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LITERATURVERZEICHNIS THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M.M., PASTAN, I., WILLINGHAM, M.C., 1987. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U.S.A. 84: 7735–7738. THOMAS, W.E., 1999. Brain macrophages: on the role of pericytes and perivascular cells. Brain Res Rev. 31: 42-57. THOMAS, H., COLEY, H.M., 2003. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10: 159 –165. TIMSIT, Y.E., NEGISHI, M., 2007. CAR and PXR: the xenobiotic-sensing receptors. Steroids 72: 231- 46. TISHLER, D.M., WEINBERG, K.I., HINTON, D.R., BARBARO, N., ANNETT, G.M., RAFFEL, C., 1995. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36: 1- 6. TROUTMAN, M.D., THAKKER, D.R., 2003. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharm Res. 20: 1192-9. TSUJI, A., TAMAI, I., 1999. Carrier-mediated or specialized transport of drugs across the bloodbrain barrier. Adv Drug Deliv Rev. 36: 277-290. URICH, E., LAZIC, S.E., MOLNOS, J., WELLS, I., FRESKGÅRD, P.O., 2012. Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models. PloS One. 7(5):e38149. VAN DORPE, S., BRONSELAER, A., NIELANDT, J., STALMANS, S., WYNENDAELE, E., AUDENAERT, K., VAN DE WIELE, C., BURVENICH, C., PEREMANS, K., HSUCHOU, H., DE TRÉ, G., DE SPIEGELEER, B., 2012. Brainpeps: the blood-brain barrier peptide database. Brain Struct Funct. 217: 687-718. VAN VLIET, E.A., VAN SCHAIK, R., EDELBROEK, P.M., REDEKER, S., ARONICA, E., WADMAN, W.J., MARCHI, N, VEZZANI, A., GORTER, J.A., 2006. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia. 47: 672-80. VAN VLIET, E.A., VAN SCHAIK, R., EDELBROEK, P.M., VOSKUYL, R.A., REDEKER, S., ARONICA, E., WADMAN, W.J., GORTER, J.A., 2007. Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J Pharmacol Exp Ther. 322: 141–147. VANTELON, N., RIOUX-BILAN, A., INGRAND, S., PAIN, S., PAGE, G., GUILLARD, O., BARRIER, L., PIRIOU, A., FAUCONNEAU, B., 2007. Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress. Eur J Neurosci. 26: 689-700. VERGONI, A.V., TOSI, G., TACCHI, R., VANDELLI, M.A., BERTOLINI, A., COSTANTINO, L., 2009. Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution. Nanomedicine 5: 369-377. VOLK, H.A., BURKHARDT, K., POTSCHKA, H., CHEN, J., BECKER, A., LÖSCHER, W., 2004a. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123: 751–759. 202

LITERATURVERZEICHNIS VOLK, H.A., LÖSCHER, W., 2005. Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures. Brain 128: 1358-1368. VOLK, H., POTSCHKA, H., LÖSCHER, W., 2005. Immunohistochemial localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J. Histochem. Cytochem. 53: 517–531. VONCK, K., HERDT, V.D., SPRENGERS, M., BEN-MENACHEM, E., 2012. Neurostimulation for epilepsy. Handb Clin Neurol. 108: 955-70. VU, K., WEKSLER, B., ROMERO, I., COURAUD, P.O., GELLI, A., 2009. Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans. Eukaryot Cell. 8: 1803- 1807. WANG, H., LECLUYSE, E.L., 2003. Role of orphan nuclear receptors in the regulation of drugmetabolising enzymes. Clin. Pharmacokinet. 42: 1331-1357. WEISS, J., KERPEN, C.J., LINDENMAIER, H., DORMANN, S.M., HAEFELI, W.E., 2003. Interaction of antiepileptic drugs with human P-glycoprotein in vitro. J Pharmacol Exp Ther. 307: 262-7. WEKSLER, B.B., SUBILEAU, E.A., PERRIERE, N., CHARNEAU, P., HOLLOWAY, K., LEVEQUE, M., TRICOIRE-LEIGNEL, H., NICOTRA, A., BOURDOULOUS, S., TUROWSKI, P., MALE, D.K., ROUX, F., GREENWOOD, J., ROMERO, I.A., COURAUD, P.O., 2005. Blood–brain barrierspecific properties of a human adult brain endothelial cell line. FASEB J. 19: 1872–1874. WEN, T., LIU, Y.C., YANG, H.W., LIU, H.Y., LIU, X.D., WANG, G.J., XIE, L., 2008. Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain. J. Neurol. Sci. 270: 99-106. WHO, 2005. Atlas: Epilepsy care in the world. Geneva, Switzerland. WILLIS, C.L., TAYLOR, G.L., RAY, D.E., 2007. Microvascular Pgp expression at the blood-brain barrier following focal astrocyte loss and at the fenestrated vasculature of the area postrema. Brain Res. 1173: 126-136. WOLBURG, H., NEUHAUS, J., KNIESEL, U., KRAUß, B., SCHMID, E.M., ÖCALAN, M., FARRELL, C., RISAU, W., 1994. Modulation of tight junction structure in blood-brain endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes. J Cell Sci. 107: 1347- 1357. WU, C., SHARAN, A.D., 2012. Neurostimulation for the Treatment of Epilepsy: A Review of Current Surgical Interventions. Neuromodulation Sep 4. doi: 10.1111/j.1525-1403.2012.00501.x. XU, C., LI, C.Y., KONG, A.N., 2005. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. 28: 249-268. YANG, H.W., LIU, H.Y., LIU, X., ZHANG, D.M., LIU, Y.C., LIU, X.D., WANG, G.J., XIE, L., 2008. Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro. Neurosci. Lett. 434: 299-303. YARMOLINSKY, M.B., DE LA HABA,G.L., 1959 . Inhibition by puromycin of amino acid incorporation into protein. Proc . Natl . Acad. Sci. U. S. A. 45: 1721. 203

