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Colons epiteliale tumorer - Gastro.patologi.org

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Familiær Adenomatøs Polypose<br />

• Autosomal dominant<br />

(FAP)<br />

• Germline mutation i APC genet på kromosom 5q21<br />

– Tab af normal APC funktion → øget celleproliferation og nedsat<br />

celleadhæsion<br />

• Mellem 30 og 50% af FAP tilfælde er solitære og<br />

skyldes nye mutationer<br />

• Incidens<br />

– DK: 1-2/10 6<br />

• Prævalens<br />

– DK: 25/10 6<br />

• Udgør

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