgery, 25. – 30.4.<strong>2021</strong> (online)<br />
Virtual Instructional Pelvic (VIP) Course,<br />
2.9.<strong>2021</strong> (online)<br />
57. ÖGU & 2. ÖGOuT Jahrestagung „Minimalinvasive<br />
Unfallchirugie & Orthopädie”, 7. – 9.10.<strong>2021</strong><br />
(online)<br />
34. Wissenschaftliche Sitzung der ADNANI<br />
„Neuro-Radiologie eine Erfolgsgeschichte“<br />
15. – 16.10.<strong>2021</strong> Hannover/Deutschland<br />
AE-Online-Kompaktkurs Spezial: Periprothetische<br />
Frakturen, 10. – 11.11.<strong>2021</strong> (online)<br />
Trauma Oggi, 25.11.<strong>2021</strong>, Rom/Italien (online)<br />
Aldrian S<br />
ÖGU: Öffentliche Sitzung des Arbeitskreises Knie –<br />
15.1.<strong>2021</strong> (online)<br />
70. ÖGU Fortbildung/„Alterstraumatologie – Frakturversorgung<br />
bei Osteoporose und perioperatives<br />
Management“ – 19.3.<strong>2021</strong> und 20.3.<strong>2021</strong><br />
(online)<br />
57. Jahrestagung der ÖGU und 2. Jahrestagung<br />
der ÖGOuT – Minimalinvasive Unfallchirurgie &<br />
Orthopädie, 7. – 9.10.<strong>2021</strong><br />
ÖGU öffentliche Sitzung des Arbeitskreises<br />
Knorpel, 26.11.<strong>2021</strong>, (online)<br />
2. Tiroler Osteotomie Kurs, Rum, Austria,<br />
18.6.<strong>2021</strong><br />
Benca E<br />
Thermal effects during bone preparation for- and<br />
during insertion of osseointegrated transfemoral<br />
implants 26. Congress of the European Society of<br />
Biomechanics (online). 14.7.<strong>2021</strong><br />
Bumberger A<br />
7. Master Class Symposium: Funktionelle Anatomie<br />
und periphere Ligamentrekonstruktion des<br />
Kniegelenks. Münster November <strong>2021</strong><br />
Chiari C<br />
34. Jahrestag und der Vereinigung der Kinderorthopädie<br />
e.V., 30.9. – 2.10.<strong>2021</strong>, Graz.<br />
AGA Akademie Kurs, Arthroskopie des Hüftgelenks<br />
Würzburg, 5. – 6.11.<strong>2021</strong><br />
ÖGO Ausbildungsseminar Kinderorthopädie<br />
18.11.<strong>2021</strong>, OSS Wien<br />
ÖGO/BVDO Tagung, 20.11.<strong>2021</strong> Wien<br />
„Advanced Orthopedics and Traumatology – Aktuelle<br />
Konzepte der Orthopädie und Traumatologie<br />
(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-<br />
und traumatologie, Osteotomien“,<br />
25. – 27.11.<strong>2021</strong>
Publikationen<br />
85<br />
Döring K<br />
Wiener Handkurs – Basiskurs, 17. – 21.5.<strong>2021</strong>, Wien<br />
Sharkscrew – Operationskurs Fuß, 30.9. – 1.10.<strong>2021</strong>,<br />
Oberösterreich<br />
Frenzel S<br />
70. ÖGU Fortbildung „Alterstraumatologie –<br />
Fraktur versorgung bei Osteoporose und perioperatives<br />
Management“ (19.3.<strong>2021</strong>, online)<br />
71. ÖGU Fortbildung „Der Fuß das unbekannte Wesen<br />
– Diagnostik und Therapie der akuten Verletzung<br />
und Möglichkeiten der späteren Korrektur“<br />
(28. – 29.5.<strong>2021</strong>, online)<br />
41. SICOT Orthopaedic World Congress, Budapest,<br />
Ungarn; 15. – 18.9.<strong>2021</strong><br />
57. Jahrestagung der Österreichischen Gesellschaft<br />
für Unfallchirurgie, 7. – 9.10.<strong>2021</strong><br />
72. ÖGU Fortbildung „Das Hüftgelenk – Von der Rekonstruktion<br />
bis zum Gelenksersatz“, 12.11.<strong>2021</strong>,<br />
(online)<br />
IRCAD- Wrist Surgery Course, 10. – 11.12.<strong>2021</strong>;<br />
Strasbourg, Frankreich<br />
4. interdisziplinäre Polytraumasymposium, „Aktuelle<br />
Herausforderungen in der Schwerstverletztenversorgung“,<br />
7.5.<strong>2021</strong><br />
Grohs J<br />
22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.<br />
Wirbelsäule mit Abstand, Wien 30.1.<strong>2021</strong><br />
Nextar Kurs Luzern 22. – 23.6.<strong>2021</strong><br />
Haider T<br />
Deutscher Kongress für Orthopädie und Unfallchirurgie<br />
(DKOU <strong>2021</strong>), 26. – 29.10.<strong>2021</strong>, Berlin<br />
Halát G<br />
4. Interdisziplinäres Polytraumasymposium „Aktuelle<br />
Herausforderungen in der Schwerstverletztenversorgung“,<br />
7.5.<strong>2021</strong>, Wien<br />
Symposium der Deutschsprachigen Arbeitsgemeinschaft<br />
für Handchirurgie (DAH)<br />
Rhizarthrose, Radius, PIP Gelenk und 3-D Planung,<br />
7. – 8.5.<strong>2021</strong>(online)<br />
Ehrensymposium für Prof. Dr. Leixnering, Der<br />
Aufstieg der Handchirurgie in Österreich,<br />
1.10.<strong>2021</strong>, Wien<br />
Rheumahandkurs (Wiener Handkurse),<br />
10. – 12.11.<strong>2021</strong>, Wien<br />
IRCAD – Wrist Surgery Course „All around the Scaphoid“,<br />
10. – 11.12.<strong>2021</strong>, Strasbourg, Frankreich<br />
Hruby L<br />
81. Jahreskongress swiss orthopaedics <strong>2021</strong> online<br />
AGA Kongress September <strong>2021</strong> Innsbruck<br />
Kolb A<br />
34. Jahrestag und der Vereinigung der Kinderorthopädie<br />
e.V., 30.9. – 2.10.<strong>2021</strong>, Graz<br />
Negrin L<br />
Minimal invasive Hüfttotalendoprothetik, Salzburg,<br />
