Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Type of ionising
radiation applied
in irradiated
group
Radiation dose regimen or
reconstructed total body
dose (TBD)
Belkacemi et al., 1998 TBI s-TBI: 10 Gy to midplane/8 Gy
to lungs, or
f-TBI: 12 Gy/9Gy resp., over 3
days;
3 instantaneous dose rate
groups
Belkacemi et al., 1996 TBI s-TBI: 10 Gy or f-TBI: 12 Gy
over 3 days;
3 instantaneous dose rate
groups
Michel et al., 1997 TBI s-TBI: 10 Gy/ with lung
shielding 6-8 Gy to the lungs,
or f-TBI: 11-15 Gy in 5 to 11
fractions
Benyunes et al., 1995 TBI s-TBI: 10 Gy, or
f-TBI: 12 Gy and >12 Gy in 6
or 7 fractions, dose rates of
0.04-0.08 Gy per min.
Tichelli et al., 1993 and
1994
TBI s-TBI: with max. lung dose of
10 Gy at a rate of 7.5 cGy/min.
f-TBI: 6 doses of 2 Gy on 3
consecutive days, dose rate in
most patients 3.5 cGy/min
Calissendorff et al., 1993 TBI 10 Gy except lungs, which
were shielded to receive no
more than 9 Gy
Lens dose (LD) Exposure assessment Outcome assessment
– 121 –
Risk estimates for cataract
Estimated cumulative
incidence (ECI),
or other results of
incidence
n.a. Medical records Ophthalmic examination ECI at 5 years in s-
TBI vs. f-TBI, 29% vs.
9% (p = 0.003); in low
vs. medium, or high
instantaneous dose
rate groups (0% vs.
27% vs. 33%; p <
0.0001).
n.a. Medical records Slit-lamp and/or direct
ophthalmoscopy
ECI at 5 years in s-
TBI vs. f-TBI, 34% vs.
11% (p = 0.004); in
low vs. medium, or
high instantaneous
dose rate groups (3.5%
vs.30% vs. 54%; p <
0.0001).
n.a. Medical records Ophthalmic examination ECI at 6 years 70% ±
13% in the TBI group
and 0% in the nonirradiated
group.
n.a. Medical records Slit-lamp biomicroscopy ECI at 11 years 85%,
50%, 34%, and 19% in
s-TBI, >12 Gy f-TBI,
12 Gy f-TBI, and no
TBI, resp. (p