Rahmenprogramm des HNE-Club Meetings 2017
Rahmenprogramm des HNE-Club Meetings 2017
Rahmenprogramm des HNE-Club Meetings 2017
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Memorial and Scientific Program<br />
Wednesday, September 13th<br />
18:00<br />
Registration & Get together<br />
Schubertstrasse 1, 8010, Graz<br />
Thursday, September 14th<br />
9:00 Hermann Esterbauer Memorial Session<br />
Venue: Schubertstrasse 1, 8010, Graz<br />
Chair: Neven Zarkovic (Zagreb), Valery Bochkov (Graz)<br />
Valery Bochkov<br />
(Graz)<br />
Christa Neuper<br />
(Rector,<br />
University of Graz)<br />
Sepp Kohlwein<br />
(Graz)<br />
Giuseppe Poli<br />
(Turin)<br />
Koji Uchida (Tokyo)<br />
Introduction<br />
Welcome<br />
Hermann Esterbauer and the University of Graz<br />
Hermann Esterbauer – a pioneer of lipid peroxidation<br />
research<br />
Hermann Esterbauer Decennial Lecture:<br />
What we know about 4-hydroxynonenal?<br />
10:30 Coffee Break<br />
11:00-13:45<br />
Scientific session 1: Intracellular signaling<br />
mechanisms activated by lipid peroxidation<br />
products<br />
Henry Jay<br />
Forman<br />
(Los Angeles)<br />
Nikolaus Bresgen<br />
(Salzburg)<br />
Chair: Peter Eckl (Salzburg), Randy Jirtle (Raleigh)<br />
4-Hydroxynonenal-mediated cell signaling<br />
Oxidative stress and cell death: The role of iron<br />
1
Huveyda Basaga<br />
(Istanbul)<br />
Short break<br />
Randy Jirtle<br />
(Raleigh)<br />
Fulvio Ursini<br />
(Padova)<br />
Shlomo Sasson<br />
(Jerusalem)<br />
Cross-talk between Bcl-2 and IKK in 4-hydroxynonenalinduced<br />
apoptosis<br />
Radiation-induced oxidative stress alters disease<br />
susceptibility by modifying the epigenome<br />
GPx4 is the controller of a specific form of programmed<br />
cell death executed by lipid peroxidation products<br />
4-Hydroxyalkenal-activated PPAR-delta complexes<br />
mediate glucohormetic and lipohormetic interactions in<br />
diabetes<br />
13:45-15:00 Lunch<br />
15:00-16:15<br />
Corinne Spickett<br />
(Birmingham)<br />
Maria Fedorova<br />
(Leipzig)<br />
Willibard<br />
Wonisch (Graz)<br />
Scientific session 2: Analytical approaches for<br />
structural and functional analysis of lipid<br />
peroxidation products<br />
Chair: Giuseppe Poli (Turin), Giulia Coliva (Leipzig)<br />
Analysis of phospholipid peroxidation and protein<br />
lipoxidation products by LC-MS<br />
Analytical strategies to uncover the diversity of lipid<br />
peroxidation products and their biological effects<br />
High-throughput screening of oxidative stress<br />
biomarkers: Significance, precision and costeffectiveness<br />
16:15-16:45 Coffee break<br />
16:45-17:45 Poster session<br />
19:30 Reception by the Lord Mayor of the City of Graz and Conference Dinner<br />
Hotel WIESLER, Salon Frühling, Grieskai 4-8, 8010 Graz<br />
2
Friday, September 15th<br />
9:00-10:40<br />
Anne Negre-<br />
Salvayre<br />
(Toulouse)<br />
Gabriella Marisa<br />
Leonarduzzi<br />
(Turin)<br />
Norbert Leitinger<br />
(Charlottesville)<br />
Giovanni E.<br />
Mann<br />
(London)<br />
Scientific session 3: Lipid oxidation products in<br />
disease pathogenesis (1)<br />
Chair: Giovanni Mann (London), Anne Negre-Salvayre<br />
(Toulouse)<br />
Pro-atherogenic effects of 4-Hydroxynonenal<br />
Oxidized lipids in age-related diseases<br />
Oxidized phospholipids and phenotypic polarization of<br />
macrophages<br />
Enhanced sensitivity to 4-hydroxynoneal and impaired<br />
redox signaling in human endothelial cells in<br />
gestational diabetes<br />
10:40-11:10 Coffee break<br />
11:10-12:50<br />
Françoise<br />
Guéraud<br />
(Toulouse)<br />
Ana Čipak<br />
Gašparović<br />
(Zagreb)<br />
Huiyong Yin<br />
(Shanghai)<br />
Tilman Grune<br />
(Nuthetal)<br />
Scientific session 4: Lipid oxidation products in<br />
disease pathogenesis (2)<br />
Chair: Etsuo Niki (Tokyo), Françoise Guéraud<br />
(Toulouse)<br />
Dietary 4-hydroxynonenal and other lipid oxidation<br />
products in the development of colorectal<br />
carcinogenesis<br />
Role of 4-hydroxynonenal in communication between<br />
cancer stem cells and microenvironment<br />
The role of lipid peroxidation during the progression of<br />
human hepatocellular carcinoma<br />
Redox regulation in aging: Role of protein aggregates<br />
12:50-14:20 Lunch<br />
3
14:20-16:50<br />
Etsuo Niki<br />
(Kyoto)<br />
Elżbieta<br />
Skrzydlewska<br />
(Białystok)<br />
Giancarlo<br />
Aldini<br />
(Milan)<br />
Short break<br />
Luigi Iuliano<br />
(Rome)<br />
Werner Siems<br />
(Bad Harzburg)<br />
Giuseppe Poli<br />
(FRBM Associate<br />
Editor)<br />
Scientific session 5: Oxidative stress,<br />
antioxidants and pharmacological interventions<br />
Chair: Tilman Grune (Nuthetal), Franz Tatzber (Graz)<br />
Oxidative stress and antioxidants: Distress or eustress?<br />
Antioxidants and 4-hydroxynonenal in regulation of<br />
redox homeostasis<br />
Novel molecular approaches for improving enzymatic<br />
and nonenzymatic detoxification of 4-hydroxynonenal:<br />
Toward the discovery of a novel class of bioactive<br />
compounds<br />
Translational implications of cholesterol autoxidation<br />
Lipid peroxidation and pharmaceutical drugs<br />
Presentation of a special issue of Free Radical Biology<br />
and Medicine entitled „4-Hydroxynonenal and Related<br />
Lipid Peroxidation Products“<br />
16:50-17:15 Coffee break<br />
17:15-18:15<br />
Etsuo Niki<br />
(Kyoto)<br />
Randy Jirtle<br />
(Raleigh)<br />
Neven Zarkovic<br />
(Zagreb)<br />
Public panel discussion:<br />
The Janus face of oxidative stress<br />
Moderation: Sonja Saurugger (Kleine Zeitung), Antony<br />
Newman (Elsevier)<br />
Oxidative stress: what does it mean?<br />
Oxidative stress induced by ionizing radiation<br />
Pro- and anti-proliferative effects of lipid peroxidation<br />
products on cancer cells<br />
18:15 Closing remarks: Neven Zarkovic (Zagreb)<br />
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