Unser Haushund: Eine Spitzmaus im Wolfspelz? - Wolf-Ekkehard ...

387[…] "Untreated acromegaly leads to increased mortality as a result of cardiovascular, cerebrovascular, andpulmonary dysfunction and is associated with a 30% decrease in life expectancy. Acromegalic gigantismis most often caused by a pituitary adenoma that secretes excess growth hormone, with the onset of thedisorder before epiphyseal fusion.”(p. 45)"…the aryl hydrocarbon–interacting protein (AIP) sequence change c.910C→T […] generates apremature stop codon, resulting in a truncated protein with loss of the final 26 amino acids. The siteappears to be a mutational hot spot, since it is located at a typical CpG site and has been identified in fivefamilies from three countries (three from Italy, one from England, and one from Romania), as well as intwo patients with apparently sporadic cases in France and India, in addition to the Irish cases we describehere. [...] The AIP protein has three pairs of conserved antiparallel α helixes (tetratricopeptide repeatdomains [TPR]) and a final extended α helix, α7. These helical structures are important for the protein–protein binding and antiproliferative action of AIP.”Die Frage ist bisher ungeklärt, welche Mutationen beim Bernhardiner vorliegen. Auch sollte die Frage,inwieweit das Krankheitsbild der Akromegalie mit den Merkmalen des Bernhardiners übereinstimmt,noch etwas genauer untersucht werden.Der folgende Punkt trifft nicht nur auf Bernhardiner zu: "Wie die meisten grossen Hunderassen hat der Bernhardinereine vergleichsweise geringe Lebenserwartung. 30 Prozent der Hunde sterben vor dem Alter von fünf Jahren, 52Prozent vor dem Alter von acht Jahren, und 74 Prozent werden keine zehn Jahre alt.[5] 792 "The median age at deathfor the St Bernard breed was 7 years (min = 6 months, max = 12 years and 9 months).” 793 Andere Quellen gebenein höheres Durchschnittssalter an. 794Report from the Kennel Club/ British Small Animal Veterinary Association Scientific Committee Summaryresults of the Purebred Dog Health Survey for the St Bernard breed: (siehe wieder 244 )Mortality dataA total of 53 deaths were reported and this represents 0.33% of all deaths reported in the survey (53/15,881). Themedian age at death for the St Bernard breed was 7 years (min = 6 months, max = 12 years and 9 months) and thiswas lower than the overall median of 11 years and 3 months (Figure 1). Table 1 shows the causes of death for the StBernard breed. Age at death is presented for the most common causes of death (Figure 2).Table 1. Causes of death by organ system/category for the St Bernard breed. Cause of death N % Mostcommon specific causes in descending orderCause of Death N %_______________________________________________________________________________1 Cardiac 15 28.3 Cardiomyopathy unspecified; heart failure2 Cancer 9 17.0 Type unspecified (bone)3 Gastrointestinal 8 15.1 Gastric dilatation/volvulus (GDV)4 Old age 4 7.5 Old age & age combinations5 Cerebral vascular 2 3.8 Stroke or cerebral vascular accident6 Musculoskeletal 2 3.8 Arthritis; hip dysplasia7 Perioperative 2 3.88 Urologic 2 3.8 Kidney failure9 Behaviour 1 1.9 Aggression10 Combinations 1 1.911 Endocrine 1 1.9 Addisons disease12 Hepatic 1 1.9 Liver failure13 Hyperthermia 1 1.914 Neurologic 1 1.9 Seizures15 Other 1 1.9 Uncodeable16 Reproductive 1 1.9 Pyometra17 Septicaemia 1 1.9_____________________________________________________________________________Total 53 100.0792 http://de.wikipedia.org/wiki/Bernhardiner793 http://www.thekennelclub.org.uk/download/1630/hsstbernard.pdf794 http://en.wikipedia.org/wiki/St._Bernard_(dog)