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LITERATURVERZEICHNIS CAEMAERT, J., VAN ROOST, D., 2007a. Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia 48: 1551-1560. BOURNISSEN, F.G., MORETTI, M.E., JUURLINK, D.N., KOREN, G., WALKER, M., FINKELSTEIN, Y., 2009. Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia 50: 898–903. BRANDT, C., BETHMANN, K., GASTENS, A.M., LÖSCHER, W., 2006. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis. 24: 202-211. BRIGGER, I., MORIZET, J., AUBERT, G., CHACUN, H., TERRIER-LACOMBE, M.J., COUVREUR, P., VASSAL, G., 2002. Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting. J Pharmacol Exp Ther. 303: 928-936. BRINKMANN, U., EICHELBAUM, M., 2001. Polymorphisms in the ABC drug transporter gene MDR1. Pharmacogenomics J. 1: 59-64. CALABRIA, A.R., WEIDENFELLER, C., JONES, A.R., DEVRIES ,H.E., SHUSTA, E.V., 2006. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. J. Neurochem. 97: 922–933. CARDOSO, F.L., BRITES, D., BRITO, M.A., 2010. Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res Rev. 64: 328-363. CARL, S.M., LINDLEY, D.J., COURAUD, P.O., WEKSLER, B.B., ROMERO, I., MOWERY, S.A., KNIPP, G.T., 2010. ABC and SLC transporter expression and pot substrate characterization across the human CMEC/D3 blood-brain barrier cell line. Mol Pharm. 7: 1057-1068. CECCHELLI, R., BEREZOWSKI, V., LUNDQUIST, S., CULOT, M., RENFTEL, M., DEHOUCK, M.P., FENART, L., 2007. Modelling of the blood–brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 6: 650–661. CECCHELLI, R., DEHOUCK, B., DESCAMPS, L., FENART, L., BUÉE-SCHERRER, V., DUHEM, C., LUNDQUIST, S., RENTFEL, M., TORPIER, G., DEHOUCK, M.P., 1999. In vitro model for evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 36: 165-178. CERVENY, L., PAVEK, P., MALAKOVA, J., STAUD, F., FENDRICH, Z., Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia 47: 461-468. CHEN, C.J., CHIN, J.E., UEDA, K., CLARK, D.P., PASTAN, I., GOTTESMAN, M.M., RONINSON, I.B., 1986. Internal duplication and homology with bacterial transport proteins in the mdr1 (Pglycoprotein) gene from multidrug-resistant human cells. Cell 47: 381–389. CHEN, J., RAYMOND, K., 2006. Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann. Clin. Microbiol. Antimicrob. 5: 3. CHEN, T., 2010. Overcoming drug resistance by regulating nuclear receptors. Adv. Drug Deliv. Rev. 62: 1257-1264. CHEN, Y., FERGUSON, S.S., NEGISHI, M., GOLDSTEIN, J.A., 2004. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 308: 495-501. 182

LITERATURVERZEICHNIS CISTERNINO, S., MERCIER, C., BOURASSET, F., ROUX, F., SCHERRMANN, J.M., 2004. Expression, up-regulation, and transport activity of the multidrugresistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res. 64: 3296-3301. CLAUDE, P., 1978. Morphologic factors influencing transepithelial permeability. A model for the resistance of the zonula occludens. J Membr Biol 39: 219-232. COISNE, C., DEHOUCK, L., FAVEEUW, C., DELPLACE, Y., MILLER, F., LANDRY, C., MORISSETTE, C., FENART, L., CECCHELLI, R., TREMBLAY, P., DEHOUCK, B., 2005. Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab. Invest. 85: 734–746. COLABUFO, N.A.; BERARDI, F.; CANTORE, M.; CONTINO, M.; INGLESE, C.; NISO, M.; PERRONE, R., 2010. Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials. J. Med. Chem. 53: 1883-1897. COLE, S.P., BHARDWAJ, G., GERLACH, J.H., MACKIE, J.E., GRANT, C.E., ALMQUIST, K.C., STEWART, A.J., KURZ, E.U., DUNCAN, A.M., DEELEY, R.G., 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 2: 1650-1654. CORDON-CARDO, C., O'BRIEN, J.P., CASALS, D., RITTMAN-GRAUER, L., BIEDLER, J.L., MELAMED, M.R.,, BERTINO, J.R., 1989. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood–brain barrier sites. Proc Natl Acad Sci USA 1989; 86: 695–698. CROWE, A., TEOH, Y.K., 2006. Limited P-glycoprotein mediated efflux for anti-epileptic drugs. J. Drug. Target. 14: 291-300. CUCULLO, L., COURAUD, P.O., WEKSLER, B., ROMERO, I.A., HOSSAIN, M., RAPP, E., JANIGRO, D., 2008. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J. Cereb. Blood Flow Metab. 28: 312–328. CUCULLO, L., HOSSAIN, M., RAPP, E., MANDERS, T., MARCHI, N., JANIGRO, D., 2007. Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia. 48: 505-516. CUCULLO, L., MCALLISTER, M.S., KIGHT, K., KRIZANAC-BENGEZ, L., MARRONI, M., MAYBERG, M.R., STANNESS, K.A., JANIGRO, D., 2002. A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood–brain barrier. Brain Res. 951: 243–254. DANIELS, B.P., CRUZ-ORENGO, L., PASIEKA, T.J., COURAUD, P.O., ROMERO, I.A., WEKSLER, B., COOPER, J.A., DOERING, T.L., KLEIN, R.S., 2013. Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier. J Neurosci Methods. 212: 173-179. DALTON, W. S., GROGAN, T.M., MELTZER, P.S., SCHEPER, R.J., DURIE, B.G., TAYLOR, C.W., MILLER, T.P., SALMON, S.E., 1989. Drug-resistance in multiple myeloma and non-Hodgkin's 183

