5 Postoperativ strålebehandling - DBCG
5 Postoperativ strålebehandling - DBCG
5 Postoperativ strålebehandling - DBCG
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<strong>DBCG</strong>-retningslinier 2009<br />
5.1.8.1 <strong>DBCG</strong>´s anbefalinger for adjuverende <strong>strålebehandling</strong><br />
Lumpektomi<br />
• Alle patienter uanset alder.<br />
• Indikationen for boost afhænger af alder og resektionsmargen. Således gives<br />
boost, hvis resektionsmargen er ≤ 5 mm og/eller alder < 50 år.<br />
• Omfanget af target afhænger derudover af radikaliteten af det kirurgiske indgreb i<br />
aksillen, lymfeknudestatus og sidelokalisation (venstre eller højre).<br />
Mastektomi<br />
• Alle patienter < 75 år med T > 50 mm og/eller positive lymfeknuder i aksillen (> 2<br />
mm).<br />
• Omfanget af target afhænger af radikaliteten af det kirurgiske indgreb i aksillen og<br />
sidelokalisation (venstre eller højre).<br />
• Alle patienter uanset alder med invasivt karcinom i profunde resektionsflade.<br />
• Højrisikopatienter ≥ 75 vurderes individuelt mht. forventet effekt og co-morbiditet.<br />
Referencer:<br />
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Eur J Cancer 2001; 37 Suppl 7: S33-43. Review.<br />
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survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet<br />
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3. Morris AD, Morris RD, Wilson JF et al. Breast-conserving therapy vs mastectomy in early-stage<br />
breast cancer: a meta-analysis of 10-year survival. Cancer J Sci Am 1997; 3: 6-12.<br />
4. Consensus statement: treatment of early-stage breast cancer. National Institutes of Health Consensus<br />
Development Panel. J Natl Cancer Inst Monogr 1992:1-5.<br />
5. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences<br />
in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an<br />
overview of the randomised trails. Lancet 2005, 366: 2087-106.<br />
6. Paszat LF, Mackillop WJ, Groome PA et al. Mortality from myocardial infarction following postlumpectomy<br />
radiotherapy for breast cancer: a population-based study in Ontario, Canada. Int J Radiat<br />
Oncol Biol Phys 1999; 43: 755-62.<br />
7. START Trialists' Group, Bentzen SM, Agrawal RK, Aird EG et al. The UK Standardisation of Breast<br />
Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer:<br />
a randomised trial. Lancet 2008; 371: 1098-107.<br />
8. Whelan T, MacKenzie R, Julian J et al. Randomized trial of breast irradiation schedules after lumpectomy<br />
for women with lymph node-negative breast cancer. J Natl Cancer Inst 2002; 94: 1143-50.<br />
9. Romestaing P, Lehingue Y, Carrie C et al. Role of a 10-Gy boost in the conservative treatment of<br />
early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol 1997; 15:<br />
963-8.<br />
10. Bartelink H, Horiot JC, Poortmans P et al. Recurrence rates after treatment of breast cancer with<br />
standard radiotherapy with or without additional radiation. N Engl J Med 2001; 345: 1378-87.<br />
11. Bartelink H, Horiot JC, Poortmans P et al. Impact of a Higher Radiation Dose on Local Control and<br />
Survival in Breast-Conserving Therapy of Early Breast Cancer: 10-Year Results of the Randomized<br />
Boost Versus No Boost EORTC 22881-10882 Trial. J Clin Oncol 2007; 25: 3259-65.<br />
12. Vinh-Hung V, Verschraegen C. Breast-conserving surgery with or without radiotherapy: pooledanalysis<br />
for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst 2004; 96:<br />
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13. Liljegren G, Holmberg L, Adami HO et al. Sector Resection With or Without <strong>Postoperativ</strong>e Radiotherapy<br />
for Stage I Breast Cancer: Five-Year Results of a Randomized Trial. J Natl Cancer Inst 1994;<br />
86(9): 717-22.<br />
14. Livi L, Paiar F, Meldolesi E et al. The management of elderly patients with T1-T2 breast cancer<br />
treated with or without radiotherapy. Eur J Surg Oncol 2005; 31(5): 473-8.<br />
15. Fisher B, Bryant J, Dignam JJ et al. Tamoxifen, Radiation Therapy, or Both for Prevention of Ipsilateral<br />
Breast Tumor Recurrence After Lump-ectomy in Women With Invasive Breast Cancers of One<br />
Centimeter or Less. J Clin Oncol 2002; 20(20): 4141-9.<br />
16. Smith BD, Gross CP, Smith GL et al Effectiveness of Radiation Therapy for Older Women With<br />
Early Breast Cancer. J Natl Cancer Inst 2006; 98(10): 681-90.<br />
14-05-2009 5-10