4. – 5.11.<strong>2021</strong><br />
ITS-Beckenkurs, Salzburg, 6.10.<strong>2021</strong><br />
Master Knee Course <strong>2021</strong>, Hochrum, 23. – 24. 9.<strong>2021</strong><br />
IOC World Conference on Prevention of Injury & Illness<br />
in Sport, Monaco, 25. – 27.11.<strong>2021</strong><br />
12 th IOC Advanced Team Physician Course, Istanbul,<br />
1. – 3.11.<strong>2021</strong><br />
Deutscher Kongress für Orthopädie und Unfallchirurgie,<br />
Berlin, 27. – 28.10.<strong>2021</strong><br />
57. Jahrestagung der ÖGU und 2. Jahrestagung der<br />
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,<br />
(online), 7. – 9.10.<strong>2021</strong><br />
36. Jahreskongress der der Gesellschaft für<br />
Orthopädisch-Traumatologische Sportmedizin,<br />
1. – 2.7.<strong>2021</strong> (online),<br />
Virtual EFFORT Congress – VEChybrid, Online,<br />
30.6.<strong>2021</strong><br />
SPORTMED GRAZ 21 – Spitzensport braucht<br />
Spitzenbehandlung, Graz, 11.6.<strong>2021</strong><br />
Payr S<br />
57. ÖGU & 2. ÖGOuT Jahrestagung (online)<br />
„Minimal invasive Unfallchirurgie und Orthopädie“,<br />
7. – 9.10.<strong>2021</strong>, Wien<br />
Hüftsonographie bei Säuglingen (Stolzalpe)<br />
Rentenberger C<br />
Wiener Handkurs – Basiskurs, 7. – 11.6.<strong>2021</strong>, Wien<br />
57. Jahrestagung der Österreichischen Gesellschaft<br />
für Unfallchirurgie (07. – 09.10.<strong>2021</strong>, online)<br />
Deutscher Kongress für Orthopädie und Unfallchirurgie<br />
(Berlin 26. – 29.10.<strong>2021</strong>, online)
Publikationen<br />
86<br />
Salzmann S<br />
ORS (Orthopaedic Research Society) <strong>2021</strong> Annual<br />
Meeting, 12. – 15.2.<strong>2021</strong><br />
International Society for the Study of the Lumbar<br />
Spine (ISSLS) Virtual Annual meeting<br />
31.5. – 4.6.<strong>2021</strong><br />
AO Spine Basis Kurs–Notfälle und Degeneration in<br />
der Wirbelsäulenchirurgie<br />
10. – 11.9.<strong>2021</strong>, Anatomischen Institut der Paracelsus<br />
Medizinische Universität Salzburg<br />
North American Spine Society 36. Annual Meeting<br />
29.9. – 2.10.<strong>2021</strong>, Boston, MA<br />
Global Spine Congress, 3. – 6.11.<strong>2021</strong><br />
Scheider P<br />
Wiener Handkurs (Basis) Nr. 167/2 (12. – 16.04.<strong>2021</strong>)<br />
Virtual EFORT Congress <strong>2021</strong> (30.6. – 2.7.<strong>2021</strong>)<br />
34. Jahrestagung der VKO in Graz mit Operationskurs<br />
(30.9. – 2.10.<strong>2021</strong>)<br />
Sigmund IK<br />
EBJIS (Webinar) 18.5.<strong>2021</strong> Infection after<br />
arthroscopy & sport-orthopaedic procedures<br />
AE Masterkurs Knie, Linz 1. – 2.10.<strong>2021</strong><br />
39. EBJIS annual meeting Ljubljana, Slovenia,<br />
7. – 9.10.<strong>2021</strong><br />
DKOU Berlin, 26. – 29.10.<strong>2021</strong><br />
Springer B<br />
57. Jahrestagung der ÖGU und 2. Jahrestagung der<br />
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,<br />
7. – 9.10.<strong>2021</strong> (online)<br />
Stelzeneder B<br />
ÖGU: Öffentliche Sitzung des Arbeitskreises Knie -<br />
15.1.<strong>2021</strong> (online)<br />
70. ÖGU Fortbildung / „Alterstraumatologie - Frakturversorgung<br />
bei Osteoporose und perioperatives<br />
Management“, 19.03.<strong>2021</strong> und 20.03.<strong>2021</strong> (online)<br />
4. Interdisziplinäres Polytraumasymposium „Aktuelle<br />
Herausforderungen in der Schwerstverletztenversorgung“,<br />
7.5.<strong>2021</strong> (online)<br />
71. ÖGU Fortbildung „Der Fuß – das unbekannte<br />
Wesen – Diagnostik und Therapie der akuten Verletzung<br />
und Möglichkeiten der späteren Korrektur-<br />
28. – 29.5.<strong>2021</strong> (online)<br />
57. Jahrestagung der ÖGU und 2. Jahrestagung der<br />
ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,<br />
7. – 9.10.<strong>2021</strong> (online)<br />
72. Fortbildung „Das Hüftgelenk - Von der Rekonstruktion<br />
bis zum Gelenksersatz“, 12. – 13.11.<strong>2021</strong><br />
(online)<br />
Sportmedizin Leistungsphysiologisch-Internistisch-Pädiatrischer<br />
Grundkurs IV + Traumatologisch-Pädiatrischer<br />
Grundkurs III + Praxisseminar<br />
+ Ärztesport, 18. – 21.11.<strong>2021</strong>, St. Pölten<br />
ÖGU öffentliche Sitzung des Arbeitskreises Knorpel,<br />
26.11.<strong>2021</strong>, (online)<br />
Thalhammer G<br />
Surgery of the Spastic Upper Limb, 16.4.<strong>2021</strong><br />
4. Interdisziplinäres Polytraumasymposium „Aktuelle<br />
Herausforderungen in der Schwerstverletztenversorgung“,<br />
7.5.<strong>2021</strong><br />
Virtuelles DAH Symposium, „Rhizarthrose, Radius,<br />
PIP Gelenk und 3-D Planung“, 7. – 8.5.<strong>2021</strong><br />
71. Fortbildung ÖGU: „Der Fuß das unbekannte Wesen<br />
– Diagnostik und Therapie der akuten Verletzung<br />
und Möglichkeiten der späteren Korrektur“,<br />
28. – 29.5.<strong>2021</strong><br />
