PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
PROGRAMM JAHRESTAGUNG 2012 30. Nov. – 2. Dez ... - ÖGDV
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Poster Tumore der Haut<br />
P 42<br />
Pre-therapeutic laboratory findings, extent of metastasis and choice of treatment<br />
as prognostic markers in ocular melanoma - a single center experience<br />
Nikolaus Schicher 1<br />
Gundula Edelhauser 2<br />
Kaan Harmankaya 1<br />
Katja Schindler 1<br />
Andreas Gleiss 3<br />
Hubert Pehamberger 1<br />
Christoph Höller 1<br />
1 Medizinische Universität Wien, Allgemeine Dermatologie<br />
2 Medizinische Universität Wien, Kardiovaskuläre und Interventionelle Radiologie<br />
3 Medizinische Universität Wien, Zentrum für Medizinische Statistik und Informatik,<br />
Währinger Gürtel 18-20, 1090 Wien<br />
Background: Uveal melanoma is the most common intraocular neoplasm with a high<br />
tendency to metastasize predominantly to the liver. Prognostic parameters for<br />
progression and overall survival are not well defined. The aim of this study was to assess<br />
the value of pre-therapeutic serum levels of CRP, LDH, albumin and fibrinogen in<br />
patients with uveal melanoma and to evaluate their significance as prognostic parameters<br />
for survival.<br />
Methods: 49 patients with metastatic uveal melanoma treated between 2000 and 2010<br />
were retrospectively analyzed. The potential influence of levels of CRP, LDH, fibrinogen<br />
and albumin as well as other commonly known prognostic variables on progressionfree<br />
and overall survival were investigated.<br />
Results: Patients age and treatment with systemic chemotherapy were the only<br />
variables to show significant influences on progression-free and overall survival in a<br />
univariate analysis. Multivariate analysis confirmed the influence of these variables on<br />
progression-free survival, presence of metastasis, pre-therapeutic CRP levels and<br />
treatment with systemic chemotherapy were associated with overall survival.<br />
Conclusion: In this patient cohort elevated pre-therapeutic CRP and extent of<br />
metastasis are independent prognostic factors for decreased overall survival, whereas<br />
treatment with systemic chemotherapy showed a significant association with improved<br />
overall survival.<br />
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