Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...
Teilen Einbetten Melden
ePaper herunterladen

Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...

Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ... Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...

bads.de
10.12.2012 Aufrufe

276 Verner/Schneider/Gebel/Panning/Wiese/Tröger/Breitmeier, Blood ethanol concentrations and inebriation symptoms following percutaneous ethanol injection therapy (PEIT) carried out on patients suffering from hepatocellular carcinoma Table 2 summarises the data of maximal measured and calculated blood ethanol concentration (c max), gender (male/female), height (h), weight (w), ethanol in millilitre (ml), gram (g) and gram per kilogram body weight (g/kg bw), correction factor (r), individual correction factor (r ind), reduced body weight, and sexual reduced body weight. The average amount of ethanol injected was 56.1ml ± 16.5ml ranging from 20.0ml to 92.0 ml corresponding to 15.2 g and 69.7 g (mean 43.1 g ± 12.5 g) ethanol, respectively. The amount of injected ethanol in g per kg body weight ranged between 0.24 g kg –1 and 1.42 g kg –1 (mean 0.61 g kg –1 ± 0.26 g kg –1). The median serum ethanol level for all 14 patients was 1.03 g/kg ± 0.41 g/kg (ranged between 0.26 g/kg and 1.62 g/kg). The maximum of the blood ethanol concentration after the beginning of the percutaneous ethanol injection into the tumour was reached between 5 to 25 minutes (ranged between 13 minutes ± 4.9 minutes). The elemination phase was reached and could be evaluated for each patient. In all cases the peak level of alcohol in the blood was reached. Nevertheless it is possible that in the elimination phase an ethanol release out of the tumour into the hepatic veins can overlap this phase. BLUTALKOHOL VOL. 42/2005 Age 63.9 ± 9.9 years (ranged from 47 to 81 years) Body height 171 ± 9.9 cm (ranged from 157 to 197 cm) Body weight 71.9 ± 12.5 kg (ranged from 49 to 86 kg) Child class A/B/C 11/3/0 Okuda class I/II/III 3/10/1 Tab. 1: Mean anthropometric and clinical characteristics of the 14 patients. No. m/f h w Ethanol Ethanol Ethanol r r ind rbw srbw mc max cc m,r cc m,rind [cm] [kg] [ml] [g] [g/kg bw] [kg] [kg] [g/kg] [g/kg] [g/kg] 1 m 174 86 56.0 42.5 0.49 0.70 0.71 60.2 61.1 0.68 0.70 0.70 2 m 170 63 48.5 36.8 0.58 0.70 0.80 44.1 50.4 1.34 0.73 0.83 3 m 173 63 48.0 36.4 0.58 0.70 0.81 44.1 51.0 1.13 0.71 0.82 4 m 165 86 55.0 41.7 0.49 0.70 0.67 60.2 57.6 0.90 0.72 0.69 5 m 183 85 65.0 49.3 0.58 0.70 0.75 59.5 63.8 1.54 0.77 0.82 6 m 170 68 66.0 50.0 0.74 0.70 0.78 47.6 53.0 1.34 0.94 1.05 7 m 197 82 51.0 38.7 0.47 0.70 0.83 57.4 68.1 0.65 0.57 0.67 8 m 172 82 48.0 36.4 0.44 0.70 0.72 57.4 59.0 0.54 0.62 0.63 9 m 170 70 60.0 45.5 0.65 0.70 0.77 49.0 53.9 1.30 0.84 0.92 10 m 170 71 68.0 51.5 0.73 0.70 0.76 49.7 54.0 1.62 0.95 1.03 11 f 163 63 20.0 15.2 0.24 0.60 0.63 37.8 39.7 0.72 0.38 0.40 12 f 157 54 39.5 29.9 0.55 0.60 0.67 32.4 36.2 0.26 0.83 0.92 13 f 175 84 68.0 51.5 0.61 0.60 0.55 50.4 46.2 1.13 1.11 1.02 14 f 160 49 92.0 69.7 1.42 0.60 0.71 29.4 34.8 1.32 2.00 2.37 Tab. 2: Anthropometric data, injected amount of ethanol in millilitre (ml), gram (g), and gram pro kilogram (g/kg) body weight, correction factor (r), individual correction factor (r ind), reduced body weight (rbw), sexual reduced body weight (srbw), measured and calculated c max for each patient (mc max, cc m,r, cc m,rind).

Verner/Schneider/Gebel/Panning/Wiese/Tröger/Breitmeier, Blood ethanol concentrations and inebriation symptoms following percutaneous ethanol injection therapy (PEIT) carried out on patients suffering from hepatocellular carcinoma After clinical examination the following inebriation symptoms were revealed: drowsiness, euphoria, slurring and lalling speech, nausea, vomiting, smell of alcohol, and desorientation. BECs were plotted versus time for all 14 patients in figure 1. Fig. 1: Blood ethanol concentrations versus time after PEI for all 14 patients. Some curves shows a significant peak after reaching the maximum of the blood ethanol concentration, here there appears to be a release of ethanol from the tumour into the venous system. Other curves shows a significant plateau up to 75 minutes after the beginning of the instillation procedure. We modeled the relationship between ethanol dose and the blood ethanol concentration level by comparing linear, quadratic, cubic, power, exponential, and logarithmic models. By using the coefficient of determination (R 2 ) to measure goodness of fit, we found a significant positiv relationship that can be expressed with the following non-linear logarithmic model: y=A/(1+B*exp(–C*x)), where x is the amount of ethanol administered in g per kg of body weight, and y is the predicted blood ethanol level in gram per kilogram (Fig. 2). 277 BLUTALKOHOL VOL. 42/2005

Verner/Schneider/Gebel/Panning/Wiese/Tröger/Breitmeier,<br />

Blood ethanol concentrations and inebriation symptoms following percutaneous ethanol injection<br />

therapy (PEIT) carried out on patients suffering from hepatocellular carcinoma<br />

After clinical examination the following inebriation symptoms were revealed: drowsiness,<br />

euphoria, slurring and lalling speech, nausea, vomiting, smell of alcohol, and desorientation.<br />

BECs were plotted versus t<strong>im</strong>e for all 14 patients in figure 1.<br />

Fig. 1: Blood ethanol concentrations versus t<strong>im</strong>e after PEI for all 14 patients.<br />

Some curves shows a significant peak after reaching the max<strong>im</strong>um of the blood ethanol<br />

concentration, here there appears to be a release of ethanol from the tumour into the venous<br />

system. Other curves shows a significant plateau up to 75 minutes after the beginning of the<br />

instillation procedure.<br />

We modeled the relationship between ethanol dose and the blood ethanol concentration<br />

level by comparing linear, quadratic, cubic, power, exponential, and logarithmic models.<br />

By using the coefficient of determination (R 2 ) to measure goodness of fit, we fo<strong>und</strong> a significant<br />

positiv relationship that can be expressed with the following non-linear logarithmic<br />

model: y=A/(1+B*exp(–C*x)), where x is the amount of ethanol administered in g per<br />

kg of body weight, and y is the predicted blood ethanol level in gram per kilogram (Fig. 2).<br />

277<br />

BLUTALKOHOL VOL. 42/<strong>2005</strong>

logo

Produkte

Ressourcen

Unternehmen

AGB
Datenschutzerklärung
Cookie-Richtlinien
Cookie-Einstellungen
Impressum
Change language
Made with love in Switzerland
© 2024 Yumpu.com all rights reserved

Hurra! Ihre Datei wurde hochgeladen und ist bereit für die Veröffentlichung.

Erfolgreich gespeichert!

Leider ist etwas schief gelaufen!