„Operationskurs Hand - Osteosynthese mit humanbiologischem<br />
Gewebe“ 7. – 8.6.<strong>2021</strong><br />
ISAKOS Innovative Techniques in Elbow Arthroscopy,<br />
17.6.<strong>2021</strong><br />
57. ÖGU & 2. ÖGOuT Jahrestagung (online) „Minimalinvasive<br />
Unfallchirurgie und Orthopädie“,<br />
7. – 9.10.<strong>2021</strong>, Wien<br />
72. Fortbildung ÖGU: „Das Hüftgelenk – Von der Rekonstruktion<br />
bis zum Gelenksersatz, 12.11.<strong>2021</strong><br />
IRCAD - Wrist Surgery Course / Open Wrist Surgery<br />
Workshop, 10. – 11.12.<strong>2021</strong>, Strasbourg, Frankreich<br />
Tiefenböck T<br />
ÖGU Jahrestagung<br />
AGA Jahrestagung<br />
ÖÄK ärztliche Wundbehandlung<br />
Toegel S<br />
<strong>2021</strong> OARSI Virtual World Congress on Osteoarthritis,<br />
29.4. – 1.5.<strong>2021</strong><br />
Scientific Advisory board meeting <strong>2021</strong> of the Ludwig<br />
Boltzmann Institute for Arthritis and Rehabilitation.<br />
7.5.<strong>2021</strong> ( online).<br />
Waldstein W<br />
DKOU Berlin 26. – 29.10.<strong>2021</strong>
Publikationen<br />
87<br />
Weihs V<br />
Wiener Handkurse - Rheuma Handkurs<br />
10. – 12.11.<strong>2021</strong><br />
ESICM 34 th ESICM LIVES Digital Annual Congress<br />
<strong>2021</strong>, 3. – 6.10.<strong>2021</strong><br />
SICOT 41.SICOT Orthopaedic World Congress,<br />
Budapest 15. – 18.9.<strong>2021</strong><br />
Jahrestagung <strong>2021</strong> Österreichische Kardiologische<br />
Gesellschaft 27. – 28.5.<strong>2021</strong><br />
DAH Symposium <strong>2021</strong>, 8.5.<strong>2021</strong> (online)<br />
4. Interdisziplinäres Polytrauma Symposium<br />
„Akutelle Herausforderungen in der Schwerverletztenversorgung“,<br />
7.5.<strong>2021</strong><br />
Widhalm HK<br />
Knie Konsensus Meeting – Update Kreuzband –<br />
Transplantatwahl und extraartikuläre Zusatzeingriffe,<br />
15.1.<strong>2021</strong>, (online)<br />
The Meniscus – Webinar NEWS – ESSKA,<br />
30.1.<strong>2021</strong><br />
Modern Trauma Care – Expertenforum zur Zukunft<br />
der Orthopädie und Traumatologie, AUVA<br />
Webinar, 25. – 26.2.<strong>2021</strong><br />
Orthopädisch-Traumatologisch-Physikalischer<br />
Grundkurs II – Ärztekammer, 27. – 28.2.<strong>2021</strong> (online)<br />
ÖGO-Ausbildungsseminar: Tumor-Orthopädie,<br />
12.3.<strong>2021</strong> (online)<br />
70. ÖGU-Fortbildungsveranstaltung: „Alterstraumatologie<br />
– Frakturversorgung bei Osteoporose<br />
und perioperatives Management“ ONLINE,<br />
19. – 20.3.<strong>2021</strong><br />
4.Interdisziplinäres Traumasymposium – MUW<br />
Unfall, Wien, Online, 7.5.<strong>2021</strong><br />
GOTS-Webinar, 29.6.<strong>2021</strong><br />
AGA-Jahrestagung, Innsbruck – Hybrid Online,<br />
9. – 11.09.<strong>2021</strong><br />
Fusskurs – Fußchirurgie in der Orthopädie – ÖGO<br />
Ausbildungsseminar – Speising, 10. – 11.9.<strong>2021</strong><br />
TNT-Traumaregister-Jahrestreffen-Meeting, Salzburg<br />
(Hybrid & Online), 17.9.<strong>2021</strong><br />
Mathys Hüfte – optimys / RM Pressfit, Salzburg –<br />
Paracelsus Privatuniversität Salzburg (PMU), 29.-<br />
30.9.<strong>2021</strong><br />
57. ÖGU & 2. ÖGOuT Jahrestagung (Online) „Minimalinvasive<br />
Unfallchirurgie und Orthopädie“ vom<br />
7. – 9.10.<strong>2021</strong>, Wien<br />
5. Österr. Symposium für Perioperative Medizin –<br />
Hybridveranstaltung, MUW, 29. – 30.10.<strong>2021</strong><br />
Behandlung von Wirbelkörperfrakturen - Hands-<br />
On Training, Düsseldorf – Stryker, 2. – 3.11.<strong>2021</strong><br />
72.ÖGU Fortbildung - Das Hüftgelenk –Von der Rekonstruktion<br />
bis zum Gelenksersatz, AUVA Online,<br />
12. – 13.11.<strong>2021</strong><br />
Öffentliche Sitzung des Arbeitskreises Knorpel der<br />
österreichischen Gesellschaft für Unfallchirurgie –<br />
Update in der Knorpelchirurgie, 26.11.<strong>2021</strong> (online)<br />
Willegger M<br />
IPOS – International Paediatric Orthopaedic Symposium<br />
<strong>2021</strong> – 7. – 11.12.<strong>2021</strong>, Orlando, FL, USA<br />
Vorträge<br />
Aldrian S<br />
Eingeladender Vortrag: Update in der Knorpelchirurgie<br />
Sitzung des Arbeitskreis Knorpel der ÖGU<br />
Österreich<br />
Eingeladender Vortrag: State of the Art der Knorpelchirurgie<br />
Fachgruppensitzung der Ärztekammer<br />
Österreich<br />
Eingeladender Vortrag: Kniegelenksarthroskopie –<br />
Grundlagen und Expertentipps 57. ÖGU & 2. ÖGOuT<br />
Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie<br />
und Orthopädie‘ vom 7. – 9.10.<strong>2021</strong> Österreich<br />
Eingeladender Vortrag: Das Polytrauma aus unfallchirurgischer<br />
Sicht (Thorax, Abdomen, Becken)<br />
1. Notarztkurs der Univ. <strong>Klinik</strong> für Anästhesie, Allg.<br />
Intensivmedizin & Schmerztherapie in Kooperation<br />
mit der Univ. <strong>Klinik</strong> für Notfallmedizin und dem<br />
WIGEV Österreich<br />
Antoni A<br />
