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Colons epiteliale tumorer - Gastro.patologi.org

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Sessil serrat læsion (SSL (SSP/SSA) )<br />

• Klinik<br />

– Hyppigst lokaliseret i højre colonhalvdel<br />

– Hyppigere hos kvinder<br />

– Større (over 5 mm)<br />

– Repræsenterer ”serrated pathway” til MSI-H<br />

KRC?<br />

– Epigenetisk mekanisme<br />

• Methylering af promotorregionen i hMLH1 (CpG<br />

island methylator phenotype – CIMP)

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