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LITERATURVERZEICHNIS lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol. 7: 415-424. DAUCHY, S., MILLER, F., COURAUD, P.O., WEAVER, R.J., WEKSLER, B., ROMERO, I.A., SCHERRMANN, J.M., DE W, I., DECLEVES, X., 2009. Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochem. Pharmacol. 77: 897-909. DEAN, M., RZHETSKY, A., ALLIKMETS, R., 2001. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11: 1156-1166. DE BRUIN, M., MIYAKE, K., LITMAN, T., ROBEY, R., BATES, S.E., 1999. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett. 146: 117-126. DEEKEN, J.F., LÖSCHER, W., 2007. The blood-brain barrier and cancer: transporters, treatment, and Trojan horses. Clin. Cancer Res. 13: 1663-1674. DEHOUCK, M.P., MÉRESSE, S., DELORME, P., FRUCHART, J.C., CECCHELLI, R., 1990. An easier, reproducible and mass production method to study the blood-brain barrier in vitro. J Neurochem. 54: 1790- 1797. DELI, M.A., ABRAHÁM, C.S., NIWA, M., FALUS, A., 2003. N,N-diethyl-2-[4- (phenylmethyl)phenoxy]ethanamine increases the permeability of primary mouse cerebral endothelial cell monolayers. Inflamm Res. 52 Suppl 1: 39-40. DELI, M.A., ABRAHÁM, C.S., KATAOKA, Y., NIWA, M., 2005. Permeability studies on in vitro bloodbrain barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol. 25: 59- 127. DEMEUSE, P., FRAGNER, P., LEROY-NOURY, C., MERCIER, C., PAYEN, L., FARDEL, O., COURAUD, P.O., ROUX, F., 2004. Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines. J. Neurochem. 88: 23-31. DEMEUSE, P., KERKHOFS, A., STRUYS-PONSAR, C., KNOOPS, B., REMACLE, C., VAN DEN BOSCH DE AGUILAR, P., 2002. Compartmentalized coculture of rat brain endothelial cells and astrocytes: a syngenic model to study the blood-brain barrier. J Neurosci Methods. 121: 21-31. DEVINSKY, O., 2003. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy Behav. 4, Suppl 4: 2-10. DIDZIAPETRIS, R., JAPERTAS, P., AVDEEF, A., PETRAUSKAS, A., 2003. Classification analysis of P-glycoprotein substrate specificity. J Drug Target. 11: 391-406. DIXIT, S.G., D'SOUZA, V.M., BUCKLEY, D.J., BUCKLEY, A.R., PAULETTI, G.M., 2002. Rifampicinmediated Induction of P-glycoprotein in Caco-2 cells. Role of the Pregnane X Receptor (PXR). Abstract annual meeting of american association of pharmaceutical scientists. DOMBROWSKI, S.M., DESAI, S.Y,. MARRONI, M., CUCULLO, L., GOODRICH, K., BINGAMAN, W., MAYBERG, M.R., BENGEZ, L., JANIGRO, D., 2001.Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42: 1501- 1506. 184

LITERATURVERZEICHNIS DOHGU, S., TAKATA, F., YAMAUCHI, A., NAKAGAWA, S., EGAWA, T., NAITO, M., TSURUO, T., SAWADA, Y., NIWA, M., KATAOKA, Y., 2005. Brain pericytes contribute to the induction and up-regulation of bloodbrain barrier functions through transforming growth factor-beta production. Brain Res. 1038: 208-215. DORAN, A., OBACH, R.S., SMITH, B.J., HOSEA, N.A., BECKER, S., CALLEGARI, E., CHEN, C., CHEN, X., CHOO, E., CIANFROGNA, J., COX, L.M., GIBBS, J.P., GIBBS, M.A., HATCH, H., HOP, C.E., KASMAN, I.N., LAPERLE, J., LIU, J., LIU, X., LOGMAN, M., MACLIN, D., NEDZA, F.M., NELSON, F., OLSON, E., RAHEMATPURA, S., RAUNIG, D., ROGERS, S., SCHMIDT, K., SPRACKLIN, D.K., SZEWC, M., TROUTMAN, M., TSENG, E., TU, M., VAN DEUSEN, J.W., VENKATAKRISHNAN, K., WALENS, G., WANG, E.Q., WONG, D., YASGAR, A.S., ZHANG, C., 2005. The impact of Pgp on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the mdr1a/1b knockout mouse model. Drug Metabol Disp. 33: 165-174. DOYLE, L.A., ROSS, D.D., 2003. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22: 7340-7358. DOYLE, L.A., YANG, W.D., ABRUZZO, L.V., KROGMANN, T., GAO, Y.M., RISHI, A.K., ROSS, D.D., 1998. A multidrug resistance transporter from human MCF-7 breast cancer cells. Pro Natl Acad Sci USA 95: 15665-15670. DUNCAN, J.S., SANDER, J.W., SISODIYA, S.M., WALKER, M.C., 2006. Adult epilepsy. Lancet. 367: 1087-1100. DURING, M.J., SPENCER, D.D., 1993. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet. 341: 1607-1610. EFFERTH, T., LOHRKE, H., VOLM, M., 1989. Reciprocal correlation between expression of P- glycoprotein and accumulation of rhodamine 123 in human tumors. Anticancer Res 9: 1633- 1637. EHRLICH, P., 1885. Das Sauerstoff-Bedürfniss des Organismus: Eine farbenanalytische Studie. August Hirschwald, Berlin (die Habilitationsschrift von Paul Ehrlich). EKINS, S., ERICKSON, J.A., 2002. A pharmacophore for human pregnane X receptor ligands. Drug Metab. Dispos. 30: 96-99. ENGEL, J., Jr., 2001. Mesial Temporal Lobe Epilepsy: What Have We Learned? The Neuroscientist 7: 340-352. ENGEL, J., 2006. ILAE classification of epilepsy syndromes. Epilepsy Res. 70, Suppl (0): 5-10. ENGEL, J. Jr., 2011. Biomarkers in epilepsy: foreword. Biomark Med. 5: 529–530. ENOKIZONO, J., KUSUHARA, H., OSE, A., SCHINKEL, A.H., SUGIYAMA, Y., 2008. Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds. Drug Metab Dispos. 36: 995-1002. EVERS, R., ZAMAN, G.J., VAN DEEMTER, L., JANSEN, H., CALAFAT, J., OOMEN, L.C., OUDE ELFERINK, R.P., BORST, P., SCHINKEL, A.H., 1996. Basolateral localization and export activity of the human multidrug resistanceassociated protein in polarized pig kidney cells. J Clin Invest. 97: 1211-1218. 185