Eingeladender Vortrag: Diagnostik & Management<br />
des leichten Schädel-Hirn Traumas bei antithrombotischer<br />
Therapie 34. Wissenschaftliche Sitzung<br />
der ADNANI, 16.10.<strong>2021</strong>, Hannover/Deutschland<br />
Deutschland<br />
Complex Pelvic Trauma: A territory disputed by<br />
orthopedics and trauma surgeons Trauma Oggi,<br />
25.11.<strong>2021</strong>, Rom/Italien (online)<br />
Casado-Losada I<br />
Técnicas de descelularización para regeneración<br />
de cartílago (translation: decellularization
Publikationen<br />
88<br />
techniques for cartilage regeneration III Congreso<br />
Internacional de Tecnología Médica – EAP Tecnología<br />
Médica. Universidad Norbert Wiener, Perú.<br />
(Translation: III International Congress of Medical<br />
Technology) 22. – 24.10.<strong>2021</strong> Peru<br />
Pitch talk: in vitro model of decellularized cartilage<br />
scaffolds for articular cartilage regeneration 1st<br />
Annual Retreat of the Ludwig Boltzmann Institut<br />
für Traumatologie, das <strong>Forschung</strong>szentrum in Kooperation<br />
mit der AUVA. 22. – 24.9.<strong>2021</strong> Österreich<br />
It’s the stiffness not the density – decellularized auricular<br />
cartilage scaffold (AuriScaff) as a model for<br />
migration research Annual Meeting of the Austrian<br />
Cluster for Tissue Regeneration, 30. – 31.8.<strong>2021</strong>.<br />
Veterinary Medicine of Vienna (Vetmed). Österreich<br />
Laser-engraving auricular cartilage scaffolds<br />
enhance scaffold recellularization TERMIS SYIS<br />
Virtual Seminar Series (online) Österreich<br />
Cartilage Regeneration Group presentation from<br />
LBI Traumatology TERMIS-EU Virtual Lab Tour series<br />
Österreich<br />
Stiffness or GAGs, what counts? A story of cell infiltration<br />
Lunch seminars from the Ludwig Boltzmann<br />
Institut Traumatologie, das <strong>Forschung</strong>szentrum in<br />
Kooperation mit der AUVA Österreich<br />
Chiari C<br />
Grundkonzept „FAI und Dysplasie“. AGA Akademie<br />
Kurs, AGA Hüftkomitee, Arthroskopie des Hüftgelenks<br />
Würzburg, 5. – 6.11.<strong>2021</strong><br />
Wichtige Zugangswege zum Hüftgelenk. AGA Akademie<br />
Kurs, AGA Hüftkomitee, Arthroskopie des<br />
Hüftgelenks Würzburg, 5. – 6.11.<strong>2021</strong><br />
Grenzen der Hüftarthroskopie. Welche offenen Verfahren<br />
haben sich bewährt? AGA Akademie Kurs,<br />
AGA Hüftkomitee, Arthroskopie des Hüftgelenks<br />
Würzburg, 5. – 6.11.<strong>2021</strong><br />
Epiphysiolysis capitis femoris. ÖGO<br />
Ausbildungsseminar Kinderorthopädie<br />
18.11.<strong>2021</strong>, OSS Wien<br />
Gutartige Knochentumore. ÖGO Ausbildungsseminar<br />
Kinderorthopädie 18.11.<strong>2021</strong>, OSS Wien<br />
Wachstum. „Advanced Orthopedics and Traumatology<br />
– Aktuelle Konzepte der Orthopädie und Traumatologie<br />
(MSc)“ Modul 11 „Extremitätenkorrektur,<br />
Kinderorthopädie- und traumatologie, Osteotomien“<br />
25. – 27.11.<strong>2021</strong><br />
Beinachsenvermessung, Deformitätenanalyse,<br />
Wachstumsprognose. „Advanced Orthopedics and<br />
Traumatology – Aktuelle Konzepte der Orthopädie<br />
und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,<br />
Kinderorthopädie- und traumatologie,<br />
Osteotomien“ 25. – 27.11.<strong>2021</strong><br />
Behandlung der SCFE, spezielle Techniken und<br />
Komplikationen: Pinning, Verschraubung, SH Osteotomie,<br />
Trochanter-Flip. „Advanced Orthopedics<br />
and Traumatology – Aktuelle Konzepte der Orthopädie<br />
und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,<br />
Kinderorthopädie- und traumatologie,<br />
Osteotomien“ 25. – 27.11.<strong>2021</strong><br />
DDH: Epidemiologie, Screening, wissenschaftliche<br />
Basis. „Advanced Orthopedics and Traumatology –<br />
Aktuelle Konzepte der Orthopädie und Traumatologie<br />
(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-<br />
und traumatologie, Osteotomien“<br />
25. – 27.11.<strong>2021</strong><br />
Overview of malignant bone tumors, 39 th EPOS Annual<br />
Meeting, European Paediatric Orthopaedic<br />
Society, 14.4.<strong>2021</strong> (online)<br />
Tumor und Hüfte: Reliabilität und Unterschiede verschiedener<br />
Messmethoden der Fermoralen Torsion<br />
im Rotations-MRT. 34. Jahrestag und der Vereinigung<br />
der Kinderorthopädie e.V., 30.9. – 2.10.<strong>2021</strong>, Graz<br />
3 beste Vorträge, 3 beste Poster: Die Verwendung<br />
der BImalleolar-Methode zeigt die reliabelsten Ergebnisse<br />
zur Vermessung der Tibialen Torsion im<br />
MRT. 34. Jahrestag und der Vereinigung der Kinderorthopädie<br />
e.V., 30.09. – 2.10.<strong>2021</strong>, Graz<br />
Döring K<br />
<strong>Klinik</strong>wissen 21.1.<strong>2021</strong>: Grundlagen in der Diagnostik<br />
und Therapie des Hallux Valgus Results in<br />
the surgical treatment of aneurysmal bone cysts,<br />
EMSOS <strong>2021</strong>, 1.12.<strong>2021</strong><br />
