Unser Haushund: Eine Spitzmaus im Wolfspelz? - Wolf-Ekkehard ...

91A Short +Fully functionalWildtype alleleB Wire +Fully functionalWildtype alleleC Wire and Curly +Fully functionalWildtype alleleD Long -Highly conserved Cys is changed to Phe(Cys95→Phe)ELong withFurnishings-Highly conserved Cys is changed to Phe(Cys95→Phe)F Curly -Highly conserved Cys is changed to Phe(Cys95→Phe)GCurly withFurnishings-Highly conserved Cys is changed to Phe(Cys95→Phe)+Fully functionalWildtype allele-167-bp deletion at the 3' end of the R-spondin-2 (RSPO2) gene-167-bp deletion at the 3' end of the R-spondin-2 (RSPO2) gene+Fully functionalWildtype allele-167-bp deletion at the 3' end of the R-spondin-2 (RSPO2) gene+Fully functionalWildtype allele-167-bp deletion at the 3' end of the R-spondin-2 (RSPO2) gene+Fully FunctionalWildtype allele+Fully functionalWildtype allele-A coding SNP within highlyconserved part of the KRT71 gene*+Fully functionalWildtype allele+Fully functionalWildtype allele-A coding SNP within highlyconserved part of the KRT71 gene*-A coding SNP within highlyconserved part of the KRT71 gene*Die Tabelle nach Cadieu et al. korrigiert nach der Funktionalität der Allele: 'Plus (+) and minus signs (−) indicatethe presence or absence of a fully functional genotype.' Überdies wurden Veränderungen auf der DNA-Ebenevermerkt.*Zum KRT71 gene: "The SNP occurs in the protein-encoding part of the gene and changes an arginine to a tryptophan. This alteration could affect cellulartargeting, receptor binding, or proper folding of the protein. The conclusion that this mutation is a cause of curly hair is supported by previous experiements, whichhave described mutations in KRT71 in curly haired mice” (http://www.bio.davidson.edu/courses/genomics/2011/Miller/Coat_Variation.html). Mouse/human: "A number of independentspontaneous mutations in this gene result in a similar dominant phenotype, with curved vibrissae and wavy hair. ENU mutants have also been characterized forabnormalities of keratinization in the inner root sheath of the hair follicle, including one recessive allele” (http://www.informatics.jax.org/marker/MGI:1861586).Dog: "R151W occurs within the highly conserved 1A region of the keratin alpha-helical rod domain, which is important for keratin dimerization (Hatzfeld andWeber, 1990) and which is a frequent site for curly/wavy coat mutations in other species” [several references] (Kaelin and Barsh 2012, p. 75). Scheint aber komplexerzu sein (dazu neuerdings die Entdeckung eines "keratin cluster distinct from KRT71 cluster" - Kaelin und Barsh).Mein Eindruck ist, dass die Begriffe Komplexität und Evolution in deransonsten exzellenten wissenschaftlichen Arbeit von Cadieu et al. (2009) auf eineWeise gebraucht werden, dass dadurch die Richtung in der 'Hundeevolution' nichtmehr deutlich zum Ausdruck kommt oder vielleicht etwas stärker formuliert:Funktionsabbau und Integrationsverluste werden dadurch zum Teil 'verschleiert'.Das trifft genauso auf die oben gezeigte Abbildung zu ("Plus (+) and minus signs (−) indicatethe presence or absence of variant (nonancestral) genotype.") und passt zum oben nach Dawkinsund vielen anderen Autoren dokumentierten Ziel, die Entstehung der Hunderassenals Argument für die Makroevolution einzusetzen (was in den Schlusssätzen desPapers ja auch von den Autoren selbst, wenn auch weniger direkt, praktiziert wird).9. 11 Rhodesian Ridgeback