Nachweis von Plastizität im cerebro-cerebellären Netzwerk zur ...

SCA4
SCA5
Rare
Rare
SCA6 15%
SCA7 5%
4th - 7th
decade
(19-72)
3rd - 4th
decade
(10-68)
5th - 6th
decade
(19-71)
3rd - 4th
decade
(0.5 - 60)
Decades
68
decreased saccade velocity;
amyotrophy fasciculations,
sensory loss
Sensory axonal
neuropathy, deafness
>25 years Early onset, slow course
>25 years
20 years
(1-45; early
onset correlates
with shorter
duration)
SCA8 2-5% 39 yrs (18-65) Normal lifespan
SCA9
Category not assigned
Sometimes episodic ataxia, very
slow progression
Visual loss with retinopathy
Brisk DTRs and decreased
vibration sense
SCA10 Rare 36 yrs 9 years Occasional seizures
SCA11 Rare 30 yrs (15-70) Normal lifespan Mild, remain ambulatory
SCA12 Rare 33 yrs (8-55)
SCA13 Rare Childhood Unknown
SCA14 Rare 28 yrs (12-42)
Decades
(1-30)
SCA15 Rare Unknown Decades
Early tremor,
late dementia
Mild mental retardation, short
stature
Early axial myoclonus
Pure ataxia, very slow
progression
SCA16 Rare 39 yrs (20-66) 1-40 years Head tremor
SCA17 Rare 6-34 yrs >8 years Mental deterioration
SCA19
SCA20
Rare
Rare
34 years (20-
45)
46 years (19-
64)
Decades
Decades
Cognitive impairment,
myoclonus, tremor
Early dysarthria, dystonia,
dentate calcification
SCA21 Rare 6-30 yrs Decades Mild cognitive impairment
SCA22 Rare 10-46 yrs Decades Slowly progressive ataxia
SCA23
Rare
5th-6th
decade
>10 years
Late-onset ataxia and sensory
loss
SCA25 Rare 1.5-39 yrs Unknown Sensory neuropathy