Frenzel S<br />
Eingeladender Vortrag: Versorgungskonzepte bei<br />
periprothetischen Frakturen 72. ÖGU Fortbildung<br />
„Das Hüftgelenk – Von der Rekonstruktion bis zum<br />
Gelenksersatz“ 12.11.<strong>2021</strong> (online) Österreich<br />
Compex pelvic fractures with soft tissue injuries:<br />
What to treat first International Conference of the<br />
„Kazakhstan Association of Traumatologists and<br />
Orthopedists“ 29.9. – 1.10.<strong>2021</strong> (online) Kasachstan<br />
ORIF in Tibial Plateau Fractures- Planning and Strategy<br />
International Conference of the „Kazakhstan<br />
Association of Traumatologists and Orthopedists“<br />
29.9. – 1.10.<strong>2021</strong> (online) Kasachstan
Publikationen<br />
89<br />
Emergency room requirements- the Vienna experience<br />
International Conference of the “Kazakhstan<br />
Association of Traumatologists and Orthopedists”<br />
29.9. – 1.10.<strong>2021</strong> (online) Kasachstan<br />
Compex pelvic fractures with soft tissue injuries:<br />
What to treat first 41. SICOT Orthopaedic World<br />
Congress (Budapest, Ungarn; 15. – 18.9.<strong>2021</strong>)<br />
Ungarn<br />
Funovics Ph<br />
Eingeladender Vortrag: Tumoren am Fuß – mit welcher<br />
Inzidenz muss ich rechnen? 16.KLAUSURTA-<br />
GUNG ZUR KONSENSUSFINDUNG DER ÖSTERREI-<br />
CHISCHEN GESELLSCHAFT FÜR FUSSCHIRURGIE<br />
Fuss-Tumoren und „PROMINENZEN“. 25.6.<strong>2021</strong>.<br />
Fürsatz M<br />
TERMIS SYIS Virtual Seminar Series, 29.6.<strong>2021</strong><br />
„Induction of spheroid-self assembly via growth<br />
surface compartmentation“<br />
Annual Meeting Austrian Cluster for Tissue Regeneration,<br />
30. – 31.8.<strong>2021</strong> „SpheroWell – a platform<br />
technology for (cartilage) spheroids“<br />
6 th World Congress of the Tissue Engineering and<br />
Regenerative Medicine International Society (TER-<br />
MIS <strong>2021</strong>), Maastricht, 15. – 19.11.<strong>2021</strong> „Self-assembly<br />
of chondrogenic spheroids from cell-monolayers<br />
via growth surface subdivision“<br />
Haider T<br />
Revisionsendoprothetik oder ORIF in Periprothetischen<br />
Proximalen Femurfrakturen vom Typ Vancouver<br />
B2 & B3: Systematischer Review und Meta-Analyse.<br />
Deutscher Kongress für Orthopädie<br />
und Unfallchirurgie (DKOU <strong>2021</strong>), 26. – 29.10.<strong>2021</strong>,<br />
Berlin<br />
Halát G<br />
Eingeladender Vortrag: Das Thoraxtrauma 32. NÖ<br />
Notärztetagung der Ärztekammer Niederösterreich<br />
am 30.5.<strong>2021</strong> Österreich<br />
Refixationstechniken bei Beugesehnenverletzungen<br />
Arthrex Future Group Meeting – Distal Extremity<br />
Österreich<br />
Hobusch G<br />
Eingeladender Vortrag: Functional Results after<br />
Bone Sarcoma – Should we allow sports, virtual<br />
EMSOS Graz <strong>2021</strong> (1. – 3.12.<strong>2021</strong>)<br />
Expert Opinions about Sports Activity after Tumorendoprostheses-do<br />
they differ in different parts of<br />
the world? Virtual EMSOS Graz <strong>2021</strong>(1. – 3.12.<strong>2021</strong>)<br />
Functional Outcome and QOL after Sarcomas of the<br />
Foot and Ankle Region-is early Amputation justified?<br />
Virtual EMSOS Graz <strong>2021</strong> (1. – 3.12.<strong>2021</strong>)<br />
Training day-Interactive Cases Soft tissue Sarcoma-Vienna<br />
cases, virtual EMSOS Graz <strong>2021</strong><br />
(1. – 3.12.<strong>2021</strong>), invited talk<br />
Biopsy as the final point of staging, VEC (Virtual<br />
EFORT Congress) Vienna <strong>2021</strong> (30.6.<strong>2021</strong>), invited<br />
talk<br />
Shall we improve sarcoma outcome and function<br />
towards sporting activities? Functional Outcome in<br />
Musculoskeletal Oncology, ISOLS Orthopedic Oncology<br />
Webinar Series, 19.10.<strong>2021</strong><br />
Hruby L<br />
Iatrogenic nerve injuries in primary and revision<br />
reverse total shoulder arthroplasty Morgenfortbildung<br />
Universitätsklinik für Orthopädie und Unfallchirurgie<br />
Österreich<br />
Bionische Rekonstruktion, Wiederherstellung an<br />
der Grenze zwischen Mensch und Maschine Morgenfortbildung<br />
Universitätsklinik für Orthopädie<br />
und Unfallchirurgie Österreich<br />
Iatrogenic nerve injury in primary and revision reverse<br />
total shoulder arthroplasty 38. AGA Kongress,<br />
9 – 11.9.<strong>2021</strong>, Innsbruck Österreich<br />
Kdolsky R<br />
Complications in pilon fractures. ESTES virtual<br />
week: “Skeletal – Intraarticular fractures of the distal<br />
tibia / Pilon tibiale” – 28.4.<strong>2021</strong><br />
Lass R<br />
Senior Mentoring-Programm der MedUniWien im<br />
Studienjahr 2020/21, <strong>2021</strong>/22<br />
Wahlpflichtfach Orthopädie-Konservativ-Operativ,<br />
WS 21<br />
Medacta Surgical Days, 15. – 18.6.<strong>2021</strong>, Graz<br />
AE-Masterkurs Knie, 1. – 2.10.<strong>2021</strong> Linz<br />
