2006 - Institut für Klinische Chemie - UniversitätsSpital Zürich

Universität Zürich > Medizinische Fakultät > Klinische Chemie, Institut für > Prof. Dr.
Arnold von Eckardstein
Biomarkers of Cardiovascular Disease and Risk
Summary / Zusammenfassung
Because of its broad method spectrum the Institute of Clinical Chemistry is an attractive partner
for collaborations in clinical studies. In most cases this partnership is searched by clinical
investigators. However, the institute of clinical chemistry is also driving clinical research projects
to apply the fore mentioned knowledge and expertise. A special effort is given to clinical and
epidemiological studies for the analysis of biomarkers which help to identify individuals at
increased cardiovascular risk. To reach this goal we have established collaborations with clinicians
of the university hospital (e.g clinics for cardiology or angiology), with epidemiological cohorts
which are under prospective observation in Switzerland (SAPALDIA) and other countries (e.g.
CORA cohort in Augsburg or MMKD study in Innsbruck). Frequently these studies are following
a candidate approach, ie we analyse markers which have been pre-defined because of
pathophysiological considerations or preliminary data of other studies. Supported by a grant from
an industrial partner we will continue and extend this effort to lipidomic and proteomic approaches
towards the identification of novel markers for atherosclerotic plaque instability.
Publications / Publikationen
Maier W, Altwegg, LA, Corti R, Gay S, Hersberger M, Maly FE, Sütsch G, Roffi M, Neidhart M,
Eberli FR, Tanner FC, von Eckardstein A, Lüscher TF (2005). Inflammatory Markers at the Site of
Ruptured Plaque in Acute Coronary Syndrome: Locally Increased Interleukin-6 and Serum
Amyloid A, but Decreased C-Reactive Protein. Circulation 111:1355-61
Altwegg LA, Neidhart M, Hersberger M, Müller S, Eberli FR, Corti R, Roffi M, Sütsch G, Gay S,
von Eckardstein A, Lüscher TF, Maier W. (2007). Myeloid-Related Protein 8/14 Complex: A
Novel Early and Sensitive Marker of Acute Coronary Syndromes. Eur. Heart J. in press
Nitsch D, Felber Dietrich D, von Eckardstein A, Gaspoz J-M, Downs S-H, Leuenberger P,
Tschopp J-M, Brändli O, Keller R, Gerbase MW, Probst-Hensch NM , Zemp Stutz E, Ackermann-
Liebrich U and the SAPALDIA team (2006). Prevalence of renal impairment and its association
with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study.
Nephrology, Dialysis and Transplantation, 21(4):935-44.
Felber Dietrich D, Schwartz J, Schindler C, Gaspoz JM, Barthélémy JC, Tschopp JM, Roche F,
von Eckardstein A, Brändli O, Leuenberger P, Gold DR, Ackermann-Liebrich U and the
SAPALDIA-team (2007). Effects of passive smoking on heart rate variability, heart rate and blood
pressure: an observational study. Int J Epidemiol, in press
Spanaus KS, Kronenberg F, Ritz E, Schlapbach R, Fliser D, Hersberger M, Kollerits B, König P,
von Eckardstein A for the MMKD Study Group (2007). B-type Natriuretic Peptides Predict the
Progression of Non-Diabetic Chronic Kidney Disease: The Mild to Moderate Kidney Disease
(MMKD) Study. Clinical Chemistry in press
Keywords / Suchbegriffe
coronary heart disease, instable plaque, heart failure, cardiovascular risk factors, brain natriuretic
peptides, inflammation, lipidomics, proteomics
Project 7486
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