Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Tabelle 9-4: Studien zu therapeutischer Exposition mit ionisierender Strahlung und der Entstehung von Katarakt, Teil II
Reference:
First author (year)
Type of ionising
radiation applied
in irradiated
group
Radiation dose regimen or
reconstructed total body
dose (TBD)
Treatment of malignant neoplasms of eye and adnexa and of brain
COMS group, 2004 and
2007
I-125 brachytherapy
(IBT)
Kivela et al., 2003 IBT Prescription dose 100 Gy to
the apex of the tumor
Marcus et al., 2001 external beam
irradiation by 6-MV
photon beam
described in detail
Gunduz et al., 1999 Plaque radiotherapy
(I-125, Ru-106, Co-
60, Irid-192
Shields et al., 2006
Plaque radiotherapy
(I-125)
85 Gy to the prescription point LD to center of lens: 12-23
Gy;
dose to foveola: 39-173 Gy
Lens dose (LD) Exposure assessment Outcome assessment
Median dose 98 Gy (55-
126) to apex of tumor,
median dose rate 77
cGy/hour (17-182)
Fractionated 7x2 Gy LD in ionizing chamber:
0.17 Gy, measured with
thermoluminiscent
dosimeter (TLD) 0.13 Gy
Median apex dose 9,120 cGy,
median fovea dose 12,207 cGy
Median apex dose 4,000 cGy
(range 2,982-5,000), median
foveola dose2,831cGy (range
226-22,186cGy)
Median LD: 1,168 cGy
(554-7,326);
lens dose rate 12 cGy/hr
Dose to center of lens: mean
531, median 634, range 142-
2434 cGy
– 116 –
Lens dose calculated locally
and independently by
radiological physics center
Ophthalmic examination
incl. lens status without
grading
Risk estimates for cataract
Estimated cumulative
incidence (ECI),
or other results of
incidence
ECI at 5 years in
studied eyes: 83%
(95% CI:79-87%),
Cataract surgery in
18% if exposed to ≥24
Gy, 4% if 60 with
increased risk.
Medical records Not stated ECI at 5 years: 43%
(standard error 9.9), at
10 and 15 years 51%
(SE 11.3%).
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