11. Wiener Schmerztag, 8.10.<strong>2021</strong> Rathaus Wien<br />
DKOU <strong>2021</strong>, 26. – 29.10.<strong>2021</strong>, Berlin<br />
Negrin L<br />
Serum Levels Of SRAGE Assessed AT Hospital Admission<br />
may Provide Valuable Insights Regarding<br />
The Appropriate Treatment Regimen in Polytrau-
Publikationen<br />
90<br />
matized Patients Virtual EFFORT Congress – VEC<br />
hybrid, Online, 30.6.<strong>2021</strong> Österreich<br />
Morphologische MRT-Auswertungen liefern Größenvorgaben<br />
für die adäquate Entnahme eines<br />
Quadrizepssehnen-Knochenblocks 36. Jahreskongress<br />
der der Gesellschaft für Orthopädisch-Traumatologische<br />
Sportmedizin, Online, 1.7.<strong>2021</strong> Österreich<br />
Eingeladender Vortrag: Frakturversorgung 1. Notarztkurs<br />
der Universitätsklinik für Anästhesie, Allgemeine<br />
Intensivmedizin und Schmerztherapie<br />
in Kooperation mit der Universitätsklinik für Notfallmedizin<br />
und dem Wiener Gesundheitsverbund,<br />
Wien, 9.2.<strong>2021</strong> Österreich<br />
Eingeladender Vortrag: Wintersport „Ski alpin“ Universitätslehrgang<br />
‚Sportmedizin, MSc‘, Donauuniversität<br />
Krems, 20.6.<strong>2021</strong> Österreich<br />
Nürnberger S<br />
Eingeladender Vortrag: Cartilage for Cartilage Regeneration:<br />
Development of a new scaffold generation.<br />
Internationaler Tag der Frauen und Mädchen<br />
in der Wissenschaft 11.2.<strong>2021</strong> virtual<br />
Scaffold based biological enhancement of cartilage<br />
regeneration. EORS 15. – 17.9.<strong>2021</strong> Rome Italy<br />
Pajenda G<br />
Konservative Behandlung der thorakolumbalen<br />
Wirbelsäulenverletzungen AO Spine Kurs, Salzburg<br />
September <strong>2021</strong> Österreich<br />
Salzmann S<br />
Thoracic Bone Mineral Density measured by Quantitative<br />
Computed Tomography in Patients undergoing<br />
Spine Surgery. International Society for the<br />
Study of the Lumbar Spine (ISSLS) Virtual Annual<br />
meeting May 4. Juni <strong>2021</strong><br />
Preoperative MRI-based Vertebral Bone Quality<br />
(VBQ) Score Assessment in Patients undergoing<br />
Lumbar Spinal Fusion. North American Spine Society<br />
36th Annual Meeting 29.9. – 2.10.<strong>2021</strong> Boston, MA<br />
Thoracic Bone Mineral Density measured by Quantitative<br />
Computed Tomography in Patients undergoing<br />
Spine Surgery. Global Spine Congress Paris,<br />
France, (online) 3. – 6.11.<strong>2021</strong><br />
Preoperative MRI-based Vertebral Bone Quality<br />
(VBQ) Score Assessment in Patients undergoing<br />
Lumbar Spinal Fusion. Global Spine Congress Paris,<br />
France, (online) 3. – 6.11.<strong>2021</strong><br />
Scheider P<br />
Posttraumatischer Wachstumsfugenverschluss<br />
an der kindlichen oberen Extremität Morgenfortbildung<br />
Universitätsklinik für Orthopädie und Unfallchirurgie<br />
Österreich<br />
Schreiner MM<br />
The influence of biologicals on aseptic arthroplasty<br />
loosening, DKOU <strong>2021</strong>, Berlin<br />
Sigmund IK<br />
Eingeladener Vortrag: Giftiger Dienstag, Wien –<br />
Protheseninfektionen, 11.5.<strong>2021</strong><br />
(Ärztekammer, Wien) Webinar<br />
Eingeladener Vortrag: AE Masterkurs Knie, Linz –<br />
Infektdiagnostik bei PPI – Standardvorgehen ein<br />
Muss! 2.10.<strong>2021</strong><br />
Eingeladener Vortrag: 39 th Annual Meeting of the<br />
European Bone and Joint Infection society, Ljubljana<br />
– The use of histology in the diagnosis of bone<br />
and joint infections 7.10.<strong>2021</strong><br />
39 th Annual Meeting of the European Bone and Joint<br />
Infection society, Ljubljana: Performance of routinely<br />
available Serum Parameters in diagnosing periprosthetic<br />
joint infections<br />
DKOU Berlin 26. – 29.10.<strong>2021</strong>: Wilhelm- Roux-Preis-<br />
Session: Der optimale Grenzwert der neutrophilen<br />
Granulozyten in histologisch aufgearbeiteten Gewebeproben<br />
zur Diagnostik von periprothetischen<br />
Gelenksinfektionen<br />
Block 21: Septische Arthritis und Osteomyelitis<br />
Thalhammer G<br />
Eingeladender Vortrag: Das instabile Handgelenk<br />
Symposium Blickpunkt – Die instabile obere Extremität,<br />
16.10.<strong>2021</strong>, Graz Österreich<br />
Handgelenksarthroskopie – Grundlagen und Expertentipps<br />
57. ÖGU & 2. ÖGOuT Jahrestagung<br />
(Online) ‚Minimalinvasive Unfallchirurgie und Orthopädie‘,<br />
07. – 09.10.<strong>2021</strong> Österreich<br />
Toegel S<br />
Glycobiology: An emerging regulator of OA pathobiology.<br />
Oral presentation at the 11 th Scientific Meeting<br />
of the Ludwig Boltzmann Institute for Arthritis<br />
and Rehabilitation. 24.3.<strong>2021</strong>.<br />
Presentation of the Programme line „Chondrocyte<br />
biology“. Oral presentation at the Online Evaluation<br />
Meeting of the Ludwig Boltzmann Institute for Arthritis<br />
