Bekanntmachung 910 "Bekanntmachung zu Risikowerten und ...

Bekanntmachung 910 - Seite - 97 -
after spontaneous occurrence (Reynolds et al., 1984; Stromberg et al., 1985). So far,
there is no evidence for a viral etiology..
A considerable number of genotoxic and non-genotoxic chemicals was associated
with an increased incidence of this tumor.
Examples are:
NTP bioassay program non-NTP studies
- 2-Amino-5-nitrothiazol - Ethylene Oxide
- 3,3’-Dimethoxy-benzidine4.4-diisocyanate
- Arocolor 1254
- 2.4.6.-TCP
- Phenol
- Sulfisoxazole
- Pyridine
- Piperonylbutoxide
- Lasiocarpine
- Dimethylmorpholinophosphoramidate
- Diazinone
- Ally(l)thiocyanate
- Ally(l)isovalerate
- Diallylphthalate - Ethylene Glycol (males)
- Butylbenzylphthalate - DINP
- (DEHP) - Sanitizer 900
This shows that many compounds associated with increased LGL leukemia were
non-genotoxic.
Other compounds have shown reduced LGL leukemia incidence, e.g.:
NTP bioassay program:
- 1.1-Aminoundecanoic acid
- 2-Biphenylamine
- CI-Disperse yellow
- CI-Solvent yellow
- CI-Acid orange
- D & C red 9
- Propylgallate
- Monuron
- Ethoxyethanol
A review in 1983 described correlations between decreased incidence of leukemia
and elevated incidence of liver tumor (Haseman, 1983). Over the past decades, there
is a general trend for an increase in leukemias rates among male F344 rats in
NCI/NTP studies. This is possibly related to the higher body weights in more recent
studies (Haseman et al., 1989).
Conclusion:
LGL leukemia is a typical and frequent tumor in ageing Fischer rats. The etiology so
far is unknown. Many compounds that were associated with an increased occurrence
of LCL cells leukemia did not show genotoxicity. Quite frequently, it was the only increased
tumor incidence that was observed in the course of a 2-year bioassay, either
- Ausschuss für Gefahrstoffe - AGS-Geschäftsführung - BAuA - www.baua.de -