Solubilisierung stark lipophiler Arzneistoffe in lipidhaltige ...

Solubilisierung stark lipophiler Arzneistoffe in lipidhaltige ... Solubilisierung stark lipophiler Arzneistoffe in lipidhaltige ...

23.10.2012 Aufrufe

“I often quote myself, it adds spice to my conversation.” George Bernard Shaw “When you steal from one author, it's plagiarism; if you steal from many, it's research.“ Wilson Mizner (1876-1933)

Literaturverzeichnis 1. Pliška, V., Testa, B. und van de Waterbeemd, H., Lipophilicity in Drug Action and Toxicology, VCH, Weinheim, DE & NY, USA, (1996). 2. Buurma, N. J., Water, a Unique Medium for Organic Reactions, Diss., University of Groningen, Neth., (2003). 3. Bauer, K. H., Froemming, K.-H., Fuehrer, C., Graf, E., Leuenberger, H., Merkle, H. P., Mielck, J. B. und Schilcher, H., Lehrbuch der Pharmazeutischen Technologie, (6. Auflage), Wiss. Verl.-Ges. mbH (WVG), Stuttgart, DE, (1999), S. 209. 4. Pfeifer, S., Pflegel, P. und Borchert, H.-H., Biopharmazie, (3. Auflage), Ullstein/Mosby GmbH & Co. KG, Berlin/Wiesbaden, DE, (1995), S. 47. 5. Wils, P., Warnery, A., Phung-Ba, V., Legrain, S., und Scherman, D., High lipophilicity decreases drug transport across intestinal epithelial cells, J. Pharmacol. Exp. Ther. 269 (1994) 654-658. 6. Bretschneider, B., Charakterisierung und Beeinflussung des intestinalen Cephalosporintransportes, Diss., Martin-Luther-Universität Halle-Wittenberg, DE, (1999). 7. Gibaldi, M. und Feldman, S., Mechanisms of surfactant effects on drug absorption, J. Pharm. Sci. 59 (1970) 579-589. 8. Hammad, M. A., Solubility and stability of drugs in mixed micelles, Diss., Christian-Albrecht- Universität Kiel, DE, (1998). 9. Swarbrick, J., Solubilized systems in pharmacy, J. Pharm. Sci. 54 (1965) 1229-1237. 10. Borrego, E., Sicilia, D., Rubio, S., und Pérez-Bendito, D., Determination of drugs based on the formation of mixed aggregates with surfactants, Analytica Chimica Acta 362 (1998) 285-297. 11. Shao, Z. und Mitra, A. K., Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport, Pharm. Res. 9 (1992) 1184-1189. 12. Park, G. B., Shao, Z., und Mitra, A. K., Acyclovir permeation enhancement across intestinal and nasal mucosae by bile salt-acylcarnitine mixed micelles, Pharm. Res. 9 (1992) 1262-1267. 13. Gershanik, T. und Benita, S., Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs, Eur. J. Pharm. Biopharm. 50 (2000) 179-188. 14. Son, K., Detergent and Phospholipid mixed micelles as proliposomes for an intraveneous delivery of water-insolubale drugs, Diss., University of Illinois at Chicago, Health Sciences Center, USA, (1991). 15. Pace, S. N., Pace, G. W., Parikh, I., und Mishra, A. K., Novel injectable formulations of insoluble drugs, Pharmaceutical Technology 23 (1999) 116-135. 16. Bader, S., Guarneri, M., Fini, A., Fazio, G., und Rabasco, A. M., Cosmetic applications of lecithin/bile salt mixed micelles, Cosmet. Toiletries 108 (1993) 63-68. 17. Small, D. M., Size and structure of bile salt micelles. Influence of structure, counterion, pH, and temperature., Adv. Chem. Ser. 84 (1968) 31-52. 18. Shankland, W., The equilibrium and structure of lecithin-cholate mixed micelles, Chem. Phys. Lipids 4 (1970) 109-130. 19. Mazer, N. A., Benedek, G. B., und Carey, M. C., Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions, Biochemistry 19 (1980) 601-615. 20. Ulmius, J., Lindblom, G., Wennerstrom, H., Johansson, L. B., Fontell, K., Soderman, O., und Arvidson, G., Molecular organization in the liquid-crystalline phases of lecithin- sodium cholate- water systems studied by nuclear magnetic resonance, Biochemistry 21 (1982) 1553-1560. 21. Nichols, J. W. und Ozarowski, J., Sizing of lecithin-bile salt mixed micelles by size-exclusion highperformance liquid chromatography, Biochemistry 29 (1990) 4600-4606. cix

Literaturverzeichnis<br />

1. Pliška, V., Testa, B. und van de Waterbeemd, H., Lipophilicity <strong>in</strong> Drug Action and Toxicology,<br />

VCH, We<strong>in</strong>heim, DE & NY, USA, (1996).<br />

2. Buurma, N. J., Water, a Unique Medium for Organic Reactions, Diss., University of Gron<strong>in</strong>gen,<br />

Neth., (2003).<br />

3. Bauer, K. H., Froemm<strong>in</strong>g, K.-H., Fuehrer, C., Graf, E., Leuenberger, H., Merkle, H. P., Mielck, J.<br />

