PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
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Poster Psoriasis<br />
dendritic cells, myeloid dendritic cells, neutrophils and macrophages/histiocytes in the<br />
inflammatory infiltrate was seen. However, the number of CD8+ T-cells as well as<br />
Langerin+ Langerhans cells was not affected by MK-3222 treatment. Importantly,<br />
psoriatic skin contained a significant amount of p19+ target cells in the epidermal and<br />
dermal compartment, which were completely abolished after treatment with MK-322<strong>2.</strong><br />
Conclusion: Our data shows that administration of MK-3222 in psoriatic patients<br />
induces a marked reduction of cutaneous inflammation. The clinical and<br />
immunohistological improvement observed strongly suggests that targeting of IL-23<br />
by anti-p19 treatment controls downstream inflammatory pathways important for<br />
disease development.<br />
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