Blutalkohol 2005 - BADS (Bund gegen Alkohol und Drogen im ...

Breitmeier/Verner/Albrecht/Fieguth/Geerlings/Kleemann/Panning/Gebel/Tröger,
Arteriovenous differences (A-V differences) by patients with a hepatocellular carcinoma
in relation to percutaneous ethanol injection therapy (PEIT)
These results indicate that the ethanol concentration in the arterial blood samples is
significantly higher (p = 0.000 – 0.008) than in the peripheral venous blood samples during
the resorption phase until the maximum ethanol concentration in the compartments is
reached. Significant differences between the peripheral and the central venous blood compartment
were not found in the time period until maximum blood ethanol concentration
(p = 0.610 – 0.945) is reached. Differences between the blood compartments disappeared
in the elimination phase after the maximum BEC was reached. Further in the resorption
phase no correlation between the amount of injected ethanol and the BEC could be observed
(r = 0.656 – 0.982). In the elimination phase we were able to show such a correlation
between the injected ethanol and the BEC (r = 0.998 – 1.000).
Figure 1–3 shows the average concentration-time profile of alcohol in arterial, central
venous, and peripheral venous blood. According to JONES et al. we also found a typical triphasic
distribution for ethanol after injection into the tumor in all blood compartments [20].
Fig. 1
Fig. 2
Blood Ethanol ( ‰)
Blood Ethanol ( ‰)
1,0
0,9
0,8
0,7
0,6
0,5
0,4
0,3
0,2
0,1
arterial
0,0
0 25 50 75 100 125 150 175 200 225
1,0
0,9
0,8
0,7
0,6
0,5
0,4
0,3
0,2
0,1
Time (min)
central venous
0,0
0 25 50 75 100 125 150 175 200 225
Time (min)
201
BLUTALKOHOL VOL. 42/2005