B. und Schilcher, H., Lehrbuch der Pharmazeutischen Technologie, (6. Auflage), Wiss. Verl.-Ges.<br />

mbH (WVG), Stuttgart, DE, (1999), S. 209.<br />

4. Pfeifer, S., Pflegel, P. und Borchert, H.-H., Biopharmazie, (3. Auflage), Ullste<strong>in</strong>/Mosby GmbH &<br />

Co. KG, Berl<strong>in</strong>/Wiesbaden, DE, (1995), S. 47.<br />

5. Wils, P., Warnery, A., Phung-Ba, V., Legra<strong>in</strong>, S., und Scherman, D., High lipophilicity decreases<br />

drug transport across <strong>in</strong>test<strong>in</strong>al epithelial cells, J. Pharmacol. Exp. Ther. 269 (1994) 654-658.<br />

6. Bretschneider, B., Charakterisierung und Bee<strong>in</strong>flussung des <strong>in</strong>test<strong>in</strong>alen Cephalospor<strong>in</strong>transportes,<br />

Diss., Mart<strong>in</strong>-Luther-Universität Halle-Wittenberg, DE, (1999).<br />

7. Gibaldi, M. und Feldman, S., Mechanisms of surfactant effects on drug absorption, J. Pharm. Sci.<br />

59 (1970) 579-589.<br />

8. Hammad, M. A., Solubility and stability of drugs <strong>in</strong> mixed micelles, Diss., Christian-Albrecht-<br />

Universität Kiel, DE, (1998).<br />

9. Swarbrick, J., Solubilized systems <strong>in</strong> pharmacy, J. Pharm. Sci. 54 (1965) 1229-1237.<br />

10. Borrego, E., Sicilia, D., Rubio, S., und Pérez-Bendito, D., Determ<strong>in</strong>ation of drugs based on the<br />

formation of mixed aggregates with surfactants, Analytica Chimica Acta 362 (1998) 285-297.<br />

11. Shao, Z. und Mitra, A. K., Nasal membrane and <strong>in</strong>tracellular prote<strong>in</strong> and enzyme release by bile<br />

salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport, Pharm. Res.<br />

9 (1992) 1184-1189.<br />

12. Park, G. B., Shao, Z., und Mitra, A. K., Acyclovir permeation enhancement across <strong>in</strong>test<strong>in</strong>al and<br />

nasal mucosae by bile salt-acylcarnit<strong>in</strong>e mixed micelles, Pharm. Res. 9 (1992) 1262-1267.<br />

13. Gershanik, T. und Benita, S., Self-dispers<strong>in</strong>g lipid formulations for improv<strong>in</strong>g oral absorption of<br />

lipophilic drugs, Eur. J. Pharm. Biopharm. 50 (2000) 179-188.<br />

14. Son, K., Detergent and Phospholipid mixed micelles as proliposomes for an <strong>in</strong>traveneous<br />

delivery of water-<strong>in</strong>solubale drugs, Diss., University of Ill<strong>in</strong>ois at Chicago, Health Sciences<br />

Center, USA, (1991).<br />

15. Pace, S. N., Pace, G. W., Parikh, I., und Mishra, A. K., Novel <strong>in</strong>jectable formulations of <strong>in</strong>soluble<br />

drugs, Pharmaceutical Technology 23 (1999) 116-135.<br />

16. Bader, S., Guarneri, M., F<strong>in</strong>i, A., Fazio, G., und Rabasco, A. M., Cosmetic applications of<br />

lecith<strong>in</strong>/bile salt mixed micelles, Cosmet. Toiletries 108 (1993) 63-68.<br />

17. Small, D. M., Size and structure of bile salt micelles. Influence of structure, counterion, pH, and<br />

temperature., Adv. Chem. Ser. 84 (1968) 31-52.<br />

18. Shankland, W., The equilibrium and structure of lecith<strong>in</strong>-cholate mixed micelles, Chem. Phys.<br />

Lipids 4 (1970) 109-130.<br />

19. Mazer, N. A., Benedek, G. B., und Carey, M. C., Quasielastic light-scatter<strong>in</strong>g studies of aqueous<br />

biliary lipid systems. Mixed micelle formation <strong>in</strong> bile salt-lecith<strong>in</strong> solutions, Biochemistry 19<br />

(1980) 601-615.<br />

20. Ulmius, J., L<strong>in</strong>dblom, G., Wennerstrom, H., Johansson, L. B., Fontell, K., Soderman, O., und<br />

Arvidson, G., Molecular organization <strong>in</strong> the liquid-crystall<strong>in</strong>e phases of lecith<strong>in</strong>- sodium cholate-<br />

water systems studied by nuclear magnetic resonance, Biochemistry 21 (1982) 1553-1560.<br />

21. Nichols, J. W. und Ozarowski, J., Siz<strong>in</strong>g of lecith<strong>in</strong>-bile salt mixed micelles by size-exclusion highperformance<br />

liquid chromatography, Biochemistry 29 (1990) 4600-4606.<br />

cix

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