Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...
Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...
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Reference:<br />
First author (year)<br />
Van Kempen-<br />
Harteveld et al., 2000<br />
and 2002<br />
Area of<br />
study<br />
Type of study Diagnosis of patients treated<br />
with ionising radiation<br />
Netherlands Cohort study BMT in leukaemia, non-<br />
Hodgkin lymphoma, multiple<br />
myeloma, aplastic anaemia<br />
Aristei et al., 2002 Italy Cohort study Haematological malignancies<br />
Beyzadeoglu et al.,<br />
2002<br />
Turkey Comparative<br />
clinical study<br />
Haematological malignancies<br />
Zierhut et al., 2000 Germany Cohort study Haematological malignancies<br />
(leukaemia, lymphoma,<br />
myeloma)<br />
Frisk et al., 2000 Sweden Comparative<br />
clinical study<br />
Ng et al., 1999 Hong Kong Comparative<br />
clinical study<br />
Belkacemi et al.,<br />
June 1998<br />
Belkacemi et al., Feb.<br />
1998<br />
Belkacemi et al.,<br />
1996<br />
Haematological or lymphoid<br />
malignancy<br />
Acute lymphocytic leukaemia<br />
(ALL)<br />
Europe Cohort study Acute leukaemia patients<br />
(Data of European BMT<br />
registry)<br />
Number<br />
irradiated<br />
patients<br />
Control group definition Number nonirradiated<br />
controls<br />
– 113 –<br />
Recruitment<br />
period<br />
Follow-up<br />
period<br />
n=93 - - 1982-1995 Median: 74<br />
months<br />
(range 23–<br />
161)<br />
n=193 - - 1985-1998 Median in<br />
f-TBI: 7.6,<br />
in s-TBI:<br />
3.0 years<br />
n=46<br />
survivors of<br />
105 treated<br />
n=85<br />
survivors<br />
n=21 treated<br />
with TBI and<br />
chemotherapy<br />
- - 1987-2001 Median: 32<br />
months<br />
- - 1982-1994 Median:<br />
5.8 years<br />
(range1.7-<br />
13)<br />
Same diagnosis,<br />
only conditioned with<br />
chemotherapy<br />
n=6 ALL and other patients,<br />
non-irradiated<br />
n=8 1985-1994 10 years<br />
after BMT<br />
n=23 1991-1995<br />
20.2<br />
months<br />
(range, 3–<br />
54)<br />
n=1,063 - - not stated Median: 74<br />
(12-206)<br />
months in<br />
s-TBI, 49<br />
(12-166)in<br />
f-TBI<br />
Median:<br />
68 months<br />
(range 24-<br />
130)<br />
n=494 - - 1980-1992 Median: 60<br />
months<br />
(range 24-<br />
130)<br />
Europe Cohort study ANLL and ALL patients n=326 - - 1980-1993<br />
France Cohort study Several malignancies<br />
(incl. most of Belkacemi et al.,<br />
1998 in the line above)<br />
Type of ionising radiation<br />
applied in irradiated group<br />
(as given in the paper)<br />
TBI with 8-10 MV linear<br />
accelerator<br />
TBI with Co-60 or an 18 MV<br />
linear accelerator<br />
TBI with Cobalt-60 teletherapy<br />
machine<br />
Photons with an energy of 23<br />
MV from a linear accelerator<br />
TBI<br />
TBI<br />
TBI with Co-60 teletherapy<br />
unit or a 4–25 MV linear<br />
accelerator<br />
s-TBI with a 6-MV linear<br />
accelerator; f-TBI with a<br />
teletherapy unit<br />
1980-1985 with a 6-MV linear<br />
accelerator or Co-60 teletherapy,<br />
since 1985 only Co-60
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