Leitlinie „Behandlung der Akne“ - AWMF

013/017 - Behandlung der Akne aktueller Stand: 02/2010
korrigierte Fassung: 10/2011
191. Cunliffe WJ, Danby FW, Dunlap F, Gold MH, Gratton D, Greenspan A. Randomised,
controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream
0.05% in patients with acne vulgaris. Eur J Dermatol. 2002; 12: 350-4.
192. Pariser DM, Thiboutot DM, Clark SD, Jones TM, Liu Y, Graeber M. The efficacy and
safety of adapalene gel 0.3% in the treatment of acne vulgaris: A randomized,
multicenter, investigator-blinded, controlled comparison study versus adapalene gel
0.1% and vehicle. Cutis. 2005; 76: 145-51.
193. Wolf JE, Jr., Kaplan D, Kraus SJ, Loven KH, Rist T, Swinyer LJ, Baker MD, Liu YS,
Czernielewski J. Efficacy and tolerability of combined topical treatment of acne
vulgaris with adapalene and clindamycin: a multicenter, randomized, investigatorblinded
study. J Am Acad Dermatol. 2003; 49: S211-7.
194. Zhang JZ, Li LF, Tu YT, Zheng J. A successful maintenance approach in
inflammatory acne with adapalene gel 0.1% after an initial treatment in combination
with clindamycin topical solution 1% or after monotherapy with clindamycin topical
solution 1%. J Dermatolog Treat. 2004; 15: 372-8.
195. Thiboutot DM, Weiss J, Bucko A, Eichenfield L, Jones T, Clark S, Liu Y, Graeber M,
Kang S. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of
acne vulgaris: results of a multicenter, randomized double-blind, controlled study. J
Am Acad Dermatol. 2007; 57: 791-9.
196. Del Rosso JQ. Study results of benzoyl peroxide 5%/clindamycin 1% topical gel,
adapalene 0.1% gel, and use in combination for acne vulgaris. J Drugs Dermatol.
2007; 6: 616-22.
197. Gollnick H, Draelos Z, Glenn MJ. Adapalene-benzoyl peroxide, a unique fixed-dose
combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized,
double-blind, controlled study in 1,670 patients. Br J Dermatol. 2009; 161: 1180-9.
198. Thiboutot D, Gollnick H, Stein-Gold L, Loesche C, Ma YM, Tan J. Adapalene 0.1 %
and benzoyl peroxide 2.5 % demonstrate synergistics efficacy in the fixed-dose
combination gel among 3855 acne vulgaris patients. Br J Dermatol. submitted.
199. Cunliffe WJ, Meynadier J, Alirezai M, George SA, Coutts I, Roseeuw DI, Hachem JP,
Briantais P, Sidou F, Soto P. Is combined oral and topical therapy better than oral
therapy alone in patients with moderate to moderately severe acne vulgaris? A
comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%, versus
lymecycline plus gel vehicle. J Am Acad Dermatol. 2003; 49: S218-26.
200. Thiboutot DM, Shalita AR, Yamauchi PS, Dawson C, Arsonnaud S, Kang S.
Combination therapy with adapalene gel 0.1% and doxycycline for severe acne
vulgaris: a multicenter, investigator-blind, randomized, controlled study. Skinmed.
2005; 4: 138-46.
201. Brand B, Gilbert R, Baker MD, Poncet M, Greenspan A, Georgeian K, Soto P.
Cumulative irritancy potential of adapalene cream 0.1% compared with adapalene gel
0.1% and several tretinoin formulations. Cutis. 2003; 72: 455-8.
202. Dosik JS, Homer K, Arsonnaud S. Cumulative irritation potential of adapalene 0.1%
cream and gel compared with tretinoin microsphere 0.04% and 0.1%. Cutis. 2005; 75:
238-43.
203. Dosik JS, Homer K, Arsonnaud S. Cumulative irritation potential of adapalene 0.1%
cream and gel compared with tazarotene cream 0.05% and 0.1%. Cutis. 2005; 75:
289-93.
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