PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV

Poster Tumore der Haut
P 42
Pre-therapeutic laboratory findings, extent of metastasis and choice of treatment
as prognostic markers in ocular melanoma - a single center experience
Nikolaus Schicher 1
Gundula Edelhauser 2
Kaan Harmankaya 1
Katja Schindler 1
Andreas Gleiss 3
Hubert Pehamberger 1
Christoph Höller 1
1 Medizinische Universität Wien, Allgemeine Dermatologie
2 Medizinische Universität Wien, Kardiovaskuläre und Interventionelle Radiologie
3 Medizinische Universität Wien, Zentrum für Medizinische Statistik und Informatik,
Währinger Gürtel 18-20, 1090 Wien
Background: Uveal melanoma is the most common intraocular neoplasm with a high
tendency to metastasize predominantly to the liver. Prognostic parameters for
progression and overall survival are not well defined. The aim of this study was to assess
the value of pre-therapeutic serum levels of CRP, LDH, albumin and fibrinogen in
patients with uveal melanoma and to evaluate their significance as prognostic parameters
for survival.
Methods: 49 patients with metastatic uveal melanoma treated between 2000 and 2010
were retrospectively analyzed. The potential influence of levels of CRP, LDH, fibrinogen
and albumin as well as other commonly known prognostic variables on progressionfree
and overall survival were investigated.
Results: Patients age and treatment with systemic chemotherapy were the only
variables to show significant influences on progression-free and overall survival in a
univariate analysis. Multivariate analysis confirmed the influence of these variables on
progression-free survival, presence of metastasis, pre-therapeutic CRP levels and
treatment with systemic chemotherapy were associated with overall survival.
Conclusion: In this patient cohort elevated pre-therapeutic CRP and extent of
metastasis are independent prognostic factors for decreased overall survival, whereas
treatment with systemic chemotherapy showed a significant association with improved
overall survival.
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