Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Type of ionising
radiation applied
in irradiated
group
Radiation dose regimen or
reconstructed total body
dose (TBD)
Stem-cell transplantation/Bone Marrow transplantation in cancer treatment
Whelan et al., 2010 Several types of
radiation therapy
Leung et al., 2007
Fahnehjelm et al., 2007
Radiation exposure calculated
per segments of the brain
TBI f-TBI over 4 days: n=59 with
14.4 Gy, n= 64 with 8-12 Gy
TBI s-TBI: 10 Gy (TBD),
f-TBI: 3 Gy/day x 4 days
(TBD)
Lens dose (LD) Exposure assessment Outcome assessment
Radiation dose on the eye
analysed in 7 categories
from 0 to >4000 cGy
– 119 –
Dose calculation for right
and left eye with corrections
made for eye shielding
Questionnaires (selfreported)
Risk estimates for cataract
Estimated cumulative
incidence (ECI),
or other results of
incidence
Cumulative incidence
of cataracts continued
to increase up to 20
years after diagnosis
for those who received
radiation to the eye.
Not available Medical records Ophthalmic examination Cumulative incidence
over all patients:
43.4% (95% CI: 33.0-
53.1), cataracts only in
irradiated patients.
n.a.
(eyes not shielded)
Medical records Slit- lamp biomicroscopy,
lens opacities
scored into grades 1–3
Gurney et al., 2006 TBI Not stated n.a. Medical records Self-reported; questionnaire,
validated in 100
cases
Faraci et al., 2005
Van Kempen-Harteveld et
al., 2000 and 2002
TBI all f-TBI treated over 3 days:
n=25 patients with 330 cGy
daily (990 cGy), and n=17 with
200 cGy twice daily (1200
cGy)
TBI single fraction of 8 Gy, or
2 fractions of 5 or 6 Gy on 2
consecutive days, dose rate 9
Gy/h. (TBI dose and schedules
changed since 1982.)
s-TBI: all patients with
cataracts;
f-TBI: 83% with
cataracts, but f-TBI
shorter follow-up.
ECI at 15 years after
treatment was 36% in
all patients, cataracts
only in irradiated
patients.
n.a. Medical records Slit-lamp examination 78% with PSC,
diagnosed after a
median of 5.7 years
(range: 0.6-12.1
years).
n.a. Medical records Annual ophthalmic
examination with grading
of visual impairment
Overall incidence of
cataract 93%;
probability of cataract
with severe visual
impairment 44%.
Comparative
analyses; risk ratio
(RR), or hazard
rate (HR)
RR=10.8 (95% CI:
6.2-18.9) of cancer
survivors compared
to siblings at ≥ 5
years from
diagnosis.
Increased risk with
higher radiation
dose, younger age
at radiation and
acute GVHD.
s-TBI increased risk
of having cataract
earlier.
RR=270 (p