Unser Haushund: Eine Spitzmaus im Wolfspelz? - Wolf-Ekkehard ...

186AMY2B copy numbers.”Dazu passt auch die Erhöhung des Expressionslevels und der Enzymaktivität:"To assess whether this change correspond[s] to a difference in amylase activity, we first compared AMY2Bgene expression in pancreas from dog (n=9) and wolf (n=12) and noted a 28-fold higher averageexpression in dog (P < 0.001, Wilcoxon, Fig. 2d). We then quantified amylase activity in frozen serum(Fig. 2e) and found a 4.7-fold higher activity in dog (9.6–18.4 μkat l -1 (n=12)) relative to wolf (1.4–4.3μkat l -1 (n=13)) (P < 0.001, Wilcoxon). Similar results were obtained in comparisons of a limited number offresh samples (Supplementary Tables 12 and 13).”Schlussfolgerung der Autoren (2013, p. 3):"The change in AMY2B gene copy number together with a correlated increase in both expression level (rho= 0.84, P < 0.0001, Spearman) (Supplementary Fig. 3) and enzyme activity (rho = 0.63, P