Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Type of ionising
radiation applied
in irradiated
group
Radiation dose regimen or
reconstructed total body
dose (TBD)
Dunn et al., 1993 TBI 2 Gy daily for 4 days with lung
shielding for 2-4 Gy, or
3 Gy daily for 4 days, with
lungs shielded for the third
dose.
Ozsahin et al., 1992 and
1994
TBI s-TBI: 10 Gy to the midplane
(dose rate 1.8 - 42 cGy/min);
f-TBI: 12 Gy in 6 fractions on
3 consecutive days to the
midplane; randomized to two
instantaneous dose rates in
both s-TBI and f-TBI
Bray et al. 1991 TBI f-TBI: 10.5 Gy as three
fractions of 3.5 Gy over 36
hours, or 12 Gy as six fractions
of 2 Gy over 3 days; midline
tissue dose rate of 0-25
Gy/min.
Van Weel-Sipman et al.,
1990
TB I s-TBI: 7-8 Gy, overall
calculated midline dose-rate of
20 cGy/min. From May
1987shielding of eyes
Livesey et al., 1989 TBI s-TBI: 950 cGy; f-TBI: total
dose 1125 cGy in 5 fractions)
Lens dose (LD) Exposure assessment Outcome assessment
n.a. Medical records Standardized ophthalmic
examination incl. slitlamp
biomicroscopy
n.a. Medical records, in vivo
dosimetry by semiconductor
diodes at five main areas
n.a. Medical records Degree graded by Oxford
Clinical Cataract
Classification and
Grading System
– 122 –
Risk estimates for cataract
Estimated cumulative
incidence (ECI),
or other results of
incidence
Cumulative probability
of remaining
cataract free 5 years
after BMT was 98%
with TBI-no steroids,
77% with steroids-no
TBI, and 74% with
both, and 95% with
neither.
Not stated 4-year ECI in s-TBI
group 53.3% (95% CI,
18% to 89%) in f-TBI
13.4% (95% CI, 0.1%
to 27%) (p=0.26),
Differences between
low and high dose rate
sign. in s-TBI group,
but not in f-TBI group.
Cataract in 63% of
irradiated and 9% in
non-irradiated
patients.
n.a. Medical records n.a. Ocular cataract
developed in all
patients irradiated
without shielding of
the eyes. No numbers
given.
n.a. Medical records Ophthalmic examination Cataracts in 83% of
n=18 s-TBI patients,
none in f-TBI patients
(n=9), one in not
irradiated patients
(n=7).
Comparative
analyses; risk ratio
(RR), or hazard
rate (HR)
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