Rahmenprogramm des HNE-Club Meetings 2017

Memorial and Scientific Program
Wednesday, September 13th
18:00
Registration & Get together
Schubertstrasse 1, 8010, Graz
Thursday, September 14th
9:00 Hermann Esterbauer Memorial Session
Venue: Schubertstrasse 1, 8010, Graz
Chair: Neven Zarkovic (Zagreb), Valery Bochkov (Graz)
Valery Bochkov
(Graz)
Christa Neuper
(Rector,
University of Graz)
Sepp Kohlwein
(Graz)
Giuseppe Poli
(Turin)
Koji Uchida (Tokyo)
Introduction
Welcome
Hermann Esterbauer and the University of Graz
Hermann Esterbauer – a pioneer of lipid peroxidation
research
Hermann Esterbauer Decennial Lecture:
What we know about 4-hydroxynonenal?
10:30 Coffee Break
11:00-13:45
Scientific session 1: Intracellular signaling
mechanisms activated by lipid peroxidation
products
Henry Jay
Forman
(Los Angeles)
Nikolaus Bresgen
(Salzburg)
Chair: Peter Eckl (Salzburg), Randy Jirtle (Raleigh)
4-Hydroxynonenal-mediated cell signaling
Oxidative stress and cell death: The role of iron
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Huveyda Basaga
(Istanbul)
Short break
Randy Jirtle
(Raleigh)
Fulvio Ursini
(Padova)
Shlomo Sasson
(Jerusalem)
Cross-talk between Bcl-2 and IKK in 4-hydroxynonenalinduced
apoptosis
Radiation-induced oxidative stress alters disease
susceptibility by modifying the epigenome
GPx4 is the controller of a specific form of programmed
cell death executed by lipid peroxidation products
4-Hydroxyalkenal-activated PPAR-delta complexes
mediate glucohormetic and lipohormetic interactions in
diabetes
13:45-15:00 Lunch
15:00-16:15
Corinne Spickett
(Birmingham)
Maria Fedorova
(Leipzig)
Willibard
Wonisch (Graz)
Scientific session 2: Analytical approaches for
structural and functional analysis of lipid
peroxidation products
Chair: Giuseppe Poli (Turin), Giulia Coliva (Leipzig)
Analysis of phospholipid peroxidation and protein
lipoxidation products by LC-MS
Analytical strategies to uncover the diversity of lipid
peroxidation products and their biological effects
High-throughput screening of oxidative stress
biomarkers: Significance, precision and costeffectiveness
16:15-16:45 Coffee break
16:45-17:45 Poster session
19:30 Reception by the Lord Mayor of the City of Graz and Conference Dinner
Hotel WIESLER, Salon Frühling, Grieskai 4-8, 8010 Graz
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Friday, September 15th
9:00-10:40
Anne Negre-
Salvayre
(Toulouse)
Gabriella Marisa
Leonarduzzi
(Turin)
Norbert Leitinger
(Charlottesville)
Giovanni E.
Mann
(London)
Scientific session 3: Lipid oxidation products in
disease pathogenesis (1)
Chair: Giovanni Mann (London), Anne Negre-Salvayre
(Toulouse)
Pro-atherogenic effects of 4-Hydroxynonenal
Oxidized lipids in age-related diseases
Oxidized phospholipids and phenotypic polarization of
macrophages
Enhanced sensitivity to 4-hydroxynoneal and impaired
redox signaling in human endothelial cells in
gestational diabetes
10:40-11:10 Coffee break
11:10-12:50
Françoise
Guéraud
(Toulouse)
Ana Čipak
Gašparović
(Zagreb)
Huiyong Yin
(Shanghai)
Tilman Grune
(Nuthetal)
Scientific session 4: Lipid oxidation products in
disease pathogenesis (2)
Chair: Etsuo Niki (Tokyo), Françoise Guéraud
(Toulouse)
Dietary 4-hydroxynonenal and other lipid oxidation
products in the development of colorectal
carcinogenesis
Role of 4-hydroxynonenal in communication between
cancer stem cells and microenvironment
The role of lipid peroxidation during the progression of
human hepatocellular carcinoma
Redox regulation in aging: Role of protein aggregates
12:50-14:20 Lunch
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14:20-16:50
Etsuo Niki
(Kyoto)
Elżbieta
Skrzydlewska
(Białystok)
Giancarlo
Aldini
(Milan)
Short break
Luigi Iuliano
(Rome)
Werner Siems
(Bad Harzburg)
Giuseppe Poli
(FRBM Associate
Editor)
Scientific session 5: Oxidative stress,
antioxidants and pharmacological interventions
Chair: Tilman Grune (Nuthetal), Franz Tatzber (Graz)
Oxidative stress and antioxidants: Distress or eustress?
Antioxidants and 4-hydroxynonenal in regulation of
redox homeostasis
Novel molecular approaches for improving enzymatic
and nonenzymatic detoxification of 4-hydroxynonenal:
Toward the discovery of a novel class of bioactive
compounds
Translational implications of cholesterol autoxidation
Lipid peroxidation and pharmaceutical drugs
Presentation of a special issue of Free Radical Biology
and Medicine entitled „4-Hydroxynonenal and Related
Lipid Peroxidation Products“
16:50-17:15 Coffee break
17:15-18:15
Etsuo Niki
(Kyoto)
Randy Jirtle
(Raleigh)
Neven Zarkovic
(Zagreb)
Public panel discussion:
The Janus face of oxidative stress
Moderation: Sonja Saurugger (Kleine Zeitung), Antony
Newman (Elsevier)
Oxidative stress: what does it mean?
Oxidative stress induced by ionizing radiation
Pro- and anti-proliferative effects of lipid peroxidation
products on cancer cells
18:15 Closing remarks: Neven Zarkovic (Zagreb)
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