and Rehabilitation. 5. – 6.10.<strong>2021</strong>
Publikationen<br />
91<br />
Waldstein W<br />
VSOU <strong>2021</strong>: Die radiologische Beurteilung der<br />
Funktionalität des vorderen Kreuzbandes bei Patienten<br />
mit Varusgonarthrose.<br />
Weihs V<br />
Comparison of characteristics of polytraumatized<br />
patients with or without severe traumatic brain<br />
injury and patients with isolated traumatic brain<br />
injury 41 st SICOT Orthopaedic World Congress,<br />
15.09. – 18.9.<strong>2021</strong>, Budapest Ungarn<br />
Widhalm H<br />
Polytrauma Strategies Weill Cornell Seminar:<br />
Trauma & Emergency Surgery: Austrian American<br />
Foundation (AAF), 12. – 18.12.<strong>2021</strong>, Salzburg Österreich<br />
Traumatic Brain Injuries Weill Cornell Seminar:<br />
Trauma & Emergency Surgery: Austrian American<br />
Foundation (AAF), 12. – 18.12.<strong>2021</strong>, Salzburg Österreich<br />
Windhager R<br />
Eingeladener Vortrag: BMP signalling in Bone and<br />
Cartilage Biology, 13.1.<strong>2021</strong>, BMP Virtual Forum<br />
Eingeladender Vortrag: Therapie von Knochentumoren,<br />
Online Ausbildungskurs „Tumororthopädie“<br />
ÖGO, 12.3.<strong>2021</strong><br />
Eingeladener Vortrag: Spondylitis, Tumor und<br />
Rheuma der Wirbelsäule, Lehrgang „Advanced Orthopedics<br />
and Traumatology“, 19.3.<strong>2021</strong>, Zentrum<br />
für Gesundheitswissenschaften und Medizin der<br />
Donau-Universität Krems<br />
Eingeladener Vortrag: Recombinant human BMP6<br />
applied within Autologous Blood Coagulum accelerates<br />
bone healing: Randomized controlled trials“,<br />
14.4.<strong>2021</strong>, Salzburg<br />
Eingeladener Vortrag: Reconstruction after tumor<br />
resection in the extremities, OMI Hospital for Special<br />
Surgery Seminar in Bone and Joint Surgery,<br />
15.4.<strong>2021</strong>, Salzburg<br />
Eingeladener Vortrag: Management of bone metastases,<br />
OMI Hospital for Special Surgery Seminar in<br />
Bone and Joint Surgery, 15.4.<strong>2021</strong>, Salzburg<br />
„Survival of megaprostheses in oncology and revision“,<br />
ISOLS Webinar, 20.4.<strong>2021</strong>, Houston, Texas<br />
Keynote: Orthopädie 2030: Fokus Endoprothetik, 6.<br />
Praevenire Gesundheitstage, 17. – 21.5.<strong>2021</strong>, Stift<br />
Seitenstetten<br />
Eingeladener Vortrag: „Kragen bei zementfreiem<br />
Hüftschaft – hilfreich oder hinderlich?“ 26.5.<strong>2021</strong>,<br />
Österreichischer Kongress für Orthopädie und<br />
Traumatologie, Graz<br />
Honorary Lecture: „Erwin Morscher Award”, EFORT<br />
Annual Congress, 30.6. – 2.7.<strong>2021</strong>, Wien, Austria<br />
Moderation: Blöcke Knie und Hüfte, Medacta Surgical<br />
Days, 17.6.<strong>2021</strong>, Graz<br />
„Der Kurzschaft in der Revisionsendoprothetik –<br />
Was ist möglich?“, 1. Wiener Kurzschaftsymposium,<br />
11.9.<strong>2021</strong>, Wien<br />
Moderation: Functional Outcome in Musculoskeletal<br />
Oncology, ISOLS Orthopedic Oncology Webinar<br />
Series, 19.10.<strong>2021</strong><br />
Eingeladener Vortrag: „Hüftgelenknahe Tumoren:<br />
Differentialdiagnostik und Therapie“, DKOU <strong>2021</strong>,<br />
Berlin, 28.10.<strong>2021</strong><br />
Eingeladener Vortrag: „Battle: Silver coating: Risk or<br />
reason?“ 1.12.<strong>2021</strong>, 33 rd Annual Meeting of EMSOS<br />
to take place on 1. – 3.12.<strong>2021</strong>, Graz Austria.<br />
Moderation: „New guidelines and studies in sarcoma“,<br />
2.12.<strong>2021</strong>, 33 rd Annual Meeting of EMSOS to<br />
take place on 1. – 3.12.<strong>2021</strong>, Graz Austria.<br />
Willegger M<br />
Rotations-MRT, Accessorische Knochen am Fußskelett<br />
und deren Relevanz. 16. Klausurtagung<br />
zur Konsensfindung der Österreichischen Gesellschaft<br />
für Fußchirurgie 25.6.<strong>2021</strong>, Mondsee<br />
Österreich<br />
Poster<br />
Casado-Losada I<br />
An in vitro model to unravel the mysteries of the<br />
chondrogenic niche.<br />
Osteoarthritis Research Society International<br />
(OARSI) Virtual World Congress on Osteoarthritis<br />
Connect 21, 29.4. – 1.5.<strong>2021</strong>.<br />
Laser-engraving auricular cartilage scaffolds enhance<br />
scaffold recellularization.<br />
Young Scientist Association (YSA) MUW Symposium,<br />
Wien, 17. – 18.6.<strong>2021</strong>.<br />
Laser-engraved auricular cartilage scaffolds: the<br />
next step on recellularization.<br />
6 th World Congress of the Tissue Engineering and
Publikationen<br />
92<br />
Regenerative Medicine International Society (TER-<br />
MIS <strong>2021</strong>), Maastricht, 15. – 19.11.<strong>2021</strong>.<br />
Chiari C<br />
Die Verwendung der Bimalleolar-Methode zeigt die<br />
reliabelsten Ergebnisse zur Vermessung der Tibialen<br />
Torsion im MRT. 34. Jahrestag und der Vereinigung<br />
der Kinderorthopädie e.V., 30.9. – 2.10.<strong>2021</strong>, Graz<br />
