Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...

Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ... Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...

10.12.2012 Aufrufe

202 Fig. 3 Breitmeier/Verner/Albrecht/Fieguth/Geerlings/Kleemann/Panning/Gebel/Tröger, Arteriovenous differences (A-V differences) by patients with a hepatocellular carcinoma in relation to percutaneous ethanol injection therapy (PEIT) Blood Ethanol (‰) At first, during the injection of ethanol into the carcinoma, the arterial, central venous, and peripheral venous BEC increased rapidly for at least 8 to 39 minutes (mean 22 ± 10 minutes). The highest arterial BEC was 1.47 g/kg and was reached after 22 minutes. The arterial BEC ranged between 0.23 and 1.47 g/kg (mean 0.85 ± 0.32 g/kg), the peripheral venous BEC ranged between 0.21 and 1.34 g/kg (mean 0.79 ± 0.31 g/kg), and the central venous BEC ranged between 0.19 and 1.38 g/kg (mean 0.79 ± 0.29 g/kg). After injection the second phase begins, while the ethanol is equilibrated throughout all body fluids and tissues. At this time the BECs of the compartments decreased abruptly in an exponential manner. During the third phase the concentration of the blood compartments decreased distinctly until 0.1 g/kg. Since we got only a few blood samples from intubated patients during the injection therapy we were not able to calculate exact pharmakokinetic parameters, especially to determine the �-slope. Figure 4–6 shows the differences between blood compartments after starting injection therapy. Significant differences between arterial / peripheral venous BEC and arterial / central venous BEC can be identified in Figure 4 and 5 during the resorption phase. When the ethanol equilibrates throughout the body fluids and tissues such differences were not seen. Figure 6 demonstrates very small or negligible differences between peripheral / central venous BEC. BLUTALKOHOL VOL. 42/2005 1,0 0,9 0,8 0,7 0,6 0,5 0,4 0,3 0,2 0,1 peripheral venous 0,0 0 25 50 75 100 125 150 175 200 225 Time (min) Figures 1–3: Concentration-time profiles of ethanol in arterial, central venous, and peripheral venous blood of the 20 patients.

Fig. 4 Fig. 5 Fig. 6 Breitmeier/Verner/Albrecht/Fieguth/Geerlings/Kleemann/Panning/Gebel/Tröger, Arteriovenous differences (A-V differences) by patients with a hepatocellular carcinoma in relation to percutaneous ethanol injection therapy (PEIT) Blood Ethanol ( ‰) Blood Ethanol ( ‰) Blood Ethanol (‰) 0,150 0,125 0,100 0,075 0,050 0,025 0,000 -0,025 -0,050 0,150 0,125 0,100 0,075 0,050 0,025 0,000 -0,025 -0,050 0,150 0,125 0,100 0,075 0,050 0,025 0,000 -0,025 -0,050 _ ] ] _ ] ] ] ] arterial - peripheral venous 0 1. 2. 3. 4. 5. 6. Blood Bloodletting sample central venous - peripheral venous _ _ arterial - central venous ] 0 1. 2. 3. 4. 5. 6. Blood sample Bloodletting ] ] ] ] ] _ _ 0 1. 2. 3. 4. 5. 6. Blood Bloodletting sample Figures 4–6: Differences in the concentrations of ethanol in arterial, central venous, and peripheral venous blood. Mean curves ± SD (standard deviation) are shown as a function of each blood sample of the 20 patients. _ ] ] 203 BLUTALKOHOL VOL. 42/2005

Fig. 4<br />

Fig. 5<br />

Fig. 6<br />

Breitmeier/Verner/Albrecht/Fieguth/Geerlings/Kleemann/Panning/Gebel/Tröger,<br />

Arteriovenous differences (A-V differences) by patients with a hepatocellular carcinoma<br />

in relation to percutaneous ethanol injection therapy (PEIT)<br />

Blood Ethanol ( ‰)<br />

Blood Ethanol ( ‰)<br />

Blood Ethanol (‰)<br />

0,150<br />

0,125<br />

0,100<br />

0,075<br />

0,050<br />

0,025<br />

0,000<br />

-0,025<br />

-0,050<br />

0,150<br />

0,125<br />

0,100<br />

0,075<br />

0,050<br />

0,025<br />

0,000<br />

-0,025<br />

-0,050<br />

0,150<br />

0,125<br />

0,100<br />

0,075<br />

0,050<br />

0,025<br />

0,000<br />

-0,025<br />

-0,050<br />

_<br />

]<br />

]<br />

_<br />

]<br />

]<br />

] ]<br />

arterial - peripheral venous<br />

0 1. 2. 3. 4. 5. 6.<br />

Blood Bloodletting sample<br />

central venous - peripheral venous<br />

_ _<br />

arterial - central venous<br />

]<br />

0 1. 2. 3. 4. 5. 6.<br />

Blood sample<br />

Bloodletting<br />

]<br />

] ]<br />

] ]<br />

_ _<br />

0 1. 2. 3. 4. 5. 6.<br />

Blood Bloodletting sample<br />

Figures 4–6: Differences in the concentrations of ethanol in arterial, central venous, and peripheral venous<br />

blood. Mean curves ± SD (standard deviation) are shown as a function of each blood sample of the 20 patients.<br />

_<br />

]<br />

]<br />

203<br />

BLUTALKOHOL VOL. 42/<strong>2005</strong>

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