Solubilisierung stark lipophiler Arzneistoffe in lipidhaltige ...

Anhang
Bestimmung der Vesikelgröße des für das Kaninchenmodell entwickelten liposomalen
Systems: Messgerätsausdruck
M A L V E R N A N A L Y S I S R E P O R T
----------------------------------------------------------------------------
Calculated from Data from accumulation file
Temperature 20.5 Viscosity 0.9910 Refractive Index (Liquid) 1.000 Angle 90.0
Particle Refractive Index (real) 0,000 (imag) %0.331E+%9
Count rate 81,8 (1000’s /sec)
% 50
20
10
5
2
DISTRIBUTION OF NUMBER
+ + + + + + + + + + + +
+ + + + + + + + + + + +
+ + + + + + + + + + + +
+ + + + + + + + + + + +
+ + + + + + + + + + + +
1 2 5 10 20 50 100 200 500 1000 5000
PARTICLE SIZE DISTRIBUTION (nm) {log gra}
z Avarage Mean Poly 0.637
PARTICLE SIZE DISTRIBUITION (nm)
DISTRIBUTION OF NUMBER
Class : amount % below Class : amount % below
20.6 – 25.7 0.0 : 0.0 291.1 – 363.0 0.0 : 99.9
25.7 – 32.0 0.0 : 0.0 363.0 – 452.6 0.0 : 99.9
32.0 – 39.9 0.0 : 0.0 452.6 – 564.5 0.0 : 99.9
39.9 – 49.8 0.0 : 0.0 564.5 – 703.9 0.0 : 99.9
49.8 – 62.1 0.0 : 0.0 703.9 – 877.8 0.0 : 99.9
62.1 – 77.4 0.0 : 0.0 877.8 – 1094.6 0.0 : 99.9
77.4 – 96.5 71.9 : 0.0 1094.6 – 1365.0 0.0 : 99.9
96.5 – 120.4 28.0 : 71.9 1365.0 – 1702.2 0.0 : 99.9
120.4 – 150.1 0.0 : 99.9 1702.2 – 2122.7 0.0 : 100.0
150.1 – 187.2 0.0 : 99.9 2122.7 – 2647.1 0.0 : 100.0
187.2 – 233.4 0.0 : 99.9 2647.1 – 3301.0 0.0 : 100.0
233.4 – 291.1 0.0 : 99.9 3301.0 – 4116.4 0.0 : 100.0
Dist. Mean 93.9 St.Dev. 51.0
Analysis Range 200 Fit 2.65E-02 Channels 18 Spacing 1.20
Peaks : 92.4 [99.9] fwhm 429.8 [ 0.0] fwhm 114.2 1665.7
107