PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV

Poster Gemischtes
P 21
Actinic damage on the back is a better marker for previous sun exposure and is
associated with MC1R variants
Judith Wendt 1
Sabine Rauscher 1
Ingrid Fae 2
Gottfried Fischer 2
Hubert Pehamberger 1
Ichiro Okamoto 1
1 Department of Dermatology, Division of General Dermatology, Medical University of
Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
2 Department of Transfusion Medicine, Division of Blood Group Serology, Medical
University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
Only recently, we have identified site dependent signs of actinic damage as
independent risk factors of melanoma. We now aimed to elucidate causal factors of
actinic damage on different sites of the body in a central European population. 2122
participants recruited as part of the M3 Study were included in the analyses. Our study
revealed differences between risk factors of actinic damage on the face and on the
trunk. The only risk factor that remains consistently significant for all three facial skin
alterations was age, whereas alterations on the back were additionally associated with
male sex, sunburns, holidays and the presence of MC1R variants. Particularly the
associations of MC1R variants with dorsal freckling and wrinkling on the neck were
pronounced (R/R: OR 3.70, p=0.011; R/r: OR 3.13, p=0.001; R/0: OR 2.19, p=0.004; r/r: OR
2.09, p=0.045; vs. 0/0 for freckling and R/R: OR 4.80, p=0.001; R/r: OR 4.00, p