Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...
Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...
Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...
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Reference:<br />
First author (year)<br />
Type of ionising<br />
radiation applied<br />
in irradiated<br />
group<br />
Radiation dose regimen or<br />
reconstructed total body<br />
dose (TBD)<br />
Dunn et al., 1993 TBI 2 Gy daily for 4 days with lung<br />
shielding for 2-4 Gy, or<br />
3 Gy daily for 4 days, with<br />
lungs shielded for the third<br />
dose.<br />
Ozsahin et al., 1992 and<br />
1994<br />
TBI s-TBI: 10 Gy to the midplane<br />
(dose rate 1.8 - 42 cGy/min);<br />
f-TBI: 12 Gy in 6 fractions on<br />
3 consecutive days to the<br />
midplane; randomized to two<br />
instantaneous dose rates in<br />
both s-TBI and f-TBI<br />
Bray et al. 1991 TBI f-TBI: 10.5 Gy as three<br />
fractions of 3.5 Gy over 36<br />
hours, or 12 Gy as six fractions<br />
of 2 Gy over 3 days; midline<br />
tissue dose rate of 0-25<br />
Gy/min.<br />
Van Weel-Sipman et al.,<br />
1990<br />
TB I s-TBI: 7-8 Gy, overall<br />
calculated midline dose-rate of<br />
20 cGy/min. From May<br />
1987shielding of eyes<br />
Livesey et al., 1989 TBI s-TBI: 950 cGy; f-TBI: total<br />
dose 1125 cGy in 5 fractions)<br />
Lens dose (LD) Exposure assessment Outcome assessment<br />
n.a. Medical records Standardized ophthalmic<br />
examination incl. slitlamp<br />
biomicroscopy<br />
n.a. Medical records, in vivo<br />
dosimetry by semiconductor<br />
diodes at five main areas<br />
n.a. Medical records Degree graded by Oxford<br />
Clinical Cataract<br />
Classification and<br />
Grading System<br />
– 122 –<br />
Risk estimates for cataract<br />
Estimated cumulative<br />
incidence (ECI),<br />
or other results of<br />
incidence<br />
Cumulative probability<br />
of remaining<br />
cataract free 5 years<br />
after BMT was 98%<br />
with TBI-no steroids,<br />
77% with steroids-no<br />
TBI, and 74% with<br />
both, and 95% with<br />
neither.<br />
Not stated 4-year ECI in s-TBI<br />
group 53.3% (95% CI,<br />
18% to 89%) in f-TBI<br />
13.4% (95% CI, 0.1%<br />
to 27%) (p=0.26),<br />
Differences between<br />
low and high dose rate<br />
sign. in s-TBI group,<br />
but not in f-TBI group.<br />
Cataract in 63% of<br />
irradiated and 9% in<br />
non-irradiated<br />
patients.<br />
n.a. Medical records n.a. Ocular cataract<br />
developed in all<br />
patients irradiated<br />
without shielding of<br />
the eyes. No numbers<br />
given.<br />
n.a. Medical records Ophthalmic examination Cataracts in 83% of<br />
n=18 s-TBI patients,<br />
none in f-TBI patients<br />
(n=9), one in not<br />
irradiated patients<br />
(n=7).<br />
Comparative<br />
analyses; risk ratio<br />
(RR), or hazard<br />
rate (HR)<br />
-<br />
-<br />
-<br />
-<br />
-