LITERATURVERZEICHNIS<br />

CAEMAERT, J., VAN ROOST, D., 2007a. Deep brain stimulation in patients with refractory<br />

temporal lobe epilepsy. Epilepsia 48: 1551-1560.<br />

BOURNISSEN, F.G., MORETTI, M.E., JUURLINK, D.N., KOREN, G., WALKER, M., FINKELSTEIN,<br />

Y., 2009. Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to<br />

anticonvulsant drugs: a meta-analysis. Epilepsia 50: 898–903.<br />

BRANDT, C., BETHMANN, K., GASTENS, A.M., LÖSCHER, W., 2006. The multidrug transporter<br />

hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe<br />

epilepsy. Neurobiol Dis. 24: 202-211.<br />

BRIGGER, I., MORIZET, J., AUBERT, G., CHACUN, H., TERRIER-LACOMBE, M.J., COUVREUR,<br />

P., VASSAL, G., 2002. Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres<br />

display a combined effect for brain tumor targeting. J Pharmacol Exp Ther. 303: 928-936.<br />

BRINKMANN, U., EICHELBAUM, M., 2001. Polymorphisms in the ABC drug transporter gene MDR1.<br />

Pharmacogenomics J. 1: 59-64.<br />

CALABRIA, A.R., WEIDENFELLER, C., JONES, A.R., DEVRIES ,H.E., SHUSTA, E.V., 2006.<br />

Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier<br />

properties in response to glucocorticoid induction. J. Neurochem. 97: 922–933.<br />

CARDOSO, F.L., BRITES, D., BRITO, M.A., 2010. Looking at the blood-brain barrier: molecular<br />

anatomy and possible investigation approaches. Brain Res Rev. 64: 328-363.<br />

CARL, S.M., LINDLEY, D.J., COURAUD, P.O., WEKSLER, B.B., ROMERO, I., MOWERY, S.A.,<br />

KNIPP, G.T., 2010. ABC and SLC transporter expression and pot substrate characterization<br />

across the human CMEC/D3 blood-brain barrier cell line. Mol Pharm. 7: 1057-1068.<br />

CECCHELLI, R., BEREZOWSKI, V., LUNDQUIST, S., CULOT, M., RENFTEL, M., DEHOUCK, M.P.,<br />

FENART, L., 2007. Modelling of the blood–brain barrier in drug discovery and development.<br />

Nat. Rev. Drug Discov. 6: 650–661.<br />

CECCHELLI, R., DEHOUCK, B., DESCAMPS, L., FENART, L., BUÉE-SCHERRER, V., DUHEM, C.,<br />

LUNDQUIST, S., RENTFEL, M., TORPIER, G., DEHOUCK, M.P., 1999. In vitro model for<br />

evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 36: 165-178.<br />

CERVENY, L., PAVEK, P., MALAKOVA, J., STAUD, F., FENDRICH, Z., Lack of interactions between<br />

breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia 47:<br />

461-468.<br />

CHEN, C.J., CHIN, J.E., UEDA, K., CLARK, D.P., PASTAN, I., GOTTESMAN, M.M., RONINSON, I.B.,<br />

1986. Internal duplication and homology with bacterial transport proteins in the mdr1 (Pglycoprotein)<br />

gene from multidrug-resistant human cells. Cell 47: 381–389.<br />

CHEN, J., RAYMOND, K., 2006. Roles of rifampicin in drug-drug interactions: underlying molecular<br />

mechanisms involving the nuclear pregnane X receptor. Ann. Clin. Microbiol. Antimicrob. 5: 3.<br />

CHEN, T., 2010. Overcoming drug resistance by regulating nuclear receptors. Adv. Drug Deliv. Rev.<br />

62: 1257-1264.<br />

CHEN, Y., FERGUSON, S.S., NEGISHI, M., GOLDSTEIN, J.A., 2004. Induction of human CYP2C9 by<br />

rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol<br />

Exp Ther. 308: 495-501.<br />

182

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