LITERATURVERZEICHNIS<br />

THIEBAUT, F., TSURUO, T., HAMADA, H., GOTTESMAN, M.M., PASTAN, I., WILLINGHAM, M.C.,<br />

1987. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal<br />

human tissues. Proc. Natl. Acad. Sci. U.S.A. 84: 7735–7738.<br />

THOMAS, W.E., 1999. Brain macrophages: on the role of pericytes and perivascular cells. Brain Res<br />

Rev. 31: 42-57.<br />

THOMAS, H., COLEY, H.M., 2003. Overcoming multidrug resistance in cancer: an update on the<br />

clinical strategy of inhibiting p-glycoprotein. Cancer Control 10: 159 –165.<br />

TIMSIT, Y.E., NEGISHI, M., 2007. CAR and PXR: the xenobiotic-sensing receptors. Steroids 72: 231-<br />

46.<br />

TISHLER, D.M., WEINBERG, K.I., HINTON, D.R., BARBARO, N., ANNETT, G.M., RAFFEL, C., 1995.<br />

MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36: 1-<br />

6.<br />

TROUTMAN, M.D., THAKKER, D.R., 2003. Rhodamine 123 requires carrier-mediated influx for its<br />

activity as a P-glycoprotein substrate in Caco-2 cells. Pharm Res. 20: 1192-9.<br />

TSUJI, A., TAMAI, I., 1999. Carrier-mediated or specialized transport of drugs across the bloodbrain<br />

barrier. Adv Drug Deliv Rev. 36: 277-290.<br />

URICH, E., LAZIC, S.E., MOLNOS, J., WELLS, I., FRESKGÅRD, P.O., 2012. Transcriptional profiling<br />

of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain<br />

barrier models. PloS One. 7(5):e38149.<br />

VAN DORPE, S., BRONSELAER, A., NIELANDT, J., STALMANS, S., WYNENDAELE, E.,<br />

AUDENAERT, K., VAN DE WIELE, C., BURVENICH, C., PEREMANS, K., HSUCHOU, H., DE<br />

TRÉ, G., DE SPIEGELEER, B., 2012. Brainpeps: the blood-brain barrier peptide database.<br />

Brain Struct Funct. 217: 687-718.<br />

VAN VLIET, E.A., VAN SCHAIK, R., EDELBROEK, P.M., REDEKER, S., ARONICA, E., WADMAN,<br />

W.J., MARCHI, N, VEZZANI, A., GORTER, J.A., 2006. Inhibition of the multidrug transporter<br />

P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia.<br />

47: 672-80.<br />

VAN VLIET, E.A., VAN SCHAIK, R., EDELBROEK, P.M., VOSKUYL, R.A., REDEKER, S., ARONICA,<br />

E., WADMAN, W.J., GORTER, J.A., 2007. Region-specific overexpression of P-glycoprotein<br />

at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J Pharmacol Exp<br />

Ther. 322: 141–147.<br />

VANTELON, N., RIOUX-BILAN, A., INGRAND, S., PAIN, S., PAGE, G., GUILLARD, O., BARRIER, L.,<br />

PIRIOU, A., FAUCONNEAU, B., 2007. Regulation of initiation factors controlling protein<br />

synthesis on cultured astrocytes in lactic acid-induced stress. Eur J Neurosci. 26: 689-700.<br />

VERGONI, A.V., TOSI, G., TACCHI, R., VANDELLI, M.A., BERTOLINI, A., COSTANTINO, L., 2009.<br />

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution. Nanomedicine<br />

5: 369-377.<br />

VOLK, H.A., BURKHARDT, K., POTSCHKA, H., CHEN, J., BECKER, A., LÖSCHER, W., 2004a.<br />

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after<br />

limbic seizures. Neuroscience 123: 751–759.<br />

202

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