Use of the bimalleolar method for tibial torsion<br />
measurement shows the most reliable results in<br />
MRI of paediatric patients, 39 th EPOS Annual Meeting,<br />
European Paediatric Orthopaedic Society,<br />
14.4.<strong>2021</strong> (online)<br />
Hofer C<br />
Using means of transport and walking aids after<br />
treatment for primary malignant bone tumors in the<br />
lower extremity – A minimum follow-up of 20 years.<br />
EMSOS <strong>2021</strong>, 1. – 3.12.<strong>2021</strong>, Graz, Austria<br />
Funovics P<br />
Do extended reconstructions compensate prognostically<br />
unfavourable soft tissue sarcoma? Deutscher<br />
Kongress für Orthopädie und Unfallchirurgie<br />
(DKOU <strong>2021</strong>), 26.. – 29.10.<strong>2021</strong>, Berlin<br />
Kolb A<br />
Entwicklung eines elektronischen Navigationssystems<br />
zur Eliminierung untersucherabhängiger Faktoren<br />
in der Säuglings-Hüftsonographie nach Graf:<br />
Preliminary Results. 34. Jahrestag und der Vereinigung<br />
der Kinderorthopädie e.V., 30.9. – 2.10.<strong>2021</strong>,<br />
Graz<br />
Morgenbesser R<br />
Verbessert lokales Östrogen Prolaps-assoziierte<br />
Beschwerden bei postmenopausalen Patientinnen<br />
mit symptomatischem Beckenorganprolaps?<br />
Jahrestagung der Österreichischen Arbeitsgemeinschaft<br />
für Urogynäkologie und rekonstruktive<br />
Beckenbodenchirurgie (AUB) 1. – 2.10.<strong>2021</strong><br />
Innsbruck<br />
Salzmann S<br />
A Comprehensive MRI Analysis of Paraspinal and<br />
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration<br />
in Patients undergoing Lumbar Spinal Fusion.<br />
ORS (Orthopaedic Research Society) <strong>2021</strong> Annual<br />
Meeting, 12. – 15.2.<strong>2021</strong><br />
Preoperative MRI-based Vertebral Bone Quality<br />
(VBQ) Score Assessment in Patients undergoing<br />
Lumbar Spinal Fusion. ORS (Orthopaedic Research<br />
Society) <strong>2021</strong> Annual Meeting, 12. – 15.2.<strong>2021</strong><br />
Thoracic Bone Mineral Density measured by Quantitative<br />
Computed Tomography in Patients undergoing<br />
Spine Surgery. ORS (Orthopaedic Research<br />
Society) <strong>2021</strong> Annual Meeting, 12. – 15.2.<strong>2021</strong><br />
A Comprehensive MRI Analysis of Paraspinal and<br />
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration<br />
in Patients undergoing Lumbar Spinal<br />
Fusion. International Society for the Study of the<br />
Lumbar Spine (ISSLS) Virtual Annual meeting<br />
31.5. – 4.6.<strong>2021</strong><br />
Preoperative MRI-based Vertebral Bone Quality<br />
(VBQ) Score Assessment in Patients undergoing<br />
Lumbar Spinal Fusion. International Society for the<br />
Study of the Lumbar Spine (ISSLS) Virtual Annual<br />
meeting 31.5. – 4.6.<strong>2021</strong><br />
A Comprehensive MRI Analysis of Paraspinal and<br />
Psoas Muscle Size, Lean Muscle, and Fatty Infiltration<br />
in Patients undergoing Lumbar Fusion. Global<br />
Spine Congress Paris, France, 3. – 6.11.<strong>2021</strong><br />
Scheider P<br />
Temporary epiphysiodesis in adolescent patients<br />
with ulnocarpal impaction syndrome 22 nd EFORT<br />
Congress <strong>2021</strong> in Wien Österreich<br />
Temporary epiphysiodesis in adolescent patients<br />
with ulnocarpal impaction syndrome 34. Jahrestagung<br />
der Vereinigung für Kinderorthopädie, Graz<br />
Staats K<br />
Langzeituntersuchungen des Zweymüller-Alloclassic<br />
Geradschaftes mit einem Minimum-follow-up<br />
von 30 Jahren, Deutscher Kongress für<br />
Orthopädie und Unfallchirurgie (DKOU <strong>2021</strong>),<br />
26. –29.10.<strong>2021</strong>, Berlin<br />
Weihs V<br />
Psychocardiological Assessment in the Acute Phase<br />
of the Takotsubo Syndrome. Somatic and Depressive<br />
Disorders, Resilience and Illness Perception Jahrestagung<br />
<strong>2021</strong> Österreichische Kardiologische<br />
Gesellschaft 27. –28.5.<strong>2021</strong>, Österreich<br />
Treatment of Polytraumatized Patients in a Level 1<br />
Trauma center between 1995 and 2019. 25-Year Experience<br />
– what has changed? 34 th ESICM LIVES Digital<br />
Annual Congress <strong>2021</strong>, 3. –6.10.<strong>2021</strong> Österreich
Publikationen<br />
93<br />
Willegger M<br />
Die Verwendung der Bimalleolar-Methode zeigt<br />
die reliabelsten Ergebnisse zur Vermessung der<br />
Tibialen Torsion im MRT. Jahrestagung Vereinigung<br />
für Kinderorthopädie (VKO), Graz, Austria,<br />
Oktober <strong>2021</strong><br />
Accessibility of the metatarsal head comparing<br />
distraction and plantarflexion in a 2-portal<br />
technique for first metatarsophalangeal (MTP 1)<br />
joint arthroscopy.<br />
Annual Meeting American Association for Anatomy,<br />
April <strong>2021</strong><br />
Gastärzte/Beobachter<br />
Zaur Mugutdinov, Russland, 6.9. – 29.10.<strong>2021</strong>
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