LITERATURVERZEICHNIS<br />

lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to<br />

chemotherapy. J Clin Oncol. 7: 415-424.<br />

DAUCHY, S., MILLER, F., COURAUD, P.O., WEAVER, R.J., WEKSLER, B., ROMERO, I.A.,<br />

SCHERRMANN, J.M., DE W, I., DECLEVES, X., 2009. Expression and transcriptional<br />

regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral<br />

microvascular endothelial cells. Biochem. Pharmacol. 77: 897-909.<br />

DEAN, M., RZHETSKY, A., ALLIKMETS, R., 2001. The human ATP-binding cassette (ABC)<br />

transporter superfamily. Genome Res. 11: 1156-1166.<br />

DE BRUIN, M., MIYAKE, K., LITMAN, T., ROBEY, R., BATES, S.E., 1999. Reversal of resistance by<br />

GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett. 146: 117-126.<br />

DEEKEN, J.F., LÖSCHER, W., 2007. The blood-brain barrier and cancer: transporters, treatment, and<br />

Trojan horses. Clin. Cancer Res. 13: 1663-1674.<br />

DEHOUCK, M.P., MÉRESSE, S., DELORME, P., FRUCHART, J.C., CECCHELLI, R., 1990. An<br />

easier, reproducible and mass production method to study the blood-brain barrier in vitro. J<br />

Neurochem. 54: 1790- 1797.<br />

DELI, M.A., ABRAHÁM, C.S., NIWA, M., FALUS, A., 2003. N,N-diethyl-2-[4-<br />

(phenylmethyl)phenoxy]ethanamine increases the permeability of primary mouse cerebral<br />

endothelial cell monolayers. Inflamm Res. 52 Suppl 1: 39-40.<br />

DELI, M.A., ABRAHÁM, C.S., KATAOKA, Y., NIWA, M., 2005. Permeability studies on in vitro bloodbrain<br />

barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol. 25: 59-<br />

127.<br />

DEMEUSE, P., FRAGNER, P., LEROY-NOURY, C., MERCIER, C., PAYEN, L., FARDEL, O.,<br />

COURAUD, P.O., ROUX, F., 2004. Puromycin selectively increases mdr1a expression in<br />

immortalized rat brain endothelial cell lines. J. Neurochem. 88: 23-31.<br />

DEMEUSE, P., KERKHOFS, A., STRUYS-PONSAR, C., KNOOPS, B., REMACLE, C., VAN DEN<br />

BOSCH DE AGUILAR, P., 2002. Compartmentalized coculture of rat brain endothelial cells<br />

and astrocytes: a syngenic model to study the blood-brain barrier. J Neurosci Methods. 121:<br />

21-31.<br />

DEVINSKY, O., 2003. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and<br />

treatment. Epilepsy Behav. 4, Suppl 4: 2-10.<br />

DIDZIAPETRIS, R., JAPERTAS, P., AVDEEF, A., PETRAUSKAS, A., 2003. Classification analysis of<br />

P-glycoprotein substrate specificity. J Drug Target. 11: 391-406.<br />

DIXIT, S.G., D'SOUZA, V.M., BUCKLEY, D.J., BUCKLEY, A.R., PAULETTI, G.M., 2002. Rifampicinmediated<br />

Induction of P-glycoprotein in Caco-2 cells. Role of the Pregnane X Receptor (PXR).<br />

Abstract annual meeting of american association of pharmaceutical scientists.<br />

DOMBROWSKI, S.M., DESAI, S.Y,. MARRONI, M., CUCULLO, L., GOODRICH, K., BINGAMAN, W.,<br />

MAYBERG, M.R., BENGEZ, L., JANIGRO, D., 2001.Overexpression of multiple drug<br />

resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42: 1501-<br />

1506.<br />

184

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