PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV

Poster Psoriasis
dendritic cells, myeloid dendritic cells, neutrophils and macrophages/histiocytes in the
inflammatory infiltrate was seen. However, the number of CD8+ T-cells as well as
Langerin+ Langerhans cells was not affected by MK-3222 treatment. Importantly,
psoriatic skin contained a significant amount of p19+ target cells in the epidermal and
dermal compartment, which were completely abolished after treatment with MK-3222.
Conclusion: Our data shows that administration of MK-3222 in psoriatic patients
induces a marked reduction of cutaneous inflammation. The clinical and
immunohistological improvement observed strongly suggests that targeting of IL-23
by anti-p19 treatment controls downstream inflammatory pathways important for
disease development.
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